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Effects of n-Hexane Fraction of Angelica acutiloba on Antioxidative System and Lipid peroxidation in Ethanol-Induced Hepatotoxicity of rats (일당귀 n-hexane분획이 에탄올을 투여한 흰쥐의 항산화계 및 지질과산화에 미치는 영향)

  • Choo Myung-Hi;Choi Hyun-Suk;Seo Young-Nam;Lee Myung-Yul
    • Food Science and Preservation
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    • v.11 no.3
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    • pp.364-372
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    • 2004
  • To investigate antioxidative effects of n-hexane fraction of Angelica acutiloba on the ethanol-induced hepatotoxicity of rats, Sprague-Dawley rats weighing 100 $\pm$ 20 g were divided into 5 groups; normal group(NOR), ethanol(10 mL/kg, 35$\%$) treated group(CON), n-hexane fraction of Angelica acutiloba 70 mg/kg treated group(Al), n-hexane fraction of Angelica acutiloba 70 mg/kg and ethanol treated group(A2) and n-hexane fraction of Angelica acutiloba 140 mg/kg and ethanol treated group(A3), respectively. The antioxidative activities of ethanol extract of Angelica acutiloba in vitro were decreased in order of n-hexane > ethylacetate > chlorofonn > n-butanol (>) water fraction. The growth rate and feed efficiency rate decreased by ethanol were gradually increased to the adjacent level of the normal group by administering n-hexane fraction of Angelica acutiloba. It was also observed that the activities of SOD of liver, ALT and AST of serum increased by ethanol were markedly decreased in n-hexane fraction of Angelica acutiloba administered group, and not in activites of XO, catalase, as compared with the control group. The depleted content of GSH by ethanol was increased adjacent to normal level by administering n-hexane fraction of Angelica acutiloba. as a dose-dependent manner. These results suggested that n-hexane fraction of Angelica acutiloba has a possible protective effect on the ethanol-induced hepatotoxicity of rats.

Correlation of the External Otic Diseases and the Ear Canal Length in Dogs (개에서 외이도의 길이와 외이도 질환과의 연관성)

  • 엄기동;윤정회
    • Journal of Veterinary Clinics
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    • v.15 no.2
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    • pp.263-266
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    • 1998
  • 외이도의 직경 및 길이와 외이도 질환과의 연관성을 알아보고자 73두 성견을 실 험에 이웅하였다. 임상중상, 배양 및 도말 검사를 통하여 외이 질환이 얼는 정상군 57개의 이 관과, 질환이 있는 비정상군 89개의 이관에 직경과 길이를 평가하기 위한 간접적인 방법으로 이관내 조영술을 실시하였다. 비정상군은 정상군에 비하여 윤상연골 및 귓바퀴 연골의 직경 이 더 넓었다. 수직외이도를 구성하는 귓바퀴 연골의 길이는 비정상군4(12.79{\pm} 3.08)이 정상 군(12.79{\pm}5.87 mm)$에서 보다 유의성 있게 길게 나타났다(p<0.001). 심한 외이도 협착증을 보이는 21개의 귀에서는 외이도 질환을 발견할 수 없었으며, 외이도 질환이 심한 귀에 있어 서 그 직경과 길이가 정상군에 비하여 넝고 길게 나타났다(p<0.05). 본 실험의 결과로 보아 외이도관의 협착증과 외이도 질환과는 연관성이 발견되지 않았으나, 환기와 귀내 분비물의 배출을 방해하는 긴 수직외이도를 갖는 귀가 외이도 질환과 밀접한 관계가 있는 것으로 생각 되었다.

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A Study on the Changes in Gwi-po from Tang to Jin Dynasty in China - Focusing on the connection type of Jwau-dae(左右隊) - (중국 당대~금대 목조 건축의 귀포 변천에 관한 연구 - 좌우대의 결구 유형을 중심으로 -)

  • Lee, Byung-Chun;Lee, Ho-Yeol
    • Korean Journal of Heritage: History & Science
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    • v.48 no.3
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    • pp.96-119
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    • 2015
  • This research has studied the changes of Gwi-po(轉角包) by taking the cases of China's medieval wooden buildings as objects. The purpose of the study is to examine the time-periodic transition process of Gwi-po through the cases of 71 wooden buildings which were built from Tang(唐) dynasty(AD 618~690 & 705~907) until Jin(金) dynasty(AD 1115~1234) and also designated as 'Major Historical and Cultural Sites Protected at the National Level'. This research has taken note of various frame types of Jwau-dae(左右隊), which are architectural components of Gwi-po, to study the changes and development process of Gwi-po. The results are as follows. An important factor in the transformations of Gwi-po format is the changes in perception of the craftsmen about Jwau-dae, who took charge in the building process. In the early periods, the principles of Yidou sanshen dougong(一斗三升) in constructing ancons of Gwi-po had been well-maintained, while there appeared many different types of Gwi-po in later periods, due to the usage of Jwau-dae and $Shu{\check{a}}$ $t{\acute{o}}u$(?頭) in each Chulmok of Gwi-po. Transitional types of Gwi-po, which were evolved from the earlier ones, are divided into 3 categories by different forms of Jwau-dae, placed on odd number stages. The first one is 'none-$f{\bar{a}}ng$ $t{\acute{o}}u$(無枋頭) type' of Song(AD 960~1127, 1127~1279) and Liao dynasty(AD 907~1125) buildings, which doesn't have $f{\bar{a}}ng$ $t{\acute{o}}u$(枋頭)s, for the reason that Jwau-dae(左右隊) is in direct contact with Gwihan-dae(耳限大). The second one is '$Shu{\check{a}}$ $t{\acute{o}}u$ $f{\bar{a}}ng$ $t{\acute{o}}u$(?頭枋頭) type' of Song(AD 960~1127, 1127~1279) and Jin dynasty(AD 1115~1234), that has $f{\bar{a}}ng$ $t{\acute{o}}u$(枋頭)s of Jwau-dae(左右隊) identical to $Shu{\check{a}}$ $t{\acute{o}}u$(?頭) in form. The last one is '$Xi{\check{a}}o$ $g{\check{o}}ng$ $t{\acute{o}}u$(小?頭) type' of Jin(AD 1115~1234) and Yuan dynasty(AD 1271~1368), which has $f{\bar{a}}ng$ $t{\acute{o}}u$(枋頭)s of Jwau-dae identical to $Xi{\check{a}}o$ $g{\check{o}}ng$ $t{\acute{o}}u$(小?頭) in form. The earlier forms of Gwi-po, which appeared between Tang dynasty(AD 618~690 & 705~907) and Five Dynasties periods(907~960) went through transitional forms of 'non-$f{\bar{a}}ng$ $t{\acute{o}}u$(無枋頭) type', '$Shu{\check{a}}$ $t{\acute{o}}u$ $f{\bar{a}}ng$ $t{\acute{o}}u$(?頭枋頭) type' and '$Xi{\check{a}}o$ $g{\check{o}}ng$ $t{\acute{o}}u$(小?頭) type' and finally had its form settled between Yuan(元, AD 1271~1368) and Ming(明. AD 1368~1644) dynasty periods. In Liao(遼) dynasty period(AD 907~1125), as the buildings got bigger and the tendency of longer eave-exposure was implemented, there grew a certain need to structurally reinforce Gwi-po, on which load of the whole roof is concentrated. Especially, the transition from Tōuxīn $z{\grave{a}}o$(偸心造) style to Jì xīn $z{\grave{a}}o$(計心造) style in this period had a great influence on standardization of Gwi-po, along with None-${\acute{A}}ng$(無仰) style. Furthermore, Wing-type Gong(翼型?), which developed in Liao dynasty(AD 907~1125), is also thought to have had a great influence on the transition from Tōuxīn $z{\grave{a}}o$(偸心造) style to Jì xīn $z{\grave{a}}o$(計心造) style by changing the forms of Gongs(?), such as Gwi-po. However, unlike None-${\acute{A}}ng$(無仰) style, there occurred a gradual change from '$Shu{\check{a}}$ $t{\acute{o}}u$ $f{\bar{a}}ng$ $t{\acute{o}}u$(?頭枋頭) type' to '$Xi{\check{a}}o$ $g{\check{o}}ng$ $t{\acute{o}}u$(小?頭) type' of Gwi-po in $Xi{\grave{a}}$ ${\acute{a}}ng$ style.

The Press Coverage of the Cyber Defamation Laws: Framing Effects of Core Values and Attributional Patterns (사이버모욕죄 보도의 프레이밍 효과: 핵심 가치와 귀인 양식을 중심으로)

  • Hur, Suk-Jae;Min, Young
    • Korean journal of communication and information
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    • v.52
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    • pp.48-68
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    • 2010
  • In covering the controversies surrounding the so-called cyber defamation laws, the Korean press offered competitive frames in terms of values (security vs. freedom of speech) and attributional patterns (episodic vs. thematic attribution). By attending to core values and attributional patterns as two essential components of news frames, this study explored the cognitive and affective processes of value and attributional framing and their effects on issue opinion. According to a 3-group online experiment, first, it was found that core values increased the perceived importance of relevant beliefs, which further affected individuals' attitudes toward the laws. The affective effects of core values were also found marginally significant. The value of security increased the intensity of anger toward deviant netizens (so-called defamatory repliers), and it further increased individuals' support for the laws. It was not substantiated, however, that individualistic attribution, than social attribution, would provoke stronger anger toward defamatory repliers. Instead, episodic frames appeared to be more effective in driving issue opinion as indicated by the value frame.

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Effects of Baicalein on Picryl Chloride-induced Contact Dermatitis in BALB/c Mice (Baicalein의 BALB/c Mice에서의 접촉성 피부알레르기 예방효과)

  • Kim, Soo-Hyun;Kim, Hyeong-Jin;Jung, Ji-Youn
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.38 no.2
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    • pp.160-165
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    • 2009
  • Contact dermatitis is induced by allergy response from a lot of chemical substances brought on by environmental contamination. In this study, we investigated allergy prevention effect of baicalein which is Scutellaria radix extract. Scutellaria radix is the dried roots of Scutellaria baicalensis Georgi (Labiatae). It has been used in oriental traditional medicine for treatment of fever, diarrhea and inflammation. We have induced allergy by PCL after oral administration of 0 mg/kg, 50 mg/kg or 100 mg/kg baicalein dose for 8 times during 8 days in BALB/c mice and measured ear thickness, IgE level, histamine level, mast cell number and histopathological changes. The ear thickness of the 100 mg/kg baicalein group was thinner than that of the 0 mg/kg baicalein group. IgE level and histamine level of the 100 mg/kg baicalein group were lower than those of 0 mg/kg baicalein group. The number of mast cells of 0 mg/kg baicalein group more than that of 100 mg/kg baicalein group in the ear tissue. In addition, intradermal edema with prominent inflammatory cell infiltration was observed at 0 mg/kg baicalein group more than 100 mg/kg baicalein group in the ear tissue. These results suggest that baicalein has allergy prevention effect in BALB/c mice.

Effect of Otitis Media and Cerumen Occlusion on Body Temperature Measured by Thermometers (중이염과 귀지가 고막 체온에 미치는 영향)

  • Jeong, Seong Nam;Kim, Eun Sung;You, Ju Hee;Cho, Hyung Min;Yoo, Eun Jung;Kim, Eun Young;Kim, Kyoung Sim;Kim, Yong Wook
    • Pediatric Infection and Vaccine
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    • v.17 no.2
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    • pp.114-121
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    • 2010
  • Purpose : To examine the effect of unilateral otitis media and unilateral cerumen occlusion of the ear canal on thermometers. Methods : One hundred eighty six children with unilateral otitis media, fifty children with unilateral cerumen occlusion, and fifty children with neither otitis media nor cerumen were enrolled. Temperature was measured in both ear canals using thermometers. After 15 minutes, second temperature was measured again in both ears. Unilateral otitis media was graded by video otoscope for 7 grades. Differences in temperatures between affected ears and unaffected ears were analyzed. Results : No temperature difference between the normal and cerumen groups was observed. The mean temperature of the otitis media ear canal was $0.13{\pm}0.20^{\circ}C$ higher than that of the intact ear canal ($36.99{\pm}0.54^{\circ}C$ vs $36.86{\pm}0.52^{\circ}C$; P<0.001). There was no statistically significant temperature difference between grades. Conclusion : Unilateral otits media can affect estimation of body temperature measured by thermometers.

A Study of the Effect of Acoustic Noise Attenuator on Auditory Functional MRI (소음 감쇠기를 이용한 청각의 뇌기능 자기공명영상)

  • Kim, S.H.;Kim, I.S.;Lee, J.J.;Park, J.A.;Lee, Y.J.;Yeo, J.R.;Bae, S.J.;Lee, S.H.;Chang, Y.
    • Investigative Magnetic Resonance Imaging
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    • v.9 no.2
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    • pp.134-139
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    • 2005
  • Purpose : To evaluate the usefulness of acoustic noise attenuator on auditory fMRI examination. Materials and methods : The acoustic noise attenuator consists of mask, earmuff and silicon earplug. The soft polyurethane sheet and polyurethane form , which has a good soundproof characteristic were used for mask and earmuff. Auditory fMRI experiments of 500 Hz pure tone stimulation were performed in three different cases; first all of mask, earmuff and earplug, secondly earmuff and earplug only and finally without attenuator in 4 normal hearing volunteers. For data acquisition, BOLD MR imaging technique was employed at a 1.5T MR scanner equipped with high performance gradient system. The raw data were analyzed using a SPM-99 analysis software and the activation maps were obtained. Results : In case of all items of acoustic attenuator used, the results revealed that activation was focused on primary auditory area. When only earmuff and earplug were used, the results showed that the activation spread over primary auditory and secondary associative areas. Last, when no device used, only weak activation was observed on the right auditory cortex. Conclusion : It is expected that the acoustic noise attenuator, which consists of earplugs, earmuffs and mask, is a very useful device in auditory fMRI study.

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Efficacy of Twice a Week Selamectin Application as a Treatment for Mixed Canine Scabies and Ear Mite Infestation in a Dog (개에서 피부개선충(Canine Scabies)과 귀진드기(Ear Mite) 혼합감염에 대한 주 2회 selamectin 적용 일례)

  • Woo Pil Hoh;A-Young Jeong;Hyo Hoon Jeong;Ki Dong Eom;Tae Ho Oh
    • Journal of Veterinary Clinics
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    • v.19 no.4
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    • pp.401-404
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    • 2002
  • A 6-month-old, male, American cocker spaniel was presented with severe pruritus, alopecia and head shaking. In physical examination generalized erythema, papules, scales and crust were observed. Otic discharge was dark-brown colored in both ear canals. After extensive dermatologic diagnostic evaluations, the infestation of scabies, ear mites, Malassezia spp, cocci were proved. Therefore, he was treated with selamectin 6 ㎎/㎏ which was applied to the skin in a single spot twice a week for 2 weeks in order to investigate the effect of selamectin on canine scabies and ear mites by this treatment protocol. When he was rechecked at 14th day after fourth being administered, scabies and ear mites wasn't seen. The dermatological signs, pruritus, papules were remarkably decreased and only slight scales were observed. After treatment of scabies and ear mites, the clavamox and koto-conazole was administered for cocci and Malassezia spp, respectively, for 1 week and topical therapy was initiated. with sebolytic and chlorhexidine shampoo once a week for 3 weeks. Two months later skin lesions were normal dermatologically and the hair was fully recovered. Despite of the expensiveness the selamectin is very effective in the dogs that infected by scabies and ear mites as this treatment protocol.

Changes in the Quality and Physiological Activity of Angelica acutiloba Leaves in Various Packaging Materials during Storage (일당귀 잎의 포장방법이 저장 중 품질 및 생리활성에 미치는 영향)

  • Choi, Ji-Weon;Lee, Ji Hyun;Kim, Won Bae;Kim, Chang-Kug;Jung, Hyun Kyung;Hong, Yoon Pyo;Kim, Ji Gang
    • Korean Journal of Plant Resources
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    • v.30 no.1
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    • pp.29-37
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    • 2017
  • The effect of packaging materials on the quality and physiological activity of Angelica acutiloba leaves during storage at $4^{\circ}C$ for 20 days and after being transferred to room temperature for 2 days was studied. The experiment was conducted using three packaging materials: the corrugated box (control); corrugated box with $20{\mu}m$ HDPE perforated film liner; and corrugated box with paraffin wax coated paper $+20{\mu}m$ HDPE perforated film liner. Changes in weight, color, aroma, overall visual quality, antioxidant activity, and total flavonoids were investigated. Based on the result, the treatments using corrugated box with $20{\mu}m$ HDPE perforated film liner and the corrugated box with paraffin wax coated paper $+20{\mu}m$ HDPE perforated film liner, were effective in minimizing weight loss, and maintaining external color and overall quality as compared to corrugated box only (control). The corrugated box with paraffin wax coated paper $+20{\mu}m$ HDPE perforated film liner was more effective in maintaining antioxidant activity and total flavonoids than other treatments. Prolonging the freshness using corrugated box with paraffin wax coated paper $+20{\mu}m$ HDPE perforated film liner could increase the marketability of Angelica acutiloba leaves in the domestic market.

예비구조설계에서의 상호작용방식에 따른 컴퓨터 활용방안

  • 정종현
    • Computational Structural Engineering
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    • v.12 no.1
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    • pp.86-94
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    • 1999
  • 예비구조설계에서는 구조시스템 대안의 생성과 발전, 여러 방법과 대상에 따른 해석과 설계 다양한 요구조건과 구조적 특성을 고려한 여러 구조시스템 대안의 비교 및 선택 과정을 거친다. 그리고, 이러한 각 과정은 구조설계자의 경험적 지식을 바탕으로 하는 종합적인 사고와 판단에 따라서 단계적, 반복적으로 이루어진다. 그러므로, 예비구조설계에서는 정형화된 자료와 작어뿐 아니라 비정형화된 자료와 작업도 처리해야 한다. 따라서, 컴퓨터는 정형화된 자료와 작업을, 구조설계자는 비정형화된 자료와 작업을 직접 처리하고 이를 상호작용을 통하여 교환 및 지시하는 방식, 즉 구조설계자와 컴퓨터의 역할분담에 기초한 상호작용방식을 통하여 예비구조설계에 컴퓨터를 효율적으로 활용할 수 있을 것이다. 구조설계자와 컴퓨터의 역할분담에 기초한 상호작용을 원활히 지원하기 위해서는 구조시스템 대안의 기하학적 향상, 재료에 대한 자료를 효과적으로 제시할 수 있는 3차원 관점, 각 구조시스템 대안을 검토하고 비교하는 사항이 되는 다양한 요구조건에 대한 자료들을 관리하고 제시할수 있는 요구조건 관점이 필요하다. 그리고 예비 구조설계가 진행되어 온 과정, 방향, 설계의도등의 파악을 위한 바탕이 될 수 있는 작업과정관점, 구조시스템 대안 발전 관점이 필요하다. 예비구조설계의 프로세스 조절을 위한 상호작용을 효과적으로 지원하기 위해서는 컴퓨터가 수행 할 수 있는 정형화된 작업들을 예비구조설계의 진행순서인 구조시스템 대안의 생성과 발전, 구조시스템 대안의 해석과 설계, 구조시스템 대안의 선택에 따라서 나열하여 제시할 필요가 있다. 이를 통해서 구조설계자는 자신의 판단에 따라서 다음에 수행해야 할 작업을 결정하고, 그에 해당하는 정형화된 작업을 컴퓨터가 제시한 작업 중에서 선택하고 그 수행을 지시하여 자신의 경험적 지식과 설계의도에 맞추어 예비구조설계의 프로세스를 조절할 수 있다.정조합력은 유의차가 컸으나, 상반조합 능력은 없었다. 교배친의 우성효과는 컸다. 잡종강세 환경변이 및 상가적 작용도 컸다. 우성의 방향은 정의 방향이었으므로 우성귀전자가 크게 작용하였다. 이들 형질들의 귀전자들은 초우성을 나타내었다. 교배친의 자견층중의 우성순서는 잠120>잠114>잠108>잠119>잠118>잠107>잠117>잠113 순이었고, 웅견층중에서는 잠114>잠108>잠120>잠117>잠118>잠107>잠119>잠119>잠113 순이었다. 자견층 비율에서는 광의의 귀전력이 협의의 귀전력보다 컸고, 웅견층 비율에서는 같았다, 견층 비율에서는 일반조합 능력은 크게 나타났으나, 특정조합 능력과 상반조직 능력은 나타나지 않았다. 자견층 비율에서 교배친의 우성효과는 컸다. 자견층 비율에서는 교배친의 우성효과는 적었다. 자웅견층 비율의 잡종 강세는 적게 나타났다. 환경변이와 상가적 작계는 자웅견층 비율에서는 크게 나타났다. 우성의 방향은 자견층 비율에서는 정의 방향으로 우성 귀전자가 크게 작용하였으며, 자견층 비율에서는 정의 방향으로 우성 귀전자가 부분적으로 작용하였다. 교배친의 자견층 비율의 우성순서는 잠117>잠114>잠108>잠120>잠118>잠119>잠107>잠113 순이었고, 자견층 비율에서는 잠114>잠117>잠108>잠118>잠107>잠119>잠113>잠120의 순이었다.지방산의 조성이 많은 차이를 보였다.{2+}$ 26 및 $Na^+$ 26 mg $L^{-1}$이었다. 양액 재배 후 버려지는 폐양액 중의 무기성분 함량은 양액재배에 이용되는 원수에 비해 상당히 높아졌다.료로서 응용 가능성이 있음을 시사한다.약재료인 약초류 등을 이용하였는데 오랫동안 푹 삶아 그물에 곡류 등을 넣어 죽이나 밥으로 조리하였으며 면으로도 조리하였다. 이상과 같이 조선시대 주식류의 종류 및 조리방법에 대한

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