• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.285-297
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• 2014

The purpose of this study is to examine the associations among attention deficit/hyperactivity, social withdrawal, peer relationships, and depression in early adolescence. Gender differences in the associations were also examined. This study investigated these relationships and the gender differences using structural equation modeling multi-group analysis. The third wave data from Korea Children and Youth Panel Survey (KCYPS) of fourth graders were analyzed. The results indicated that attention deficit/hyperactivity had significant effects on depression directly and indirectly through social withdrawal and peer relationships. These results suggest that new programs should be developed to prevent or alleviate depression associated with attention deficit/hyperactivity among adolescents. Specifically, social withdrawal and peer relationships need to be emphasized in planning prevention or intervention programs to promote mental health of adolescents with attention deficit/hyperactivity.

• Clinical and Experimental Pediatrics
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• v.51 no.11
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• pp.1222-1227
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• 2008

Restless legs syndrome (RLS) is a common neurological sleep disorder in adults characterized by the following diagnostic criteria: an urge to move that is usually associated with unpleasant sensations and symptoms that are worse at rest, relieved by movement, and most severe at night. The definite diagnosis of RLS in children is stricter and consists of self-description of leg discomfort or the presence of 2 of 3 supportive criteria combined with 4 essential criteria for diagnosis in adults. RLS in childhood has often been misdiagnosed as growing pains or a part of normal development. As a result, physicians have often missed the chance for proper management. We diagnosed a case of RLS in a 5-year-old boy presenting with growing pains, whose mother was found to have had RLS since childhood. We confirmed RLS by using a polysomnograph, in which the indices of periodic limb movement syndrome (PLMS) and periodic limb movement during wakefulness (PLMW) were recorded to be compatible with RLS criteria. The patient's ferritin level was low normal, and his symptoms improved after taking iron supplements.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.3 no.1
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• pp.84-96
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• 1992

The present study was designed to investigate variables associated with mother-child interaction patterns of Attention Deficit Hyperactivity Disorder(ADHD), and also to evaluate short-term effects of stimulant medication on the behaviors of ADHD children and their mothers during interaction. 15 ADHD boys(ages 5${\sim}$10 years) were treated with metylphenidate(0.5mg/kg per day) for 1 month, and their behaviors as well as their mothers for the 10 minute free play and 20 minute task performance period were videotaped through one-way mirror. The childrens attention was also evaluated using the Continuous Performance Task(CPT) and ratings of their hyperactive behaviors were obtained from their mother prior to the treatment. The videotaped interaction were rated according to the Response Class Matrix developed by Mash, Terdal & Anderson(1973). Results indicated that percentage of behavior of the mother and child during interaction was highly correlated with each other, which, in turn, was highly correlated with the symptom severity of the ADHD child. That is the more severe the cognitive and behavioral symptoms of ADHD, the more negative the interaction behavior pattern was. After 4 weeks of stimulant medication the mothers as well as the ADHD children showed a significant decrease in the percentage of negative-aggressive behavior during the task performance period. The results indicated that negative interaction behavior of the mothers was in large part a response to the negative behavior of their ADHD children.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.1
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• pp.18-23
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• 2017

${\beta}$-ureidopropionase deficiency (${\beta}$-UPD; OMIM # 613161) is a rare autosomal recessive inborn error of pyrimidine metabolism caused by mutations in the UPB1 gene and approximately 30 cases have been reported in the world. The clinical features of patients with ${\beta}$-UPD have been reported to vary from asymptomatic to severe developmental delays. However, the long-term clinical courses of patients with ${\beta}$-UPD have not yet been reported. A Korean girl was diagnosed with ${\beta}$-UPD at the age of 8 years and 10 months by targeted next-generation sequencing which was subsequently confirmed by Sanger sequencing. She had many clinical features such as poor oral feeding, failure to thrive, global developmental delay, microcephaly, frequent infection, and intractable epilepsy. She died suddenly of an unknown cause at the age of 11 years and 5 months. Here we report the long-term (i.e. lifelong) clinical aspects of a Korean patient with ${\beta}$-UPD.

• Journal of Nutrition and Health
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• v.10 no.4
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• pp.33-42
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• 1977

강원도(江原道) 원성군(原城郡) 종합영양(綜合營養) 시범사업(示範事業)의 영양평가(營養評價)의 일익(一翼)으로 해당 영양시범사업시행전(營養示範事業施行前)의 기초자료(基礎資料) 수집을 위(爲)한 예비조사(豫備調査)로서 시행(施行)한 것이다. 조사시행기간(調査施行期間)은 1976년(年) 7월(月) 중순(中旬)에 8일간(日間)에 걸쳐 2명(名)의 의사(醫師)를 포함(包含)한 16명(名)으로 구성(構成)된 조사진(調査陣)으로서 4개리(個里)에서 40개(個) 세대(世帶)(각리(各里)에서 10개(個) 세대(世帶))를 무작위임의선정(無作爲任意選定)하며 한 세대(世帶)에 대(對)하여 연(漣) 3일간(日間) 조사(調査)하고 조사기간중(調査期間中) 식품섭취상태조사(食品攝取狀態調査)와 아울러 신체계측(身體計測) 임상조사(臨床調査) 및 혈액채취(血液採取)를 하여 영양섭취상태(營養攝取狀態), 신체발육상태(身體發育狀態), 임상증상(臨床症狀) 및 혈색소양(血色素量)을 측정(測定)하여 평가(評價)하였다. 특(特)히 학령전기아동(學齡前期兒童)의 영양상태(營養狀態)에 중점(重點)을 두었다. 조사결과(調査結果)를 요약(要約)하면 다음과 같다. 1. 일반적(一般的)으로 열양섭취양(熱量攝取量)이 부족(不足)하다. 2. 섭취식품(攝取食品)의 대부분(大部分)이 식물성식품(植物性食品)이고 양질(良質)의 단백질(蛋白質)이 부족(不足)되어 있다. 3. 비타민 A와 $B_2$ 그리고 칼슘 섭취양(攝取量)도 부족(不足)하다. 4. 대상주민(對象住民)의 전체적(全體的)인 임상검사(臨床檢査)로 뚜렷한 영양실조(營養失調)나 결핍증상(缺乏症狀)은 희유(稀有)하나 아동(兒童)에서는 비타민 $B_2$ 부족성(不足性) 증상(症狀)이 많다. 5. 아동(兒童)의 체위(體位)는 대체(大體)로 전국(全國) 평균치(平均値)에 미급(未及)하다. 6. 가임부(可妊婦)의 75%와 아동(兒童)의 23.7%에서 혈색소치(血色素値)가 빈혈(貧血)에 속(屬)하고 있다. 7. 특별(特別)한 이유식(離乳食)이 전무(全無)한 실정(實情)이고 임신부(妊娠婦)나 수유부(授乳婦)를 위(爲)한 보충식(補充食)도 따로 없다.

• Journal of the Korea Convergence Society
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• v.9 no.11
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• pp.333-343
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• 2018

The ADHD, a common condition of childhood onset, is of critical educational and social concern at every level of school. Investigating the determinants of teachers' ADHD coaching and their relative importance is important for improving teaching and counseling practice in inclusive education setting. Based on three hundred and fifty three survey responses from elementary, junior and high school teachers, this research examines the impact of knowledge level, facilitating condition, cooperation with parents, attitude of teachers toward teachers' ADHD coaching. Statistical analysis shows that the knowledge level and facilitating condition influence the level of teachers' attitude, and that attitude has some impact on the cooperation level with parents, at 5% significance level. The cooperation with parent, one of two precedence factors of ADHD coaching, was identified to be significant, but attitude was shown to be nonsignificant predictor of ADHD coaching. A brief discussion concerning the critical needs of teachers is also presented.

• Journal of environmental and Sanitary engineering
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• v.5 no.1
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• pp.1.2-6
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• 1990

The purpose of this experiment was to investigate boron deficient symptom of sugar beet. Sugar beet affected by boron deficiency was anatomized and observed by microscope and electron microscope. The sugar beet plants affected onboron deficiencyu with water culture and those of the experimental farm alike contained a small amount of boron. The symptom of boron deficiency began to show dark-brown lines at the ventral suface of the basal part of petiole and then, in the ridge of young leaf, growing point became darkened due to necrosis. The leaf blade was wrinked severely and finally the growth was stunted. The boron deficiency began with necrosis of the epidermis of the ventral surface of the basal part of petiole, and parenchyma under it. Necrosis and disintegration of the ridge of young leaf began to take place and were expanded gradually. Electron microscopic examination of boron deficient sugar beet plants revealed that chloroplasts degenerated, and appeared to contain larger amounts of starch, also observed larger number of osmophilic granules. And they peculiarly were found polyhedral crystals in the certain deficient chloroplasts.

• Journal of the korean academy of Pediatric Dentistry
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• v.37 no.2
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• pp.207-212
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• 2010

Protein C deficiency increases the risk of thrombosis due to the lack of anticoagulant factor protein C. Among the numerous congenital protein C deficiencies, homozygous protein C deficiency has an especially low protein C activity level, that it is almost undetectable. It is a rare disease with a probability of 1:250000~500000. The signs and symptoms of homozygous protein C deficiency include purpuric, necrotic dermatosis, ecchymosis, blindness, and thrombosis in central nervous system. A 4-year-old girl was brought to the clinic with a chief complaint of extensive caries. The child was under warfarin medication in order to prevent possible complications during dental treatment. We consulted the pediatric department. Without warfarin intake, serious complications may occur due to thrombosis during dental treatment. Therefore, certain warfarin dosage (INR 3~5) and fresh frozen plasma as a backup for excessive hemorrhage were recommended. This child was a severely disabled child with the loss of vision, and it was difficult to manage her behavior effectively. Thus, dental treatment was carried out under general anesthesia, where bleeding control would be also easier to achieve.This report presents the case of a 4-year-old girl with protein C deficiency, who has received dental treatment for extensive caries under general anesthesia.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.9 no.2
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• pp.209-217
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• 1998

Object：The purpose of this study was to investigate that infection with group $A[{\beta}]$ hemolytic streptococcus may associate the mechanisms that cause or exacerbate the tic symptoms in some cases of Tourette's disorder Method：Fourteen cases with abrupt worsening of tics participated in this study：10 males,4 females. The subjects were divided into two groups composing of the group with increasing level of ASO titer and the group with normal level of ASO titer. The subjects were administered Yale Global Tic Severity Scale(YGTSS). Result：The global severity scores and overall TS impairment rating scores of YGTSS in the group with increasing level of ASO titer were more higher than in the group with normal level of ASO titer Conclusion：These results suggest that increasing level of ASO titer, resulting from group $A[{\beta}]$ hemolytic streptococcal infection has affected worsening the tic symptoms in Touette's disorder.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.12 no.1
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• pp.149-156
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• 2001

After the fact that obsessive-compulsive symptoms or tic symptoms are common in Sydenham's chorea which is a sequale of rheumatic fever produced by group A beta-hemolytic streptococcus was reported, the association between group A beta-hemolytic streptococcus and a subgroup of obsessivecompulsive disorder(OCD) or tic disorder has been attentioned. This subgroup shared a unique clinical course, characterized by an abrupt onset of symptoms and/or dramatic exacerbations. And this subgroup was distinguished by pre-pubertal onset of symptoms, neurological abnormalities(choreiform movements and a unique pattern of motoric hyperactivity), as well as by relapsing and remitting symptom course. Acronym PANDAS(pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) was used to denote a subgroup of OCD or tic disorder patients with these clinical characteristics. Then, there was a report suggesting that PANDAS category include some of attention-deficit/hyperactivity disorder(ADHD) and were two case reports of anorexia nervosa and body dysmorphic disorder with characteristics of PANDAS. This case is a patient who developed normally until age of 7, but after pharyngeal inflammation with high fever, he showed disturbance of cognition, social relationship, and language and communication, as well as tic symtoms and abnormal movement on face, hand, and foot. We report this case with review of literatures, because we think that this case belongs to the PANDAS category. Based on this observation, we suggest that PANDAS category include some of childhood disintegrative disorder as well as OCD, tic disorder, and ADHD.