• Journal of Chest Surgery
• /
• v.34 no.12
• /
• pp.964-967
• /
• 2001

Giant thymic Hyperplasia is a rare lesion in children. We report a case of giant thymic hyperplasia in the right anterior mediastinum in a 2 year-old male patient. Presenting symptom was frequent cough and sputum, plain chest X-ray and computed tomography showed huge mass in the right anterior mediastinum. The tumor resection was done through a median sternotomy for the prevention of progression to atelectasis caused by mass effect and tissue diagnosis. An open biopsy specimen showed normal thymic architecture. The patient recovered without any problem and is doing well untill now. We report this rare case of giant thymic hyperplasia with review of the literature.

• Journal of Chest Surgery
• /
• v.40 no.7 s.276
• /
• pp.517-519
• /
• 2007

Nodular Lymphoid hyperplasia of the lung has a very low incidence and both the nomenclature and this disease entity have changed since its appearance in the 1960s. It has recently been classified as lymphoid hyperplasia of the B cell associated lymphoid tissue. Ground glass opacity was incidentally diagnosed in the right lower lobe of the a 60 year old male and he underwent right lower lobe lobectomy. The opacified lesion in the chest CT was diagnosed as nodular lymphoid hyperplasia under microscopic examination.

• Journal of Life Science
• /
• v.19 no.11
• /
• pp.1514-1521
• /
• 2009

To evaluate the feasibility of cathepsin-B levels in preoperatively screening patients with thyroid cancer, we assigned these patients to either the thyroid cancer group (n=32) or the nodular hyperplasia group (n=7). Five healthy volunteers served as controls (n=5). We quantified cathepsin-B expressions in cancerous lesions with follicular carcinoma and hyperplastic lesions with nodular hyperplasia, and compared the degrees to those of normal thyroid tissue, which was obtained from matched contralateral lobe. The activity of serum cathepsin B was significantly higher in patients with thyroid carcinoma ($284.87{\pm}79.32$, ${\times}10^{-2}\;mU$) and those with nodular hyperplasia ($255.45{\pm}95.68$, ${\times}10^{-2}\;mU$) than compared to normal control ($168.94{\pm}15.10$, ${\times}10^{-2}\;mU$) (p<0.05). Based on the results of immunoassay, the concentrations of cathepsin B in the thyroid cancer group ($15.50{\pm}7.86\;ng/ml$) and the nodular hyperplasia group ($17.64{\pm}7.49\;ng/ml$) were higher than those of the control group ($4.85{\pm}0.61\;ng/ml$). The degree of cathepsin-B mRNA expression was significantly higher in cancerous or hyperplastic lesions than normal thyroid tissues from matched contralateral lobe with follicular carcinoma or non-neoplastic thyroid disease. Our results indicate that the activity of serum cathepsin B is a useful indicator in screening patients with nodular hyperplasia or neoplastic thyroid disease and it may be involved in the abnormal proliferation of cells.

• 대한치주과학회:학술대회논문집
• /
• 2006.11a
• /
• pp.167-167
• /
• 2006

• Journal of the Korean Society of Radiology
• /
• v.82 no.3
• /
• pp.756-763
• /
• 2021

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, multi-systemic disease primarily affecting young male adults with a history of smoking. The two patients with PLCH in our report showed relatively early and atypical radiologic presentations at initial evaluation. On chest CT, PLCH presents variable radiologic features depending on the evolutional stage of the disease. Atypical CT features of PLCH may render precise radiologic diagnosis difficult and usually require lung biopsy for a confirmation of the diagnosis. Our case review is aimed at raising the awareness of radiologists on the atypical CT features of PLCH, to help make accurate radiologic diagnosis and prevent unnecessary and invasive diagnostic procedures.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2015.08a
• /
• pp.255-255
• /
• 2015

국제핵융합실험로(ITER)의 3대 목표 중 하나는 핵융합로 개발을 위한 삼중수소증식블랑켓 개념을 시험하고 검증하는 것이며, 이를 위해 시험증식블랑켓(TBM, Test Blanket Module) 프로그램을 마련, 각국이 참여할 수 있도록 하고 있다. 한국도 2012년 국가핵융합위원회 결정에 따라, EU, 일본, 중국, 인도와 함께 TBM 프로그램에 참여하고 있으며, 2021년 설치를 목표로 헬륨냉각 고체증식재 개념의 HCCR (Helilum Cooled Ceramic Reflector) TBM을 설계, 개발하고 있다. 한국형 TBM은 총 4개의 서브모듈과 하나의 후벽(Back Manifold, BM) 으로 구성되며, 각 서브모듈은 플라즈마와 대면하는 일차벽(First Wall, FW), 증식재와 증배재, 반사재를 담고 있는 증식영역(Breeding Zong, BZ), 냉각재 매니폴드 및 구조물 역할을 하는 측벽(Side Wall, SW) 등의 기능부품으로 구성되어 있다. 냉각재는 8 MPa, $300-500^{\circ}C$의 고온고압헬륨을 사용하고, Li2SiO4 혹은 Li2TiO4 형태의 Li 세라믹 증식재를 사용하며, 중성자 증배를 위해 Be 증배재 및 흑연 반사재를 사용한다 [1-3]. 2015년 2월 개념설계검토(CDR, Conceptual Design Review)를 위해, TBM-shield를 포함한 TBM-set 설계가 완료되었으며, 열수력, 구조, 지진, 전자기, 복합하중에 대한 평가가 진행되었다. 본 논문에서는 이 중 H/He-phase에 시험될 EM-TBM과 D-T phase에 시험될 INT-TBM에 대한 열수력 성능 결과를 소개하였다[5]. 각각의 열부하 조건은 0.17과 $0.3MW/m^2$이며, 중성자 조사는 D-T phase 에서만 고려되었다. 구조재 및 사용된 기능소재별 온도 요건을 정의하고, 성능해석 결과와 비교하였으며, 이를 통해 모든 온도 요건을 만족함을 최종 확인하였다. 이러한 온도 분포는 열응력 평가를 위해 구조해석 입력자료로 활용되었다.

• Clinical and Experimental Pediatrics
• /
• v.46 no.10
• /
• pp.1029-1031
• /
• 2003

Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment of systemic lupus erythematosus and did not show any underlying disease.

• The Journal of the Korean bone and joint tumor society
• /
• v.15 no.1
• /
• pp.59-64
• /
• 2009

Intravascular papillary endothelial hyperplasia (IPEH, Masson's hemangioma) is a non neoplastic reactive endothelial proliferation most commonly located in the skin or subcutaneous tissues although it has been reported in multiple locations throughout the body. This lesion may arise from malformed or normal vessels primarily, and may develop with hemangioma, pyogenic granuloma, or lymphangioma. This lesion, though benign, is clinically important since it may present as a mass and be confused histologically with angiosarcoma. The authors report a 27 years old patient with a mass in his forearm which results in intravascular papillary endothelial hyperplasia.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1993.05a
• /
• pp.89-89
• /
• 1993

The laryngeal epithelial cell kinetics of 26 laryngeal lesions(invasive squamous cell carcinoma 14, epithelial hyperplasia 5, laryngeal nodule 7) were studied by immunehistochemical analysis with the monoclonal antibody Ki-67, which reacts with nuclear antigen in proliferating cells using paraffin embedded tissue. For DNA analysis, touch implint with fresh biopsy specimens were stained with feulgen and analyzed by image analyzer in 22 cases. 1) The proportion of Ki-67-positive cells were 32.65$\pm$ 11.59% in invasive squamous cell ca, 20.14$\pm$3.38% in epithelial hyperplasia lesion and 11.66$\pm$3.02% in laryngeal nodule. 2) DNA aneuploidy was found in 7 cases of 10(70%) invasive squamous cell carcinomas, 2 cases of 5(40%) epithelial hyperplasia lesions and all cases of laryngeal 3) Proliferation index(S phase+G2/M phase) show 23.42$\pm$11.33% in squamous cell carcinoma, 13.09$\pm$ 10.90% in epithelial hyperplasia lesion and 4.50$\pm$1.19% in laryngeal nodule. As the results, measuring the DNA content from touch imprint method together positivity of Ki-67 antibody from the microtissue during the laryngeal microscopic surgery, cell kinetics can be assessed as an effort of deciding the prognosis and provide a key to the management of precancerous lesions.

• Journal of Periodontal and Implant Science
• /
• v.6 no.1
• /
• pp.20.2-20.2
• /
• 1976