• Journal of the Korean Applied Science and Technology
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• v.40 no.5
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• pp.1010-1021
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• 2023

In this study, we would like to confirm the collagen recovery effect through cell experiments of the flavonoid apigenin and baicalein and propose results that can support the collagen recovery effect through comparative transcriptome analysis. As a result of the study, it was confirmed that apigenin and baicalein were effective in recovering type I collagen damaged by UV in the HS68 cell line, and that both substances resulted in changes in the expression of ECM-related genes. Not only did it show a common mechanism for regulating the ECM, but it also showed the results of changing different categories of genes, making it possible to predict that it would have various effects on cells.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.46-53
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• 2017

알츠하이머병은 치매를 유발하는 가장 주된 원인 질환으로 환자들은 인지장애를 겪게 된다. 현재 치료약으로 사용되는 약으로는 acetylcholinesterase 저해재가 있지만 이 약들의 효과는 미비하다. 그래서 인지기능에 영향을 미친다고 알려진 신경전달물질인 GABA, Glutamate, acetylcholine의 수치를 조절 할 수 있는 $5-HT_6$ receptor antagonist가 현재 개발되고 있다. 현재 여러 antagonist들이 임상실험 되었고, 인지 능력향상에 효과를 보이고 있다. 그러나, $5-HT_6$ receptor의 구조가 밝혀지지 않아 아직 원자적 수준의 결합 분석이 이루어지지 않았으므로 이 부분에 대한 연구가 필요하다. 따라서 본 연구에서는 Homology modeling을 통해 receptor의 구조를 예측하고, 현재 임상실험 중인 antagonist들 중 7개를 docking을 통해 단백질과 리간드의 결합을 예측하였다. Edison에서 Galaxy TBM과 Galaxy Refine을 사용하여 Homology modeling 한 결과 GPCR의 전형적인 모델에 특징적으로 긴 cterminal을 가졌다는 것을 확인 할 수 있었다. 생성된 구조를 가지고 Edison의 Dock 프로그램으로 7개의 antagonist가 어떠한 결합을 하는지 분석하였다. 그 결과, binding pose에 공통적으로 Trp102, Asp106, Val107, Pro177, Phe188, Val189, Ala192, Phe284, Phe285, Asn288, Thr306, Tyr310이 관여하는 것을 docking을 통해 알 수 있었다. 특히, Phe285는 7개의 antagonist 중에 4개와의 interaction을 하고 있는 것을 관찰하였다. 이 연구를 통하여 $5-HT_6$에 효과적으로 결합하여 치료효과를 낼 수 있는 신약을 개발할 수 있다.

• Science of Emotion and Sensibility
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• v.25 no.4
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• pp.157-172
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• 2022

Using the adaptation aftereffect paradigm, this study investigated whether adaptation to baby schema features of the face and body could affect facial age perceptions. In Experiment 1, participants were asked to determine whether the test faces that morphed at a certain ratio of a baby face and an adult face were perceived as 'baby' or 'adult' after being adapted to either a baby or an adult face. The result of Experiment 1 showed that after being adapted to baby faces, test faces were assessed as belonging to an adult more often than when being adapted to adult faces. In the subsequent experiments, participants carried out the same facial age judgment task after being adapted to baby or adult body silhouettes (Experiment 2) or hand images (Experiment 3). The results revealed that age perceptions were biased in the direction of the adaptors (i.e., an assimilative aftereffect) after adaptation to body silhouettes (Experiment 2) but did not change after being adapted to hands (Experiment 3). The present study showed that contrastive aftereffects in the perception of facial age were induced by adaptation to the baby face but failed to determine the cross-category transfer of age adaptation from hands or body silhouettes to faces.

• 한국사회정책
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• v.19 no.3
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• pp.215-245
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• 2012

The purpose of this study is to examine pathways of factors that influence job satisfaction for full-time and part-time married female employees with children of 18 or under and to compare path coefficients for two groups. Simultaneously analyzing multiple populations, we found that the path model was appropriate for both groups with significant differences in path coefficients. Income, workplace size, husband's support for wife's work, and work-to-family conflict had direct effects on job satisfaction for both groups whereas health had a direct effect only among full-time workers. Family-to-work conflict had an indirect effect for both types of workers, while health had an indirect effect among full-time employees only, and income and having children under school age among part-time employees only. The results indicate that differentiated approaches to increase job satisfaction for full- and part-time employees are needed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.466-472
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• 2021

This paper aims to guide experts who manage dementia by exploring the various non-drug interventions and analyzing the effective intervention methods applicable according to the functional level of the elderly with dementia. Fourteen studies were analyzed in this study. Meta-analysis was performed using the means, standard deviations, and the number of samples. Subsequent meta-analysis showed that the Holnis program had the largest effect size in cognitive function, the bakery activity program in memory, and the composite intermediation program with ADL was the largest. In addition, client-centric cognitive stimulation interventions showed the most significant effect sizes, while in depression and BPSD, rhythmic movement activities had the most significant effect size. Elderly with dementia exhibit various symptoms depending on their characteristics and the progress of the disease. Therefore, more efficient arbitration could be provided if the effects of each intervention can be applied differently.

• KDI Journal of Economic Policy
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• v.32 no.3
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• pp.33-69
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• 2010

This paper examines the causes of the terms of trade decline in Korea since the mid-1990s, using the decomposition methodology suggested by Baxter and Kouparitsas (2000) as well as regression analysis. The main empirical results are summarized as follows. The decomposition exercise of changes in terms of trade showed that Korea's terms of trade decline for the past decade or so is attributable to goods price effect which were driven by the rise of oil prices relative to manufactures. The decomposition of terms of trade change for 55 countries showed that terms of trade decline due to goods price effect is a phenomenon that was commonly observed for exporters of manufactures since mid-1990s. These results suggest that external factors such as China's trade expansion, rather than internal factors, are mostly responsible for the decline in terms of trade. In accordance with these results, the regression results suggest that China's trade expansion contributed to Korea's terms of trade decline, especially in 2000s, by raising the import prices of oil and raw materials and lowering the export prices of manufacturing products.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2002.11a
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• pp.363-370
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• 2002

A substrate network model characterizing substrate effect of submicron MOS transistors for RF operation and its parameter extraction with physically meaningful values are presented. The proposed substrate network model includes a single resistance and inductance originated from ring-type substrate contacts around active devices. Model parameters are extracted from S-parameter data measured from common-bulk configured MOS transistors with floating gate and use where needed with out any optimization. The proposed modeling technique has been applied to various-sized MOS transistors. Excellent agreement the measurement data and the simulation results using extracted substrate network model up to 30GHz.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2002.11a
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• pp.363-370
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• 2002

A substrate network model characterizing substrate effect of submicron MOS transistors for RF operation and its parameter extraction with physically meaningful values are presented. The proposed substrate network model includes a single resistance and inductance originated from ring-type substrate contacts around active devices. Model parameters are extracted from S-parameter data measured from common-bulk configured MOS transistors with floating gate and use where needed with out any optimization. The proposed modeling technique has been applied to various-sized MOS transistors. Excellent agreement the measurement data and the simulation results using extracted substrate network model up to 30㎓

• Proceedings of the Korea Information Processing Society Conference
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• 2000.04a
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• pp.912-915
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• 2000

본 논문은 웹을 통한 학습활동(WBI)에서 초등학생들의 창의력 신장을 위한 시스템 구축 방안을 제시하였다. 제안된 시스템은 학습자 모듈과 관리자 모듈로 구성하였으며 창의력 신장을 위한 학습자 모듈은 유창성, 융통성, 독창성을 신장시킬 수 있는 학습활동을 수행하게 하며 관리자 모듈은 학습자의 학습활동을 지원하고 평가한다. 유창성 향상은 끝말잇기 놀이, 낱말 연상하기, 낱말가방, 용도 찾기, 융통성은 비유하기 놀이, 공통점 찾기, 만약에 놀이, 독창성은 만화 대사 넣기, 그림보고 이야기 꾸미기, 아이디어 공모 등의 학습방안이 제시되었다. 관리자 모듈은 학습자의 학습활동 결과를 열람하고 즉시 평가하여 피드백을 제공할 수 있으며, 학습자의 학습 효과를 극대화하기 위하여 학습 활동 내용을 수정할 수 있도록 하였다. 본 WBI 시스템은 창의력 신장 프로그램을 Web상에서 구현한 것으로 인터넷의 장점을 교육에 효과적으로 이용한 경우가 될 것으로 보인다.

• Journal of Korea Society of Industrial Information Systems
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• v.18 no.5
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• pp.15-18
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• 2013

This paper presents an analog front-end for electroencephalogram(EEG) signal processing. Since EEG signals are typically weak and located at very low frequencies, it is imperative to implement an amplifier with high gain, high common-mode rejection ratio(CMRR) and good noise immunity at very low frequencies. The analog front-end of this paper consists of a programmable-gain instrumentation amplifier and a band-pass filter. A frequency chopping technique is employed to remove the low-frequency noise. The circuits were fabricated in 0.18um CMOS technology and measurements showed that the analog front-end has the maximum gain of 60dB and >100dB CMRR over the programmable gain range.