• Journal of Chest Surgery
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• v.23 no.6
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• pp.1244-1250
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• 1990

Hamartoma had been considered as a congenital malformation of a tumerous lesion since the original description by Albrecht in 1904. Pulmonary hamartoma is able to classified as endobronchial and intrapulmonary hamartoma clinically, and is considered to benign mesenchymal neoplasms which originated in peribronchial connective tissue, and so called mesenchymoma by someone. We have experienced 3 cases intrapulmonary hamartoma which were discovered during routine chest film check up at all cases and are able to detailed histologic examination by electron microscopy at one case.

• Journal of Chest Surgery
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• v.28 no.4
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• pp.423-425
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• 1995

Endobronchial hamartoma is a extremely rare lesion. The patient was 47 years old female and complained of cough and dyspnea for several years. On bronchoscopy, a finger tip size mass, nearly occluding the left main bronchus and located 4cm from the carina, was found. Bronchoscopic biopsy showed the chronic inflammatory findings.We performed bronchotomy and removed the mass through left thoracotomy. The endobronchial tumor was confirmed hamartoma histopathologically.

• Journal of the Korean Child Neurology Society
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• v.26 no.4
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• pp.284-287
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• 2018

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central nervous system and various parts of the body, causing various symptoms. Crohn's disease (CD) is a chronic immune-mediated disease that has not been clearly elucidated. It is thought to be caused by an excessive immune response of the body to bacteria that normally exist in the digestive tract with genetic factors. No cases have been reported in which both of the above-mentioned diseases occurred simultaneously. We report a case of CD in a patient with TSC. A 12-year-old boy was brought to our hospital because of abdominal pain. Skin lesions were observed in the TSC. Fundus examination revealed a hamartoma in the right retina. Brain magnetic resonance imaging revealed a subendothelial giant cell astrocytoma (SEGA). On the basis of these findings, he was diagnosed as having TSC. Blood test results showed increased levels of inflammatory markers. On abdominal ultrasonography, his colon walls were observed to be thickened with increased vascularity of the proximal ascending colon, ileocecal valve, and terminal ileum. Colonoscopy revealed discontinuous ulcerations and inflammations of the ileum, IC valve, and cecum, similar to those found in CD. Everolimus was administered orally for the SEGA but was discontinued frequently owing to the exacerbation of CD. The possibility of CD should be kept in mind in patients with TSC considering to undergo treatment for SEGA.

• The Journal of the Korean bone and joint tumor society
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• v.6 no.4
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• pp.168-172
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• 2000

Benign soft tissue mesenchymoma is a tumor composed of at least 2 mesenchymal elements, not ordinarily found together in a tumor. Very few cases are reported worldwide and even more, preponderance for cartilage in benign mesenchymoma is extremely rare. Up to our knowledge, total of 11 cases are reported to have cartilaginous rich benign soft tissue mesenchymoma. We are reporting a case of three-year-old male who developed benign soft tissue mesenchymoma rich in cartilaginous materials that occurred on the lower aspect of the back.

• Journal of the korean academy of Pediatric Dentistry
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• v.39 no.1
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• pp.97-102
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• 2012

Odontoma is a mixed tumor formed by the overgrowth of ectodermal epithelial cells and mesodermal cells. It arises during normal tooth development and only grows to a certain level. It is not a true neoplasm and therefore it is considered as hamartomas. Odontomas are classified into compound and complex types based on morphology. Compound odontoma is commonly found in the anterior region of the maxilla, and has a radiopaque lesion that resembles small teeth. Usually, odontoma is treated by conservative surgical removal and there is little probability of recurrence. This paper describes three cases of compound odontoma diagnosed in children with 1 year of follow-up. These case reports present patients having eruption disturbance of primary and permanent teeth due to the presence of compound odontoma. In order to induce spontaneous eruption, conservative surgical removal was performed showing favorable results.

• The Korean Journal of Cytopathology
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• v.3 no.1
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• pp.30-36
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• 1992

Pulmonary hamartoma is the most common benign tumor of the lung but rarely encountered in routine cytologic work-up. We recentely experienced a case of fine needle aspiration cytology of pulmonary hamartoma in a 65-year old male patient. The characteristic cytopathologic features were 1) The mesenchymal components with cuboidal epithelial cells in a clean background, 2) The presence of fibromyxoid mesenchymal component composed of fibroblasts in a loose fibrillary stroma, and 3) Antler-liker fibromyxoid cluster having the rimming of epithelial cells which correspond to the epithelial glowing in cleft-like fashion in pulmonary hamartoma.

• Journal of Chest Surgery
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• v.28 no.12
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• pp.1178-1182
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• 1995

We experienced one case of endobronchial hamartoma on left lower lobar bronchus in sixty year old male patient. Less than 1 % of lung tumors are benign, and the prevalence of endobronchial hamartoma is reported to be from 3 % to 40 %. The mean age was 52.9 years, and equal gender prevalence.Symptoms were related to intraluminal growth, including fever, chill, productive cough, hemoptysis, exertional dyspnea, recurrent pneumonia and so on. Bronchoscopic finding was tumor present as polypoid mass in the lumen of a left main stem bronchus,distal to 3 cm from carina. Biopsy was done. The histopathologic pattern showed several nodules of loose myxoid tissue and islands of cartilage. We performed partial resection of the affected bronchus,1cm anterior to the superior segmental bronchial opening to just distal from superior segmental orifice. Including superior segmentectomy, partial resection of the left lower lobar bronchial resection and end-to-end anastomosis with 4-0 Poly dioxanone sutere materials interruptedly. We report this case with the brief review of literatures.

• Journal of Chest Surgery
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• v.14 no.4
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• pp.345-349
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• 1981

Pulmonary hamartoma is relatively common among the benign tumors of lung, and is credited to Albrecht who In 1904 described a disorganized arrangement of tissue normally present In an organ. But hamartoma has rare incidence of total pulmonary tumors, and especially endobronchial origin is extremely rare. We have experienced three cases of pulmonary hamartoma Including one bronchial origin. First case was a 27 years old woman who had multiple hamartomas, located all in right middle lobe and middle lobectomy was performed. Second case, a 56 years old woman, had endobronchial hamartoma, l x l .5x l .8cm in size and located at right intermediate bronchus. Right pneumonectomy was Inevitable because of It`s proximal location near the hilum. Third case, a 55 years old man, revealed sclerosing hemangioma microscopically, 4x4x5 cm In size, in right lower lobe and right lower lobectomy was performed. Postoperative course of all of them were uneventful and discharged with good general condition on the ~ 4th to 26th day postoperatively.

• Journal of the korean academy of Pediatric Dentistry
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• v.27 no.3
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• pp.394-399
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• 2000

Odontoma is defined as a benign odontogenic tumor containing enmel, dentin as well as cementum. It has come to mean a growth in which both the epithelial and the mesenchymal cells exhibit complete differentiation. Most authorities accept the view today that the odontoma represents a hamartomatous malformation rather than a true neoplasm. The etiology of odontomas is uncertain but hypothesized to involve local trauma, infection, inheritance or mutant gene. The odontomas often cause various disturbances in the eruption and position of the teeth. The steps in removal of an odontoma in close relation to an adjacent impacted normal tooth should comprise 1) removal of odontoma and 2) exposure of the impacted tooth. Orthodontic therapy may be applied. Before treatment, the necessary space for the impacted tooth should be evaluated. If there is lack of space in the dental arch, orthodontic treatment should be carried out before operation.

• Journal of the korean academy of Pediatric Dentistry
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• v.39 no.3
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• pp.301-305
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• 2012

The odontoma is a hamartoma of odontogenic origin and consists of enamel, dentin, cementum and pulp tissue. Two types of odonotma are histologically recognized: complex and compound. Odontoma may be the cause of noneruptoin or impaction of teeth, formation of cyst and resorption of adjacent bone. The recommended treatment for an odontoma is conservative surgical excision. No propensity for recurrence has been noted. Peripheral odontoma is relatively rare lesion and shows the histological characteristics of an intraosseous odontoma. This report described a 3-year-old Korean girl with a firm gingival mass in the posterior mandibular area, which had been gradually enlarging over 18months. Radiographic examination showed a radiopaque mass but no evidence of underlying intraosseous lesion. Excisional biopsy was performed for the mass removal and histopathological examination. The result of histopathological study was identified as hamartous supernumerary tooth germ. Based on the clinical presentation, radiographic and histopathologic findings, we concluded that the final diagnosis was peripheral odontoma. For three years after surgery, there is no clinical sign of recurrence.