• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1993.04a
• /
• pp.103-103
• /
• 1993

목적: Estroge 결핍으로 나타나는 폐경기의 주요 증상을 경감 치료하기 위해, estrogen경구 투여시 위장장애, 위장에서의 대사, 간 초회효과, 자주 투여로 인한 환자의 불편 등의 단점이 있나, 이러한 점을 개선하기 위한 투여경로의 하나로 피부를 통해 일정약물을 장기간 일정속도로 송달시키는 경피 흡수 시스템의 개발이 필요하다. 따라서 (EE)의 장기제어방출을 위해 ethylene vinyl acetate (EVA)를 사용하여 장기 제어방출 및 경피 흡수의 최적화 조건을 설정하여 경피흡수 시스템을 위한 막의 개방을 목적으로 한다. 방법: VA 함량이 18-40％까지의 EVA를 사용하여 EE를 함유한 matrix를 casting 방법으로 제조하고 변형된 Keshary-Chien cell을 이용하여 방출실험을 실행하였다. 이때 방출에 미치는 여러 가지 인자로서 EVA 주의 VA함량, 막의 두께, receptor 중 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 량 등에 대해 검토하였다. 그리고 점개한 mouse skin에 대한 투과 실험을 행하고 이에 미치는 PEG 400과 자질층의 역할을 검토하였다. 결과: EE의 용해도는 saline so PEG 400의 용량 비율이 증가함에 따라 지수 함수적으로 증가하였다. 그리고 VA 함량이 증가될수록, PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 EE의 방출속도와 부과속도는 증가하였다. 또한 투과속도는 막두께의 역수와 직선상의 상관 관계를 보였다. 그리고 EVA matrix로부터 EE가 방출되는 양상은 diffusion-controlled model을 따랐으며 이때 단위면적당 방출된 총량은 T에 비례되었다. 절개한 mouse skin을 통한 EE의 permeation은 PEG 400의 첨가에 의해 상승되었다. 이와 같이 EVA 막이 EE의 부과 및 방출을 조절하는 것으로 보아 경피 흡수를 위해 사용될 수 있다고 사료된다.

• Journal of the Korean Society of Radiology
• /
• v.84 no.6
• /
• pp.1350-1360
• /
• 2023

Purpose To evaluate the factors that predict symptomatic dislodgement of a percutaneous transhepatic biliary drainage (PTBD) catheter in patients with malignant biliary obstruction. Materials and Methods This retrospective study included 572 patients with malignant biliary obstruction who underwent 733 PTBD catheter insertions between January 2010 and February 2015. The duration of catheter placement, approach site, location of the catheter tip, insertion angle, presence of a closed-loop pigtail, and tube diameter were evaluated. Results During the follow-up period, 224 PTBD catheter dislodgements (30.56%) were observed in 157 patients. Among them, 146 (19.92%) were symptomatic. The mean duration from catheter insertion until dislodgement was 32 days (range: 1-233 days). Male (odds ratio [OR]: 1.636, 95% confidence interval [CI]: 1.131-2.367, p = 0.009), right-sided approach (OR: 1.567, 95% CI: 1.080-2.274, p = 0.018), increased insertion angle (OR: 1.015, 95% CI: 1.005-1.026, p = 0.005), and incomplete closed-loop pigtail formation (OR: 1.672, 95% CI: 1.098-2.545, p = 0.016) were independent factors predictive of symptomatic dislodgement of a PTBD catheter. Conclusion Factors predictive of symptomatic catheter dislodgement included male sex, a right-sided approach, increased insertion angle, and incomplete closed-loop pigtail formation.

• The Journal of the Korean bone and joint tumor society
• /
• v.9 no.1
• /
• pp.84-92
• /
• 2003

Purpose: To report two cases of bone tumors other than osteoid osteoma in the proximal femur and treated with percutaneous high frequency radioablation method. Cases: We reviewed two cases with intracortical chondroma and enchondroma in the femoral head retrospectively. The patient with intracortical chondroma was a thirty one year old woman and had suffered right hip pain of 1 year duration. The lesion was located in the head of right femur and treated with CT guided percutaneous high frequency radioablation after needle biopsy under general anesthesia. The symptom was gone immediately after the procedure and was discharged postop. 1 day. 15 months has passed without symptom recurrence. Second case having enchondroma, was 56 year old woman complaining of gluteal area pain for 3 months. Radiologic evaluation showed osteolytic lesion with sclerotic rim on the inferior portion of the left femoral head. She received a same therapy with CT guided radiofrequency ablation following needle biopsy. She reported dramatic pain relief after the procedure and was discharged postop. 1 day. No symptom has occurred for 3 months until now. Conclusion: We present 2 cases of bone tumor occurred in the hip joint area other than osteoid osteoma which were treated with CT guided radiofrequency ablation.

• Journal of Korean Academy of Fundamentals of Nursing
• /
• v.12 no.2
• /
• pp.215-222
• /
• 2005

Purpose: To identify the incidence of cutaneous injury in clinical nurses. Method: From Feb.1 to 28, 2005, 276 clinical nurses were surveyed by questionnaire. Results: 1. Of the nurses, 53.6% had at least one incidence of cutaneous injury, and the mean number of injuries was 1.34. A higher incidence rate for cutaneous injury was found in nurses who were under the age of 25, unmarried and who had less than 3 years career experience. 2. The major causes of injury were syringe needles at 65.0%, and medical instrument were next followed by sharp objects or blades. The injuries occurred when the nurses were rearranging equipment after care (25.2%), taking blood samples (22.8%), separating syringes and needles (17.1%), during surgical operations (14.2%), and distribution of medications, treatments and recapping of needles (5.7% each). The hands were the most common body parts injured, and the most prevalent pathogens contaminating the instruments causing the injury were HBV syphilis, HCV and HIV in that order. 3. Of the injured nurses, 77.9% did not report the accident and 25.8% did not receive any treatment because there were no pathogens, it was a bother or there was difficulty reporting the incident. Conclusion: To reduce cutaneous injuries, intensive training and supervision may be needed for those of nurses under the age of 25, unmarried and with less than 3 years career experience.

• Journal of the Korea Convergence Society
• /
• v.8 no.1
• /
• pp.77-87
• /
• 2017

The purpose of This study was to compare the effect of Convergence-Based russian current(RC) and transcutaneous electrical nerve stimulation(TENS) on pain, muscle strength, function of knee who had a surgical anterior cruciate ligament reconstruction(ACLR). A total of 40 Participants divided into 2 groups, with ACLR, were assigned to russian current group(RCG) or transcutaneous electrical nerve stimulation group(TENSG). Both groups were measured by varieties of tests: visual analog scale(VAS), knee flexion & extension muscle strength, knee injury and osteoarthritis outcome score(KOOS), korean lower extremity functional scale(LEFS). Both groups has shown significant changes within the measurements of VAS, Knee Flexion & Extension muscle strength, KOOS and LEFS. The RCG had more significant increase within knee extension muscle strength, LEFS compared to TENSG. By studying this research, both interventions were effective to ACLR patients, moreover, RC was more effective for knee muscle strength and lower extremity function than the TENS.

• Proceedings of The Korean Society of Health Promotion Conference
• /
• 2007.04a
• /
• pp.191-195
• /
• 2007

• Journal of Chest Surgery
• /
• v.30 no.4
• /
• pp.445-448
• /
• 1997

Percutaneous transthoracic fine needle biopsy has been widely used In the diagnosis of pulmonary lesions especially lung cancer. Onc of the rarest complication's is that malignant cells are implanted within the needle tract and developed a chest wall mass subsequently. Wc expcrlenccd a case of chest wall implantatio of lung cancer after percutaneous transthoracic floe needle biopsy. A 65-ycar old man had undergone bilobectomy (right upper lobe and right middle lobe)for squamous cell (·4rcinoma (TINOMO) of the lung. 60 days after percutaneous biopsy (48 days after operation), a tiny nodule (1 mm sized) was notcd at the right anterior chcst wall where the diagnostic fine needle biopsy had been performed before operation. This tiny mass was rapidly growing to 1.5 cm sized mass for 20 days. We carried out wide excision of chest wall mass and skin grafting, and confirmed squamous cell carcinoma histopathologically as same as the lung cancer.

• Journal of Chest Surgery
• /
• v.41 no.6
• /
• pp.768-771
• /
• 2008

The use of IVUS provides information about the lumen and arterial wall, the location and extent of atherosclerotic plaque and the state of the arterial wall after PCi. The use of IVUS after insertion of an intracoronary stent has currently increased, while conflicting evidence exists concerning the long-term benefits of IVUS. We report here on a case of surgical removal of an entrapped and fractured IVUS catheter during insertion of intracoronary stents, and we include a review of the relevant literature.

• 대한두경부종양학회:학술대회논문집
• /
• 2001.11a
• /
• pp.264-264
• /
• 2001

• Journal of The Korean Radiological Technologist Association
• /
• v.29 no.1
• /
• pp.221-221
• /
• 2003