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http://dx.doi.org/10.3746/jkfn.2016.45.6.903

Natural Substance MS-10 Improves Women's Health via Regulation of Estrogen Receptor  

Noh, Yoo-Hun (Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University)
Lee, Ji Won (Department of Urology, College of Medicine, Chung-Ang University)
Park, Jiae (Department of Food Science and Nutrition, College of Natural Science, Dankook University)
Lee, Sang Hyung (Department of Neurosurgery, SMG-SNU Borame Medical Center, College of Medicine, Seoul National University)
Lee, Jun Young (Department of Neuropsychiatry, SMG-SNU Borame Medical Center, College of Medicine, Seoul National University)
Kim, Sung-Su (Department of Food Science and Nutrition, College of Natural Science, Dankook University)
Park, Kwang-Kyun (Department of Oral Biology, College of Dentistry, Yonsei University)
Kim, Tae Jin (Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine)
Myung, Soon-Chul (Department of Urology, College of Medicine, Chung-Ang University)
Jeong, Yoonhwa (Department of Food Science and Nutrition, College of Natural Science, Dankook University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.45, no.6, 2016 , pp. 903-910 More about this Journal
Abstract
In this study, the expression level of estrogen receptor in an ovariectomized rat model was effectively enhanced by MS-10, Cirsium japonicum and Thymus vulgaris extract complex, in a reversible manner. MS-10 plays a positive role in enhancing estrogen activity at low concentrations, leading to improved women's health. In order to determine whether or not MS-10 improves menopausal symptoms clinically, a randomized, double-blinded, and placebo-controlled clinical study was carried out on 62 middle-aged women treated with 500 mg of MS-10 or placebo daily for 12 weeks. Clinical menopausal symptoms were evaluated by Kupperman's index (KI) detecting various menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, dizziness, fatigue, rheumatic pain, palpitations, formication, and headaches. Total KI score decreased significantly by about 18% upon ingestion of MS-10. Colpoxerosis, a main symptom of menopause, was significantly reduced by about 21% upon ingestion of MS-10 in contrast to placebo. In addition, reduction of insulin-like growth factor-1 with age was improved by over 10% upon ingestion of MS-10, whereas there were no significant difference with placebo. No side effects appeared after treatment with MS-10. Thus, MS-10 can be suggested as a plausible natural substance for improving women's health.
Keywords
MS-10; menopause; colpoxerosis; Kupperman's index; estrogen receptor;
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Times Cited By KSCI : 6  (Citation Analysis)
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1 Enns DL, Tiidus PM. 2010. The influence of estrogen on skeletal muscle: sex matters. Sports Med 40: 41-58.   DOI
2 Nilsson N, Carlsten H. 1994. Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation. Cell Immunol 158: 131-139.   DOI
3 Saint-Criq V, Rapetti-Mauss R, Yusef YR, Harvey BJ. 2012. Estrogen regulation of epithelial ion transport: Implications in health and disease. Steroids 77: 918-923.   DOI
4 Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, Isner JM, Asahara T, Losordo DW. 2003. Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation 108: 3115-3121.   DOI
5 Oboti L, Ibarra-Soria X, Perez-Gomez A, Schmid A, Pyrski M, Paschek N, Kircher S, Logan DW, Leinders-Zufall T, Zufall F, Chamero P. 2015. Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium. BMC Biol 13: 104.   DOI
6 Cummings SR, Rubin SM, Black D. 1990. The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop Relat Res 1: 163-166.
7 Holloway D. 2011. An overview of the menopause: assessment and management. Nurs Stand 25: 47-57.   DOI
8 Nappi RE, Kokot-Kierepa M. 2010. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas 67: 233-238.   DOI
9 Chakrabarti S, Morton JS, Davidge ST. 2014. Mechanisms of estrogen effects on the endothelium: an overview. Can J Cardiol 30: 705-712.   DOI
10 Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ. 2012. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 97: 1159-1168.   DOI
11 Hooper L, Ryder JJ, Kurzer MS, Lampe JW, Messina MJ, Phipps WR, Cassidy A. 2009. Effects of soy protein and isoflavones on circulating hormone concentrations in preand post-menopausal women: a systematic review and metaanalysis. Hum Reprod Update 15: 423-440.   DOI
12 Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M. 2003. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349: 523-534.   DOI
13 Simon JA, Hunninghake DB, Agarwal SK, Lin F, Cauley JA, Ireland CC, Pickar JH. 2001. Effect of estrogen plus progestin on risk for biliary tract surgery in postmenopausal women with coronary artery disease: the Heart and Estrogen/progestin Replacement Study. Ann Intern Med 135: 493-501.   DOI
14 Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E. 1998. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 280: 605-613.   DOI
15 de la Peña JB, Kim CA, Lee HL, Yoon SY, Kim HJ, Hong EY, Kim GH, Ryu JH, Lee YS, Kim KM, Cheong JH. 2014. Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor. Arch Pharm Res 37: 263-269.   DOI
16 Brinton LA, Richesson D, Leitzmann MF, Gierach GL, Schatzkin A, Mouw T, Hollenbeck AR, Lacey JV Jr. 2008. Menopausal hormone therapy and breast cancer risk in the NIH-AARP Diet and Health Study Cohort. Cancer Epidemiol Biomarkers Prev 17: 3150-3160.   DOI
17 Noh YH, Kim DH, Lee SA, Yin XF, Park J, Lee MY, Lee WB, Lee SH, Kim JK, Kim SS, Jeong Y, Myung SC, Kim TJ, Kang IJ. 2016. The natural substance MS-10 improves and prevents menopausal symptoms, including colpoxerosis, in clinical research. J Med Food 19: 228-237.   DOI
18 Choi YJ, Yoon Y, Choi HS, Park S, Oh S, Jeong SM, Suh HR, Lee BH. 2011. Effects of medicinal herb extracts and their components on steatogenic hepatotoxicity in Sk-hep1 cells. Toxicol Res 27: 211-216.   DOI
19 Liu S, Luo X, Li D, Zhang J, Qiu D, Liu W, She L, Yang Z. 2006. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol 6: 1387-1393.   DOI
20 Yin J, Heo SI, Wang MH. 2008. Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots. Nutr Res Pract 2: 247-251.   DOI
21 Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. 2005. Open trial to assess aspects of safety and efficacy of a combined herbal cough syrup with ivy and thyme. Forsch Komplementarmed Klass Naturheilkd 12: 328-332.   DOI
22 de la Torre Rodriguez YC, Martínez Estrada FR, Flores Suarez AE, Waksman de Torres N, Salazar Aranda R. 2013. Larvicidal and cytotoxic activities of extracts from 11 native plants from northeastern Mexico. J Med Entomol 50: 310-313.   DOI
23 Kupperman HS, Blatt MH, Wiesbader H, Filler W. 1953. Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorrheal indices. J Clin Endocrinol Metab 13: 688-703.   DOI
24 Gruenwald J, Graubaum HJ, Busch R. 2006. Evaluation of the non-inferiority of a fixed combination of thyme fluidand primrose root extract in comparison to a fixed combination of thyme fluid extract and primrose root tincture in patients with acute bronchitis. Arzneimittelforschung 56: 574-581.
25 Shimelis ND, Asticcioli S, Baraldo M, Tirillini B, Lulekal E, Murgia V. 2012. Researching accessible and affordable treatment for common dermatological problems in developing countries. An Ethiopian experience. Int J Dermatol 51: 790-795.   DOI
26 Walker JM. 1994. The bicinchoninic acid (BCA) assay for protein quantitation. Methods Mol Biol 32: 5-8.
27 Chae HD, Choi SY, Cho EJ, Cho YM, Lee SR, Lee ES, Park HM. 2014. Awareness and experience of menopausal symptom and hormone therapy in Korean postmenopausal women. J Menopausal Med 20: 7-13.   DOI
28 Filus A, Zdrojewicz Z. 2015. Insulin-like growth factor-1(IGF-1)-structure and the role in the human body. Pediatr Endocrinol Diabetes Metab 20: 161-169.
29 Froesch ER, Schmid C, Schwander J, Zapf J. 1985. Actions of insulin-like growth factors. Ann Rev Physiol 47: 443-467.   DOI
30 Zapf J, Schoenle E, Froesch ER. 1978. Insulin-like growth factors I and II: some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum. Eur J Biochem 87: 285-296.   DOI
31 Alonso A, Gonzalez C. 2012. Neuroprotective role of estrogens: relationship with insulin/IGF-1 signaling. Front Biosci (Elite Ed) 4: 607-619.
32 Juul A, Holm K, Kastrup KW, Pedersen SA, Michaelsen KF, Scheike T, Rasmussen S, Muller J, Skakkebaek NE. 1997. Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency. J Clin Endocrinol Metab 82: 2497-2502.
33 Lin CM, Huang YL, Lin ZY. 2009. Influence of gender on serum growth hormone, insulin-like growth factor-I and its binding protein-3 during aging. Yonsei Med J 50: 407-413.   DOI
34 Kwon JY, Nam TJ. 2005. Effects of phytoestrogen on cell growth and insulin-like growth factor-I (IGF-I) production in MC3T3-E1 cells. J Korean Soc Food Sci Nutr 34: 743-749.   DOI
35 Sheng MH, Lau KH, Baylink DJ. 2014. Role of osteocytederived insulin-like growth factor I in developmental growth, modeling, remodeling, and regeneration of the bone. J Bone Metab 21: 41-54.   DOI