• Journal of Life Science
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• v.29 no.9
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• pp.1002-1009
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• 2019

Early life stress (ELS) increases the risk of depression. ELS may be involved in the susceptibility to subsequent stress exposure during adulthood. We investigated whether epigenetic mechanisms of p11 promoter affect the vulnerability to chronic unpredictable stress (CUS) induced by the maternal separation (MS). Mice pups were separated from their dams (3 hr/day from P1-P21). When the pups reached adulthood, we applied CUS (daily for 3 weeks). The levels of hippocampal p11 expression were analyzed by quantitative real-time PCR. The levels of acetylated and methylated histone H3 at p11 promoter were measured by chromatin immunoprecipitation. Depression-like behavior was measured by the forced swimming test (FST). The MS and CUS group exhibited significant decreases in p11 mRNA level and the MS plus CUS group had a greater reduction in this level than the CUS group. The MS plus CUS group also resulted in greater reduction in H3 acetylation than the CUS group. This reduction was associated with an upregulation of histone deacetylase 5. Additionally, the MS plus CUS group showed a greater decrease in H3K4met3 level and a greater increase in H3K27 met3 level than the CUS group. Consistent with the reduction of p11 expression, the MS plus CUS group displayed longer immobility times in the FST compared to the control group. Mice exposed to MS followed by CUS had much greater epigenetic alterations in the hippocampus compared to adult mice that only experienced CUS. ELS can exacerbate the effect of stress exposure during adulthood through histone modification of p11 gene.

• Journal of Bio-Environment Control
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• v.28 no.2
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• pp.117-125
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• 2019

This study compared the temperature and humidity measured by an aspirated radiation shield (ARS), the accuracy of which has been recently verified, and those measured by a system developed by the parent company (Company A) to investigate and improve the performance of the developed system. The results are as follows. Overall, the two-plate system had a lower radiation shielding effect than the one-plate system but showed better performance results when excluding the effect of strawberry vegetation on the systems. The overall maximum temperature ranges measured by company A's system and the ARS were $20.5{\sim}53.3^{\circ}C$ and $17.8{\sim}44.1^{\circ}C$, respectively. Thus, the maximum temperature measured by company A's system was $2.7{\sim}9.2^{\circ}C$ higher, and the maximum daily temperature difference was approximately $12.2^{\circ}C$. The overall average temperature measured by company A's system and the ARS was $12.4{\sim}38.6^{\circ}C$ and $11.8{\sim}32.7^{\circ}C$, respectively. Thus, the overall average temperature measured by company A's system was $0.6{\sim}5.9^{\circ}C$ higher, and the maximum daily temperature difference was approximately $6.7^{\circ}C$. The overall minimum temperature ranges measured by company A's system and the ARS were $4.2{\sim}28.6^{\circ}C$ and $2.9{\sim}26.4^{\circ}C$, respectively. Thus, the minimum temperature measured by company A's system was $1.3{\sim}2.2^{\circ}C$ higher, and the minimum daily temperature difference was approximately $2.9^{\circ}C$. In addition, the overall relative humidity ranges measured by company A's system and the ARS were 52.9~93.3% and 55.3~96.5%, respectively. Thus, company A's system showed a 2.4~3.2% lower relative humidity range than the ARS. However, there was a day when the relative humidity measured by company A's system was 18.0% lower than that measured by the ARS at maximum. In conclusion, there were differences in the relative humidity measured by the two company's devices, as in the temperature, although the differences were insignificant.

• Journal of Life Science
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• v.26 no.9
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• pp.1063-1073
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• 2016

Male climacteric syndrome, andropause, or testosterone deficiency syndrome (TDS) is one of the new health issues in elderly men. It is a natural phenomenon that happens with age in men, which is clinically characterized by a decline in levels of serum testosterone resulting in a significantly decreasing of physical and mental activities. The aim of this study was to investigate the putative alleviative effects of dandelion extract on the symptoms of TDS by increasing serum testosterone levels and compare the efficacy between dandelion extract (DE) and fermented dandelion extract (FDE). After daily intake of DE and FDE for 4 weeks, serum testosterone levels, muscles of vastus lateralis, forced swimming time, total sperm counts, and motile sperm counts were significantly increased in older rats (22 weeks). Additionally, SHBG, epididymal fat pad, total serum cholesterol and triglyceride were significantly decreased in DE and FDE fed groups. However, PSA levels were not different among all groups. Furthermore, DE and FDE enhanced the expression of genes related to testosterone biosynthesis in TM3 Leydig cells. Overall, these positive effects on andropause were greater in FDE compared to DE. These results suggest the potential of FDE as a safe and efficacious natural material for recovering testosterone levels and reducing andropause symptoms.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.2
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• pp.1-14
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• 2018

Objective : The present study investigated the effects of group play activities based on Ayres Sensory $Integration^{(R)}$ (ASI) on sensory processing ability, social skill ability and self-esteem of low-income children with attention deficit hyperactivity disorder (ADHD). Methods : A total of 20 low-income participants with children with ADHD were recruited and divided into an experimental group (n=10) and a control group (n=10). Sensory processing ability was measured via the Short Sensory Profile (SSP). Social skill ability was measured via the Social Skills Rating System (SSRS). To measure self-esteem, the Rosenberg's self- esteem scale was used. The experimental group received the $ASI^{(R)}$ group play activities for 50 minutes, twice per week for six weeks, while the control group did not receive an intervention. Level of significance of all statistical analyses was .05. Results : Social skill ability (F=4.443, p=.05), cooperation (F=5.328, p=.035) and self-esteem (F=5.358, p=.033) differed significantly between groups after the intervention. Conclusion : Our findings indicate that the group play activities based on $ASI^{(R)}$ are effective in improving social skill ability and self-esteem. This study provided a theoretical basis for the claim that sensory integration therapy should be applied in general elementary schools.

• Journal of the korean academy of Pediatric Dentistry
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• v.38 no.2
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• pp.109-118
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• 2011

The aims of this study were analyze the amount of stress condition when the traction force was applied to the condyle head from the chin area of mandible and amount of distortion condition when intended 0.5 mm distraction distance from surface or one point of dissected midline of mandible. For this study, 3D finite element analysis were performed. The following results were obtained : 1. When traction force of 500 g was applied to the condyle head from the chin area, condylar neck area showed the greatest amount of stress and coronoid process was the least amount of stress area. For the amount of distortion condition, infra dental area showed the greatest. 2. When 0.5 mm of intended surface distortion was applied after dissection of mid-mandible area, base anterior area showed the greatest amount of stress but the least stress area was coronoid process. For the amount of distortion, infra dental, menton area showed the greatest amount. 3. One point distortion was applied after dissection of mid-mandible area, ramus posterior area showed the greatest amount of stress and menton area were the least stress condition. For the amount of distortion, menton area showed the greatest amount of distortion condition.

• Korean Security Journal
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• no.35
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• pp.37-62
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• 2013

One of the organizational characteristics in the modern society is the emphasis placed upon individual autonomy in an effort to promote and develop each member's morale as well as the efficiency in personnel management. Therefore, it can be understood that the importance of "Self" is recognized in work places and the leadership of supervisors and each member's self-management and control are also emphasized, leading to establishment of the "Self-leadership" concept. In this study, the effect of the Transformational Leadership of the supervisors on the subordinates' Self-leadership was analyzed and the causal factor of organizational support in the relationship between Transformational Leadership and Self-leadership was defined. A survey was conducted with 182 security officials at the National Assembly and the following results were obtained. First, Transformational Leadership had a positive effect on Self-leadership and the Transformational Leadership of the supervisors had a statistically significant impact on the organizational support awareness. Furthermore, organizational support showed a statistically significant mediator effect in the relationship between the Transformational Leadership of the supervisors and the Self-leadership of the subordinates. Finally, future directions in regard to the personnel management system were suggested.

• Korean Journal of Poultry Science
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• v.31 no.4
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• pp.255-263
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• 2004

Two experiments were conducted to evaluate the feeding values of sesame oil meal (SOM) and to investigate the effects of its dietary supplementation on egg production in laying hens. In experiment I, the values of true metabolizable energy (TME), nitrogen corrected true metabolizable energy (TMEn) and true amino acid availability (TAAA) were determined by force-feeding 16 ISA-Brown roosters and collecting the total excreta from the birds, The TME and TMEn of SOM were 2.30 and 1.99 kcal/g, respectively, and the average TAAA of 15 amino acids was $76.93\%$. In experiment 2, a total of ninety, 48 weeks old ISA-Brown layer were randomly divided into 9 groups of 10 birds each and assigned to three experimental diets containing 0, 5 and $10\%$ SOM for 4 weeks (30 birds per treatment). The inclusion of SOM into laying hen diets at the 5 and $10\%$ level did not affect production and quality of egg. The C18:3 $\omega$3 content of egg yolks in the $10\%$ SOM group was higher than the other groups, but not significantly. There were no adverse effects on blood parameters in layers fed treated diets containing $5\%$ or $10\%$ SOM, The results indicate that SOM can be used for layers diet up to $10\%$ without any significant negative effects on egg production and quality.

• Current Research on Agriculture and Life Sciences
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• v.15
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• pp.69-81
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• 1997

For the prevention of worldwide prevalent disease of nuclear polyhedrosis virus (NPV), environmental conditions and their incidence of grasserie was investigated through 57 cases of silkworm rearing from the year of 1979 to 1993 in the countries of Korea, Japan, and Philippines. Relationship between the occurrence of NPV and environmental factors were also analysed from the aspect of causal pathogenesis. Unfavorable foactors related to the prevalence of NPV disease was reconfirmed by the assay of experimental rearing. Silkworms reared on mulberry leaves or artificial diet appeared similar result on the occurrence of grasserie. Disinfection by formalin and simple sweeping or washing was not significantly different on the occurrence of NPV disease. Following insufficient ventilation on the younger larvae. from the 1st to 3rd instar, the disease by NPV at the later stage was remarkably emphasized those insidence. An experimental rearing from 1993 to 1996 demonstrated the prevention of NPV disease by simple cleaning of sweeping under the condition of air forced ventilation, the customal practice of disinfection with formalin or any other chemical agents could be omissible.

• Cartoon and Animation Studies
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• s.17
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• pp.37-51
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• 2009

Immersion is the key factor in determining success or failure for fictional narrative animations. It does matter to not only for the socio-economic achievements like box-office success but to the asthetical achievement, immersion is very important prerequisite character that are raised in terms of research needs. Fictional narrative animation shares the audience's immersive method with the narrative content and Virtual Reality, since animation has the character which narrates itself with the visual image format (including sound) and added the fact that 3D format which emphasizes realism compared with the recent 2D animation has been ubiquitous phenomenon. In other words, the artistic for called 'animation' is located between the view point that text has the immersive point intrinsic and oppositely, specific function of the certain media which stays extrinsic of the text enforce the participants into the immersion. In any case, the subject who experience immersion is the audience, so the most useful theory to research the phenomenon 'immersion' is Constructivism cognitive narrotologic approach which lies the peader-spectator as the centric notion and is more useful than text analysis or research on the visual effects. In this study, research and review about the studies on the audience's immersive experience would be preceded particularly aroud the constructivism theories, and examine the uniqueness and naures of the animation which makes the audience immersive.

• Journal of Ginseng Research
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• v.32 no.4
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• pp.279-282
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• 2008

This study was conducted to compare the aerial parts growth, yield of fresh ginseng roots, quality of red ginseng roots, and photosynthesis (Fv/Fm, PSII) in leaves between non-irrigation plot and furrow irrigation plot during the ginseng growing seasons. The aerial part growth in furrow irrigation plot was higher than non-irrigation plot in all including the emergency rate, leafing rate and relatively growth rate. Root yield per 10a in irrigation plot was increased about 50% as compared with that of non-irrigation, also heaven and earth grade of red ginseng roots yield in irrigation plot was higher (40.3%) compared with that (30.6%) of non-irrigation plot in 6-years-old ginseng plant. Furrow irrigation markedly improved the ginseng quality and yield in comparison to non irrigation condition. Therefore it needs to control the soil moisture during the growing season for high yield and good qualities of ginseng roots.