• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.1
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• pp.56-63
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• 2018

The present study examined the reversal cyclic flexural behavior of walls with jacket section approach for seismic strengthening through forming the boundary elements at both ends of the wall. The prestressed wire ropes were used for the lateral reinforcement to confine the boundary element of the wall. The main parameter investigated was the height of the jacket section for strengthening. The limit height of the strengthening jacket section was determined by comparing the moment distributions between the existing and strengthened walls. Test results showed that the examined jacket section approach was significantly effective in enhancing the flexural resistance of walls, indicating 46% higher stiffness at peak strength and 210% greater work damage indicator, compared with the flexural performance of the unstrengthened wall. The ductility of the strengthened walls was insignificantly affected by the height of the jacket section when the height is greater than twice the wall length. The flexural capacity of the strengthened walls was 22% higher than the predictions obtained using the equivalent stress block specified in ACI 318-14.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.4
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• pp.874-883
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• 2007

The aqueous extract of Chungsimyeonja-eum has been used to treat palpitation, anemia, chronic fatigue, hypertension, and stroke. It also possesses various pharmacological effects including hypotensive, blood circulating, sedative, anti-inflammatory, diuretic, and anti-stress activities. In the present results, the latency time of plantar test was decreased in the immobilization stress and incusion pain-induction group. However the paw withdrawal latency values were increased in the immobilization stress and incision pain-induction groups after treatment with the aqueous extract of Chungsimyeonja-eum. The c-Fos expression in the paraventricular nucleus (PVN), and 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) in the dorsal raphe were enhanced in the immobilization stress and incision pain-induction groups. However, the treatment with the aqueous extract of Chungsimyeonja-eum suppressed the immobilization stress and incision pain-induced increase of c-Fos, 5-HT, and TPH expressions. Here in this study, we have demonstrated the protective effects of Chungsimyeonja-eum on immobilization and incision pain-induced stress. The present study revealed that Chungsimyeonja-eum treatment diminishes immobilization and pain stress.

• Herbal Formula Science
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• v.11 no.1
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• pp.99-114
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• 2003

This study aimed to investigate the effects of Chaihushugansan and Chaihuyigantang on the change of monoamine-contents in the hypothalamus of mice induced by the immobilization stress. Each formula(1.0g/kg) was injected intragastrically to mice 1 hour prior to the immobilzation stress(15 minutes) before measuring the change of monoamine-contents level in mice hypothalamus. The results were as follows: 1. DA content at control group showed significant change. CHSGS group and CHYGT group showed significant decrease.(P<0.05) 2. NE content of the control group was increased than normal group. NE content of the CHYGT group was shown a significant decrease than control group.(P<0.05) 3. DOPAC contents didn't show significant changes at any groups. 4. 5-HT contents didn't show significant changes at any groups. 5. 5-HIAA contents at CHSGS group and CHYGT group showed signifiant changes.(P<0.05, 0.01) These data revealed that chaihushugansan and chaihuyigantang might have the anti-stress effect through the control of DA and NE contents in the hypothalamus.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.217-220
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• 2008

Recently, many studies about a high-strength concrete and composite structures are being progressed to get the more economic and stable result in the construction of structure all over the world. One of those studies is about CFTA(Concrete Filled and Tied Steel Tubular Arch) girder that applies an arch structure and a pre-stressed structure to CFT(Concrete Filled Steel Tubular) Structure which is filled with a concrete and improve the stiffness and strength of the structure by the confinement effect of fillers to maximize the efficiency of structure and economic. In this study, non-linear behavior of CFTA girders filled with a general concrete and the high-strength concrete respectively were analyzed by using ABAQUS 6.5-1 and results were compared.

• Journal of the Korean Geotechnical Society
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• v.28 no.7
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• pp.5-16
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• 2012

Soil-nailing is the most popular method of reinforcing for slope stability. In general, two factors are considered as failure modes during the soil-nailing design stages: pullout failure mode and shear failure mode that will occur on the most probable failure plane. In many cases, however, shallow failure can also occur when the ground near the slope face is swept away by the horizontal stress release during the staged top-down excavation. In this paper, an optimized soil-nailing design methodology is proposed by considering the three failure modes mentioned above: pullout failure; shear failure; and shallow failure. The variables to be optimized include the bonded length and number of soil-nailings, and the confining pressure that should be applied at the slope face. The procedure to obtain the optimized design variables is as follows: at first, optimization of soil-nailings, i.e. bonded length and number, against pullout and shear failure modes; and then, optimization of confining pressure at each excavation stage that is needed to prevent shallow failure. Since the two processes are linked with each other, they are repeated until the optimized design variables can be obtained satisfying all the constrained design requirements in both of the two processes.

• Journal of Intelligence and Information Systems
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• v.22 no.3
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• pp.1-21
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• 2016

IT-based subjective well-being (SWB) services, a main part of wellness IT, should measure the SWB state of individuals in an unrestrained, cost-effective manner. The dictionaries for sentiment analysis available in the market may be useful for this purpose, but obtaining proper sentiment values using only words from the sentiment lexicon is impossible; therefore, a new dictionary including wellness vocabulary is needed. The existing sentiment dictionaries link only a single sentiment value to a single sentiment word, although sentiment values may vary depending on personal traits. In this study, we develop an extended version of the SenticNet sentiment dictionary dubbed WellnessWordNet. SenticNet is considered the best and most expressive among the already existing sentiment dictionaries. Using the information provided by SenticNet, we created a database including the wellness states (estimated values) of stress, depression, and anger to develop the WellnessWordNet system. The accuracy of the system was validated through actual tests with live subjects. This study is unique and unprecedented in that i) an extended sentiment dictionary, WellnessWordNet, is developed; ii) values for wellness state language are offered; and iii) different sentiment values, namely contextual polarity, for people of the same gender or age group are suggested.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.3 s.49
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• pp.47-55
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• 2006

Seismic performance and retrofit of reinforced concrete (RC) two-column piers widely used at roadway bridges in Korea was experimentally evaluated. Ten two-column piers that were 400 mm in diameter and 2,000 mm in height were constructed. These piers were subjected to hi-directional cyclic loadings under a constant axial load of $0.1f_{ck}A_g$. Test parameters were the confinement steel ratio, loading pattern, lap splice of longitudinal reinforcing bars, and retrofitting method. Specimens with lap-spliced longitudinal bars were retrofitted with steel jacket, pre-stressing steel wire, and steel band. Test result showed that while the specimens subjected to bi-directional lateral cyclic loadings which consisted of two main amplitudes in the transverse axis and two sub amplitudes in longitudinal axis, referred to as a T-series cyclic loadings, exhibited plastic hinges both at the top and bottom parts of the column, the specimens subjected to bi-directional lateral cyclic loadings in an opposite way, referred to as a L-series cyclic loadings, exhibited a plastic hinge only at the bottom of the column. The displacement ductility of the specimen under the T-series loadings was bigger than that of the specimen under the L-series loadings. Specimen retrofitted with pre-stressing steel wires exhibited poor ductility due to the upward shift of the plastic hinge region because of over-reinforcement, but specimens retrofitted with steel jacket and steel band showed the required displacement ductility. Steel band can be an effective retrofitting scheme to improve the seimsic performance of RC bridge piers, considering its practical construction.

• Journal of Life Science
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• v.32 no.8
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• pp.601-610
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• 2022

P. tenebrifer (PT) belongs to the Diptera order and Stratiomyidae family. Recently, insect industry have been focused as food, animal feed and environmental advantages. γ-aminobutyric acid (GABA) and melatonin have been associated with regulating sleep and depression. GABA is the primary inhibitory neurotransmitter and is synthesized via biotransformation of monosodium glutamate (MSG) to GABA by lactic acid bacteria. In this study, we first used a GABA-enhanced PT extract, wherein GABA was enhanced by feeding MSG to PT. The underlying mechanisms preventing stress and insomnia were investigated in a corticosterone (CORT)-induced endoplasmic reticulum (ER) stress and chronic restraint stress (CRS)-exposed mouse model, as well as in pentobarbital (45 mg/kg)-induced sleep behaviors in mice. In the present study, the GABA peak was detected in high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) analysis and showed in Ptecticus tenebrifer water extract (PTW) but not in non-PTW extract. The results showed that PTW and Ptecticus tenebrifer with 70% ethanol extract (PTE) exerted neuroprotective effects by protecting against CORT-induced downregulation of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and cAMP-response element binding protein (CREB) expression. In addition, PTW (300 mg/kg) significantly reduced CORT levels in CRS-exposed mice. Furthermore, PTW (100 and 300 mg/kg) significantly reduced sleep latency and increased total sleep duration in pentobarbital (45 mg/kg)-induced sleeping behaviors, which was related to serum melatonin levels. In conclusion, our results suggest that PTW exerts anti-stress and sleep-enhancing effects by regulating serum CORT and melatonin levels.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1393-1403
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• 2003

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-Tang on the stress were studied with cDNA microarray analyses on hypothalamus using an immobilization-stress mouse as stress model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hours once a day, and this challenge was repeated for seven consecutive days. The body weights of the immobilization-stress mice were diminished about 25 percent degree as compared to normal ones. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with CyDye/sup TM/ fluorescence dyes (Amersham Bioscience Co., NJ), and then hybridized to cDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix 4000 series scanner and GenePix Pro/sup TM/ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis- and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 3.5 fold. The 20 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Hspe1 (protein folding), Aatk (apoptosis), Dffa (apoptosis), Itgb1 (cell adhesion), Vcam1 (cell adhesion), Fkbp5 (protein folding), BDNF (neuron survival) were restored to the normal one by the treatment of Boshimgeonbi-Tang.

• The Korean Journal of Pharmacology
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• v.23 no.2
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• pp.87-94
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• 1987

The role of central adrenergic activity in the genesis of stress ulcers was investigated by intracerebroventricular (i.c.v.) administration of catecholamines and clonidine in pylorus-ligated rats restrained for 4 hours at a temperature of $4^{\circ}C$. 1. The stress-induced ulceration was markedly decreased by the i.c.v. administration of norepinephrine, epinephrine, dopamine or low dose of clonidine. 2. After an i.c.v. administration of norepinephrine or epinephrine, the volume of gastric juice, and both acid and pepsin secretion were markedly decreased. 3. Dopamine or a low dose of clonidne decreased the volume of gastric juice and acid secretion but did not affect pepsin secretion. 4. Isoproterenol caused a decrease in the volume of gastric juice and acid secretion, however, the ulcerogenesis was similar to that of the control. 5. Gastric function as well as ulcerogenesis was little affected by a high dose of clonidine. From the above results, it is suggested that central adrenergic activation inhibits cold-restraint induced ulcerogenesis via adrenergic alpha and dopaminergic receptors, and that this effect may be mediated by a decrease in gastric acid secretion. It is also suggested that other factors may be involved in this antiulcerogenic effect.