• Journal of the Korean Society of Physical Medicine
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• v.7 no.3
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• pp.387-393
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• 2012

연구목적 : 본 연구는 Xbox 360 Kinetic Sensor를 사용한 가상현실 상호작용 게임이 무릎 골관절염을 앓는 여성 노인의 균형능력에 미치는 영향을 알아보는 것이다. 연구방법 : 65세 이상의 지역사회에 거주하는 여성 노인으로 무릎 골관절염으로 진단받은 40명을 대상자로 선정하였다. 대상자는 20명씩 무작위로 실험군과 대조군에 배치되었다. 실험군은 Xbox 360 Kinetic Sensor를 사용한 가상현실 상호작용 게임을 매 30분, 주 3회, 4주간 처치하였다. 대조군은 가상현실 상호작용 게임을 적용하지 않았다. 결과 측정은 눈을 뜬 상태와 눈을 감은 상태에서 신체 중심의 이동거리로 측정하였다. 연구결과 : 실험군의 신체중심 이동거리는 눈을 뜬 상태와 눈을 감은 상태 모두 중재 전보다 유의하게 증가하였다. 또한 중재후 실험군의 신체중심 이동거리는 눈을 뜬 상태와 눈을 감은 상태 모두 대조군보다 유의하게 높게 증가하였다. 결론 : Xbox 360 Kinetic Sensor를 이용한 가상현실 상호작용 게임은 무릎 골관절염을 앓는 여성 노인의 균형 능력을 증진시키는데 효과적이었다.

• Journal of Veterinary Clinics
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• v.30 no.3
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• pp.159-165
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• 2013

The present study was conducted to evaluate the efficacy of Cinnamomum cassia Blume (CC) extract on the repair of damaged cartilage in a rat model of osteoarthritis (OA) by anterior cruciate ligament transection (ACLT) and medial meniscus resection (MMx). Forty-eight rats were assigned to six groups (n = 8 per group): sham as negative control (NC), positive control (PC), diclofenac sodium (DS, 2 mg/kg), CC 25 mg/kg, CC 50 mg/kg and CC 100 mg/kg groups. Treatments were 12 weeks from 7 days after ACLT + MMx. Loss of cartilage and joint instability were significantly reduced in response to treatment with CC or DS compared to the PC (p < 0.05). CC significantly ameliorated cartilage degradation in a dose-dependent manner as assessed by histological findings (p < 0.01). A reduction in the severity of structural changes and a dose-dependent increase in Safranin-O staining intensity were observed in CC treatments, indicating that cartilage degradation was inhibited. Although DS did not affect the increase in active caspase-3 and cleaved poly(ADP-ribose) polymerase-induced apoptosis during the progression of OA, cells reactive to these apoptotic markers were decreased significantly by CC (p < 0.05). However, treatments with CC or DS did not influence the uptake of 5-bromo-2'-deoxyuridine. The findings suggest that CC can exert a chondroprotective action on OA through anti-inflammatory and anti-apoptotic properties.

• Journal of the Korean Orthopaedic Association
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• v.54 no.1
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• pp.67-71
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• 2019

Klebsiella pneumoniae causes that liver abscess mostly, also spread to pneumonia, meningitis, urinary tract infections. Septic arthritis caused by K. pneumoniae is a quite rare and has not been reported in Korea. Therefore, the authors report a case of the septic arthritis in the knee joint caused by K. pneumoniae in a patient with type 2 diabetes mellitus and osteoarthritis of the knee that successfully treated by early detection and arthroscopic synovectomy.

• Proceedings of the Korean Nutrition Society Conference
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• 2004.05a
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• pp.122-122
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• 2004

골관절염은 관절연골의 퇴행성 변화로 연골기질의 분해로 인하여 연골 강도와 cushion으로서의 능력이 감소되는 질환이다. 골관절염의 대부분 약물치료는 통증과 염증을 감소시키는 목적으로 사용되며, 근본적인 치료효과를 주는 약물은 현재까지 개발되어 있지 않다. 영양약학 제품에 대한 질병의 예방적, 치료 보조적 차원에서 인체에 대한 기초적인 생리활성의 중요성을 인식하게 됨으로써 그 역할이 중요하게 인식되고 있다. 특히, 골관절염 치료에 쓰이는 glucosamine은 proteoglycan (PG)와 glucosaminoglycans(GAGs)의 합성의 전구물질로서 연골세포 생성을 자극하며, 통증, 염증의 경감 및 진행과정을 억제시키고, 관절기능 회복을 촉진하는 것으로 알려져 있다. 그러나 glucosamine이 어떤 기전에 의해 관절연골세포에 직접적인 영향을 주는지 밝혀져 있지 않다. 본 연구에서는 glucosamine sulfate가 연골세포에 미치는 영향을 규명하고자 하였다.

• The Journal of Korea CHUNA Manual Medicine
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• v.1 no.1
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• pp.139-143
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• 2000

통증감소를 위주로 하는 기존의 슬 골관절염 치료는 슬관절의 퇴행을 가속화시킬 수 있기 때문에 한의학적 각종 침구요법 및 물리요법, 약물요법이나 의학적 주사요법 등을 '슬관절에 대한 부하 힘을 감소시킨 상태'에서 시행하는 진료형식을 제안한다. 그리고 이러한 슬관절질환 치료의 추나요법을 채택하여 임상적용이 가능하도록 이를 기계화 도구화하고, 진단과 치료를 동시에 시행할 수 있는 방식이 되도록 연구할 필요가 있다.

• Journal of Life Science
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• v.22 no.8
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• pp.1034-1040
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• 2012

Synovium is the soft tissue that lines the non-cartilaginous surfaces within joints. It has been reported that synovial cells are activated during the pathogenesis of rheumatoid arthritis. In this study, we quantitate and compare the cellular composition of synovia derived from individuals with non-inflammatory osteoarthritis (OA) and those with inflammatory rheumatoid arthritis (RA). Synovia from OA (n=8) and RA (n=5) patients were used for hematoxylin and eosin (H&E) staining. A light microscopic examination has shown that RA synovia were morphologically thickened and hypertrophied as compared to OA synovia. We also performed an immunohistochemistry (IHC) analysis to classify cell types in the synovia using CD68, CD90, or PGP9.5 markers. As a result, we obtained quantitative data regarding the cell populations, which are macrophages in the lining layer and FLSs in the subintimal layer of the synovium. Further Photoshop analyses of the H&E images could allow the counting of the number and layer of the cells in the synovium. The number and layers of the macrophage cells were increased in the lining layer of the RA synovia as compared to the OA synovia. FLS cells also were increased in the subintimal layer of RA synovia. Therefore, quantification of the H&E stained images via Photoshop is a possible analysis protocol for synovium study. This quantitation also supports the idea that the increases in cell number and cell activation are important processes for RA pathogenesis.

• Journal of Nutrition and Health
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• v.48 no.4
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• pp.310-318
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• 2015

Purpose: The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM). Methods: NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-$1{\beta}$, and IL-6 were measured by Luminex and $PGE_2$, MMP-2, MMP-9, TIMP-1, $LTB_4$, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Results: Production of NO, IL-$1{\beta}$, IL-6, $PGE_2$, MMP-2, MMP-9, TIMP-1, $LTB_4$, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue. Conclusion: The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.

• Journal of Oral Medicine and Pain
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• v.33 no.2
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• pp.195-204
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• 2008

Osteoarthritis is caused by joint degeneration, a process that includes progressive loss of articular cartilage accompanied by attempted repair of articular cartilage, remodeling and sclerosis of subchondral bone, and osteophyte formation. The most common causative factor that either causes or contributes to osteoarthritis is overloading of the articular structures of the joint. The diagnosis of temporomandibular joint(TMJ) osteoarthritis is based on the patient's history and clinical findings such as limited mandibular opening, crepitation and tenderness to palpation on TMJ. The diagnosis is usually confirmed by TMJ radiographs, which will reveal evidence of structural changes in the subarticular bone of the condyle or fossa. Plain radiography techniques such as panoramic, transcranial, transpharyngeal views can be used in most dental offices for evaluation of the TMJs. However, plain radiographs are often limited due to overlapping and distortion of anatomical structures. The aim of this study was to compare the clinical examination and panoramic view with computed tomography for diagnosis of temporomandibular degenerative joint disease, and to compare the findings of condylar bony changes through panoramic radiography with that of computed tomography, hence, to confirm the limitations of clinical and panoramic radiography, and the validity of the computed tomography for diagnosis of temporomandibular degenerative joint disease. The pathophysiology of the TMJ osteoarthritis remains poorly understood, and current treatments are based more on speculation than science, and symptomatic treatments often fail to provide satisfactory pain relief. For diagnosis of TMJ osteoarthritis, clinical examination and radiographic examination for confirmation of the bony changes are essential, and computed tomography are clearly superior to plain radiographs for their limitations.

• Journal of Acupuncture Research
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• v.19 no.5
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• pp.219-233
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• 2002

면역억제활성이 알려진 Cerves korean TEMMINCK var. manchur-icus Swinhoe(Nokyong) 약침(CPH)은 다모 뿔의 녹용을 열수추출한 용액이다. 본 연구에서는 녹용 약침의 효과를 adjuvant 유발 관절염 실험용쥐를 이용하여 골체, 골강도 및 골대체율의 감소를 평가하였다. 위의 골 대사 관련 검정실험을 위하여 6주령의 암컷 실험용쥐에 20일간 약물투여를 실시하였다. 실험적인 관절염유발은 실험용쥐의 뒤쪽 다리에 Adjuvant를 주사하여 유발시킨 결과, 요부의 골 무기질함량과 밀도(BMC, BMD) 그리고 압축강도는 관절염 실험용쥐에서 감소되었다. 10일 경과 후 골형성도(BFR/BS, BFR/BV)의 조직형태학적 기준척도인 혈청 osteocalcin 수가 정상대조군과 비교해 볼 때 현저하게 감소되었다. 그러나, 몸무게로 나눈 BMC치는 관절염 유발군과 정상군 사이에 큰 차이가 보이지 않았다. 그리고 골무기질 함량은 정상군에 비해 감소하지 않았다. 20일 경과후 몸무게로 나누거나 나누지 않은 BMC치 모두, 관절염 군에서 요부 몸체의 골무기질 함량과 강도가 정상군과 비교해 볼 때 현저하게 감소되었다. 잔존 소주(小柱)의 무기질 침착 표면은 현저하게 감소하였으며 파골 세포의 수는 증가하였다. 초기부터 매일 Shinsu(B23)에 CPH 약침 투여(10, 20, $50{\mu}g/kg$)는 20일 경과후 만성적인 다리 부종을 현저하게 방지하였으며, 골 무기질함량, 골강도 및 소주골 형성등의 감소와 파골세포수 증가도 완화하였다. Adjuvant주사로 장애를 받았던 연령대비 요부 길이 증가도 유지되었다. 이러한 결과는 Adjuvant에 의한 관절염 실험용쥐의 2차적인 골관절염에서 충분히 요추 몸체뼈와 강도 감소를 나타내기 위해서는 적어도 20일이 필요하다는 것을 제시하였다. 본 결과로부터 CPH가 실험용쥐의 관절염에 대한 골체, 골강도 및 골대체율을 조절하는데 유효하게 작용하고 있음을 알 수 있었다.

• Journal of dental hygiene science
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• v.15 no.2
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• pp.145-152
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• 2015

In this study, PASW Statistics ver. 18.0 was used to analyze the correlation between chewing difficulty and osteoarthritis in the population of 8,498 persons aged 50 years and older who had completed the health related questionnaire in the fifth Korea National Health and Nutrition Examination Survey in 2010~2012. The following conclusion was drawn: The distribution of the chewing difficulty status showed that 38.8% of the respondents had chewing difficulty and that there was no significant difference by gender. Older respondents tended to have significantly greater chewing difficulty 34.3% of the respondents aged from 50 to 64 years and 46.4% of those aged 65 years and older, those who had lower levels of education and income, who were smokers, and who had higher levels of depression and stress suffered from significantly greater chewing difficulty. Chewing difficulty and osteoarthritis were correlated with each other: the respondents having chewing difficulty had 1.44 (95% confidence interval [CI], 1.23~1.70) higher prevalence of osteoarthritis than those with no such difficulty. In addition, such correlation was not found in males: the former had 1.36 (95% CI, 0.98~1.88) higher prevalence of osteoarthritis than the latter, which was not statistically significant. Such correlation was found in females: the former had 1.47 (95% CI, 1.22~1.76) higher prevalence of osteoarthritis than the latter, which was statistically significant. Therefore, the chewing difficulty status affected osteoarthritis for females aged 50 years and older. Therefore, the efforts to solve oral health problems through oral hygiene would help prevent osteoarthritis from worsening and manage the condition.