• 대한한의학원전학회지
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• 제19권4호
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• pp.136-146
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• 2006

파(把) "상한론(傷寒論)" 지중풍여상한적발병원인(之中風與傷寒的發病原因), 인위구분성풍사여한사(認爲區分成風邪與寒邪), 시불태적당(時不太適當). 우시(于是), 논자이사기적경중여체질(論者以邪氣的輕重與體質)(양기(陽氣))적성쇠(的盛衰), 진행중풍여상한적분석(進行中風與傷寒的分析), 득도료여하적결론(得到了如下的結論). 기일시(基一是), 중풍시양기허적인감수료경적풍한사(中風是陽氣虛的人感受了輕的風寒邪), 소이사기침입우기육(所以邪氣侵入于肌肉). 상한시양기성적인감수료중적풍한사(傷寒是陽氣盛的人感受了重的風寒邪), 소이사기유우부표(所以邪氣留于膚表). 기이시(其二是), 중풍인정사적대치상태소완(中風因正邪的代置狀態疎緩), 소이기맥위부완(所以其脈爲浮緩). 상한시정사대치우부표이집중우피모(傷寒是正邪代置于膚表而集中于皮毛), 소이기맥위부긴(所以其脈爲浮緊). 기삼시(其三是), 중풍지사기직접거영향우인체(中風之邪氣直接去影響于人體), 소이위(所以爲)“즉발열(卽發熱)”. 상한적(傷寒的) “혹미발열(或未發熱)”시(是), 성적양기가이억제사기적상태(盛的陽氣可以抑制邪氣的狀態). “혹기발열(或己發熱)” 시양기수성이부가이억제중사적상태(是陽氣雖盛而不可以抑制重邪的狀態). 기사시(其四是), 중풍시인양기허이불가이고섭(中風是因陽氣虛而不可以固攝), 소이위자한(所以爲自汗). 상한시강성적정사도취우부표이울폐(傷寒是强盛的正邪都聚于膚表而鬱閉), 소이위무한(所以爲無汗). 기오시(其五是), 중풍감수료경적사기(中風感受了輕的邪氣), 소이견풍이재손양기(所以見風而再損陽氣), 재회유악풍한적증상(才會有惡風寒的症狀). 상한시감수료중적사기(傷寒是感受了重的邪氣), 소이수거밀실이유악풍한적증(所以雖居密室而有惡風寒的症). 기육시(其六是), 계지탕유해기적효능(桂枝湯有解肌的效能), 소이능치중풍증(所以能治中風證). 마황탕유축부표지사기적효능(麻黃湯有逐膚表之邪氣的效能), 소이치상한증(所以治傷寒證). 기칠시(其七是), “발어양(發於陽)”시당우상한(是當于傷寒), “양(陽)”적의사상당시최표층부적부표(的意思相當是最表層部的膚表). “발어음(發於陰)”시당우중풍(是當于中風), “음(陰)”적의사상당우비부표교심부적기육(的意思相當于比膚表較深部的肌肉). 기팔시(其八是), “풍가(風家)”시인양허이역환중풍적인(是因陽虛而易患中風的人).

• 대한한방내과학회지
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• 제24권1호
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• pp.94-103
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• 2003

In order to investigate the effects of Kaejibokryungwhan, Sobokchugeotang and Dohongsamultang on mesangial cell proliferation and fibronectin synthesis, laboratory study was performed. The results are summarized as follows; 1. Mesangial cell proliferation was significantly decreased in the Kaejibokryungwhan group and the Dohongsamultang group compared with the Control group. In the Sobokchugeotang group, the mesangia1 cell proliferation activity was lesser than Control group, but it was statistically non-significant. In Kaejibokryungwhan group, the Sobokchugeotang group and Dohongsamultang group, mesangial cell proliferation was significantly decreased compared with the Hydrocortisone group 2. In the group, which contained fetal bovine serum, fibronectin synthesis was decreased in the Kaejibokryungwhan group, the Sobokchugeotang group and Dohongsamultang group compared with Control group, but the difference was statistically non-significant. In Kaejibokryungwhan group, Sobokchugeotang group and Dohongsamultang group, fibronectin was less decreased compared with that of Hydrocortisone group. 3. In the group, which contained fetal bovine serum, fibronectin synthesis was significantly decreased in Kaejibokryungwhan group and Sobokchugeotang group than those of Control group. In Dohongsamultang group, the fibronectin synthesis was decreased than Control group, but the difference was statistically non-significant. In Sobokchugeotang group, the fibronectin synthesis was decreased than Hydrocortisone group, but it was statistically non-significant. According to the above results, the mesangial cell proliferation and fibronectin systhesis could be reduced by Kaejibokryungwhan group significantly.

• 대한한방내과학회지
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• 제27권4호
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• pp.936-944
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• 2006

Shoulder pain is a common problem after stroke. This study was done to examine the effect of Cheongungkyeoji-tang for three stroke patients with shoulder pain. Cheongungkyeoji-tang was prescribed for these patients suffering from shoulder pain. In the morning, the grade of shoulder pain was evaluated by visual analogue scale (VAS). Results were taken as three cases of effective treatment of shoulder pain with Cheongungkyeoji-tang. This study suggests that Cheongungkyeoji-tang is an effective treatment for shoulder pain after stroke.

• 동의생리병리학회지
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• 제17권4호
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• pp.952-957
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• 2003

To certify the protective effect of herbal medicine against oxygen free radical-induced myocardiotoxicity, cytotoxicity was measured using LDH activity and TBARS assay in the presence of Jisilhaebaekgyejitang(JHGT) extracts or single constituents of this prescription, In the present study, xanthine oxidase/hypoxanthine (XO/HX) resulted in a cell damage such as increases in LDH activity in culture medium and lipid peroxidation in cultured myocardial cells. In the effect of JHGT extract and its single constituents, which are Fructus Ponciri Seu Aurantii Immaturus (FPSAI), Cortex Magnoliae Officinalis (CMO), Bulbus Allii Macrostemi (BAM), Ramulus Cinnamomi (RC) and Fructus Trichosanthis (FT), they showed the prevention from the XO/HX-induced cardiotoxicity by the decrease of LDH activity and lipid peroxidation. From these results, they show that XO/HX is cardiotoxic in cultured myocardial cells derived from neonatal rat, and it suggests that JHGT, FPSAI, PT, CMO, BAM, RC and FT extracts are positively effective in the blocking in XO/HX-induced cardiotoxicity.

• 한방안이비인후피부과학회지
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• 제23권1호
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• pp.8-22
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• 2010

Objectives : The purpose of this study is to investigate the effects of Gyejijakyakjimo-Tang on the Allergic Contact Dermatitis caused by 2,4-dinitro-chlorobezene(DNCB). Methods : Twenty eight mice were divided into four groups ; normal, control, experimental group A and B. Control and experimental groups were induced allergic contact dermatitis by DNCB. Experimental group A was orally administered the Gyejijakyakjimo-Tang and experimental group B was orally administered the prednisolone. In this study, ear thickness measurement, auricle microphotograph observation, MPO(Myeloperoxidase) activity measurement, Reverse transcription-polymerase chain reaction(RT-PCR) analysis of the mRNA level of TNF-$\alpha$, IL-$1{\beta}$ were performed on these four groups. In addition, the effect of Gyejijakyakjimo-Tang on cell viability and the effect of Gyejijakyakjimo-Tang on the compound 48/80-induced histamine release from HMC and RPMC were measured. Results: 1. Both experimental group A and B had decreased ear thickness compared with control group In contact hypersensitivity assay. 2. In experimental group A, inflammatory edema was similarly observed comparing to control group. Nevertheless, inflammatory edema was obviously reduced in experimental group B. In both experimental group A and B, pathological lesion of dermatitis were alleviated. In addition, the numbers of infiltrated inflammatory cells were decreased compared with control group. 3. Compared to the normal group, there was a noticeable increase in MPO activity in control group. However, in experimental group A and B, it showed remarkable inhibition of the increase in MPO activity comparing with control group. 4. The level of expression of TNF-$\alpha$, IL-$1{\beta}$ in experimental group A and B were meaningfully lower than those in control group. 5. In MTT assay, the concentrations of Gyejijakyakjimo-Tang that were used on the test had no cytotoxicity. 6. Gyejijakyakjimo-Tang dose-dependently inhibited the compound 48/80-induced histamine release from both HMC and RPMC. Conclusions : According to above experiments, Gyejijakyakjimo-Tang was effective on allergic contact dermatitis.

• 대한한방내과학회지
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• 제45권1호
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• pp.31-54
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• 2024

Objectives: This study assessed the effectiveness of Hwanggigyejiomul-tang for postoperative breast cancer-related lymphedema (BCRL) by a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: A search was conducted using keywords such as "breast cancer", "lymphedema", "edema", "Huangqi Guizhi Wuwu decoction", "Huangqi Guizhi Wuwu tang", and "Hwanggigyejiomul tang" in 10 databases (PubMed, Cochrane, ScienceDirect, CNKI, CiNii, RISS, KISS, ScienceON, OASIS, DBpia) on February 11, 2024. There were no limits on the publication period and language, and the quality of the studies was evaluated using Cochrane's risk of bias tool. A meta-analysis was performed based on the outcome measurements, such as total effective rate (TER), increase in shoulder joint mobility (flexion, extension, abduction, adduction), Fugl-Meyer assessment (FMA), and visual analog scale (VAS) using Review Manager Web. Results: Eleven RCTs were selected. The treatment group (Hwanggigyejiomul-tang-gagambang or hapbang with control group intervention) showed a more statistically significant effect compared with the control group (physical therapy or western medicine) in TER (upper limb circumference change), TER (upper limb edema grade change), increase in flexion angle, increase in extension angle, increase in adduction angle, FMA, and VAS. Conclusions: Hwanggigyejiomul-tang is effective in treating postoperative BCRL. However, because of the low quality of the included studies, more clinical studies are required to increase the possibility of clinical use.

• 대한한의학방제학회지
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• 제20권1호
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• pp.25-40
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• 2012

The purpose of this study explain the experimental effects of Guizhishaoyaozhimu-Tang (桂枝芍藥知母湯) that have clinical efficacy in rheumatoid Arthritis. Materials of present study were Guizhishaoyaozhimu-Tang freeze dried powder (GSZT), Sprague-dawley rats (300 g or so, male), various kinds of needing experimental studis. In order to study the therapeutic effects of GSZT, this Prescription (GSZT 500 mg/kg, 1,000 mg/kg) were administered per oral to the rats with the arthritis induced by Freund's complete adjuvant ($0.2m{\ell}/kg$), several experimental items were measured and compared each other ; that is body weight, rate of edema, analgesic effect by hot plate method, WBC, total protein, TNF-${\alpha}$, IL-10 and expression and localization of H&E, COX-2 staining in synovial tissues from rat with rheumatoid arthritis by immunohistochemical staining using polyclonal COX-2 antibodies. Rats were divided into four groups. Normal group was not treated with Freund's complete adjuvant and treated with DDW 1.0 $m{\ell}$, Control group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and DDW 1.0 $m{\ell}$, Sample A group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (500 $mg/m{\ell}$) $1.0m{\ell}$, Sample B group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (1,000 $mg/m{\ell}$) 1.0 $m{\ell}$. 0 was day that did not start experiment, 14 was day that confirmed rheumatism induced by Freund's complete adjuvant, 28 was day that completed experiment. The following results were obtained in this study ; Sample A group was increased in body weight, escape time and paw licking time statistical significance compared with Control group, and were decreased in edema, WBC, total protein, TNF-${\alpha}$ with statistical significance compared with Control group. Sample B group was increased in escape time with statistical significance compared with Control group, and were decreased in edema, WBC, total protein with statistical significance compared with Control group. Sample A and Sample B groups were increased in IL-10 compared with Control group, and Sample B group was decreased in TNF-${\alpha}$ compared with Control group. And, Control, Sample A and Sample B groups were showed considerable reduction of positive expression in comparison to Normal group. Especially, Sample B group was most significantly reduction of positive expression than the other groups. From above results, I suggest that GuizhiShaoyaoZhimu-Tang can be used for curing rheumatoid arthritis.

• 사상체질의학회지
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• 제11권1호
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• pp.63-77
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• 1999

1. 연구목적 : '연변조선족민족의약연구회(延邊朝鮮族民族醫藥硏究會)'에서 1984년에 영인한 "동의수세보원사상초본권(東醫壽世保元四象草本卷)"의 필사본(筆寫本)은 여러 정황과 글의 내용으로 보아 동무(東武) 이제마(李濟馬)의 글로 추정되며 "동의수세보원(東醫壽世保元)"저술 이전의 초기 저작과 같은 글임을 확인할 수 있어 이를 밝히고자 하였다. 이 논고는 문헌의 내용을 언급하기 이전에 반드시 선행이 되어야 할 서지학적(書誌學的)인 고찰과 문헌 연구의 일환이다. 2. 연구방법 : 문헌 제공자인 손영석(孫永錫)의 진술 내용과 문염(文厭)의 내용을 중심으로 "동의수세보원사상초본권(東醫壽世保元四象草本卷)"이 "동의수세보원(東醫壽世保元)" 내용으로 발전 과정과 개념 및 병증약리(病證藥理)의 변화를 문헌적 고찰을 통해 살펴보았다. 또한 동무공의 기타 저술과 비교하여 저술 시기를 추정해 보았다. 3. 연구 결과 및 결론 : 이상의 연구에서 얻은 결론은 아래와 같다. 1) "동의수세보원사상초본권(東醫壽世保元四象草本卷)"은 함흥의 최겸강(崔謙鋼)이 소장하던 것을 김구익(金九翌)이 수초(手抄)하여 1984년 필사본(筆寫本)이 영인(影印)되었고 1985년 10월 연변조선족자치주민족의약연구소(延邊朝鮮族自治州民族醫藥硏究所)에서 발간한 "조의학(朝醫學)" 제1편(第一冊) 사상의학론(四象醫學論)에서 부록으로 '사상의학초본권(四象醫學草本卷)'이라는 제목으로 출판되었다. 2) "동의수세보원사상초본권(東醫壽世保元四象草本卷)"은 그 편제에서 "동의수세보원(東醫壽世保元)"의 내용이 각 편마다 함축되어 있고 권지삼(卷之三)의 태양인약방(太陽人藥方)에서 동무공(東武公) 자신이 태양인(太陽人)임과 태양인(太陽人)의 병증약리(病證藥理)를 성립하게 되는 과정을 서술하고 있어 동무공(束武公)의 저술임을 확인할 수 있다. 3) "권지삼약방(卷之三藥方)"에서 "동의수세보원(東醫壽世保元)" 신정방(新定方)의 기원이 되는 처방을 확인할 수 있으며 대표적으로 "소음약방(少陰藥方)"의 반강탕(半薑湯)은 계지반하생강탕(桂枝半夏生薑湯)으로 "태음약방(太陰藥方)"의 구미천문동탕(九味天門冬湯)은 청심운자탕(淸心運子湯)으로 발전한 것으로 추정된다. 4) "권지삼약방(卷之三藥方)"을 통해 태소음양인(太小陰陽人)의 병증약리(病證藥理)의 성립 과정을 알 수 있으며 소양인(少陽人)의 병증약리(病證藥理)가 비교적 초기에 완성되고 태음인(太陰人) 병증약리(病證藥理)가 완성되고 소음인(少陰人)의 병증약리(病證藥理)는 증치의학(證治醫學)의 처방을 이용하다 비교적 후기에 완성되었음을 확인할 수 있다. 5) "동의수세보원사상초본권(東醫壽世保元四象草本卷)" 권지일(卷之一)의 지(知)와 행(行)에 대한 인식은 "성명론(性命論)"의 사고와는 달리 비교적 정제되지 않은 상태이며 "격치고(格致藁)" "유약(儒略)"과 "반성잠(反誠箴)"의 사고와 유사함을 볼 수 있다. 6) "동의수세보원사상초본권(東醫壽世保元四象草本卷)"의 저술시기는 "동무유고(東武遺稿)" 약성가(藥性歌)나 39세 망음증(亡陰證) 치험례 이후이며 저술로 "격치고(格致藁)" "유약(儒略)" "반성잠(反誠箴)" 저술 전이나 저술 당시로 추정되어 40대 후반과 50대 초반 사이의 저술로 추정된다.