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Anti-stress and Anti-nociceptive Effects of the Aqueous Extracts of Chungsimyeonja-eum against Immobilization Stress and Incision Pain in Rats  

Yoon, Jeong-Hwan (Department of Physiology, College of Oriental Medicine, Kyungwon University)
Ko, Il-Gyu (Department of Physiology, College of Medicine, Kyung Hee University)
Shin, Mal-Soon (Department of Physiology, College of Medicine, Kyung Hee University)
Kim, Chang-Ju (Department of Physiology, College of Medicine, Kyung Hee University)
Lee, Chung-Yeol (Department of Physiology, College of Oriental Medicine, Kyungwon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.4, 2007 , pp. 874-883 More about this Journal
Abstract
The aqueous extract of Chungsimyeonja-eum has been used to treat palpitation, anemia, chronic fatigue, hypertension, and stroke. It also possesses various pharmacological effects including hypotensive, blood circulating, sedative, anti-inflammatory, diuretic, and anti-stress activities. In the present results, the latency time of plantar test was decreased in the immobilization stress and incusion pain-induction group. However the paw withdrawal latency values were increased in the immobilization stress and incision pain-induction groups after treatment with the aqueous extract of Chungsimyeonja-eum. The c-Fos expression in the paraventricular nucleus (PVN), and 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) in the dorsal raphe were enhanced in the immobilization stress and incision pain-induction groups. However, the treatment with the aqueous extract of Chungsimyeonja-eum suppressed the immobilization stress and incision pain-induced increase of c-Fos, 5-HT, and TPH expressions. Here in this study, we have demonstrated the protective effects of Chungsimyeonja-eum on immobilization and incision pain-induced stress. The present study revealed that Chungsimyeonja-eum treatment diminishes immobilization and pain stress.
Keywords
Chungsimyeonja-eum; immobilization stress; c-Fos; 5-hydroxytryptamine; tryptophan hydroxylase;
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