• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.1
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• pp.54-63
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• 2010

Baicalin, a flavonoid, was shown to have diverse effects such as anti-inflammatory, anti-cancer, anti-viral, anti-bacterial and others. Recently, we found that the baicalin inhibits adipogenesis through the modulations of anti-adipogenic and pro-adipogenic factors of the adipogenesis pathway. In the present study, we further characterized the molecular mechanism of the anti-adipogenic effect of baicalin using microarray technology. Microarray analyses were conducted to analyze the gene expression profiles during the differentiation time course (0 day, 2 day, 4 day and 7 day) in 3T3-L1 cells with or without baicalin treatment. We identified a total of 3972 genes of which expressions were changed more than 2 fold. These 3972 genes were further analyzed using hierarchical clustering analysis, resulting in 20 clusters. Four clusters among 20 showed clearly up-regulated expression patterns (cluster 8 and cluster 10) or clearly down-regulated expression patterns (cluster 12 and cluster 14) by baicalin treatment for over-all differentiation period. The cluster 8 and cluster 10 included many genes which enhance cell proliferation or inhibit adipogenesis. On the other hand, the cluster 12 and cluster 14 included many genes which are related with proliferation inhibition, cell cycle arrest, cell growth suppression or adipogenesis induction. In conclusion, these data provide detailed information on the molecular mechanism of baicalin-induced inhibition of adipogenesis.

• Journal of Nutrition and Health
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• v.36 no.4
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• pp.352-358
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• 2003

This study was performed to investigate the effects of liquid culture of Agaricus blazei on the lipid metabolism and enzyme activities in growing male rats. Sprague-Dawley rats were given four different types of diets for a succeeding period of 5 weeks, respectively: a normal diet group (7% corn oil), a high fat diet group (7% com oil + 15% lard), a 20 or 30% Agaricus diet groups (high fat diet + 20 or 30% Agaricus in water) according to the levels of Agaricus supplementation. The body weight gains, food intake, food efficiency ratios, and hepatic, kidney, spleen and pancreas weights of the rats fed 20 or 30% Agaricus diets were similar to those of the rats fed high fat diet. The epididymal fat pad weight of the rats fed high fat diet and 20 or 30% Agaricus diets were significantly higher than that of the rats fed normal diet. The concentrations of serum triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol, and the activity of glutamic pyruvic transaminase in the rats fed 30% Agaricus diet were significantly lower than those in the rats 114 high fat diet. But the concentrations of hepatic total cholesterol and triglyceride of rats fed the 20 or 30% Agaricus diets were similar to those of rats fed the high fat diet. The HDL-oholesterol/total-cholesterol ratio of the rat fed 30% Agaricus diet was significantly higher than that of the rats fed high fat diet, The activity of glutamic oxaloacetic transaminase in the rats fed 20 or 30% Agaricus diets were similar to those in the rats fed high fat diet. There were no differences in the concentrations of total protein, hemoglobin and glucose, and the activities of alkaline phosphatase, and the atherogenic index in the serum among the experimental groups. These results showed that the 30% Agaricus diet feeding decreased the total cholesterol, the triglyceride and the LDL-cholesterol, and increased the HDL-oholesterol/total cholesterol ratio in serum of rats.

• The Korean Journal of Food And Nutrition
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• v.14 no.6
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• pp.512-520
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• 2001

Kimchi is one of the traditional Korean food and a very popular side dish in Korea. To obtain funda mental data on how to prevent over ripening in kimchi after acidity of 0.4% was reached during the lactate fermentation, the physicochemical characteristics such as pH. acidity. organic acids, enzyme activity were measured and the time dependent ecology of microorganism were observed. In the initial stages of fermentation, the pH of kimchi was markedly changed and slowly decreased in 0.5% acidity The acidity was slowly increased and markedly increased in pH 4 by growth of microorganism. HPLC analysis showed oxalic acid, lactic acid, acetic acid, malic acid and succinic acid and this results reconfirmed by GC-MSD. Lactic acid was changed a lot during fermentation period as the time of storage went on, where as malic was decreased. Kimchi A, having acidity of 0.75%, showed the highest acidic Protease and lipase activity. Also, the amylase activity was high in kimchi C, having 0.95% acidity. The total viable bacteria showed 8.1$\times$10$^{5}$ , 4.7$\times$10$^4$, 1.2$\times$10$^3$, 3.2$\times$10$^4$, 4.9$\times$10$^{5}$ cfu/ml in the kimchi A, B, C, D and E, respectively. The numbers of lactic acid bacteria counted 1.0$\times$10$^{5}$ , 1.3$\times$10s, 1.2$\times$10$^3$, 2.3$\times$ 10$^3$, 2.1$\times$10$^4$c1u/m1 in the kimchi A, B, C, D and E, respectively. The numbers of acetobactor were counted 1.8$\times$10$^{5}$ , 9.3$\times$10$^4$, 7.0$\times$10$^1$, 4.5$\times$10$^4$, 5.3$\times$10$^3$cfu/m1 in the kimchi A, B, C, D and E, respectively.

• Korean Journal of Environmental Biology
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• v.18 no.1
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• pp.77-93
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• 2000

Field survey on the spatio-temporal distribution of water quality and chlorophyll a concentration, and the environmental factors on the variation of phytoplankton biomass were carried out at the 23 stations for four seasons in the Shiahae, southwestern coast of Korean Peninsula from February to October in 1995. I made an analysis on biological factor as chlorophyll a concentration as well as environmental factors such as water temperature, salinity and nutrients; ammonia, nitrite, nitrate, dissolved inorganic nitrogen, phosphate, N/P ratio, silicate and Si/P ratio. The waters in the Shiahae were not stratified due to the tidal mixing and high velocity of tidal current. And the high productivity in photic layer were supported by high nutrients concentration from freshwater on lands and bottom waters The low depth of transparency in the Shiahae had a bad influence upon primary production and marine biology. In Shiahae had a sufficient nutrients for primary production during a year. Especially dissolved inorganic nitrogen and silicate were high, the other side, phosphate was low. The source of nutrients in summer and silicate supply depend on input of freshwater from lands, the other side, dissolved inorganic nitrogen and phosphate were depend on rather supplied from bottom layer by the mixing and input of seawater from outside than input of freshwater from lands. Phosphate seemed to become a limiting nutrient for the primary production at all area of Shiahae in winter and at the northern parts in other seasons. However, dissolved inorganic nitrogen seemed to do it at the southern parts in other seasons except winter. Silicate didn't become a limiting nutrient for diatoms in Shiahae. Phytoplankton biomass as measured by chlorophyll a concentration was very high all the year round, it was controlled by the combination of the several environmental factors, especially of nitrogen, phosphorus and the physical factors such as light intensity. [Spatio-temporal distribution, Seasonal fluctuation, Nnutrients, Chlorophyll a, Environmental factors, Nutrient source, Limiting Nutrient, Light, Shiahae] .

• Journal of Animal Science and Technology
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• v.50 no.5
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• pp.677-686
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• 2008

This study was conducted to evaluate the effects of dietary wild-ginseng adventitious root meal on growth performance, blood characteristics and meat quality characteristics in growing-finishing pigs. Ninety six pigs[(Landrace×Yorkshire)×Duroc] with average initial body weight of 68.29±0.31kg were used in 70d growth trial. Dietary treatments included 1) CON(Basal diet), 2) WGR1(Basal diet+0.5% wild- ginseng adventitious root meal), 3) WGR2(Basal diet+1.0% wild-ginseng adventitious root meal) and 4) WGR3(Basal diet+1.5% wild-ginseng adventitious root meal). The pigs were allotted into four dietary treatments with six replicate pens and four pigs per pen in a completely randomized design. For the whole period, final body weight and ADG were increased in CON treatment compared to WGR3 treatment(Linear effect, P=0.005). In blood characteristics, red blood cell(RBC) was significantly increased in CON and WGR2 treatments compared to WGR1 treatment (Quadratic effect, P=0.019). WGR2 treatment resulted in higher white blood cell(WBC) than CON and WGR1 treatments(Linear effect, P=0.041). WBC difference was significantly improved in WGR2 treatment compared to other treatments (Linear effect, P=0.042). Total protein was increased in WGR2 treatment compared to CON treatment (Quadratic effect, P=0.011). In cholesterol concentration of blood, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride were not significantly different among treatments. In meet quality, pH in WGR1 treatment was higher than WGR3 treatment(Quadratic effect=0.022). Water holding capacity(WHC) was significantly increased in WGR2 treatment compared to WGR3 treatment(Quadratic effect, P=0.050).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.601-613
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• 2018

This study aims to find out the types of convergence types between devices/technology and artifact in smart city space. The main contents of the research are in-depth analysis on the convergence change of ET, IT, and ET+IT in a smart city. First, the devices/technology and artifacts through 31 cases study are found out below. There are 92 artifacts and 134 devices/technologies (ET:83, IT:51). Second, the convergence change between devices/technology and artifacts is evolved by 7 types. Type 1, the Evolutionary ET type of ET-centric, is Period 1 (Separation fusion between ET and IT), Period 2 (ET-centric fusion), and Period 3 (Growth IT and ET+IT fusion of ET-centric). Type 2, the Advanced ET type of ET+IT-centric, is Period 1 (ET+IT fusion), Period 2 (Advanced ET of ET+IT-centric), and Period 3 (Hyper-advanced ET of ET+IT-centric). Type 3, the All-in-One type of ET+IT, is Period 1 (Separation fusion between ET and IT), Period 2 (Mixed fusion between ET and IT), and Period 3 (All-in-One fusion of ET and IT). Type 4, the Advanced type of IT-centric, is Period 1 (Development of IT-centric), Period 2 (Advanced IT-centric), and Period 3 (Hyper-advanced IT-centric). Types 5 and 6, the Advanced together type of ET+IT, is Period 1 (Developed IT of ET+IT-centric), Period 2 (Advanced IT of ET+IT-centric), and Period 3 (Hyper-advanced IT of ET+IT-centric). Type 7, the Advanced IT type of ET+IT-centric, is Period 1 (ET+IT fusion), Period 2 (Sub-fusion of ET, Advanced IT), and Period 3 (Sub-fusion of ET, Hyper-advanced IT). This study results are going to expect making new types of convergence through further study.

• Journal of Music and Human Behavior
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• v.4 no.2
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• pp.1-17
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• 2007

Huge growth in developmental level, new accomplishment, and The period of adolescents is not only the transition stage but also improvement of academic level. In this level of stage, adolescents have difficulties in development, so they show psychological abnormality such as stress and depression. They could develop mental disorder such as depression or anxiety if they do not overcome the abnormality. According to the situation of the insufficiency of the decent program for adolescents' mental health in the current society, we are strongly requested to develop the psycho-therapeutic program for them. Therefore, in this study, we examined the effect of the musical activities as blues music structure on the improvement of the Self-Efficacy in the female middle school students who have depressive tendencies as well as what they experienced through the activities. The 3 participants were selected out of 70 students in the first year at the "D" middle school in Seoul by being tested with Child Depression Inventory(CDI) and Self-Efficacy Scale(SES). The musical activities were built with 3 steps. Of which, the first one was the introduction to each other, the formation of rapport, and induction of their interests to the musical activities through blues. The second one was letting participants learn the blues music structure by practice and play assigned music(including improvisation) during later 5 sessions with different difficulties at each session. The third one was giving them opportunities to play a music out of the acquired ones during the session or creative music by their own, which results in maximizing musical activities and an acquired experience. As a result, first of all, the scores of CDI test of 3 participants in 10 time sessions showed slight changes, suggesting the negative correlation between CDI and SES even though changes were not big differences. Secondly, the scores of SES test of 3 subjects in 10 time sessions were all changed and especially preference for tasking was significant. Thirdly, the scores of SES for musical playing test of 3 participants in 10 time sessions were all changed and especially preference for musical tasking was significant shown. Finally, according to answers of 3 participants in 10 time sessions for the after questionnaire on musical activities, participants experienced affirmative self-confidence and positive emotion. Taken together, it was suggested that musical activities using blues music structure could be promising therapeutic intervention method.

• Journal of radiological science and technology
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• v.34 no.3
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• pp.239-244
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• 2011

In this study, we evaluated diffusion weighted imaging (DWI) to investigate whether the DWI parameters can predict characteristic parameters on pathologic specimens of tumor or not. CFPAC-1 was injected subcutaneously on the back flank of athymic nude mice (n=13) then two tumors were initiated on each mouse (2${\times}$13=26 tumors). The mice were sacrificed to make specimen immediately after initial MR imaging then were compared with the MR image. A dedicated high-field (7T) small-animal MR scanner was used for image acquisitions. A T1 and T2 weighted axial image using RARE technique was acquired to measure the T2 values and tumor size. DWI MR was performed for calculating ADC values. To evaluate tumor cellularity and determine the levels of MVD, tumor cells were excised and processed for H-E staining and immunostaining using CD31. T2 values and ADC values were computed and analyzed for each half of the tumors and compared to the correlated specimens slide. Median ADC within each half of mass was compared to the cellularity and MVD in the correlated area of pathologic slide. The mean of ADC value is $0.7327{\times}10^{-3}$ $mm^2/s$ and standard deviation is $0.1075{\times}10^{-3}$ $mm^2/s$. There is a linear relationship between ADC value and tumor necrosis (R2=0.697, p< 0.001). DW image parameters including the ADC values can be utilized as surrogate markers to assess intratumoral neoangiogenesis and change of the internal structure of tumor cells.

• Korean Journal of Remote Sensing
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• v.30 no.1
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• pp.109-126
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• 2014

We improved the Land Surface Emissivity (LSE) data (Kongju National University LSE v.2: KNULSE_v2) over the Communication, Ocean and Meteorological Satellite (COMS) observation region using recent(2009-2012) Moderate Resolution Imaging Spectroradiometer (MODIS) data. The surface emissivity was derived using the Vegetation Cover Method (VCM) based on the assumption that the pixel is only composed of ground and vegetation. The main issues addressed in this study are as follows: 1) the impacts of snow cover are included using Normalized Difference Snow Index (NDSI) data, 2) the number of channels is extended from two (11, 12 ${\mu}m$) to four channels (3.7, 8.7, 11, 12 ${\mu}m$), 3) the land cover map data is also updated using the optimized remapping of the five state-of-the-art land cover maps, and 4) the latest look-up table for the emissivity of land surface according to the land cover is used. The updated emissivity data showed a strong seasonal variation with high and low values for the summer and winter, respectively. However, the surface emissivity over the desert or evergreen tree areas showed a relatively weak seasonal variation irrespective of the channels. The snow cover generally increases the emissivity of 3.7, 8.7, and 11 ${\mu}m$ but decreases that of 12 ${\mu}m$. As the results show, the pattern correlation between the updated emissivity data and the MODIS LSE data is clearly increased for the winter season, in particular, the 11 ${\mu}m$. However, the differences between the two emissivity data are slightly increased with a maximum increase in the 3.7 ${\mu}m$. The emissivity data updated in this study can be used for the improvement of accuracy of land surface temperature derived from the infrared channel data of COMS.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.5 no.4
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• pp.1-34
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• 2010

Recently, failure rates of Kosdaq IPO firms are increasing and their survival rates tend to be very low, and when these firms do fail, often times backed by a number of governmental financial supports, they may inflict severe financial damage to investors, let alone economy as a whole. To ensure investors' confidence in Kosdaq and foster promising and healthy businesses, it is necessary to precisely assess their intrinsic values and survivability. This study investigates what contributed to the failure of IPO firms and analyzed how these elements are factored into corresponding firms' stock returns. Failure risks are assessed at the time of IPO. This paper considers factors reflecting IPO characteristics, a firm's underwriter prestige, auditor's quality, IPO offer price, firm's age, and IPO proceeds. The study further went on to examine how, if at all, these failure risks involved during IPO led to post-IPO stock prices. Sample firms used in this study include 98 Kosdaq firms that have failed and 569 healthy firms that are classified into the same business categories, and Logit models are used in estimate the probability of failure. Empirical results indicate that auditor's quality, IPO offer price, firm's age, and IPO proceeds shown significant relevance to failure risks at the time of IPO. Of other variables, firm's size and ROA, previously deemed significantly related to failure risks, in fact do not show significant relevance to those risks, whereas financial leverage does. This illustrates the efficacy of a model that appropriately reflects the attributes of IPO firms. Also, even though R&D expenditures were believed to be value relevant by previous studies, this study reveals that R&D is not a significant factor related to failure risks. In examing the relation between failure risks and stock prices, this study finds that failure risks are negatively related to 1 or 2 year size-adjusted abnormal returns after IPO. The results of this study may provide useful knowledge for government regulatory officials in contemplating pertinent policy and for credit analysts in their proper evaluation of a firm's credit standing.