• Title/Summary/Keyword: 과학실

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A Randomized, Double-blind, Placebo-controlled Study to the efficacy and Safety of NMED-01 and NMED-02 in Mild Alcoholic Liver Subjects (NMED-01과 NMED-02의 간기능 개선에 대한 인체 효능 평가)

  • Park, Sangwoug;Kwon, Yongbeom;Kim, Ki Tae;Shin, Seon Mi;Leem, Kang-Hyun;Ko, Heung;Song, MiKyung;Jung, Yoon Chul;Kim, Hocheol;Park, Juyeon
    • The Korea Journal of Herbology
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    • v.28 no.6
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    • pp.31-38
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    • 2013
  • Objectives : The purpose of this study was to determine whether NMED-01 or NMED-02 improves laboratory test results in participants with liver function disorder. Methods : This is a randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded to treatment group. The study was conducted at Semyung university oriental medicine hospital in Jecheon where participants with high level of serum ${\gamma}$-GTP (60-350 U/L) were enrolled. The intervention consisted of three times daily ingestion of either two capsules of placebo, NMED-01 (NeuMed. co. ltd., Seoul), or NMED-02 (NeuMed. co. ltd., Seoul) for twelve weeks. To evaluate the efficacy and safety of NMED-01 and NMED-02, we primarily evaluated the degree of decrement of serum ${\gamma}$-GPT level among three groups. Secondarily the decrement of serum ALT, AST, and triglyceride level in each group were also evaluated. Adverse effects were monitored during the twelve weeks treatment. Results : The change of ${\gamma}$-GTP level of NMED-01 group was lower than that of placebo group at the end of 12-week administration ($28.1{\pm}38.7U/L$ vs. $9.3{\pm}27.0U/L$, p=0.046). Other variables including AST, ALT, and triglyceride level were not significantly reduced. The decrement of ${\gamma}$-GPT, AST, ALT, and triglyceride level of NMED-02 group was not significant. There were no significant adverse effects or toxicities during treatment period. Conclusions : Participants receiving NMED-01 had improvement in laboratory test results. Despite a modest sample size, our results suggest that NMED-01 are safe and may be potentially effective in improving liver function. However, NMED-02 have lack of a detectable effect in this study.

Literature review on the experimental method and interpretation of the edge chipping test (ECT) (Edge chipping test (ECT)의 실험방법과 해석에 관한 문헌고찰)

  • Song, Min-Gyu;Ko, Kyung-Ho;Huh, Yoon-Hyuk;Park, Chan-Jin;Cho, Lee-Ra
    • The Journal of Korean Academy of Prosthodontics
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    • v.60 no.1
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    • pp.9-18
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    • 2022
  • In vitro studies are essential to predict the clinical performance of ceramic widely used as restorative materials. Traditional experiments such as fracture toughness and flexural strength have been used to evaluate the properties of brittle ceramics. However, these experiments have a limitation that the load conditions, failure patterns, and load values at which failure occurs are not similar to human occlusal force ranges or clinical failures. On the other hand, the edge chipping test (ECT), which was recently introduced to study chipping fracture of ceramics, has similar failure patterns to clinical trials. In addition, the failure loads from ECT were similar to human occlusal force. ECT can be usefully used in the study of ceramic properties. In this literature review, a more clinically meaningful experimental study of ceramics by examining the meaning and limitations of traditional ceramic failure tests and comparing them with ECT.

Studies on Strength of Netting (3) Joint Strength of Twisted-Jointed Netting (그물감의 강도에 관한 연구 (3) 관통형 그물감의 마디의 강도)

  • KIM Dai An
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.9 no.4
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    • pp.293-298
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    • 1976
  • 1) The decrease in strength of netting twines at the twisted joint is regarded to be due mainly to tile frictional force between plied yarns, but tile rate of decresae is within $5\%$ in filament twines and 5 to $10\%$ in spun twines. 2) The variation of the twisted joint strength with the angle between the two adjacent bars draws a parabola flaying the minimum value at tile angle of $90^{\circ}$. The minimum value was revealed as about $90\%$ of the strength at the angle of $0^{\circ}$ in wet spun twiness, but regarded to hi negligibly small filament twines. 3) The knot strength is about $30{\pm}5\%$of the twisted joint strength.

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문화속의 과학 - 카멜레온 섬유의 등장

  • An, Yeong-Sul
    • The Science & Technology
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    • v.32 no.9 s.364
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    • pp.21-21
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    • 1999
  • 누에는 4천8백년이나 거슬러 올라간 옛날부터 뽕나무잎의 셀룰로오스를 소화하여 가느다란 명주실을 토해냈다. 유럽의 과학자들은 금세기 초 실크를 모방한 인조견사를 얻어냈고 현대에 이르러서는 석탄ㆍ물과 공기로부터 나일론을 얻었다. 섬유의 발달은 자연모방으로부터 이루어져 최근에는 색깔이 때때로 변하는 카멜레온 섬유가 등장하여 패션소재로 인기를 끌고 있다.

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세계과학기술사 (서양편) -헬레니즘과학-

  • 송상용
    • 발명특허
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    • v.5 no.4 s.50
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    • pp.20-23
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    • 1980
  • 알렉산드로스대왕의 정복 이후 그리스과학의 중심은 아테네에서 지중해 건너 북아프리카의 알렉산드리아로 옮아 갔다. 알렉산드로스가 죽자 제국은 셋으로 나누어 졌는데, 이집트는 프톨레마이오스 3세가 차지했다. 그는 알렉산드리아에 뤼케이온을 본땄으나 규모가 훨씬 큰 무제이온(Museion)을 세웠다. 무제이온은 도서관, 동물원, 식물원, 천문대, 해부실을 포함한 방대한 교육${\cdot}$연구기관이었다. 여기에는 본토에서 초빙해 온 교수 백여명이 있었다고 한다.

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Suggestion on Locating Method for ST36 Acupoint Based on Neuroanatomical Features (족삼리 취혈방식 제안: 신경해부학적 특성을 기반으로)

  • Heeyoung Moon;Da-Eun Yoon;Yeonhee Ryu;In-Seon Lee;Dody Chang;Poney Chiang;Younbyoung Chae
    • Korean Journal of Acupuncture
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    • v.40 no.3
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    • pp.128-133
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    • 2023
  • Objectives : There are many variations in the ST36 acupoint location. The purpose of this article is to suggest a method of locating the ST36 acupoint. Methods : Based on the available research and the neuroanatomical characteristics of the underlying acupoint, we summarized the proper procedure for finding the ST36 acupoint. Results : ST36 is 3 B-cun inferior to ST35 and is vertically situated on the line that connects ST35 and ST41. The ST36 acupoint corresponds to the deep peroneal nerve, which is situated in the tibialis anterior muscle's back. The neurovascular bundles that are located on the interosseous membrane between the interosseous crests of the tibia and fibula include the deep peroneal nerve, anterior tibial artery, and anterior tibial vein. According to both classical and modern literature, this acupoint can be found horizontally between the two muscles, tibialis anterior and extensor digitorum longus. Conclusions : Based on a review of the literature and neuroanatomical features, we suggest that ST36 can be positioned horizontally between tibialis anterior and extensor digitorum longus. Additional imaging studies and clinical proof are required to determine ST36 acupoint.

한국의 기초과학과 그 위기

  • Lee, Dong-Nyeong
    • The Science & Technology
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    • v.10 no.12 s.103
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    • pp.12-13
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    • 1977
  • 이글은 재미과협 회보 Vol.6 No.3에 게재된 이동녕 박사의 글을 옮긴 것이다. 이글은 조국의 기초과학의 침체성을 지적하고 있다. 응용과학에 치중되어 기초과학이 균형을 잃고 있음을 보아온 이박사의 제언에 눈길을 돌려야 할 것이다. 점차 기초과학에 관심을 갖는 이즈음 촉진제가 되리라 믿는다 실은 제 4차 경제개발 5개년 계획에 기초과학육성이 계획되고 있어 위기의식까지는 기우일지 모르나 긴 안목의 과학발전을 위해서는 주목될 만한 글이다.

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Building a Database of Residual Lipid Analysis of the Present Creatures(I) (고고자료(考古資料)의 잔존지방분석(殘存脂肪分析)을 위한 현생시료(現生試料)의 데이터베이스 구축(構築)(I))

  • Yu, Heisun;Yun, Eunyeong
    • Conservation Science in Museum
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    • v.4
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    • pp.63-69
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    • 2003
  • The residual lipid analysis has been used for finding out the information related to the life style of ancient people. In order to achieve this goal, it must be precedented by building a database of residual lipid analysis of the present creatures. In this study, we performed residual lipid analysis of a cow and a dog, which were the present samples. We hope the results of this study will be a primary reference for the future analysis of archaeological materials.

A Library Reservation Management System using Image Processing (영상처리를 이용한 도서관 예약관리시스템)

  • Seo, Jeong-Min;Lee, Hee-Suk;Lee, Sang-Moon;Park, Hyun-Cheol
    • Proceedings of the Korea Information Processing Society Conference
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    • 2008.05a
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    • pp.88-91
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    • 2008
  • 도서관 좌석 관리 시스템에 대한 연구 및 개발은 각 대학교 도서관뿐만이 아니라 기타 정부기관, 업체 등의 도서관에서 좀 더 효율적인 도서관 좌석 관리를 위해 이루어지고 있다. 도서관 좌석 관리를 위해 단말기를 통하여 지문이나 카드로 신분을 확인하는 등 다양한 수단을 활용하여 이용하는 사람들의 출입 및 좌석을 관리하고 있다. 하지만 현재 도서관 열람실은 특별한 좌석관리 시스템이 없으며 외부인의 출입이 제한되어있지 않아 학생들과 구분 없이 사용할 수 있다. 이러한 운영은 평소에는 문제가 되지 않으나 시험기간이 되면 수용할 수 있는 인원에 비해 사용 인원이 많고 또 제대로 된 좌석관리 시스템이 없어 항상 자리가 부족하게 된다. 이러한 문제를 근본적으로 해결하기 위해 본 논문에서는 도서관 좌석 관리 시스템에 카메라를 이용한 영상 처리 기법을 적용하여 열람실의 좌석 정보를 영상 처리를 이용하여 사용자에게 보여 줄 수 있는 무인 자동화 시스템을 제안하였다.

Protective Effect of Gatrodiae Rhizoma Extracts on the LPS-Induced Cognitive Impairment Model (LPS에 의해 유도된 인지기능 손상모델에 대한 천마 추출물의 방어효과)

  • Kwon, Kang-Beom;Kim, Ha-Rim;Kim, Ye-Seul;Park, Eun-Hee;Kang, Hyung-Won;Ryu, Do-Gon
    • Journal of Oriental Neuropsychiatry
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    • v.33 no.3
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    • pp.277-285
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    • 2022
  • Objectives: Gastrodia elata (GE) has been used to treat cognition impairment, including Alzheimer's disease (AD) in Korea. The purpose of this study was to investigate the effects of GE water extracts (GEE) on the lipopolysaccharide (LPS)-induced AD model in mice. (Aβ). Methods: We classified six groups as follow; group 1: control (CON), group 2: LPS (0.5 mg/kg/day, four times), group 3: 4 mg/kg donepezil (DP), group 4: 100 mg/kg GEE+LPS, group 5: 200 mg/kg GEE+LPS, group 6: 500 mg/kg GEE+LPS. Results: We found that GEE has an effect that inhibits decrease of discrimination index in object recognition test, as well as spontaneous alteration in the Y-maze test by LPS. Treatment with LPS increased amlyloid-β (Aβ) concentration, and decreased brain-derived neurotrophic factor (BDNF) in cerebral cortex of mice. However, GEE significantly protected against LPS-induced Aβ and BDNF changes. Our findings also showed that the inflammatory cytokines [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β)] mRNA and protein were up-regulated by the LPS injection. But GEE significantly suppressed LPS-induced inflammatory cytokines increase in a dose-dependent manner. Conclusions: This study suggests that the GEE may be an effective AD therapeutic agent, in treating neurodegenerative diseases including AD.