• Title/Summary/Keyword: 교호효과

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Effect of N-3, N-6 Fatty Acid and d-Limonene Treatment on Membrane Lipid Composition and Protein Kinase C Activity in Experimental Rat Hepatocarcinogenesis (쥐의 간 발암과정에서 N-3, N-6 지방산 섭취 및 d-Limonene 투여가 생체막 지질조성 및 Protein Kinase C 활성도에 미치는 영향)

  • 김미정;김정희
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.8
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    • pp.1328-1336
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    • 2003
  • This study was done to investigate the effects of n-3, n-6 fatty acid and d-limonene on the hepatic membrane lipid composition, protein kinase C (PKC) and glutathione S-transferase (GST) activities in experimental rat hepatocarcinogenesis. Sprague-Dawley female rats were fed with two different types of dietary oil for 20 weeks. Corn oil (CO) and sardine oil (SO) were used at 15% by weight as a source of n-6 and n-3 fatty acid, respectively. One week after feeding, rats were intraperitoneally injected twice with a dose of diethylnitrosamine (DEN, 50 mg/kg body weight) and after 1 week 0.05% phenobarbital (PB) was provided with drinking water. Membrane fractional lipid composition showed that the content of cholesterol was higher in 50 group than CO group and also significantly decreased by d-limonene. The content of phospholipid was increased by carcinogen treatment but not affected by dietary oils or d-limonene. Membrane C/PL molar ratio was significantly decreased by d-limonene or carcinogen treatment in 50 groups but not in CO groups. Fatty acid composition was changed by dietary oils but not by carcinogen treatment or d-limonene. Cytosolic PKC activity was not significantly different by dietary oils, d-limonene or carcinogen treatment. However, membrane PKC activity was significantly increased by carcinogen treatment and decreased by d-limonene. Cytosolic GST activity was affected by d-limonene or carcinogen treatment in all dietary groups. These data indicate that dietary oils, d-limonene and carcinogen treatment can not change much membrane phospholipid composition. But membrane C/PL molar ratio was changed by carcinogen treatment and d -limonene although the effect was different between dietary oils. Therefore, it is suggested that different dietary oils and d-limonene can somewhat modulate the changes of membrane fluidity and activities of membrane bound enzymes like membrane associated PKC during carcinogenesis.

Change in Gastrocnemius Pennation Angle According to Ankle Dorsiflexion among University Students (일부 대학생의 발목관절 발등굽힘 각도 변화에 따른 장딴지근 깃각의 차이)

  • Kim, Ji-Seon;Seo, Byoung-Do;Shin, Hyung-Soo;Shin, Hee-Joon;Ju, Joung-Youl
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.12
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    • pp.8684-8690
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    • 2015
  • This study aimed to investigate the influence of the ankle dorsiflexion angle ($0^{\circ}$, $10^{\circ}$, and $20^{\circ}$) on the effectiveness of gastrocnemius stretching angle. The subjects of this study were 25 young man and female women. In all participants, the pennation angle of the medial head of the gastrocnemius was evaluated using ultrasonography at an ankle dorsiflexion angle of $0^{\circ}$, $10^{\circ}$, or $20^{\circ}$. Repeated measures analysis of variance was uesd to test for differences between ankle dorsiflexion angles. The independent t-test was performed to determine the significance of sex differences. The results of this study showed that the gastrocnemius pennation angle decreased as the ankle dorsiflexion angle increased, with significant interaction between each angle of ankle dorsiflexion angle (p<0.01). Sex comparison showed that the pennation angle was greater in man than in women, but the difference was not significant (p>0.05). According to the sex the gastrocnemius pennation angle is decreased as the ankle dorsiflexion angle increased (p<0.01). These results suggest that the end range of dorsiflexion is more beneficial for gastrocnemius stretching than a small range. Further studies are needed to investigate the influence of other factors, such as stretching angle and application time, on gastrocnemius stretching.

$\frac{1}{4}$ß$\frac{1}{2}$ (주요 식량작물에 대한 시비적량 추정에 관한 연구)

  • 장석환;최재성
    • The Korean Journal of Applied Statistics
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    • v.1 no.2
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    • pp.34-44
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    • 1987
  • In order to estimate the optimum fertilizer level for rice, a major food crop, the experimental results obtained from the fertilizer trials conducted at 642 experimental sites(farmers' fields) throughout the country for the period from 1976 to 1979 were examined. Since non-significant interactions among fertilizers have been ovserved from the past experiences, only thirteen treatments(combinations of fertilizer levels) for the experiments as given in the Table 1 were chosen such that simple response curves can be fitted with independent variables being N, $P_2O_5, and K_2O$. Weighted combining analysis of variance was also carried out for each type of paddy fields to test the significance of Treatments $\times$ Experimental sites interaction, and highly significant variability in response to treatments among experimental sites in the same type of paddy fields was observed in most types of fields. For the types of paddy fields where the treatments $\times$ experimental sites interaction was not significant, separate response curves for N, $P_2O_5, and K_2O$ were estimated on the basis of the mean yields of rice, and common values of the optimum levels of fertilizers were extimated thereform. When the interaction is significant, response curves were fitted for each experimental sites. The average fertilizer doses estimated for the types of paddy fields based on the individual sites are given in Tables 7-1 and 7-2.

Shift in Weed Occurrence Accompanied Type of Direct - seeded Rice Fields (벼 직파재배(直播栽培) 유형별(類型別) 잡초발생(雜草發生)의 변화(變化))

  • Choi, C.D.;Won, J.G.;Lee, W.H.;Choi, B.S.
    • Korean Journal of Weed Science
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    • v.17 no.2
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    • pp.139-146
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    • 1997
  • The experiment was conducted at Gyeongbuk Provincial Rural Development Administration in 1996 to obtain basic information on weed ecology and effective weed control in direct-seeded rice fields under different seeding types and seeding times. A large number of upland weeds such as Echinochloa crus-galli, Digitaria sanguinalis, Capsella bursa-pastoris and Stetaria viridis etc occurred at early growth stage, while Eleocharis kuroguwai, Aneilema keisak and Cyperus serotinus dominated at late stage in dry seeded rice field. In wet seeded rice field, the dominance of E. crus-galli was lower and the occurrence of M. vaginalis and A. keisak were higher than in dry seeded field. Amount of weed occurrence in dry seeded field was 1.8 to 2.4 times greater than in wet seeded field and it increased with delaying seeding time. Increasing rate of weed occurrence through whole life cycle was the highest at 20 days after seeding (DAS) to 40 DAS, regardless of seeding types and seeding times. Simpson index in wet seeded field was higher than in dry seeded field and it gradually increased as growing of dominant species. For F-value test, it was recognized as statistical significant in seeding types, seeding times and interaction of two factors.

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Etiology and Chemical Control of Skin Sooty Dapple Disease of Asian Pear (동양배 과피얼룩병의 발생생태와 화학적 방제)

  • Park, Young-Seob;Kim, Ki-Chung;Lee, Jang-Hoon;Kim, In-Seon;Choi, Yong-Soo;Cho, Song-Mi;Kim, Young-Cheol
    • The Korean Journal of Pesticide Science
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    • v.12 no.4
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    • pp.375-381
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    • 2008
  • A new disease causing skin sooty dapple symptoms on fruits, leaves, and young shoot of Asian pear occurred in Korea. However, no chemical control approaches has been developed to control this disease. To investigate ecological aspects of this disease, we conducted field surveys in the high or low disease occurred orchards. The years with heavy rainfall caused severe occurrence of the skin sooty dapple disease than the years with lower rainfall during all growth stages of pear fruit. Different fruit-wrapping bags did not prevent occurrence of skin sooty dapple disease, and lesion numbers were higher in lower parts of fruit equatorial line inside of fruit-wrapping bags. There is a direct correlation between occurrence of the skin sooty dapple disease and frequency of fungicide application in the orchards. Among the tested commercial fungicides, thiophanate-methyl WP and penconazole WP completely inhibited the growth of the Cladosporium sp. in in vitro studies but little protection was observed in the field following fungicide applications. However, application of lime sulfur combined with the use of fruit-wrapping bags most effectively reduced incidence of the disease in the field. Our results suggest that skin sooty dapple disease could be a serious problem in sustainable organic pear farms and effective control methods for this disease urgently required.

Optimization of a Crystallization Process by Response Surface Methodology (반응표면분석법을 이용한 결정화 공정의 최적화)

  • Lee, Se-Eun;Kim, Jae-Kyeong;Han, Sang-Keun;Chae, Joo-Seung;Lee, Keun-Duk;Koo, Kee-Kahb
    • Applied Chemistry for Engineering
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    • v.26 no.6
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    • pp.730-736
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    • 2015
  • Cyclotrimethylene trinitramine (RDX) is a high explosive commonly used for military applications. Submicronization of RDX particles has been a critical issue in order to alleviate the unintended and accidental stimuli toward safer and more powerful performances. The purpose of this study is to optimize experimental variables for drowning-out crystallization applied to produce submicron RDX particles. Effects of RDX concentration, anti-solvent temperature and anti-solvent mass were analyzed by the central composite rotatable design. The adjusted determination coefficient of regression model was calculated to be 0.9984 having the p-value less than 0.01. Response surface plots based on the central composite rotatable design determined the optimum conditions such as RDX concentration of 3 wt%, anti-solvent temperature of $0.2^{\circ}C$ and anti-solvent mass of 266 g. The optimum and experimental diameters of RDX particles were measured to be $0.53{\mu}m$ and $0.53{\mu}m$, respectively. The regression model satisfactorily predicts the average diameter of RDX particles prepared by drowning-out crystallization. Structure of RDX crystals was found to be ${\alpha}$-form by X-ray diffraction analysis and FT-IR spectroscopy.

Endophytes from Natural Festuca spp. in Southwest China and Their Compatibility with Tall Fescue Cultivars (남서중국의 자생페스큐의 엔도파이트와 톨체스큐 품종과의 공생)

  • Wang, Yaoyao;Du, Yongji;Han, Liebao;Li, Deying
    • Asian Journal of Turfgrass Science
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    • v.23 no.1
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    • pp.163-176
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    • 2009
  • Investigating endophyte distribution, naturally occurring in native grasses, is important for understanding endophyte-grass associations and using the beneficial effects of endophytes in cultivated plants. The goal of this study was to investigate endophytes from natural Festuca spp. in Yunnan, Guizhou, and Sichuan Provinces of China, and to study the compatibility between the endophytes and turf type tall fescue (Festuca arundinacea) which is widely used for lawn and athletic fields in that region. Of 628 accessions in F. ovina, 421 had endophytes identified in leaf sheath from on-site microscopic examination. From Festuca spp, three isolates were obtained from the seeds and ninety isolates were obtained from seedlings established from the collected seeds. The isolates from F. ovina and F. stapfii were tentatively identified as Neotyphodium typhinum and Neotyphodiumstarii, respectively. We tested compatibility of the two fungal species with seven tall fescue cultivars, Little Hero, Sub Boy, Eldorado, Arid III, Millennium, Crossfire, and Fawn. N. typhinum or N. starii did not infect 'Fawn' with either seed injection or seed soaking method. The highest infection rate byboth N. typhinum and N. starii was in 'Sun Boy' and 'Eldorado'. There were significant interaction effects between tall fescue cultivar and type of endophyte on infection.

Effects of Pork on Cadmium Detoxification in Rats (돼지고기 급여가 흰쥐의 체내에 중독된 카드뮴의 해독과정에 미치는 영향)

  • Rho Jeong-Hae;Han Chan-Kyu;Seong Ki-Seung;Lee Nam-Hyung
    • Food Science of Animal Resources
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    • v.25 no.4
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    • pp.373-382
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    • 2005
  • This study was performed to investigate the effect of pork on the cadmium detoxification in rats. Ninety male Sprague-Dawley strains were divided into five stoups based on cadmium treatment(0, 25, 50, 100, 250 ppm) and cadmium intoxication was observed for 8 weeks. During following 8 weeks, casein was replaced by Pork and the effect of pork was compared with casein. During intoxicating, the growth mte was lessened. Feed efficiency ratio was significantly low, as cadmium intake was high Discontinuing cadmium feeding, the body weights were relieve4 Pork-fed groups seemed to have higher body weight than casein-fed groups. During intoxication, hemoglobin and hematocrit were dependent upon cadmium intake. However, they became normal at detocification stage. Cadmium accumulation of the pour-fed group was lower than that of casein. Especially, the factors which affected the cadmium content in kidney were Cd(p<0.001) and $Cd^*pork(p<0.001)$. Metallothionein(MT) was increased with cadmium, and MT was not likely to be affected by pork. This study may provide scientific background of pork for detoxification from heavy metals such as cadmium.

Variation in Larvae Development and Moth Emergence of Striped Rice Borer (Chilo suppressalis Walker) and Damages in Rice Cultivars under Different Levels of Nitrogen and Silicate Fertilizers (질소 및 규산시비수준에 따른 수도품종간 이화명충의 발육ㆍ우화 및 피해정도의 변이)

  • 손상목;김기준
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.27 no.1
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    • pp.11-19
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    • 1982
  • The average weight of larvae, the percentage of survival larvae and the percentage of moth emergence in first and second generation of striped rice borer showed lower values in Akibare(Japonica variety) compared with those in Milyang 23 (Indica variety). At higher nitrogen level the larvae weight in second generation of striped borer was increased. The percentage of survival larvae in second generation was gradually decreased by applying the silicate fertilizer in both cultivars. The moth emergences in both generations of striped rice borer were also lower at high levels of silicate fertilizer. The percentage of white head of rice plant was reduced by the application of silicate fertilizer. The ratio of SiO$_2$ to T-N of the rice stem was related negatively with the percentage of survival larvae and the moth emergence in second generation of striped rice borer, and also with the percentage of white head of rice plant.

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Correlation Analysis with Modified Barthel Index and Motor Assessment Scale in Stroke Patients (뇌졸중환자의 기능평가척도로서의 MBI와 MAS의 상관성분석)

  • Ko, Seong-Gyu;Jun, Chan-Yong
    • The Journal of Korean Medicine
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    • v.20 no.1 s.37
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    • pp.52-59
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    • 1999
  • 연구목적 : 뇌졸중환자에 기능회복도의 측정을 위해 가장 신뢰도가 높은 MBI에 대해서 순수하게 뇌졸중환자의 운동기능평가만을 위해 고안된 MAS의 상관성을 각 기간별로 분석하여 MAS의 운동기능평가척도로서의 객관성에 대해 연구한다. 또 한편으로 경과시간에 따른 운동기능 회복도의 차이를 전체그룹과 사상그룹에서 평가한다. 연구방법 : 1998년 1월부터 1998년 6월까지 6개월에 걸쳐 상지대학교 한의과대학 부속한방병원 내과에 입원하여 뇌졸중으로 진단된 환자 중 의식과 언어상태가 명료한 32명을 대상으로 하였다. 입원직후 사상의학과에 의뢰하여 QSCCII 시스템에 의하여 체질진단을 받은 후 본원 운동기능평가실에서 입원직후, 입원 후 2주와 4주 등 3회에 걸쳐 Modified Barthel Index(MBI)와 Motor Assessment Scale(MAS)을 시행하였다. 각 환자에 대한 검사는 2명의 한방순환기내과 전문의와 전공의에 의해 환자에 대한 사전 정보 없이 이루어졌다. 연구결과 : 통계처리는 상관분석을 위해서는 Pearson correlation coefficient, 사상체질에 있어서 각 경과시간에 따른 점수변화는 Repeated ANOVA, 일반적특성 분석에는 Descriptive analysis가 사용되었고, 프로그램은 SPSS/PC+ 7.5 version을 사용하였다. 1. 뇌졸중 환자의 사상의학적인 분포는 태음인이 56.3%로 가장 많았고, 소양인이 28.1%, 소음인이 12.5%, 태양인이 3.1%이었으며, 연령별로는 50대가 32.6%로 가장 많았으며, 평균연령은 60.9세였다. 2. 경과시간에 따른 사상체질간의 MBI, MAS 평균점수변화는 MBI, MAS 모두 반복측정 분산분석 결과 입원당시와 2주 후, 입원당시와 4주 후에서 모두 P<0.001의 범위에서 통계학적으로 유의하게 증가하였고, 경과시간과 사상체질간의 교호작용은 없었다. 3. MBI, MAS 모두 각 항목과 기능별 분류군에서도 경과시간에 따른 평균점수의 변화는 P<0.001 범위에서 통계학적으로 유의하게 증가하여 한방치료의 효과가 있음을 보여주었다. 4. MBI와 MAS의 경과시간별 Pearson 상관성 분석결과 입원당시의 MBI와 입원당시의 MAS에서, 2주 후의 MBI와 입원당시, 2주 후, 4주 후의 MAS에서, 4주 후의 MBI와 입원당시, 2주, 4주 후의 MAS에서 모두 높은 상관성을 보여, 두 평가방법 간에는 상관성이 높다고 본다.

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