• Korean Journal of Food Science and Technology
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• v.46 no.1
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• pp.61-67
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• 2014

This study aimed to investigate the anti-inflammatory activities of raw (P) and roasted (RP) Perilla frutescens Britton (perilla) seeds in RAW 264.7 macrophages and an ulcerative colitis mouse model. In lipopolysaccharide-treated RAW 264.7 cells, treatment with ethanol extract of P at the concentrations of 75 and $150{\mu}g/mL$ decreased nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) levels to 48-85% of the control (p<0.01). Treatment with RP extract exhibited similar effects on NO, IL-6, and TNF-${\alpha}$, decreasing those levels to 51-84% of the control (p<0.01). In dextran sulfate sodium-treated ulcerative colitis mice, dietary treatment with 1% RP for 7 days decreased the colonic levels of prostaglandin $E_2$ and leukotriene $B_4$ to 34% and 58% of the control, respectively (p<0.05). Dietary P treatment, however, did not decrease those levels significantly. These results indicate that roasted perilla seed exerts anti-inflammatory activity both in vitro and in vivo.

• Korean Journal of Plant Resources
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• v.27 no.5
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• pp.421-428
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• 2014

In general, Reucedani Radix (Peucedanum japonicum Thunbergis: PJ) is the Korean traditional herbal medicine used to remove dampness, to relieve pain, and spasm. So, PJ folium is believed to have the same effects. The aim of this study is to investigate the alleviation of dextran sulfate sodium (DSS) induced ulcerative colitis in mice by PJ folium. 25 mice were divided into 5 groups: normal, DSS, DSS + 100 mg/kg PJ folium (PJ100), DSS + 500 mg/kg PJ folium (PJ500), and DSS + 150 mg/kg 5-amino salicylic acid (5-ASA) groups. Body weights, colon lengths, histological changes in colon tissue, and spleen weights were observed. Inflammatory cytokines such as IL-$1{\beta}$, IL-6, and TNF-${\alpha}$ level in plasma were measured by ELISA. IL-$1{\beta}$, IL-6, and TNF-a mRNA expression in colon tissue were detected by RT-PCR. In the results, body weight lose was inhibited in PJ100, PJ500, and 5-ASA groups, but it was not different compared with DSS group, significantly. PJ500 group showed the preventive effects of colon length shorten and histological changes in colon tissues as good as 5-ASA group. The weight of spleen was increased in DSS group but it reduced in PJ100, PJ500, and 5-ASA groups. Moreover, IL-$1{\beta}$ and TNF-${\alpha}$ cytokine levels in plasma were reduced in PJ500 and 5-ASA groups. IL-$1{\beta}$, IL-6, and TNF-a mRNA expression in colon tissue were inhibited in PJ100, PJ500, and 5-ASA groups and it was significantly different compared with DSS group. In conclusion, PJ folium showed the alleviative effect on DSS induced ulcerative colitis in mice.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.2
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• pp.240-245
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• 2009

Pyoderma gangrenosum associated with ulcerative colitis is an unknown etiology of destructive skin disorder, characterized by progressive painful ulceration. It begins as a erythematous areola or pustule and rapidly progress into a deep ulceration with a discrete and violaceous edge. Early diagnosis followed with non-compressive moist dressing, topical application and systemic immunosuppressants are cornerstone in treating this disease. We report a case of pyoderma gangrenosum exacerbated with incision and drainage in a 15 year old girl with ulcerative colitis. This case emphasizes the importance of early consideration of pyoderma gangrenosum in patient with a background of related systemic disease and minimal traumatized wound care.

• 건강소식
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• v.30 no.7 s.332
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• pp.22-23
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• 2006

장염의 원인은 매우 다양한데, 식중독과 같은 각종 바이러스성 감염과 세균 감염 등으로 인한 감염성 장염이 흔하며, 크론씨병, 궤양성 대장염과 같은 만성 질환도 있다. 주로 나타나는 증상은 복통과 설사이며 열이 동반되는 경우도 있다. 복통은 정확히 위치를 알 수 없는 묵직한 통증이 가장 흔하며, 묵직한 통증으로 시작하여 뒤틀리는 듯이 심하게 아픈 통증으로 진행하는 경우가 흔하다. 설사는 적게는 하루에 2~3회에서, 많게는 20여 회가 넘는 경우까지 그 빈도가 다양하다. 대장이 감염된 경우 변에 코와 같은 점액이 많이 섞여 나오고, 소장이 감염된 경우에는 점액이 별로 섞여 나오지 않는다. 주로 6개월~24개월 사이의 아이에게 잘 발생하며, 춥고 건조한 늦가을부터 겨울철(10월~1월)에 가장 많이 발생하는데, 우리나라에서는 시기에 관계없이 발생하기도 한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.3
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• pp.613-619
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• 2009

The Efficacy of SHI-1909 was investigated in comparision with predinisolone in acetic acid and Picrylsulfonic acid solution (TNBS)-induced rat inflammatory bowel disease (IBD) for 5 days. 7% Acetic acid and 5% TNBS solution were administered with polyethylene (P.E) tube inserted to rats intracolon, which causing colitis to the rats. The acetic acid and TNBS control group (the saline treated colitic rat) exhibited ulceration and inflammation of the distal colon with formation of granuloma and pathologic connections. We checked the inflammatory parameters like rat's weight, food intake quantity change during administration. After 5 days, we sacrificed the rats and checked the colon's length, ulcer and pathologic condition. Oral treatment with SHI-1909 resulted in significant recovery of macroscopic parameters like weight and diet intake change. Especially, SHI-1909 had a more potent effect than prednisolone on macroscopic colonic damage score. We can suggest that SHI-1909 could be a promising drug in the treatment of IBD.

• Tuberculosis and Respiratory Diseases
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• v.51 no.5
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• pp.474-481
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• 2001

Mesalazine(5-Aminosalicylic acid,5-ASA), a component of Sulfasalazine (sulfapyridine bound to 5-ASA), is used to treat inflammatory bowel disease. Most adverse pulmonary effects caused by sulfasalazine have been attributed to sulfapyridine. However, lung toxicity associated with mesalazine(5-ASA) is rare. Here we report a case of eosinophilic pneumonia in a 44-year-old woman with ulcerative colitis, who was treated with mesalazine. She developed symptoms of a dry cough, mild night fever, and exertional dyspnea. Bilateral peripheral pulmonary infiltrates, peripheral blood eosinophilia, and histologic features were consistent with eosinophilic pneumonia. The symptoms improved quite rapidly after the discontinuation of mesalazine and initiation of steroid therapy. Therefore, adverse pulmonary reactions to mesalazine must be considered in a differential diagnosis of pulmonary involvement in patients with inflammatory bowel disease who are receiving with mesalazine therapy.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.317-326
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• 2019

The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both MAPK) and nuclear factor-kappa B (NF-${\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazin.

• Bulletin of Food Technology
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• v.15 no.3
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• pp.84-91
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• 2002

식이 섬유질에는 여러 종류가 있고 그 종류에 따라 short chain fatty acid(SCFA)의 생산 등 생리작용도 크게 다르다. 식이 섬유질 중 수용성은 장내세균의 발효를 받아 butyrate, acetate, propionate 등의 SCFA를 생산한다. 수용성 식이 섬유질을 섭취함으로서 SCFA의 생산을 증가시키고 대장점막증식, 물.전해질 흡수 촉진, 혈류량을 증가시키는 작용 외에 면역조절 작용을 가지고 있다. 식이 섬유는 장관계 질환 중의 하나인 염증성 장질환 특히 궤양성 대장염의 치료법으로서 기대되고 있으며, 암세포 연구에서는 butyrate 가 apoptosis 유도작용과 발암유전자의 억제효과가 확인되고 있으나 역학 연구에서는 식이 섬유질에 의한 대장암 예방효과는 아직 불확실하다. 모든 유형의 식이 섬유질은 건강 식품으로서 사용되고 있으며, prebiotic으로서도 주목받고 있다. 또한 경장 영양제에도 각종의 식이 섬유질이 첨가되어 있다. 그러나 충분한 양의 비타민과 무기질을 함유한 고섬유질식과, 건강 식품으로서의 식이 섬유질을 같은 의미로 해석하기에는 여러 가지 문제가 남아 있다.

• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.685-691
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• 2005

A 33 year-old male who had been diagnosed with severe ulcerative and ankylosing spondylitis was treated and observed. Even though he had been treated with western medicine, he still complained of severe diarrhia, hemafecia, abdominal pain, general weakness, mild fever($37.8^{\circ}C$) and lower back pain. On radiologic examination, the lumbar view revealed the sacroliac joint space are irregular with adjacent bony sclerosis on both sides. He was treated with Chengsim Yeunja-Tang. Having been treated for 99 days, severity of ulcerative colitis changed from severe to mild ade, lower back pain reduced from nine to three, and all other symptoms improved.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.10 no.1
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• pp.91-97
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• 2007

The Overlap syndrome is characterized by a combination of the major hepatobiliary autoimmune diseases such as autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis. It is frequently accompanied by inflammatory bowel disease. Chronic lymphoplasmacellular osteomyelitis is characterized by recurrent episodes of bacterial osteomyelitis and is associated with autoimmune diseases (especially inflammatory bowel disease). We report the case of a girl who was diagnosed with ulcerative colitis and autoimmune hepatitis at 4 years of age and with the overlap syndrome with primary sclerosing cholangitis at 6 years. At 9 years, she was diagnosed with chronic lymphoplasmacellular osteomyelitis.