• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.1
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• pp.96-101
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• 2009

Regional odontodysplasia(ROD) is relatively rare localized developmental anomaly of tooth formation in which hard tissue is affected. The maxilla is typically affected than the mandible, and especially the maxillary left quadrant is the most commonly involved. Females are affected twice as often as males, and there is no association with race. Its etiology remains undetermined, but local circulatory disorders, somatic mutations, virus infections, local trauma, hyperpyrexia, irradiation, metabolic disturbances, and hereditary transmission are considered as possible etiologic factors. The affected teeth are likely to be small, hypoplastic, brown, and grooved. Eruption failure or delay is frequently seen as well as abscess or fistulae formation in absence of caries. Radiographically, there is a lack of contrast between the enamel and dentin, both of which are less radiopaque than unaffected counterparts. Moreover, enamel and dentin layers are thin, giving the teeth a “ghost-like appearance”. The pulp chambers and canals are large, the roots seem like to be short and indistinct. A 2-year-3-month old boy came to the department of pediatric dentistry, Yonsei University, with the chief complaint of delayed eruption and abnormal tooth shape on the lower left quadrant. He was diagnosed as regional odontodysplasia based on the clinical and radiographic findings.

• Journal of the korean academy of Pediatric Dentistry
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• v.28 no.1
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• pp.175-179
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• 2001

Regional odontodysplasia is a relatively rare condition in which both enamel and dentin are hypoplastic and hypocalcified. The result is localized arrest in tooth development. The etiology of regional odontodysplasia is uncertain, but, disturbance in vascular supply, somatic mutation, latent virus infection, trauma, hyperpyrexia, irradiation, nutrition, metabolic disorders and hereditary transmission are supported to be etiologic factors. Females are more often affected than males. (1.4 : 1). The maxillary arch is more often affected than the mandibular arch with the maxillary left quadrant being the most commonly involved. Affected teeth are hypoplastic, typically discolored yellow or yellowish brown, smaller in size and display a variety of surface marking including pitting and grooving. Radiographically, the teeth affected have been described to have a "ghost like" appearance or "fuzzy" appearance. Pulp calcification and denticles may be present within the pulp chambers of the affected teeth. In it's case, a 2 years old male visited for a treatment of uneruption of lower right teeth. Partial eruption of lower right deciduous central incisor and unerupted deciduous lateral incisor, deciduous canine and deciduous first molar showed severly delayed eruption state. On radiographic appearance, "Ghost like appearance", shortened root and opened apexes on lower right region were observed. It was suspected regional odontodysplasia with clinical and radiographic condition.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.12
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• pp.1335-1341
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• 2011

The purpose of this research is to investigate how separated and reattached flow affects mass transfer, by comparing the local mass transfer characteristics on an inclined flat plate with those on a parallel flat plate. The local mass transfer coefficients for the flat plate were measured using the naphthalene sublimation technique; the inclined angle of the flat plate was varied from $-10^{\circ}$ to $10^{\circ}$ at $5^{\circ}$ intervals, and the free-stream velocity was varied from 2m/s to 15m/s. At positive inclined angles, the local Sherwood numbers decreased gradually because the boundary-layer thickness increased. On the other hand, for negative inclined angles, the local Sherwood numbers assumed the minimum value at the separation point of the recirculation flow and the maximum value at the reattachment point. The average Sherwood numbers for both positive and negative inclined angles were lower than those in the case of the parallel plate.

• Journal of Korean Society of Transportation
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• v.17 no.5
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• pp.33-42
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• 1999

본 논문은 도로투자 사업성분석시 사업주체의 현금흐름을 결정하는 항목들을 고정값(Deterministic Value)이 아닌 확률적으로 추정함으로써, 사업의 재무적 변동으로 인한 위험도를 민간사업자의 견지에서 사업성분석과정에 내재화하는 모형을 개발하는 것이다. 즉, 확률적 비용추정기법으로 국소적으로 활용되던 위험도분석을 재무모형에 내재화함으로써 사업의 재무적 변동을 보다 포괄적으로 분석할 수 있는 틀을 제공한다. 본 연구에서는 몬테카를로 시뮬레이션기법을 이용한 위험도분석(Risk Analysis)을 적용하여 사업성 평가지표와 비용의 확률밀도함수(Probability Density Function : PDF), 누적확률분포함수(Cumulative Distribution Function : CDF)를 산출하고, 그 결과로 해당 사업의 위험도를 고려하여 사업성을 평가한다. 이 모형은 사업의 모든 변동요인을 복합적으로 추정하여 사업기간 내 사업주체의 현금흐름을 분석할 수 있다. 따라서 사업주체는 효용에 따라 합리적인 위험도 관리 목표값(Target Value)을 선정하고, 사업의 위험도를 고려하여 건설비, 예비비를 결정할 수 있다. 본 연구에서 정립된 모형을 서울외곽순환고속도로(일산-퇴계원 구간)와 대전당진고속도로를 대상으로 사례분석을 수행하였다. 그 결과, 대전당진고속도로의 경우 사업성이 없으며, 서울외곽순환고속도로의 경우, 일부 위험도 발생변수를 합리적으로 관리한다면, 사업성이 충분한 것으로 분석되었다. 본 사례분석은 사업의 위험도를 반영한 사업성분석 방법으로 우리나라 민자유치대상고속도로의 사업성분석의 하나의 지침이 될 것이다.

• Korean Journal of Food Science and Technology
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• v.26 no.3
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• pp.213-220
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• 1994

Gastrodia (G) Rhizoma has been used clinically as an oriental herbal medicine with sedative, anticonvulsive, and depressor effects. The present study tested effects of G. Rhizoma extracts on the coronary circulation and myocardial oxygen consumption in perfused rat hearts. Sprague Dawley rats (SD) and spontaneously hypertensive rats (SHR) were employed as experimental animals and nonworking Langendorff heart perfusion technique introduced for heart experiments. G. Rhizoma extracts were prepared from grinding G. Rhizoma into powder, extracting in water and 50% ethanol for 4 or 16 hr and diluting with Krebs-Henseleit bicarbonate perfusion buffer to be 70%. Hearts were perfused with bicarbonate buffer oxygenated with 95% $O_{2}:$ 5% $CO_{2}$ at constant coronary perfusion pressure of $90cmH_{2}O$. The diluted extracts were infused into coronary arteries in a concentration of $1{\sim}5\;{\mu}M$ for $7{\sim}8 min. While in SD water- or ethanol-extracts of G. Rhizoma extracted for 16 hr increased coronary perfusate flow (CPF) and decreased coronary vascular resistance (CVR), ethanol-extracts in SHR produced coronary vasoconstriction associated with enhanced CVR. G. Rhizoma extracts-induced increase in CPF reduced myocardial oxygen extraction, and thus myocardial oxygen consumption ($MVO_{2}$) remained at that observed prior to infusion of extracts. In SD and SHR 16 hr-water-extracts markedly altered coronary venous effluent pH and $Pco_{2}$ and evoked metabolic acidosis, which could be a coronary vasodilator mechanism decreasing CVR. In this study, the extracts decreasing CVR in SD and SHR did not augment the lactate production. Therefore, although the effects of the extracts on cardiac function and coronary circulation depended on solvents and duration for extraction, the 16hr-water-extracts, at least, exhibited coronary vasodilation in SD and SHR. Conversely, ethanol-extracts constricted coronary arteries in SHR. G. Rhizoma extracts-induced vasodilation might be due to the metabolic acidosis rather than due to the increased lactate production. The results indicate that G. Rhizoma extracts obtained from proper extracting procedures can be used as a safe and clinically applicable herbal medicine in the cardiovascular diseases such as coronary artery disease and hypertension for vasodilatory and antihypertensive actions.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.9
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• pp.859-866
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• 2010

Nonlinear dynamics of pulsating instability-diffusional-thermal instability with Lewis numbers sufficiently higher than unity-in counterflow diffusion flames, is numerically investigated by imposing a Damkohler number perturbation. The flame evolution exhibits three types of nonlinear behaviors, namely, decaying pulsating behavior, diverging behavior (which leads to extinction), and stable limit-cycle behavior. The stable limit-cycle behavior is observed in counterflow diffusion flames, but not in diffusion flames with a stagnant mixing layer. The critical value of the perturbed Damkohler number, which indicates the region where the three different flame behaviors can be observed, is obtained. A stable simple limit cycle, in which two supercritical Hopf bifurcations exist, is found in a narrow range of Damkohler numbers. As the flame temperature is increased, the stable simple limit cycle disappears and an unstable limit cycle corresponding to subcritical Hopf bifurcation appears. The period-doubling bifurcation is found to occur in a certain range of Damkohler numbers and temperatures, which leads to extend the lower boundary of supercritical Hopf bifurcation.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.11a
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• pp.27-31
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• 1996

암환자의 생명을 가장 위협하는 암세포의 전이는 숙주와 암세포의 상호작용을 포함하는 여러단계의 연쇄적인 과정이다. 전이의 발생은 하나의 세포나 집단의 암세포가 첫번째 암발생 부위에서 분리되어 국소적으로 침투하고 순환기계에 들어가 다른곳에 흡착 후 다른 장기의 interstitium과 parcnchyma에 입출(extravasate)하게 되며 2차적 colony로서 자라나 stroma나 basement membrine과 같은 생물학적 울타리를 파괴한다. 전이의 각단계에서 암세포는 면역세포의 공격을 피하여야만 한다. 세포의 이동은 태아의 생성(embryonic events), 성장세포의 재조함(remodeling), 상처 치유(wound healing), 맥관형성 (angiogenesis), 면역 방어 (immune defence)의 경우에 아주 중요한 역활을 한다. 정상적인 경우에 세포의 이동은 잘 통제가 되지만 암세포의 이동은 비정상적으로 통제가 되거나 자체내에서 통제가 된다. 암세포는 숙주에서 생산되는 scatter factors, growth factor, extracellular matrix components, 그리고 암세포에서 발생되는 autocrine utility factors를 포함한 여러가지 인자에 의해 영향을 받는다.

• Journal of Chest Surgery
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• v.37 no.11
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• pp.918-921
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• 2004

Berry syndrome (interrupted aortic arch, aortopulmonary window, and aortic origin of right pulmonary artery with intact interventricular septum) is a very rare and complex cardiac malformation. We report a successful one-stage repair in a 14-day-old neonate without circulatory arrest.

• Proceedings of the Korean Society of Computer Information Conference
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• 2010.07a
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• pp.323-325
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• 2010

본 연구에서는 절연파괴가 일어나기 쉬운 변압기 1차권선의 절연내력을 향상시키기 위하여 전위분포가 일정하게 되도록 인입선 부근의 권선 배치를 최적화하는 프로그램을 작성하여 유한요소법(Finite Element Method; 이하 FEM)을 이용하여 반복 분석하였다. 우선 기존의 권선 배치에 대한 국소점의 전계 분포를 고찰한 후 전계의 최대치를 구하였다. 그리고 권선 배치를 자동화된 순환 계산형 시뮬레이터를 제작하여 적절한 분포로 교정하고 최초의 기대 함수치를 극소화하는 형상을 반복하여 추적하는 알고리즘을 이용하여 기존의 PT에 적용될 수 있도록 고압측의 권선 배치를 최적화하는 설계 기법을 개발하였다.

• Journal of Chest Surgery
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• v.39 no.3 s.260
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• pp.194-200
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• 2006

Background: Thoracoabdominal aortic replacement is an extensive operation that opens both the pleural cavity and abdominal cavity, which has high mortality and morbidity rate. The authors have reported 9 cases of the thoracoabdominal aortic replacement in 2001. Since 2003 we have applied the deep hypothermic circulatory arrest to the Crawford type I and II thoracoabdominal aortic replacement. Therefore, we analysed the effect of the changes in operative techniques. Material and Method: Between 1996 and 2005, we have performed 20 cases of thoracoabdominal aortic replacement. The underlying diseases were 8 cases of atherosclerotic aneurysm with 4 cases of ruptured aneurysm and 12 cases of aortic dissection with 10 cases of a previous operations. According to Crawford classification, there were 2 cases of type I, 7 cases of type II, 1 case of type III, 7 cases of type IV, and 3 cases of type V. We compaired the results of the patients who underwent thoracoabdmoninal replacement before 2001 which already has been reported and after then. Result: Before 2001 we have performed 9 cases of thoracoabdominal replacement and 5 patients were died of the operation. All three patients with type I and II were died. There was no case of thoracoabdominal replacement between 2001 and 2002, but after 2003 we have performed 11 cases of thoracoabdominal replacement which involved 1 case of type I, 5 cases of type II, 1 case of type III, 2 cases of type IV and 2 cases of type V. There was no mortality and no fetal complications. Conclusion: The deep hypothermic circulatory arrest is a safe method of extended thoracoabdominal aortic replacement.