• Title/Summary/Keyword: 구조I

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Study of HubWA Protein Folding Reaction by Measuring the Stability of Folding Intermediate (중간단계의 구조적 안정성을 통한 HubWA 단백질의 접힘(folding) 반응 탐색)

  • Soon-Ho Park
    • Journal of the Korean Chemical Society
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    • v.67 no.2
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    • pp.81-88
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    • 2023
  • The contribution of hydrophobic residues to the protein folding reaction was studied by using HubWA variant proteins with I and L to V mutation. Folding kinetics of all V variant proteins was observed to be satisfied by a three-state on-pathway mechanism, U ⇌ I ⇌ N, where U, I, and N represent unfolded, intermediate, and native state, respectively. Three-state folding reaction was quantitatively analyzed and the free energy of folding of each elementary reactions and overall folding reaction, ΔGoUI, ΔGoIN, and ΔGoUN, were obtained. From the ratio of free energy difference between the variant protein and HubWA, ΔΔGoUI/ΔΔGoUN (ΔΔGoUI = ΔGoUI (variant protein) - ΔGoUI (HubWA) and ΔΔGoUN = ΔGoUN (variant protein) - ΔGoUN(HubWA)), the contribution of hydrophobic residues to HubWA folding was analyzed. The residues which are located in the hydrophobic core between α-helix and β-sheet, I3, I13, L15, I30, L43, I61 and L67, showed ΔΔGoUI/ΔΔGoUN value of ~0.5 when each of these residues was mutated to V, indicating that these residues form relatively solid hydrophobic core in the intermediate state. Residues located at the end of secondary structures and loop, I23, L69 and I36 showed ΔΔGoUI/ΔΔGoUN value below 0.4 when each of these residues was mutated to V, indicating that the region containing these residues are loosely formed in the intermediate state. V17A, L50V and L56V showed fairly high ΔΔGoUI/ΔΔGoUN value of ~0.8. Since L50 and L56 are located in the region containing long loop (residue 46 to 62), it is suggested that the high ΔΔGoUI/ΔΔGoUN value of these residues prevents the formation of aggregate at the early stage of folding reaction.

Reinforcement Effects using V Type External Strands on PSC I Girder Bridges (V자형 배치 외부강선을 이용한 PSC I거더교의 보강 효과)

  • Back, Seung-Chul;Song, Jae-Ho;Kim, Haeng-Bae;Kim, Suk-Su
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.20 no.3
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    • pp.49-57
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    • 2016
  • This study intended to analyze reinforcement effects of PSC I girder bridges to which prestresses are introduced using V type of external strands. So that series of bridge loading tests are carried out on existing PSC I girder bridge for the cases of before-reinforcement and reinforcement. The measured results from tests being analyzed and compared with the ones from MIDAS structural analyzing program, the reinforcing effects of the reinforcement system adopted in this study were investigated. It is found out that when the V type systems are applied to the bridge girders, the slope of load distribution factor curves become lower improving soundness of bridge upper structure. And also it is confirmed that the reinforcement system in this study can be taken as helpful for improvement of both flexural and shear ability of PSC I girder bridges, as well as dynamic behavior. Furthermore it is found when the elastic pads are applied to the system, dynamic reinforcing effects are maximized.

Flexural Behavior Characteristics of Steel I-Beam Strengthened by the Post-tensioning Method on the Field Experiment (현장실험을 통한 외부 후긴장 Steel I-Beam의 휨 거동 특성)

  • Cho, Doo-Yong;Park, Dae-Yul;Park, Sun-Kyu
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.6 no.3
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    • pp.151-158
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    • 2002
  • Recently, the externally prestressed unbonded steel I-beam bridges have been increasingly built. The mechanical behavior of prestressed steel I-beams which are with external unbonded tendon is different from that of normal bonded PSC beams in a point of that the slip of tendons at deviators and the change of tendon eccentricity occurs, when external loads are applied in external unbonded steel I-beams. The concept of prestressing steel structures has not been widely considered, in spite of long and successful history of prestressing concrete members. In this study, The field experiment on prestressed steel I-beams has been performed in the various aspects of prestressed I-beam including the tend on type and profile.

A Study on the i-YOLOX Architecture for Multiple Object Detection and Classification of Household Waste (생활 폐기물 다중 객체 검출과 분류를 위한 i-YOLOX 구조에 관한 연구)

  • Weiguang Wang;Kyung Kwon Jung;Taewon Lee
    • Convergence Security Journal
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    • v.23 no.5
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    • pp.135-142
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    • 2023
  • In addressing the prominent issues of climate change, resource scarcity, and environmental pollution associated with household waste, extensive research has been conducted on intelligent waste classification methods. These efforts range from traditional classification algorithms to machine learning and neural networks. However, challenges persist in effectively classifying waste in diverse environments and conditions due to insufficient datasets, increased complexity in neural network architectures, and performance limitations for real-world applications. Therefore, this paper proposes i-YOLOX as a solution for rapid classification and improved accuracy. The proposed model is evaluated based on network parameters, detection speed, and accuracy. To achieve this, a dataset comprising 10,000 samples of household waste, spanning 17 waste categories, is created. The i-YOLOX architecture is constructed by introducing the Involution channel convolution operator and the Convolution Branch Attention Module (CBAM) into the YOLOX structure. A comparative analysis is conducted with the performance of the existing YOLO architecture. Experimental results demonstrate that i-YOLOX enhances the detection speed and accuracy of waste objects in complex scenes compared to conventional neural networks. This confirms the effectiveness of the proposed i-YOLOX architecture in the detection and classification of multiple household waste objects.

A Parallel Emulation Scheme for Data-Flow Architecture on Loosely Coupled Multiprocessor Systems (이완 결합형 다중 프로세서 시스템을 사용한 데이터 플로우 컴퓨터 구조의 병렬 에뮬레이션에 관 한 연구)

  • 이용두;채수환
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.18 no.12
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    • pp.1902-1918
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    • 1993
  • Parallel architecture based on the von Neumann computation model has a limitation as a massively parallel architecture due to its inherent drawback of architectural features. The data-flow model of computation has a high programmability in software perspective and high scalability in hardware perspective. However, the practical programming and experimentaion of date-flow architectures are hardly available due to the absence of practical data-flow, we present a programming environment for performing the data-flow computation on conventional parallel machines in general, loosely compled multiprocessor system in particular. We build an emulator for tagged token data-flow architecture on the iPSC/2 hypercube, a loosely coupled multiprocessor system. The emulator is a shallow layer of software executing on an iPSC/2 system, and thus makes the iPSC/2 system work as a data-flow architecture from the programmer`s viewpoint. We implement various numerical and non-numerical algorithm in a data-flow assembler language, and then compare the performance of the program with those of the versions of conventional C language, Consequently, We verify the effectiveness of this programming environment based on the emulator in experimenting the data-flow computation on a conventional parallel machine.

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Classroom Discourse Analysis between Teacher and Students in Science Classroom (과학 수업 시간에 발생하는 교사-학생 간 교실 담화 분석)

  • Han, Shin;Jung, Jinwoo
    • Journal of Science Education
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    • v.35 no.2
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    • pp.159-172
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    • 2011
  • The purpose of this study is to specify the quality of I-R-E pattern and question-answer affiliation between students and teacher, depending on teacher's career. This study analyzes 6 classroom discourse texts of 6th grade science class. The results of this study are as follows. First, in the case of a newly appointed teacher, I-R-E pattern is appeared repeatedly. Second, in the case of experienced teachers, expended I-R-E pattern is appeared compare with a newly appointed teacher. Third, in the case of a newly appointed teacher, independence relational structure is appeared more repeatedly than other structures. But, in the case of experienced teachers, all kinds of question-answer structures - independence, parallel, insertion, and reorganization relational structure - are appeared more evenly.

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Structure Guide Lines of Silicon-based Pocket Tunnel Field Effect Transistor (실리콘 기반 포켓 구조 터널링 전계효과 트랜지스터의 최적 구조 조건)

  • Ahn, Tae-Jun;Yu, Yun Seop
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2016.05a
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    • pp.166-168
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    • 2016
  • This paper introduces about the structure guide lines of pocket tunneling Field effect transistor. As the pocket length or thickness increase, on-current $I_{on}$ increases. As the pocket thickness is less than 3nm, subthreshold swing (SS) increase. As the dielectric constants of the gate insulator increases, the performance of on-current and subthreshold swing enhances.

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