• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.11a
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• pp.13-16
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• 1993

코카인은 열대지방에 광범위하게 분포되어 있는 Erythroxylon나무의 잎에 존재하고 있는 알칼로이드이다. 1536년 Pizarro가 스페인 침공을 마친 후 귀국하면서 유럽에 소개되었으며 Alfred Niemann에 의해서 1853년 처음으로 코카잎에서 추출되었고 "cocaine"이라고 명명되었다. 코카인은 황홀감을 일으킬 뿐 아니라 감기, 피부병, 천식, 류마치즘, 후두염 및 치통에도 효과가 좋다고 알려졌었고 국소마취효능이 좋아 아직까지도 안과 영역에서 가끔 사용되고 있다. 그러나 코카인은 인류가 알고 있는 물질중 가장 강화(reinforcement)효과가 강한 물질이기에 현재 법적으로 그 사용이 국소마취제 이외에는 금지되어 있으나 황홀감을 얻기위한 불법적인 사용이 크게 늘어있는 형편이다.늘어있는 형편이다.

• Journal of the Korean Magnetics Society
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• v.12 no.1
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• pp.20-23
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• 2002

The local coercivity distribution of CoCrPt alloy films prepared by dc magnetron sputtering has been investigated by means of a magneto-optical microscope magnetometer (MOMM) capable of simultaneously measuring the local properties on 400 nm spatial resolutions. Serial samples of CoCrPt alloy films were prepared with the Pt composition of a range from 6 to 28 at. %. We find that the local coercivity distribution crosses over from Gaussian to non-Gaussian distribution in CoCrPt alloy films with increasing Pt composition, with increasing trends in the width of the distribution as well as the average local coercivity. Transmission electron microscopy (TEM) studies reveal that our findings are closely correlated with the dependences of the grain size distribution and its average size on Pt concentration.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10d
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• pp.541-543
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• 2002

본 논문에서는 HOLA(고차국소자동상관계수)를 이용한 특징추출과 BP(Backpropagation Network) 알고리즘을 이용하여 얼굴을 인식하는 방법을 제안한다. 이를 위해 동일한 환경, 즉 일정한 조도 하에서 카메라로부터 동일거리에 있는 영상을 256$\times$256 크기의 그레이 스케일(Gray Scale)로 취득하여 영상내의 잡음을 가우시안(Gaussian) 필터를 이용하여 제거한다. 차영상을 이용하여 얼굴영역을 분리한 후 얼굴영역의 특징벡터를 구하기 위하여 HOLA(고차 국소 자동 상관함수)를 사용한다. 계산된 특징벡터는 BP 신경망의 학습을 통하여 얼굴인식을 위한 데이터로 사용된다. 시뮬레이션을 통해 제안된 알고리즘에 의한 인식률향상과 속도 향상을 입증한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2003.05a
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• pp.635-638
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• 2003

본 논문에서는 Haar 웨이블릿을 이용하여 얼굴에지영상을 추출하고 고차국소자동상관함수를 이용한 특징벡터추출과 BP(Backpropagation Network) 알고리즘을 이용하여 얼굴을 인식하는 방법을 제안한다. 이를 위한 얼굴인식에 사용된 실험영상은 $320{\times}240$ 크기의 24bit RGB 컬러 영상을 사용하였고, 차영상을 이용하여 얼굴영역을 분리한 후 Haar 웨이블릿을 이용한 에지영상 추출과 얼굴영역의 특징벡터를 구하기 위하여 고차 국소 자동 상관함수를 사용하였다. 계산된 특징벡터는 BP 신경망의 학습을 통하여 얼굴인식을 위한 데이터로 사용된다. 시뮬레이션을 통해 제안된 알고리즘에 의한 인식률향상과 속도 향상을 입증한다.

• Journal of the Korean Magnetics Society
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• v.14 no.6
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• pp.224-227
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• 2004

We have studied local magnetization reversal by laser annealing in exchange biased NiFe/FeMn bilayer. Local magnetization reversal was performed by using the DPSS laser under external magnetic field of 600G. When the laser illuminated the patterned film with the power of above 300 mW during 15 min, a magnetoresistance (MR) curve with symmetric peaks at the opposite field was obtained due to the local reversal of exchange biasing. The direction of exchange anisotropy in the locally reversed region can be restored by local laser annealing under alternating magnetic field, even if its MR peak was reduced by the damage and interdiffusion. The magnetic domain structure of the locally reversed region was measured by MFM. The new domains were generated by laser annealing near the exposed area.

• Journal of Intelligence and Information Systems
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• v.14 no.2
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• pp.193-206
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• 2008

Medical diagnosis can be considered a classification task which classifies disease types from patient's condition data represented by a set of pre-defined attributes. This study proposes a hybrid genetic algorithm based classification method to develop classifiers for multidimensional pattern classification problems related with medical decision making. The classification problem can be solved by identifying separation boundaries which distinguish the various classes in the data pattern. The proposed method fits a finite number of regional agents to the data pattern by combining genetic algorithms and local adaptive operations. The local adaptive operations of an agent include expansion, avoidance and relocation, one of which is performed according to the agent's fitness value. The classifier system has been tested with well-known medical data sets from the UCI machine learning database, showing superior performance to other methods such as the nearest neighbor, decision tree, and neural networks.

• Journal of the korean academy of Pediatric Dentistry
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• v.23 no.3
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• pp.582-592
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• 1996

본 실험은 삼차신경 자극으로 발생되는 체성 감각 유발 전위에 대한 국소마취제의 효과를 관찰하였다. 나트륨 통로차단을 통하여 약리작용을 나타내는 것으로 알려져 있는 리도카인를 뇌 피질에 국소 투여한 후 삼차신경의 체성 감각유발 전위의 강도및 지연시간을 측정하였다. 케타민으로 마취된 흰쥐의 대측성 구레나룻 자극후 뇌의 체성 감각영역으로부터 기록되는 유발전위를 분석한 결과, 리도카인을 뇌 피질에 국소 투여시 유발전위의 강도 및 지연시간의 감소가 나타났으며, 필드 전위의 형태는 이상성 (양극성 및 음극성) 혹은 삼상성 (양극성, 음극성 및 양극성) 의 파형으로 나타났다. 필드 전위의 발생 부위는 뇌 피질의 중대뇌동맥의 상행지 상방영역이었다. 본 실험에서 나타난 초기 전위변동은 피질판 상층에 존재하는 신경세포의 탈분극 과청에 의하여 생성되고 후기의 전위 변동은 동일 영역의 하층 신경세포에서 과분극 혹은 재분극이 발생한 결과라고 유추된다. 따라서 삼차신경계의 체성 감각 영역에서는 피질 상층및 하층의 과립성 피라미드 세포의 순차적인 활성화에 의하여 기본적인 신경 회로망이 형성되어 있으며 생리적 자극으로 유발되는 필드 전위는 이러한 신경망를 통하여 발생될 것으로 사료된다.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1902-1907
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• 2008

The current work presents a design and fabrication technique for a microchannel system to measure the local temperature distribution inside microchannel. This micro channel system fabricated by MEMS technique is integrated with a heater and an array of temperature sensors so that detailed heat transfer phenomena inside micro-scale channel can be studied. Materials widely used in semiconductor process were selected to fabricate a heater and temperature sensors on a silicon wafer. On these heater and sensors a channel wall was fabricated with SU-8. The friction constant and the local Nusselt number distribution measured for the deionized water flow in the microchannel is presented.

• Korean Journal of Cognitive Science
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• v.16 no.1
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• pp.17-27
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• 2005

After prolonged viewing of a moving pattern, a stationary pattern can appear to move in the opposite direction, a phenomenon known as motion aftereffect (MAE). Unlike the classical explanation MAE was not confined to an adapted region; instead it can spread to an adjacent region, which was not adapted previously. In order to examine the relative locus of the mechanism responsible for MAE spreading, a rotating harmonic spiral pattern was presented as an adapting stimulus within an annulus window, and then the duration of MAE was measured in both the adapted annulus region and the non-adapted inner region. Two different kinds of test patterns were used: the same and mirror images of the original adapting pattern. An interesting characteristic of a harmonic spiral is that the orientation of a contour at a given location is different from thar of its mirror image by 90 degrees, and consequently the adapting effect of local motion detector is not expected to occur in the mirror image. The results showed that MAE duration in an adapted region was longer in the same image condition than in its mirror image condition, while MAE duration in an non-adapted region was not found to be different between those two different image conditions. These results suggest that MAE spreading might be produced by the adaptation of global motion detectors, not by local motion detectors.

• Radiation Oncology Journal
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• v.18 no.3
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• pp.194-199
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• 2000

Purpose : Then determining the lower margin of post-operative pelvic radiation therapy field according to the traditional method (recommended by Gunderson), the organs located in the low pelvic cavity and the perineum are vulnerable to unnecessary radiation. This study evaluated the effect of individualized determination of the lower margin at 2 cm to 3 cm below the anastomotic site on the failure patterns. Materials and Methods . Authors included ぉ patients with modified Astler-Coiler (MAC) stages from B2 through C3, who received low anterior resection and post-operative pelvic radiation therapy from Sept. 1994 to May 1998 at Samsung Medical Center, Sungkyunkwan University. The numbers of male and female patients were 44 and 44, and the median age was 57 years (range: 32-81 years). Three field technique (posterior-anterior and bilateral portals) by 6, 10, 15 MV X-rays was used to deliver 4,500 cGy to the whole pelvis followed by Sn cGy's small field boost to the tumor bed over 5.5 weeks. Sixteen patients received radiation therapy by traditional field margin determination, and the lower margin was set either at the low margin of the obturator foramen or at 2 cm to 3 cm below the anastomotic site, whichever is lower. In 72 patients, the lower margin was set at 2 cm to 3 cm below the anastomotic site, irrespectively of the obturator foramen, by which the reduction of radiation volume was possible in 55 patients ($76\%$). Authors evaluated and compared survival, local control, and disease-free survival rates of these two groups. Results : The median follow-up period was 27 months (range : 7-58 months). MAC stages B2 in 32($36\%$), B3 in 2 ($2\%$), Cl in 2 ($2\%$), C2 in 50 ($57\%$), and C3 in 2 ($2\%$) Patients, respectively. The entire patients' overall survival rates at 2 and 4 years were $94\%$ and $68\%$, respectively, and disease-free survival rates at 2 and 4 years were $86\%$ and $58\%$, respectively. The first failure sites were local only in 4, distant only in 14, and combined local and distant in 1 patient, respectively. There was no significant difference with respect to local control and disease-free survival rates ( p=0.42, p=0.68) between two groups of different lower margin determination policies. Conclusion : The new concept in the individualized determination of the lower margin depending on the anastomotic site has led to the equivalent local control and disease-free survival rates, and is expected to contribute to the reduction of unnecessary radiation-related morbidity by reduction of radiation volume, compared with the traditional method of lower margin determination.