• Clinical and Experimental Pediatrics
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• v.52 no.5
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• pp.581-587
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• 2009

Purpose : To evaluate the correlation between serum methotrexate (MTX) peak levels and clinical outcome of osteosarcoma, as well as to determine the correlation of these levels with the histologic response and event-free survival (EFS). Methods : To maintain the homogeneity of the study population, we selected 52 patients with localized extremity osteosarcoma who had received two cycles of neoadjuvant chemotherapy consisting of high-dose (HD) MTX ($12g/m^2$), cisplatin ($100mg/m^2$), and doxorubicin ($60mg/m^2$). Results : Totally, 204 courses of HD MTX were administered. The serial MTX levels ($mean{\pm}SE$) at 4 h (peak), 24 h, 48 h, and 72 h were $1292.14{\pm}12.83{\mu}m$, $9.29{\pm}3.89{\mu}m$, $1.73{\pm}1.37{\mu}m$, and $0.58{\pm}0.44{\mu}m$, respectively. The peak MTX serum level was $1292.14{\pm}12.83{\mu}m$. Neither the continuous average MTX peak level nor the dichotomized MTX peak level was related to the histologic response. However, the patients with a high 24-h MTX level ($3.4{\mu}m$) had a poor histologic response (P=0.044). An inverse relationship was observed between MTX levels and survival: the EFS was better in the patients with a mean MTX peak level of less than $1,400{\mu}m$ (P=0.002) and mean 24-h MTX level of less than $3.4{\mu}m$ (P=0.011). Conclusion : The inverse correlation between the MTX level and the outcome is an unexpected finding. Further study on the pharmacokinetics of MTX is required to substantiate our findings and elucidate the mechanism involved.

• Journal of the Korean Ceramic Society
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• v.34 no.2
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• pp.123-130
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• 1997

In this study, (Sr.Pb.Ca)TiO3-Bi2O3.3TiO2(SPCT) systems were investigated to develop a new material which has a high dielectric constant, a low dielectric loss and a small TCC(Temperature Coefficient of Capa-citance), and are suitable for high voltage applications as a function of the additions of Bi2O3.3TiO2 from 5 mol.% to 9 mol.%. The result obtained from our investigation showed that up to 6 mol.% Bi2O3.3TiO ad-dition the dielectric constant increased and it deteriorated at higher concentrations with increasing amount of the acicular grains. As a result of some dopants (SiO2, Nb2O3, MnO2) addition to SPCT, the specimens with MnO2 showed good dielectric properties. The dielectric constant decreased, but the TCC was improved with the addition of MnO2 from 0.15 wt.% to 0.45 wt. %.

• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.5
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• pp.3-7
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• 2017

Holographic data storage system (HDSS) features short access times, high storage capacities, and fast transfer rates, since the data is recorded and read not by lines but by pages within a volume of holographic material. Burst error caused by physical impact on the high density storage system becomes very longer than that of conventional storage systems. This paper proposes an LDPC product code using two LDPC code to resolve burst error. When a total code rate is similar, the performance of two LDPC code having high code rate is better than that of one LDPC code having low code rate. Also, with error factors of two-dimensional intersysbol interference and misalignment, the proposed scheme can improve the performance in holographic data storage system.

• Journal of Korean Society of Transportation
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• v.28 no.2
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• pp.161-169
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• 2010

The amount of energy consumed by a transportation system in a city is influenced not just by a transportation system itself but also by city's spatial character. Yet there have been very limited studies on this subject. This study investigates the factors that influence the energy consumption by a transportation system and city's spatial character. The model of an urban area confined within a definite boundary is assumed in order to develop the relationships between the energy consumption and the transportation system. Various assumptions on the character of a city and activities are made. An equation for computation of the energy consumption is derived with such factors as modal split, densities of residents and workers, as well as technological development. Using the equation, sensitivity analyses are performed in order to identify the relationships between energy consumption and influencing factors. It is found that the modal split is the most powerful factor that determines the energy consumption by the transportation system. Yet it is also found that the densities of residents and workers and the technological factors are very important in determining the amount of energy consumption as well.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.1-2
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• 2021

3D NAND 플래시 메모리는 플래너(2D) NAND 셀을 적층하는 방식으로 단위 면적당 고용량을 제공한다. 하지만 적층 공정의 특성상 각 레이어별 또는 셀 위치에 따라 오류 발생 빈도가 달라질 수 있는 문제가 있다. 이와 같은 현상은 플래시 메모리의 쓰기/지우기(P/E) 횟수가 증가할 수록 두드러진다. SSD와 같은 대부분의 플래시 기반 저장장치는 오류 교정을 위하여 ECC를 사용한다. 이 방법은 모든 플래시 메모리 페이지에 대하여 고정된 보호 강도를 제공하므로 물리적 위치에 따라 에러 발생률이 각기 다르게 나타나는 3D NAND 플래시 메모리에서는 한계를 보인다. 따라서 본 논문에서는 오류 발생률 차이를 보이는 페이지와 레이어를 분류하여 각 영역별로 차별화된 보호강도를 적용한다. 우리는 페이지와 레이어별로 오류 발생률이 현저하게 달라지는 3K P/E 사이클에서 측정된 오류율을 바탕으로 페이지와 레이어를 분류하고 오류에 취약한 영역에 대해서는 패리티 데이터를 추가하여 차별화된 보호 강도를 제공한다. 오류 발생 횟수에 따른 영역 구분을 위하여 K-Means 머신러닝 알고리즘을 사용한다. 우리는 이와 같은 차별화된 보호정책이 3D NAND 플래시 메모리의 신뢰성과 수명향상에 기여할 수 있는 가능성을 보인다.

• Journal of Technology Innovation
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• v.25 no.4
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• pp.263-284
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• 2017

The purpose of this research is to analyze the performance of national R&D projects and to find out measures to improve the performance indicators, focusing on energy HRD projects. The main analysis target is 86 energy manpower projects supported since 2010. The performance indicators of the energy HRD projects are related to the research capacity, the number of emission workers, industry-university linkage, job creation and so on, and analyzed by using the 11 indicators of human resource performance index called KPI index. As a result of analyzing the attainment level of the proposed target by task, the index with the highest achievement level is the corporation linkage rate, and the index with the lowest achievement level is the participating company employment. As a result of examining the effects of job creation in company - linked activities, it was found that the greater the number of participating companies in the business, the greater the employment creation effect of the number of internships. As a result of the above analysis, the following policy alternatives are proposed. First, it is necessary to consider adding indicators that can express the quality performance of the business and performance indicators that can express actual business linkages. Second, it is necessary to strengthen the management of differentiated performance indicators according to policy performance targets and major target groups. Third, it is necessary to improve information input and accumulation system along with improvement of performance index.

• KDI Journal of Economic Policy
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• v.34 no.1
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• pp.169-197
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• 2012

It is often argued that the parental leave should be extended in order to help employees achieve the balance of work and family life. However, one should be careful in designing the parental leave since there is a tradeoff between the continuity of employment after childbearing and the depreciation of human capital due to the time off the work. The paper investigates whether the parental leave payment introduced in Korea in 2001 helped women's take-up of the leave and employment after giving birth. The results are as follows. First, the increase in the payment indeed raised the female take-up of the leave. Second, women returned to labor market less often after giving birth in the short run, but the size of the effect tends to decrease in the long run. However, the negative effect on returning to the same workplace after the birth remains significant in the long run. Lastly, there is no evidence that the share of women of childbearing age at workplace changed due to the increase in the parental leave payment. Although there is a limitation in that the analysis is based only on the employment covered by the Employment Insurance, these findings imply that the increase in the parental leave payment may not be an effective policy tool for promoting female labor market participation. On the other hand, it should be noted that it is necessary to pay attention to child development as well as female employment as an objective in order to make an overall judgement on the parental leave policy.

• Korean Journal of Construction Engineering and Management
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• v.14 no.4
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• pp.97-107
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• 2013

Occupational safety and health management expense in construction industry means the monetary amount that the purchaser appropriates to prevent various disaster from happening during the construction period by setting aside a certain amount from subcontract based on the construction type and scale. The current appropriation standard of the Ministry of Employment and Labor has been enforced since its stipulation in 1988 although various policy changes for the safety in construction industry, e.g. the development of occupational safety management techniques in construction industry, changes in construction field site environment, cost depreciation, etc., are happening in Korea and overseas. Therefore, it is required at this point to examine whether the current occupational safety and health management expense appropriation is proper or not on the basis of time trend and the changes in the construction industry environment. Accordingly, this study aims at investigating the appropriation of occupational safety and health management expense for construction industry by the construction type and target expense in response to current construction industry environment and proposing the proper appropriation. The above research result proposes the calibration of the appropriation as specified and stipulated by the Ministry of Employment and Labor by the construction type and target expense, which is necessary to reflect the actual condition of the current construction industry environment.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.7 no.1
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• pp.29-37
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• 2013

The purpose of this study is to suggest the potential domestic and international market conditions vehicles for people with disabilities through a review of the literature and internet resources, and to propose a road map developing South Korean vehicles for people with disabilities taking into consideration the current state of domestic and international technology and the usage of the vehicles for people with disabilities depending on the type of disability. The results of the study are as follows: First, vehicles for people with disabilities safety standards of South Korea do not meet the safety standards of developed countries and the technology of development related vehicles for people with disabilities is not as advanced as that of developed countries. Vehicles for people with disabilities installation methods, specifications, features and safety standards should be designed to be more similar to those of Japan and the United States. Second, vehicle modifications for people with disabilities will become more common as measures directed at promoting the welfare of people with disabilities, such as travel and transportation measures, employment opportunities, education, and funding for vehicle modifications, are implemented along with laws, such as The Americans with Disabilities Act, The British Disability Discrimination Act, and Japan's barrier-free transport law, that protect people with disabilities generally. Third, through a comparative analysis of domestic and international market conditions and demands of people with disabilities in vehicle modifications, important things to pay attention by purchasing a modified vehicle for people with disabilities are the employment rate for people with disabilities and monthly income. To enable this, government agencies and industry bodies should work together through the revision of the current Disability Welfare Act or the enactment of the special law for guiding principles of Disability Welfare Act. Through the future changes in vehicles for people with disabilities-related system or society of South Korean, the annual demand of the vehicles is expected to be more than 10,000.

• Korean Journal of Social Welfare
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• v.68 no.3
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• pp.51-71
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• 2016

The purpose of this study is to clarify macro causes influencing on the diversity of single-mother households poverty among OECD Countries including Korea. This study carried out pooled time series cross-section analysis applying unbalanced panel design on the period from 1981 to 2012. There is marked diversity on single-mother households poverty. GDP per capita does not contributes to reduce poverty, and female employment rate and % population 0-14 exacerbate poverty. Several factors contribute on poverty reduction including social spending, child cash spending, union density, employment protection on regular workers, proportional representation system, cumulative left cabinet, cumulative women seat. In Korea, it needs to overcome the limit of anti-poverty strategy mainly based on economic growth and labor market flexibility. And it needs to enlarge universal welfare institutions, child benefits, work-family reconciliation policy, and to design adjusted labor market institutions including union density and employment protection, to introduce consensus political model including proportional representation system to enhance left power and women's representation.