• The Korean Journal of Applied Statistics
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• v.26 no.4
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• pp.675-686
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• 2013

The Korea Food and Drug Administration(KFDA) recommends the use of a $2{\times}2$ crossover design to assess the bioequivalence of generic drugs. However, a standard $2{\times}2$ crossover design for bioequivalence trials is often considered problematic due to ethical and economic issues as highly variable drugs are usually required by large numbers of subjects when designing the trial. To overcome this problem a $2{\times}4$ crossover design has been a recommended option as per US regulations; in addition, a $2{\times}3$ crossover design has also recently drawn special attention as an efficient alternative. The current KFDA regulation requires an ANOVA table for every bioequivalence study; however, ANOVA tables of $2{\times}4$ and $2{\times}3$ crossover designs have never been published in the literature. This study shows the derivation of tables of analysis of variance for a $2{\times}4$ cross-over design and a $2{\times}3$ cross-over design. We also suggest a sample size formulas for $2{\times}2$, $2{\times}4$ and $2{\times}3$ crossover designs to provide information on the selection of efficient designs for highly variable drugs.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.2
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• pp.637-643
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• 2014

Recently there have been an increasing amount of bicycle accidents along with the increased usage of bicycles. Bicycle accidents occur frequently by perpendicular collision at the inner intersection. Bicycle traffic is especially concentrated in residential areas and around schools which results in the vulnerability of cyclists. This paper is to inform the potential risks of collisions between bicycles and cars turning right at the intersections using simulation analysis which focuses on the pavement edge of intersection geometric designs factor and checks on the drivers behavior. The result of the analysis shows that as the curve radius of pavement edge at the intersection becomes larger and the more attention drivers are paying to the rear by turning their heads to the right, the potential risk of collisions between bicycles and cars turning right will decrease.

• Korean journal of applied entomology
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• v.32 no.2
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• pp.129-133
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• 1993

The German cockroach (Blattella germanical L.) populations were successively selected with chlorpyrifos and permethrin for xis generations. The resulting resistant strains, $R_{chlorpyrifos}$(Rc) and $R_{permethrin}$(Rp) were observed resistant development and the cross-resistance. The result indicated that the values of $LC_{50}$ were increased 3.32 and 2.10 times from the susceptible strain, respectively. In the Rc strains, the values of the $LC_{50}$ of fenvalerate, propoxur, permethrin were to 3.89, 2.97, and 1.31 times higher than that of the suseptible, respectively. In the Rp strains, the values of the $LC_{50}$ of fenvalerate, chlorpyrifos, and propoxur showed 5.23, 1.42, and 1.80 times cross-resistance.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.370-370
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• 2021

태풍으로 인한 피해를 줄이기 위해 경로, 강도 및 폭풍해일의 사전 예측은 매우 중요하다. 이중, 태풍의 경로와는 달리 강도 및 폭풍해일의 예측에 있어서 바람장은 수치 모델의 초기 입력값으로 요구되기 때문에 정확한 바람장 정보는 필수적이다. 대기 바람장 예측 방법은 크게 해석적 모델링, 라디오존데 측정과 위성 사진을 통한 산출로 구분할 수 있다. Holland의 해석적 모델링은 비교적 적은 입력값이 필요하지만 정확도가 낮고, 라디오존데 측정은 정확도가 높지만 점 측정에 가깝기 때문에 이차원 바람장을 산출하기에 한계가 있다. 위성 사진을 통한 바람장 산출은 위성기술의 고도화로 관측 채널 수 및 시공간 해상도가 크게 증가하고 있기 때문에 다양한 기법들이 개발되고 있다. 본 연구에서는 생성적 적대 신경망 (Generative Adversarial Network, GAN)을 통해 일련의 연속된 과거 적외 채널 위성 사진 흐름의 패턴을 학습시켜 미래 위성 사진을 예측하고, 예측된 연속적인 위성 사진들의 교차상관 (cross-correlation)을 통해 바람장을 산출하였다. GAN을 적용함에 있어 2011년부터 2019년까지 한반도 근방에 접근했던 태풍 중에 4등급 이상인 68개의 태풍의 한 시간 간격으로 촬영된 총 15,683개의 위성 사진을 학습시켜 생성된 이미지들은 실측 위성 사진들과 매우 유사한 것으로 나타났다. 또한, 생성된 이미지들의 교차상관으로 얻어진 바람장 벡터들의 풍향, 풍속, 벡터 일관성 및 수치 모델과의 비교를 통해 각각의 벡터들의 품질 계수를 구하고 정확도가 높은 벡터들만 결과에 포함하였다. 마지막으로 국내 6개의 라디오존데 관측점에서의 실측 벡터와의 비교를 통해 본 연구 결과의 실효성을 검증하였다. 본 연구에서 확장하여, 이와 같이 AI 기법과 이미지 교차상관 기법을 사용하여 얻어진 바람장으로부터 태풍 강도예측에 필요한 요소인 태풍의 눈의 위치, 최고 속도와 태풍 반경을 직접적으로 산출할 수 있고. 이러한 위성 사진을 기반으로 한 바람장은 단순화된 해석적 바람장을 대체하여 폭풍 해일 모델링의 예측 성능 개선에 기여할 것으로 보여진다.

• The Transactions of the Korea Information Processing Society
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• v.5 no.11
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• pp.2908-2914
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• 1998

This paper presents an intelligent signal for controling the traffic lights on traffic junction network with dynamic traffic flow, When a junction is connected to adjacent junctions on four sides. Prior researches have been done on the single traffic junction. However, it is dificult to apply single junction controller to real traffic situation. In this paper, we develop a fuzzy taffic network controller which adjusts the extension time of current green phase by using teh fuzzy input variables such as the number of entering cars at the green light, the number of waiting cars during the red light, and the traffic volume. The proposed method was compared to the existing junction signal control methods on controllers in terms of average delay time of cars and the cost function defined in this paper.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06a
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• pp.130-133
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• 2010

본 논문에서는 유전 알고리즘의 성능 향상을 위해 교배(Crossover) 기법의 중요 매개변수인 교배 교차점(Crossover Point)의 수를 개체군(Population)의 진화 과정 중에 적응적으로 변화 할 수 있는 자기-적응형(Self-Adaptive) 교배 기법을 제안한다. 이를 위해 제안 교배 기법은 전체 개체군을 다수개의 작은 개체군들로 군집화(Grouping)하여 일차적으로 서로 다른 교차점을 갖는 교배 기법을 적용시키고, 그 후 각 군집의 개체(Individual)들의 선택률을 기반으로 군집들간의 경쟁을 수행한다. 이는 유전 알고리즘이 개체군의 진화 과정 중에 문제에 적합한 교차점을 갖는 교배 기법을 적응적으로 사용할 수 있도록 한다. 또한 제안 교배 기법은 진화 과정 중에 교차점이 지속적으로 변화되므로 알고리즘 초반에는 높은 탐색 능력을 보유하게 되고 후반에는 높은 부분-해(Building-Block) 보존 능력을 지니게 되어, 최적 해(Optimal Solution)로의 수렴 능력이 향상된다. Deceptive 문제를 통해 제안 자기-적응형 교배 기법과 기존 (고정 교차점) 교배 기법의 성능을 비교 하였으며, 실험 결과로부터 제안 교배의 성능 우위를 확인하였다.

• The Korean Journal of Applied Statistics
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• v.20 no.1
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• pp.39-52
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• 2007

Crossover trials of new drugs in the treatment of angina pectoris, which frequently use treadmill exercise test for the assessment of its efficacy, produce censored survival times. In this paper we consider analysis approaches for censored survival times from crossover trials. Previously, a stratified Cox model for paired observation and nonparametric methods have been presented as possible analysis methods. On the other hand, the differences of two survival times would produce interval-censored survival times and we propose a Cox model for interval-censored data as n alternative analysis method. Example data is analyzed in order to compare these different methods.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.321-325
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• 2007

3개의 매개변수(location, scale, shape)로 이루어진 GEV와 GLO 분포는, 미국의 공식적인 홍수빈도 분포인 Log Pearson Type III와 함께 수문분야에서 중요한 위치를 차지하고 있다. 본 연구에서는 Monte Carlo 실험을 이용하여 GEV와 GLO 분포에서 서로 다른 두 지점의 유출량 자료를 생성하여 L-CV(L-moment Coefficient of Variation; $\tau_2$)와 L-CS(L-moment Coefficient of Skewness; $\tau_3$)를 추정하였으며, L-moment 추정값들 간의 교차상관$(\tau_2-\tau_2,\;\tau_3-\tau_3,\;\tau_2-\tau_3)$과 유출량 자료간의 교차상관의 관계를 Simple Power 함수를 이용하여 유도하였다. 실험 과정에서 GEV와 GLO 분포가 비현실적인 음수 유출량을 생성하여, 실험 결과에 큰 영향이 있음을 확인하여, 두 분포에서 생성된 유출량 자료에서 음수값을 제외한 GEV+와 GLO+ 분포를 이용하여 관계식을 유도하고 이를 GEV와 GLO 분포의 결과와도 비교하였다. 본 연구에서 도출된 관계식은 향후 Generalized Least Square 회귀식을 이용하여 홍수분포의 지역 매개변수를 추정하기 위해 활용성이 클 것으로 기대한다.

• Journal of Korea Water Resources Association
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• v.53 no.5
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• pp.337-345
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• 2020

In order to provide information for proper management of groundwater resources, an analysis of the effects of precipitation and groundwater withdrawal on groundwater levels is needed. In this study, we analyzed the correlation of precipitation-groundwater level and groundwater withdrawal-groundwater level using time series data converted by normalized standard deviation (Nor.St.Dev) and cross correlation coefficient (CCC) for nine groundwater monitoring wells in the middle mountainous area in the southeastern Jeju Island. First, the CCCs of precipitation-groundwater level were estimated using daily time series data, and the low CCCs of up to 0.3 were obtained. However, the result of using the Nor.St.Dev showed a clearer correlation by obtaining a CCC of up to 0.8. In addition, in most cases, precipitation variability and groundwater level variability had positive CCCs, whereas groundwater withdrawal variability and groundwater level variability had negative CCCs. Therefore, the groundwater level in this study area was largely influenced by precipitation with little effect of groundwater withdrawal. Lastly, as a result of analyzing the relative effects of Seongpanak and Gyorae rainfall station on the groundwater level, the rainfall at the relatively downstream Gyorae rainfall station has more influence. The analysis method used in this study can be easily used for analyzing the effects of precipitation and groundwater withdrawal on groundwater level variability in other regions in the future.

• Journal of the Korean Society of Radiology
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• v.12 no.7
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• pp.833-844
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• 2018

Dual energy X-ray absorptiometry is mainly used as an X-ray test method. For equipment manufactured GE and Hologic, cross-calibration analyses (CCA) of machines from the same manufacturer and between units from different manufacturers have been conducted, but the CCA of equipment manufactured in Korea are inadequate. Through CCA, we present a formula of the intersections between the Korean medical equipment company (KEC) with GE and Hologic manufactured DXA, and among the KEC DXA. The CCA was conducted for the European Spine Phantom on DXA from four KEC and three global medical equipment company (GEC) manufacturers. We compared bone mineral density (BMD) values and calculated the CCA equation by linear regression analysis. The standard-deviations (SD) of the BMD values were highest for the Dexxum T for the low, medium, and high spine, which were 0.030, 0.029, and 0.037, respectively. The smallest SD in the low and medium vertebrae were 0.005 and 0.004 for the Horizon Ci, respectively, and 0.005 for the Osteo Pro Max in the high vertebrae. Based on the intersection equations of the KEC DXA established in this study, CCA of various KEC DXA should be established for more accurate follow-up of BMD tests in clinical environments.