• 한국식품영양과학회지
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• 제45권6호
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• pp.903-910
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• 2016

엉겅퀴와 타임의 복합추출물인 MS-10이 여성호르몬 수용체를 가역적으로 활성화해 여성갱년기에 감소하는 에스트로겐이 효율적으로 사용될 수 있도록 작용한다는 것이 확인되었다. 12주간의 인체적용시험에서 MS-10은 안면홍조 및 야한증, 감각마비, 수면장애, 신경과민, 우울, 현기증, 피로, 관절 및 근육통, 두통, 가슴 두근거림(심계항진), 그리고 질건조 등의 여성갱년기 증상이 개선되었음이 확인되었다. 이러한 MS-10의 여성갱년기 증상 개선은 MS-10에 의한 insulin-like growth factor-1의 개선에 기인한 것으로 판단된다. MS-10은 여성갱년기 증상을 개선하는 천연소재 건강 기능식품으로 사용될 수 있다.

• 한국식품과학회지
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• 제51권4호
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• pp.361-368
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• 2019

황칠추출분말은 여성호르몬인 에스트로겐과 구조적 유사성을 가진 루틴을 다량 함유하고 있다(황칠추출분말 1g당 11.19 mg의 루틴 함유). 루틴은 식물성 여성호르몬이라고 불리는 플라보노이드 성분의 일종으로, 에스트로겐 수용체를 통한 신호전달을 증가시킨다. 특히 $ER-{\alpha}$로부터 세포내로 전달되는 MAPK/ERK 신호 전달 경로를 활성화시킴으로써, 갱년기의 대표적인 만성증상들을 개선할 수 있는 가능성이 있다고 여겨진다. 본 연구는 루틴이 다량 함유된 황칠추출분말을 폐경의 유도를 위해 난소를 절제한 쥐에 투여하여 여성갱년기 증상의 개선에 미치는 영향을 평가하였다. 그 결과 골교체율 관련 지표로서 폐경기 여성에서 높다고 알려진 오스테오칼신이 감소하는 경향성을 나타냈고, CTX는 유의적인 감소를 나타냈을 뿐만 아니라, 에스트로겐 수용체의 활성화를 증가시키는 경향성을 나타냈다. 이를 통해, 황칠추출분말은 골다공증의 예방 및 개선 효과를 나타내는 갱년기 여성 건강에 도움을 줄 수 있는 기능성 원료로서의 가능성을 보여준다.

• 여성건강간호학회지
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• 제6권4호
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• pp.465-476
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• 2000

The purpose of this study was to investigate the relationship between climacteric symptoms and depression of middle-aged women. Data were collected from Jul. 1 to Jul. 31, 2000 by a structured questionnaire. The Subjects were 102 middle-aged women who non-hysterectomized and ranged in age from 40 to 59. The instruments were the climacteric symptoms scale developed by Neugarten and depression scale developed by Zung. The Data were analyzed by the SPSS/PC+ program using t-test, ANOVA and Pearson Correlation Coefficient. The results of the study were as follows ; 1. Mean score of climacteric symptoms was 0.72. 2. There were statistically significant differences in the score of middle-abed women's self reported climacteric symptoms according to the age(F=3.13, P<0.05), and times of pregnancy(F=3.24, P<0.05). 3. Mean score of depression scale was 49.2. About 39% of the women displayed a variety depression symptoms. 4. Women's degree of climacteric symptoms showed a positive correlation with the degree of depression(r= 0.5393, P<0.001). This study shows possible implication for nursing intervention of middle-aged women's health to prevent and relieve climacteric symptoms.

• 성인간호학회지
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• 제29권2호
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• pp.200-210
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• 2017

Purpose: The purpose of this study was to assess the relationship between menopausal symptoms and decline in cognitive functioning of menopausal women with mediating effects of health promoting behavior. Methods: Using a convenience sampling, 140 menopausal women were recruited for the cross-sectional survey. Data were collected by using the Menopause Rating Scale, Health Promoting Lifestyle Profile, Everyday Cognition, and Korean Mini-Mental State Examination. Results: The mean scores for menopausal symptoms, health promotion behavior, and subjective cognitive decline were 14.40, 153.79, and 67.40 respectively. Health promotion behavior was directly affected by menopausal symptom ($R^2=8%$). Cognitive decline was directly affected by menopausal symptom ($R^2=11%$). Menopausal symptom (${\beta}=.33$, p<.001) and health promotion behavior (${\beta}=.21$, p=.014) were found to be predictive factors in subjective cognitive decline and explained 14%. Health promotion behavior had a partial mediating effect in the relationship between menopausal symptom and perceived cognitive decline (Sobel test: Z=2.05, p=.040). Conclusion: Based on the findings of this study, developing nursing intervention programs focusing on decreasing menopausal symptoms and encouraging health promotion behavior are recommended to improve cognitive decline in menopausal women.

• Journal of Korean Biological Nursing Science
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• 제8권1호
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• pp.23-37
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• 2006

Purpose: This study was performed to identify climacteric symptoms corresponding to the use of complementary and alternative therapy(CAT) in middle aged women. Method: The subjects of the study were 603women(40-64years) and were chosen by convenient sampling from 1 April to 31 July 2004. The collected data was analyzed using descriptive statics, chi-square, t-test analysis by SPSS/WIN program. Results: 1. It was shown that 63.8% of subjects have utilized one or more types of CAT. 2. It was shown that the most frequently used types are health supplement(40.5%), gold acupuncture(31.2%), acupress(24.7%), hand acupuncture(21.8%) 3. There was significant difference in the using experience CAT by religion(p=.029), job(p=.018), hormone replacement(p=.016), exercise(p=.007), health state(p=.013). 4. There was significant difference in climacteric symptoms(p=.000) corresponding to the using experience of CAT. 5. There was significant difference in climacteric symptoms(p=.028) corresponding to the using experience hand therapy of CAT. Conclusion: We found that middle aged women used CAT more than others populations. Future research examining the determinants of CAT use, incorporating attitudinal and health conditions, as well as clinical efficacy, effectiveness, and health outcome studies of specific CAT therapies are warranted.

• 기본간호학회지
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• 제10권1호
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• pp.78-86
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• 2003

Purpose: The purpose of this study was to investigate the relationship between self concept and the climacteric symptoms in middle-aged women. Method: From a convenience sample of 123 women between 40 and 59 years of age living in P-city data were collected using a structured questioanaire. It included a self concept scale and climacteric symptom scale. With spss/pc(+), data were analyzed using descriptive statistics, t-test, ANOVA and Pearson's correlation coefficients. Result: 1 The mean score for self concept was $108.73{\pm}16.24$. 2. The variables that influenced the self concept of middle-aged women most were 'health state' and 'marriage satisfaction'. They were statistically significant at the .01 level. 3. The mean score for climacteric symptoms was 3.13. Of psychophysical, physical and psychological symptoms the scores for psychophysical symptoms were the highest. 4. There were significant negative correlations between self concept and climacteric symptoms (r=-.333, p=.000). Conclusion: This study suggests that positive self concept can reduce climacteric symptoms in middle-aged women.

• 여성건강간호학회지
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• 제9권4호
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• pp.400-409
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• 2003

Purpose: This study was to identify the correlations among climacteric symptoms, knowledge of menopause and health promoting behavior in middle-aged women. Method: 1.360 women between 40-60 years of age living in Incheon, were asked to complete a questionnaire on their health. The data was collected between October 10th and October 30th, 2002. The data was analyzed using T-test, ANOVA and Pearson's correlation coefficients with SPSS/pc program. Result: The variables significantly affecting climacteric symptoms, knowledge of menopause and health promoting behavior were education, perceived health status and family health - problems. The relationship between knowledge of menopause and health promoting behavior was statistically significant with a positive correlation. Conclusion: The knowledge of menopause by middle aged women was in positively correlated with health promoting behavior. Therefore, based on this study, we plan to develop a health education program to promote knowledge of menopause and health promoting behavior.

• 대한간호학회지
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• 제34권2호
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• pp.213-224
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• 2004

Purpose: This study was aimed to evaluate the effect of progressive muscle relaxation training using biofeedback on perceived stress, stress response, immune response and climacteric symptoms, Method: This was a crossover, pre-post test design, The study subjects are 36 middle-aged women who were selected at 2 public health centers, The independent variable was Biofeedback training for 4 weeks, twice a week and home training for 4 weeks, Dependent variables were perceived stress, stress response, immune response, and climacteric symptoms measured with Hildtch's scale (1996), Result: Progressive muscle relaxation training using biofeedback was not effective in reducing perceived stress, but it was shown to be effective in reducing physiological stress responses such as pulse rate and EMG, Though blood pressure and skin conductance were repeatedly down, and skin temperature slowly increased, there were no statistically significant differences. Progressive muscle relaxation training using biofeedback was not effective in reducing serum cortisol, enhancing immune responses, or decreasing climacteric symptoms. Conclusion: The findings point to a pressing need for further, well-controlled and designed research with consideration in selection of subjects and instruments, frequency of measurements, the sampling method, and intervention modalities.

• 여성건강간호학회지
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• 제19권4호
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• pp.275-284
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• 2013

Purpose: The purpose of this study was to identify the factors influencing self-identity and menopausal symptoms their influence on level of depression in middle-aged woman. Methods: Participants were 135 middle-aged women who were living in city B, were 45-60 years old, informed of study purpose, and agreed to participate. Data were collected from December, 2012 to January, 2013 using scales measuring depression, self-identity, and menopausal symptoms. Data were analyzed using t-test, ANOVA, Scheff$\acute{e}$ test, Pearson Correlation Coefficients, and Multiple Stepwise Regression. Results: Level of depression was low, self-identity was slightly high, and menopausal symptoms were relatively low in these middle-aged women. There were significant differences in depression by perceived health status and perceived economic status. Depression had a moderate negative correlation with self-identity (r=-.49, p<.001) and a moderate positive correlation with menopausal symptoms (r=.57, p<.001). Menopausal psychological symptoms were the factor most affecting depression and explained 37% of the variance in depression. A total of 51% of variance in depression was explained by menopausal symptoms (psychological and physical), self-identity, and perceived economic status. Conclusion: Thus, an effort to improve self-identity, especially a plan to attenuate menopausal psychological symptoms is needed to reduce depression.

• 공업화학
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• 제27권2호
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• pp.217-220
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• 2016

식물성 에스트로겐은 내분비계에서 생성되지 않고 식물성 에스트로겐 식물을 먹음으로써 소비되는 유사에스트로겐이다. "식이 에스트로겐"으로도 불리는 식물성 에스트로겐은 자연적으로 발생하는 다양한 식물성 화합물 그룹이며, 에스트로겐과 구조적인 유사성 때문에 갱년기 증상을 감소시킴으로써 건강 증진에 기여할 수 있을 것이다. 본 연구에서는 다양한 식물성 에스트로겐을 고삼, 석류, 칡으로부터 초음파공정을 이용하여 추출하였다. 다양한 초음파세기와 추출시간에서 식물성 에스트로겐의 추출 양을 비교하였다. 이로부터 얻은 결과는 천연물과 관련된 생화학적 연구에 기본적인 정보를 제공할 수 있을 것이다.