• Title/Summary/Keyword: 결합체

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Synthesis and Fungicidal Activities of Substituted Phenyl Hydrazono-3-Methyl-1, 2-Isoxazol-5-One Derivatives. (치환 Phenyl Hydrazono-3-Methyl-1, 2-Isoxazol-5-One 유도체의 합성과 살균활성)

  • Park, Kwang-Wook;Keum, Young-Su;Park, Chang-Kyu
    • Korean Journal of Environmental Agriculture
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    • v.15 no.2
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    • pp.239-245
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    • 1996
  • Fungicidal activity has been examined for a series of substituted phenylhydrazono-3-methyl-1,2-isoxazol-5-one against plant pathogenic fungi. 3-methyl isoxazol-5-one was obtained from ethyl acetoacetate and hydroxyl amine. Final products were prepared by aromatic diazo coupling with 3-methyl isoxazol-5-one. Fungicidal activities against Rhizoctonia solani, Colletotrichum gloeosporioides, Cladosporium cucumerinum, Pythium ultimum were tested and Pythium ultimum were tested and Pythium ultimum was selected for quantitative measurement of activity. Methyl, halogen, nitro derivatives possessed high fungicidal activity at p-, o-, p- position, respectively. Methyl, halogen derivatives were much more active than alkoxy, nitro derivatives and the order of activity of halogen derivatives was F > Cl > I. This result implied that the activity was related to the molecular volume of substitutents.

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Word Separation in Handwritten Legal Amounts on Bank Check by Measuring Gap Distance Between Connected Components (연결 성분 간 간격 측정에 의한 필기체 수표 금액 문장에서의 단어 추출)

  • Kim, In-Cheol
    • Journal of the Korean Institute of Intelligent Systems
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    • v.14 no.1
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    • pp.57-62
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    • 2004
  • We have proposed an efficient method of word separation in a handwritten legal amount on bank check based on the spatial gaps between the connected components. The previous gap measures all suffer from the inherent problem of underestimation or overestimation that causes a deterioration in separation performance. In order to alleviate such burden, we have developed a modified version of each distance measure. Also, 4 class clustering based method of integrating three different types of distance measures has been proposed to compensate effectively the errors in each measure, whereby further improvement in performance of word separation is expected. Through a series of word separation experiments, we found that the modified distance measures show a better performance with over 2 - 3% of the word separation rate than their corresponding original distance measures. In addition, the proposed combining method based on 4-class clustering achieved further improvement by effectively reducing the errors common to two of three distance measures as well as the individual errors.

Development of the Connection Unit with a Gas Gun Installed in a Quadcopter-type Drone (쿼드콥터형 드론에 설치된 가스총 결합유닛의 개발)

  • Jeon, Junha;Kang, Ki-Jun;Kwon, Hyun-Jin;Chang, Se-Myong;Jeong, Jae-Bok;Baek, Jae-Gu
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.46 no.9
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    • pp.774-781
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    • 2018
  • In this investigation, a gas gun is proposed driven by carbon dioxide gas and installed on a quadcopter-type small unmanned drone for the purpose of cattle vaccination, and we developed a launcher and its connection unit. The system consists of a commercial drone, a gas gun, a solenoid valve, and the remote communication controller, etc. The velocity of launched projectile is measured, and the full system is finally validated through ground test and flight examination loaded for the real aircraft. The feasibility is checked if this technology is applicable to various disease abatement and hazard mitigation in the fields of agriculture and fire-fighting with the present research and development.

브라디키닌 수용체 발현 및 길항제개발에 관한 연구

  • 정성현;이은순
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.146-146
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    • 1993
  • 신장에서 브라디키닌(Bradikinin, BK)의 생리적 역할을 규명하기 위한 첫 단계로 토끼신장 근위세뇨관의 일차배양세포를 이용, BK 수용체를 ($^3$H) BK를 이용하여 수용체결합실험을 함과 아울러 세포배양과정에서 여러 성장인자들의 BK 수용체발현에 미치는 영향을 관찰하였다. 첫째, 토끼 신장의 피질, 수질 및 근 위세뇨관 둥 각 부위에 대한 BK 수용체결합 실험결과 신수질 부분에 가장 많은 BK 수용체가 발견되었으며 이때 해리항수는 0.52 nM, 그리고 최대결합부위는 mg 단배질당 112.5 fmol이었다. 둘째, serum free 배지에서 insulin, transferrin 그리고 hydrocortisone이 성장인자로 사용될 때 BK 수용체발현이 가장 높았으며 이 중 인슐린에 가장 큰 영향을 받았다. 한편 인슐린의 최적농도를 결정하는 실험의 결과 5 $\mu\textrm{g}$/ml매서 가장 높은 수용체발현을 나타내었으며 그 이상에서는 별다른 차이를 보이지 못했다. 세째, 위의 세 성장인자에 prostaglandin E$_1$이나 triiodothyronine을 첨가시 BK 수용체발현은 오히려 저하되었다. 네째, fetal bovine serum (FBS)과 위의 세 성장인자간의 수용체발현능을 비교한 실험에서 세포배양 후 첫 일주일에는 FBS가 세 성장인자보다 약간 나은 수용체발현능을 나타내었으나 그후 이주째에는 세 성장인자가 BK 수용체발현에 더 적절한 요소임을 보여주었다. 이상의 결과로 보아 토끼 근위세뇨관 상피세포에서의 BK 수용체발현은 세포성장인자로 insulin, transferrin, hydrocortisone 중 insulin에 가장 큰 영향을 받는것으로 보이며, 이들 세가지 성장인자는 serum free 배지에서 세포성장 및 기능에 많은 영향을 주는 것으로 생각된다.prolidine이 $K_{M}$ /K$_{H}$ 비가 가장 높았고 diphenidol이 가장 낮았다. 이상의 결과로 보아 항 histamine제의 muscarinic receptor 차단작용은 이들 약물의 항 alleragy 효과에 필요한 작용이 아니며 본 실험에서 추정된 항 histamine제의 H$_1$-receptor와 muscarinic receptor에 대한 상대적 역가는 이들 약물의 선택과 평가에 중요한 지표가 될수 있을 것으로 생각된다.ing ischemic insults. The nature of the receptor is being explored by molecular genetic techniques, and we have recently cloned two of the major subunits; some of the data will be presented.LIFO, 우선 순위 방식등을 선택할 수 있도록 확장하였다. SIMPLE는 자료구조 및 프로그램이 공개되어 있으므로 프로그래머가 원하는 기능을 쉽게 추가할 수 있는 장점도 있다. 아울러 SMPLE에서 새로이 추가된 자료구조와 함수 및 설비제어 방식등을 활용하여 실제 중형급 시스템에 대한 시뮬레이션 구현과 시스템 분석의 예를 보인다._3$", chain segment, with the activation energy of carriers from the shallow trap with 0.4[eV], in he amorphous regions.의 증발산율은 우기의 기상자료를 이용하여 구한 결과 0.05 - 0.10 mm/hr 의 범위로서 이로 인한 강우손실량은 큰 의미가 없음을 알았다.재발이 나타난 3례의 환자를 제외한 9례 (75%)에서는 현재까지 재발소견을 보이지 않고 있다. 이러한 결과는 다른 보고자들과 유사한 결과를

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Activation of the M1 Muscarinic Acetylcholine Receptor Induces GluA2 Internalization in the Hippocampus (쥐 해마에서 M1 무스카린 아세틸콜린 수용체의 활성에 의한 GluA2 세포내이입 연구)

  • Ryu, Keun Oh;Seok, Heon
    • Journal of Life Science
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    • v.25 no.10
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    • pp.1103-1109
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    • 2015
  • Cholinergic innervation of the hippocampus is known to be correlated with learning and memory. The cholinergic agonist carbachol (CCh) modulate synaptic plasticity and produced long-term synaptic depression (LTD) in the hippocampus. However, the exact mechanisms by which the cholinergic system modifies synaptic functions in the hippocampus have yet to be determined. This study introduces an acetylcholine receptor-mediated LTD that requires internalization of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors on the postsynaptic surface and their intracellular mechanism in the hippocampus. In the present study, we showed that the application of the cholinergic agonist CCh reduced the surface expression of GluA2 on synapses and that this reduction was prevented by the M1 muscarinic acetylcholine receptor antagonist pirenzepine in primary hippocampal neurons. The interaction between GluA2 and the glutamate receptor-interacting protein 1 (GRIP1) was disrupted in a hippocampal slice from a rat upon CCh simulation. Under the same conditions, the binding of GluA2 to adaptin-α, a protein involved in clathrin-mediated endocytosis, was enhanced. The current data suggest that the activation of LTD, mediated by the acetylcholine receptor, requires the internalization of the GluA2 subunits of AMPA receptors and that this may be controlled by the disruption of GRIP1 in the PDZ ligand domain of GluA2. Therefore, we can hypothesize that one mechanism underlying the LTD mediated by the M1 mAChR is the internalization of the GluA2 AMPAR subunits from the plasma membrane in the hippocampal cholinergic system.

Basic Properties of Waste Wood-Plastic Composite Panels by Hot Press Molding Method (열압 성형법에 의한 폐목재-플라스틱 복합패널의 기초적 성질)

  • Choi, Nak-Woon;Mun, Kyoung-Ju;Choi, San-Ho
    • Journal of the Korea Organic Resources Recycling Association
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    • v.12 no.4
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    • pp.95-104
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    • 2004
  • A styrene solution of waste expanded polystyrene with a crosslinking agent and an initiator was used as a binder for waste wood-plastic composite panels. The waste wood-plastic composite panels are prepared with various binder contents and filler-binder ratios by using a hot press molding method. The apparent density of the composite panels is increased with increasing binder content and filler-binder ratio, while their water absorption and expansion in thickness are decreased with increasing binder content and filler-binder ratio. The maximum flexural strength and wet flexural strength of the composite panels are obtained at a binder content of 35% and a filler-binder ratio of 0.8. Decreases in the flexural strengths of the composite panels due to water immersion at 20 and $100^{\circ}C$ are hardly recognized at binder contents of 30% or more.

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A Design of Two Layer Re-entrant Microstrip Directional Coupler Improving Coupling and Isolation (결합도와 격리도를 개선한 이중층 Re-entrant 마이크로스트립 방향성 결합기 설계)

  • 최문호;이진택;천동완;신철재
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.14 no.10
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    • pp.1052-1059
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    • 2003
  • In this paper, we proposed the directional coupler using two layer microstrip substrate which is improved coupling and isolation. Also, we notified a design method. Modified re-entrant mode coupler is the structure added to the aperture on the ground plane in order to improving the coupling value. And, by adding to slits on the floating conductor, this structure has good performance in isolation, VSWR according to S$\sub$11/, and phase difference. As a result, proposed re-entrant mode microstrip directional coupler has about 1.5 dB more higher coupling and 20 dB more higher isolation than conventional coupler. And because this coupler has good performance in phase difference, it can be used multi-section coupler.

Development of the Multi-Propeller based Attitude Control Method for VTOL type Compound Aircraft (VTOL 타입의 복합형 비행체에 적용가능한 다수 프로펠러 기반 자세제어기법의 개발)

  • Seung, Myeonghun;Han, Sanghyuck;Kim, Jongchul;Gong, Hyeon Cheol
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.45 no.6
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    • pp.455-462
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    • 2017
  • In recent decades, many researchers have been struggling to developing the compound aircraft that is capable high speed and VTOL flight. And in recent years, multi-copters are very popular because of having advantages of VTOL and easy handling, but they are lack of doing long-range mission. Therefore, we presents simple aircraft architecture which is equipped fixed wing, multi propellers and no control surfaces. In this paper, we designed the attitude control for the compound aircraft prototype and measured the attitude control performance with flight test for validating prototype's performance. We analysed the attitude control test result comparing with similar size of a fixed wing aircraft. The performance was almost same as fixed wing aircraft.

A Solid Phase Synthesis of Dihydro-1,4-dioxin and Dihydro-1,4-oxathiin Carboxanilides Using Polymer-bound Oxime Ester (고체상에 연결된 옥심 에스테르를 이용한 다이하이드로-1,4-다이옥신 및 다이하이드로-1,4-옥사티인 카르복스아닐라이드 유도체의 고체상 합성)

  • Hahn, Hoh-Gyu;Bae, Su-Yeal;Nam, Kee-Dal
    • The Korean Journal of Pesticide Science
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    • v.10 no.1
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    • pp.1-6
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    • 2006
  • A methodology for the syntheses of carboxanilides using solid support of 4-chloro-3-nitorbenzophenone oxime resin 5 was developed. Condensation of 4-chloro-3-nitorbenzophenone resin 6 with hydroxylamine hydrochloride salt gave oxime resin 5. The reaction of oxime resin 5 with dioxin and oxathiin derivatives 7a-d afforded the corresponding polymer-bound dioxin and oxathiin derivatives 9a-d. These polymer-bound resins 9a-d were treated respectively with aniline in the presence of acetic acid resulted in the corresponding dioxin carboxanilides 10a-d (yield, 5%-quantitative).

Fabrication of Transparent Dielectric Green Sheet for Plasma Display Panel (PDP 투명유전체 형성용 Green Sheet 제조)

  • Heo, Sung-Cheol;Park, Duck-Kyun;Oh, Young-Jei
    • Journal of the Korean Ceramic Society
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    • v.41 no.4
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    • pp.277-283
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    • 2004
  • To fabricate green sheet of transparent dielectric for PDP front panel, dispersion of transparent dielectric slurry, density, and mechanical properties of green sheets have been investigated as a function of amount and composition of organic additives. Measurements of sedimentation and viscosity were employed to determine a proper dispersant and its amount for a well dispersed transparent dielectric powders in non-aqueous system. Green sheets, having various ratios of transparent dielectric powders to transparent dielectric powders+ binder+plasticizer and binder to binder+plasticizer, were fabricated. All the tape casting slurries showed shear thinning effect, that is, the apparent viscosity decreased with the increase of shear rate. It was found that the amount and composition of organic additives were main variables to affect densities and mechanical properties of transparent dielectric green sheets for PDP.