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Protective Effects of Jisilhaebaekgyeji-tang and Constituents Extract on Cultured Rat Myocardial Cell treated by XO/HX  

Jang Seung Ho (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Su (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kang Gil Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Gyu (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim In Seob (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 952-957 More about this Journal
Abstract
To certify the protective effect of herbal medicine against oxygen free radical-induced myocardiotoxicity, cytotoxicity was measured using LDH activity and TBARS assay in the presence of Jisilhaebaekgyejitang(JHGT) extracts or single constituents of this prescription, In the present study, xanthine oxidase/hypoxanthine (XO/HX) resulted in a cell damage such as increases in LDH activity in culture medium and lipid peroxidation in cultured myocardial cells. In the effect of JHGT extract and its single constituents, which are Fructus Ponciri Seu Aurantii Immaturus (FPSAI), Cortex Magnoliae Officinalis (CMO), Bulbus Allii Macrostemi (BAM), Ramulus Cinnamomi (RC) and Fructus Trichosanthis (FT), they showed the prevention from the XO/HX-induced cardiotoxicity by the decrease of LDH activity and lipid peroxidation. From these results, they show that XO/HX is cardiotoxic in cultured myocardial cells derived from neonatal rat, and it suggests that JHGT, FPSAI, PT, CMO, BAM, RC and FT extracts are positively effective in the blocking in XO/HX-induced cardiotoxicity.
Keywords
Jisilhaebaekgyeji-tang(枳實?白桂枝湯); Fructus Ponciri Seu Aurantii Immaturus; Cortex Magnoliae Officinalis; Bulbus Allii Macrostemi; xanthine oxidase/hypoxanthine; Myocardial cell;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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