• Journal of Chest Surgery
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• v.31 no.11
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• pp.1102-1105
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• 1998

Chronic granulomatous disease in childhood is a rare inheritable disorder of phagocytic cells in which defective production of the reactive intermediates of oxygen predisposes the patient to severe recuring pyogenic infections. The lung is the most common site of infection and pulmonary disease is the primary cause of death for greater than 50% of children with chronic granulomatous disease. Although the role of surgery in management of this disease remains undefined, rapid diagnosis of the underlying pulmonary problem is crucial to determine the most appropriate antimicrobial therapy and surgical techniques such as lobectomy of involved areas lead to more rapid recovery and thus allow the antibiotics to be more efficacious in these cases. We have treated a one month old male baby who had the chronic granulomatous disease with pulmonary infection. Wide surgical resection of the affected lobe and use of antibiotics and antifungals were carried out with good clinical results. He was well after the operation.

• Journal of Environmental Health Sciences
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• v.44 no.5
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• pp.468-479
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• 2018

Objectives: Recently, a report was published that the humidifier disinfectant CMIT/MIT did not cause developmental toxicity and was not detected in systemic circulation as a result of an inhalation toxicity test. Therefore, this study was carried out to investigate any associations between CMIT/MIT exposure and developmental toxicity using the in vivo apical toxicity test method. Methods: Groups of pregnant ICR mice were instilled in the trachea with chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a visual instillobot over a period of seven days from days 11 to 17 days post-coitum. For the in vivo apical toxicity test method, an $LD_{50}$-based dose-range finding model was applied to decide the dose range for inducing developmental toxicity. Results: Among the groups of 0, 0.1, 0.5, 1.0, and 1.5 mg ai/kg/day CMIT/MIT, the exposure groups of 0.5 mg and 1.0 ai/kg/day CMIT/MIT were estimated to reflect the thresholds for the stillbirth and death of pregnant mice, respectively. The groups of 0.5, 1.0, and 1.5 mg ai/kg/day CMIT/MIT induced stillbirth rates of 2.57, 10, and 53.8%, respectively. Another exposure group of 0.75 mg ai/kg/day CMIT/MIT did not induce any deaths of pregnant mice and resulted in a stillbirth rate of 8% in only one of six pregnant mice. Conclusions: CMIT/MIT can induce stillbirth in pregnant mice. It was also concluded that CMIT/MIT moves through the pulmonary circulation system and then continues on through systemic circulation and the placenta. There is a possibility of stillbirth and other health causalities in humans beyond the lungs caused by CMIT/MIT exposure.

• Journal of Chest Surgery
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• v.30 no.3
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• pp.330-335
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• 1997

Aspergillus Infection is a major.cause of mortality in individuals with depressed cell-mediated immunity. Despite therapy with intravenous amphotericin B and oral antifungal agents, high mortality has been reported among heart transplant recipients. We experienced two cases of pulmonary aspergillosis among 15 heart transplantation cases. Both cases were similiar in terms of age, time of diagnosis, and medication. Percutaneous needle aspiration biopsy revealed Aspergillus fumigatus in both cases. The thirst case showed multiple aspergilloma on both lung fields and were treated by IV Amphotericin B and oral itraconazole. After completion of treatment, the lesion completely disappeared and he has been followed up for more than one year in his good condition. The second case showed a single nodule on his right lower lung field and were treated by both medication and surgery. The patient recovered well and had been doing well until 4th postoperative month when he developed humoral rejection and expired.

• Journal of The Korean Society of Grassland and Forage Science
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• v.15 no.4
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• pp.245-252
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• 1995

To select a carrier as Rhizobiwn inoculants for alfalfa, severeal Rhizobium inoculants were produced by adding or not sub-materials($CaCO_3$ and sucrose) to main materials(organic or inorganic materials). The root nodule bacteria, Rhizobium meliloti 1061 distributed from KAIST, and Vemal alfalfa was used in this experiment. The Rhizobium populations and inoculation effects of the Rhizobium inoculants produced in several materials were scrutinized at laboratory and greenhouse in Livestock Experiment Station, RDA from 1993 to 1994. Moisture contents of the caniers were varied from 32 to 50% on dry weight basis according to material characteristics and the pH ranges of these were varied from pH 4.56 to 10.06 according to raw material characteristics and preparations. Initial Rhizobium numbers of the carriers were higher in organic material-inoculants than in inorganic, and among the inoculants, the inoculant made of Bentonite+Vermiculite(l:3 w/w) was excellent because of high rhizobium population($7.8~8.3\times10^8/g$ inoculant) and high rhizobium reappearance of inoculant in severed different production time. The root nodules of the alfalfa inoculated with different inoculants were fast formed in the fermented sawdust with cattle dung (FSC) inoculant, and bentonite(B)+vermiculite(V) than others. Plant length of alfalfa was differentiated on 15 days after inoculation but was not nearly different between higher inoculants than rhizobium number $10^7/g$ inoculant. Total dry matter of alfalfa was yielded by 20.65, 20.34mg per pot in FSC + sucrose 0.5% and B + V + sucrose 1% inoculants respectively that were higher inoculation effect by 17 times compared with non-inoculation, 1.2 mg per pot.

• Journal of The Korean Society of Grassland and Forage Science
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• v.15 no.4
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• pp.253-258
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• 1995

'Ihis experiment was carried out to select a carrier as rhizobium inoculant for alfalfa. The Rhizobium inoculants were produced in main materials(organic and inorganic materials) and submaterial(Ca$CO_3$, and sucrose), and than the changes of Rhizobium population of inoculants were scrutinized from directly after the production to 12 months at $4^{\circ}$C and $25^{\circ}$C. Directly after the production of inoculants, their Rhizobium numbers were 4-9 $\times$ $10^9$/ginoculant in organic materials and 1-8 $\times$ $10^8$/g inoculant in inorganic materials. When they were stored at $25^{\circ}$C, most of inoculants was being started in reduction of rhizobium numbers after 2 months and was reduced by tenfold of initial rhizobium number after 4-6 months, but inoculant of bentonite+ vermiculite+sucrose 1% was not reduced by tenfold after 12 months. When they were stored at $4^{\circ}$C, most of inoculants was being started in reduction of rhizobium numbers after 4 months but was not reduced by tenfold of initial rhizobium number after 12 months, and the effect of sucrose addition to bentonite+ vermiculik did nearly not appear. Preservation of Rhizobium inoculants was more effective at 4C than 25 C . 'Ihe Rhizobium inoalant produced in bentonite+vermiculite(l:3 w/w)+ sucrose 1% was not only high Rhizobium population(8.3 $\times$ $10^8$/g inoculant) but also survival effect of rhizobium in being stored at $25^{\circ}$C.

• Applied Biological Chemistry
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• v.41 no.3
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• pp.208-212
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• 1998

In order to develop an effective antifungal antibiotics, over 700 isolates of bacteria, mold and actinomytes were screened from soil, and LAM 97-44 were selected as a strain producing the strong antifungal antibiotics against Candida albicans. Morphological, cultural and physiological characteristics of LAM 97-44 were investigated for the indentification. The cell size of LAM 97-44 was $2{\sim}3{\times}1{\sim}1.5\;{\mu}m$, and the shape of spore was of ellipsoidal. As a carbon source, LAM 97-44 utilized fructose, glucose, glycerol, maltose and raffinose but did not utilize arabinose, cellulose and xylose. The fatty acids of the cells included various iso-type and anteiso-type. Conclusively, the strain LAM 97-44 was proved to be Bacillus subtilis.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.5 no.1
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• pp.36-40
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• 2012

Although surgical drainage has been performed in most reported cases of psoas abscess, ultrasonographically guided percutaneous drainage could be effective treatment for psoas abscess. However, utility of percutaneous drainge under ultrasound is less well established. We present a patient in whom fungal psoas abscess was managed by ultrasonographically guided percutaneous aspiration with literature review. Drainage was done by needle aspiration under ultrasound guidance and there was no procedural complication. After aspiration, Candida Albicans was found as a causing organism responsible for abscess and abscess could be successfully treated by repeated aspiration and appropriate antifungal therapy.

• KSBB Journal
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• v.24 no.1
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• pp.65-69
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• 2009

The biological production of a potent anticancer agent, epothilone, by Sorangium cellulosum was carried out using flask and fermentor cultures. Soluble starch was selected as the main carbon source and the concentrations of lactose and yeast extract were optimized at 4 and 0 g/L, respectively, when using the flask cultures. In the fermentor cultures, the cells were cultivated at a high DO level of more than 80% of air saturation in the growth stage and then the DO level was controlled at about 50, 20 or 1-2% when the carbon source was exhausted. The epothilone production increased with decreasing DO level after the exhaustion of the carbon source, and the maximum concentration of epothilone was 5.4 mg/L. It was found that the DO level had significant regulation effects on the epothilone production.

• Tuberculosis and Respiratory Diseases
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• v.51 no.1
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• pp.70-75
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• 2001

Aspergillosis refers to an infection with any species from the genus Aspergillus. Pleural aspergillosis is an uncommon disease with less than 30 cases having been reported in the literature since 1958. The etiologic factors for this aspergillosis are preexisting pulmonary tuberculosis, bronchopleural fistula, pleural drainage, and a lung resection. Surgical removal of the aspergillus-infected pleura is the main treatment for managing this disease. We have experienced two cases of pleural aspergillosis as a complication of a preexisting chronic empyema. The chest radiographs showed a pyopneumothorax with cavitation and the chest computed tomographic scans revealed a loculated pyopneumothorax with cavity formation suggesting a bronchopleural fistula. A grossly purulent fluid was extracted by thoracentesis, and Aspergillus fumigatus was grown from a fungus culture of the fluid. A decortication, wedge resection with a pleurectomy and a pleuropneumonectomy were performed. The postoperative course was satisfactory and the patients have been in good condition up to now. Pleural aspergillosis is a very rare and potentially life-threatening disease. However, good result without significant complication were obtained by treatment with systemic antifungal agents and surgical removal.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1643-1646
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• 2003

Drawing is a mechanical operation that attenuates thick material to an appropriate thickness for the next processing or end usage. When the input material has the form of a bundle or bundles made of very thin and long shaped wire or fibers, this attenuation operation is called "bundle drawing" or "drafting" Drafting is being used widely in manufacturing staple yarns. which is indispensable for the textile industry. However, the bundle processed by this operation undertake more or less defects in the evenness of linear density. Such irregularities cause many problems not only for the product quality but also for the efficiency of the next successive processes. Since long there have been many researches tying to find out factors affecting the irregularity of linear desity, to obtain optimal drafting conditions, to develop efficient measuring and analysis methods of linear density of bundle, etc., but there exists yet no fundamental equation describing the dynamic behavior of the flowing bundle during processing. In this research a mathematical model for the dynamic behavior of the bundle fluid is to be set up on the basis of general physical lows representing physical variables, i.e. linear density and velocity as the dynamic state of bundle. The conservation of mass and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. On the basis of the simplified model, the simulation was performed and the results could be confirmed by the experiments under various conditions.