• Journal of Korean Biological Nursing Science
• /
• v.18 no.1
• /
• pp.36-42
• /
• 2016

Purpose: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin levels. Thus, this study was designed to evaluate the effect of saccharin intake in restraint-induced stress response reduction in rats. Methods: Adult male Sprague-Dawley (SD) rats had stress induced by restraint for 2 hours/day for 1 week. Saccharin was provided in sufficient amounts to allow them to intake it voluntarily at 0.1% diluted in water. The Y-maze test and forced swim test (FST) were performed to evaluate cognitive function and the depressive behavior of the rats. The protein expression of the glucocorticoid receptor (GR) in hippocampal cornu ammonis (CA) 1 was investigated by using immunohistochemistry. Results: It was found that, the percentage of alternation in the Y-maze test was significantly (p<.01) higher in the Stress + saccharin group than in the Stress group. Immobility time in the FST was significantly (p<.01) lower in the Stress + saccharin group than in the Stress group. Also, the positive cells of GR in hippocampus CA1 were significantly (p<.05) lower in the Stress + saccharin group than in the Stress group. Conclusion: This study showed that there was an effect of saccharin intake in restraint-induced stress response reduction in rats.

• Journal of Oriental Neuropsychiatry
• /
• v.5 no.1
• /
• pp.81-91
• /
• 1994

This exoeriments were conducted to study anti-stress effects Samulanshintang on the weight change, ${\beta}-lipoprotein$, total cholesterol and triglyceride consentration of rats stressed by immobilization. The following results have been obtained : 1. Samulanshintang reduced significantly the body weight loss of rats stressed by immobilization. 2. Samulanshintang decreased significantly the serum cortisol level of rats stressed by immobilization. 3. Samulanshintang decreased significantly the serum ${\beta}-lipoprotein$ level of rats stressed by immobilization. 4. Samulanshintang decreased significantly the serum total cholesterol level of rats stressed by immobilization. 5. Samulanshintang decreased significantly the serum triglyceride level of rats stressed by immobilization. According to the above results, it is concluded that Samulanshintang has significant effect in reducing stress.

• Environmental Analysis Health and Toxicology
• /
• v.14 no.3
• /
• pp.127-133
• /
• 1999

To elucidate the preventive effect of oriental medicine Gungchi -hwadamsun (GH) on stress, we investigated the physiological change of rats which were applied immobilization stress. For immobilization stress, rats were placed in restrainer for 12 hours a day for 3 days. During application of stress, body weight of rats was measured. After sacrifice, 8 organs were taken for measurement of organ weight. Brain was sectioned into 4 parts that are Frontal Cortex, Corpus Striatum, Hypothalamus and Hippocampus. Each part was homogenated and its catecholamine and serotonin contents were measured with HPLC. In our study, stress mainly induced increase of concentration of neurotransmitters in brain, but had mild effect on other physical function of rats. GH inhibited stress induced changes of neurotransmitter content in brain.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2003.05a
• /
• pp.601-608
• /
• 2003

A new type of bridge superstructures referred to as Steel-confined Prestressed Concrete Girder (SCP Girder) was developed, which is composed of concrete, steel plate, and prestressing tendon. The girder may maximize structural advantages of these components : thus, long span bridges with low height girder may be constructed. For the effective design and fabrication of the girder, the design software program was developed and the process of fabrication established. The experimental girder designed using the program was manufactured in actual size to confirm the fabric ability of the girder. Propriety of design, structural safety, and applicability of the girder were verified through the load test.

• Environmental Analysis Health and Toxicology
• /
• v.13 no.3_4
• /
• pp.143-149
• /
• 1998

To elucidate the preventive effect of Danchisoyosan (DS) on stress, we investigated the physiological change of rats which were applied immobilization stress. For immobilization stress, rats were placed in restrainer for 12 hours a day for 3 days. During application of stress, body weight of rats was measured. After sacrifice, 8 organs were taken for measurement of organ weight. Brain was sectioned into 4 parts that are Frontal Cortex, Corpus Striatum, Hypothalamus and Hippocampus. Each part was homogenated and its catecholamine and serotonin contents were measured with HPLC. In our study, stress mainly induced increase of concentration of neurotransmitters in brain without other significant physical change of rats. DS inhibited stress induced changes of neurotransmitter content in brain.

• Proceedings of the KSR Conference
• /
• 2004.10a
• /
• pp.1007-1013
• /
• 2004

A new type of girder named as Steel-Confined Prestressed Concrete Girder(SCP Girder) has been developed, which is composed of concrete, steel plate, and prestressing tendon. This girder may maximize structural advantages of these components, therefore it can be used to construct the middle or long span bridge with low-height girder. To verify the propriety of design, structural safety, and applicability of this girder, static load test was carried out. In this study, a design program was developed for practical design of railway bridge using SCP girder. And to verify the applicability of SCP girder to railway bridge, structural performance and economic efficiency based on the construction cost were compared with conventional railway bridges.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2005.05a
• /
• pp.455-458
• /
• 2005

The Steel-Confined Prestressed Concrete Girder(SCP Girder) has been developed, which maximizes structural advantages of components (concrete, steel plate and tendon) and can be used to construct the middle or long span bridge with low-height girder. And recently, a continuous beam type of SCP Girder has been being developed to decrease size and self weight of girder in comparison with a simply-supported type. In this study, as part of developing the continuous beam type of SCP Girder, a new type of anchorage zone is proposed in order to address tendons effectively and decrease section size of SCP Girder efficiently. And also, the experimental test was carried out using a real scale specimen to examine the behavior of proposed anchorage zone.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.10 no.2
• /
• pp.201-211
• /
• 1999

Objectives：This study investigated the characteristics of detained delinquent adolescents and variables related to the repeated crime during 6 months after release. Methods：The socio-demographic and crime-related characteristics of 73 detained adolescents were evaluated by semi-structured interviews and police records, and the psychological characteristics of them measured by the MMPI. We also compared the characteristics between subjects with and without repeated crime during 6 months after release. Results：1) Most of detained adolescents had families with low socioeconomic status(77%) and broken families(48%). Sixty-six percent of them were dropped out of school. The most frequent crime pattern was theft(49%), and with accomplice(77%). Seventy-five percent of total subjects had the records of previous conviction. Of the previous convictions, seventy-eight percent was same with the present crimes. 2) Subjects with repeated crime during 6 months after release were younger and had higher T-score on Pa scale of MMPI than the subjects without repeated crime. More adolescents with repeated crime had broken families than those without repeated crime. They also showed the crime-related characteristics of higher percent of theft among crime patterns, higher incidence of previous conviction, younger age of the first crime, and shorter crime-free duration from the last to present crime. Conclusion：These results of present study suggest that the development and the persistence of adolescent delinquency would be resulted from interaction of factors of individual, family, school, and community. By the comparison between subjects with and without repeated crime, it was found that familial dysfunction, younger age at first crime, presence of previous conviction might be the risk factors for repeated delinquency. To prevent repeated crime of delinquent adolescents more effectively, early therapeutic intervention and the development of programs to help adaptation in school and community would be essential.

• Journal of Korean Biological Nursing Science
• /
• v.22 no.4
• /
• pp.279-287
• /
• 2020

Purpose: Some of the adolescent drinks more sugar-sweetened beverages. However, there is little evidence on the effect of eating behavior on emotional state and neurochemical changes under stress, especially on the levels of typical inhibitory neurotransmitters and gamma-aminobutyric acid. This article demonstrates that sucrose or saccharin drink reduces stress-related behavior responses and GABAergic deficits in adolescent rats. Methods: We randomly assigned 7-weeks-old Sprague-Dawley male rats to three groups: control group (Control), restraint stress only group (Stress), and restraint stress with unrestricted access to saccharin solution (Saccharin) and sucrose solution (Sucrose) as a positive control. We evaluated both anxious and depressive moods using an open field test and forced swim test, respectively. Using western blot analyses, the expression of a GABA-synthesizing enzyme, glutamate decarboxylase-67 (GAD67) and GABAergic markers, including calbindin and parvalbumin was assessed in the prefrontal cortex and the amygdala. Results: We found that both the drinks alleviated anxiety and depressive moods, induced significant attenuation in GAD67 level, and reduced calbindin level under stress in the prefrontal cortex and the amygdala. Conclusion: The results provide an understanding of the effect of sucrose or saccharin drink on stress-related responses. We propose the consumption of sweet drinks as a plausible strategy to alleviate stress-related alterations in adolescents.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.18 no.1
• /
• pp.101-110
• /
• 2014

Expansion agent is a very effective admixture for prevention of cracking due to autogenous/drying shrinkage and this can induce internal chemical prestress to embedded reinforcement. In this paper, tension-softening and hardening in cement mortar with steel and CSA expansion agent are experimentally evaluated. Cement mortar with steel reinforcement is prepared and tensile strength test is performed for evaluation of cracking and tensile behavior. In spite of slightly reduced strength and elasticity in CSA mortar, significantly increased tension-hardening behavior is evaluated in CSA mortar with induced chemical prestress. Furthermore previous tension softening models are compared with the test results and improvement are proposed.