• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.831-838
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• 2018

Objective: This study was performed to evaluate the effects of herbal medicine on an elderly patient with subclinical hyperthyroidism who could not use antithyroid medication due to an adverse reaction to methimazole. Methods: Herbal medicine was administered and a thyroid function test was used to evaluate the effects of the treatment. Results: After treatment with herbal medicine and therapy, the patient showed improvements in TSH levels. Conclusion: This case suggested that herbal medicine can be used for patients who have adverse reactions to antithyroid medication; however, additional studies with more patients are required for verification of this finding.

• The Korean Journal of Nuclear Medicine
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• v.5 no.1
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• pp.65-70
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• 1971

Blood glucose and immunoreactive insulin (IRI) were measured during oral glucose tolerance test in 15 thyrotoxic patients and 8 normal controls, to study the glucose metabolism in thyrotoxicosis. Following were the results; 1. In thyrotoxicosis, there is noticed late rise and late fall of plasma IRI durnig oral glucose tolerance test, like as phenomenon of mild diabetes mellitus. 2. When the thyrotoxic patients were divided into normal and abnormal responsive groups after the level of blood glucose by Wilkerson Criteria, no significant differences in plasma IRI levels were noticed between two groups. 3. This result may be interpreted as relative deficiency of insulin secretion from panceas and suggest genetically related defects.

• The Korean Journal of Nuclear Medicine
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• v.37 no.6
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• pp.341-354
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• 2003

Radioactive iodine therapy using I-131 for hyperthyroidism has been used for more than 50 years, and generally considered safe and devoid of major side effects. Appropriate patient selection criteria and clinical judgement concerning patient preparation should be employed for its optimal use. It has not been possible to resolve the trade-off between efficient definite cure of hyperthyroidism and the high incidence of post-therapy hypothyroidism. The dose of the I-131 needed to maintain euthyroid state remains an area of uncertainity and debate. Early side effects are uncommon and readily managable. Other than the need for long-term monitoring and, in most cases, lifelong thyroid hormone treatment for late adverse consequences of this treatment remains only conjectural. We have reviewed general principles and recent advances in radioiodine treatment for Graves' hyperthyroidism, specially regarding to several controversies.

• The Korean Journal of Nuclear Medicine
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• v.14 no.1
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• pp.17-21
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• 1980

TRH stimulation tests and $T_3$ suppression tests were done in 13 patients with clinically suspected mild or early hyperthyroidism who were all conventional thyroid function tests gave results within the accepted normal range. The results were as follows 1. 6 patients with normal $T_3$ suppression test revealed normal TRH stimulation test and could be easily diagnosed as euthyroidism. 2. 7 patients with abnormal $T_3$ suppression test exhibited no TSH response to TRH stimulation test and could be easily diagnosed as hyperthyroidism. The TRH stimulation test is a single, sensitive and reliable test of thyroid function and can well replace $T_3$ suppression test in the diagnosis of marginal hyperthyroidism.

• 대한핵의학회:학술대회논문집
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• 1967.11a
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• pp.106.1-106.1
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• 1967

• The Journal of Korean Obstetrics and Gynecology
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• v.15 no.4
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• pp.174-182
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• 2002

The patient in this case, 38 years-old female was adimitted for 8 days(2001. 7. 16 ${\sim}$ 2001. 7. 23). Her chief complain was lumbago, shoulder pain, headache, palpitation, general body weakness, insomnia, whole body heating and dyspnea. we diagnosed this patient as hyperthyroidism with originated from yinhuhwawang(陰虛火旺) and bigihu(脾氣虛). we treated this hyperthroidism patient with herbal medicine(Chonglijagamtang-gamibang(淸離滋坎湯加味方), bojungikgitang-gamibang(補中益氣湯加味方)), Acupunture, Moxa, etc. after oriental treatment during 8 days, pain(shoulder pain, headache, lumbago, whole body pain) was decreased and the symptoms were all diminished. in the days to come, we need to study further study about the superiority of Oriental Medicine healing a hyperthyroidism patient.

• Korean Journal of Medicinal Crop Science
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• v.4 no.1
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• pp.78-85
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• 1996

The effects of growth regulators, sucrose and gelling agents were investigated to increase the efficiency of the callus growth and plant regenerarion in tissue culture of Angelica koreana Max. The fresh weight and dry weight of subcultured callus was highest in MS medium supplemented with 1 mg/l 2,4-D. Callus growth was excellent in 2% sucrose, but it was inhibited in propotion to sucrose content. Effect of gelling agents on callus growth was highest on 1.2% agar and 0.4% Gelrite medium, respectively. The browning of callus was protected on the media supplemented with 10 mg/l ABA and 5 or 10 mg/l $AgNO_3$. In the callus induction and growth from the peduncle of immature inflorescence, 2,4-D was more effective than NAA, and the frequency of callus induction was highest as 81.7% in 2 mg/l 2,4-D. Plant was not regenerated from the callus derived from young leaf. Somatic embryos were developed from the surface of callus drived from the peduncle of immature inflorescence in the medium containing 0.5 mg/l 2,4-D, 1 mg/l kinetin, 5 mg/l ABA and 5 mg/l $AgNO_3$. Plants were developed from the matured somatic embryos in the medium supplemented with 0.2 mg/l 2,4-D and 1 mg/l kinetin.

• Korean Journal of Medicinal Crop Science
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• v.4 no.1
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• pp.68-73
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• 1996

Stem length, main root length and main root diameter showed rapid increasement in two-years-old and three-years-old peony. And there after, the increasement was almost finished. Occurrence of disease was increasing every cultivated year, especially the development of leaf spot was most serious. In propagation by root dividing method, the radix yield (kg/10a) was increasing every cultivated year. However, the difference of radix yield at four and five-years-old peony were not significant. The radix yield of four-years-old peony was higher 26% than three-years-old one. As cultivated year goes by, content of paeoniflorin was increasing then the content was highest at four-years-old peony (4.06%). In 1995, the content, had no certain tendency, was highest at three-years-old peony (3.14%). At hot air drying, browing of peony radix was increasing every cultivated year. If we consider radix yield and color, three-years-old peony was proper object of harvesting.

• Clinical and Experimental Pediatrics
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• v.48 no.6
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• pp.624-633
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• 2005

Purpose : This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase(TPO) and anti-thyroglobulin(TG) antibodies] in Korean patients with type 1 diabetes(T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders. Methods : A total of 59 Korean patients with type 1 diabetes[26 males, median age 13.7 years(range 5.7-29.9 years), diabetes duration 7.6 years(-1.7-22.5 years)] were enrolled in this study, and 200 healthy Koreans without a family history of diabetes were selected as a normal control for the comparison of HLA genotypes. Seventeen patients with anti-TPO or anti-TG were followed [median duration 3.96 years(1 day-10.7 years)] with measurement of anti-TPO, anti-TG, $T_3$, $T_4$ or free $T_4$, TSH levels and physical examinations. HLA-DR and DQ genotyping were done by PCR-SSO, PCR-SSCP, PCR-RFLP and PCR-SSP methods. Results : HLA analysis showed higher frequencies of HLA-DRB1*0301, *090102 and DQB1*0201, *030302 alleles, DRB1*0301/*090102, *090102/*090102 and DQB1 *0201/*030302, *030302/*030302, *0201/ *0302 genotypes in T1DM patients compared to controls(Pc<0.05). Fifteen(25.4 percent) had anti-TPO antibody, 12(20.3 percent) had anti-TG, 17(28.8 percent) had either autoantibody and 10(16.9 percent) had both autoantibodies. No clinical or subclinical hypothyroidism developed during follow-up after the first detection of anti-thyroid autoantibody. There was no significant correlation between thyroid autoimmunity and gender, onset age of T1DM, and diabetes duration, respectively(P>0.05). Conclusion : We thought this unique HLA-DR, DQ allele distribution might be an important factor for the low incidence of T1DM in Korea. And a high prevalence of thyroid autoantibodies in these populations suggests examinations of thyroid antibodies should be performed regularly. Optimal age for the initial screening and the frequency of re-screening for associated thyroid autoimmune diseases in T1DM remains to be determined through prospective follow-up.

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.347-354
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• 2014

Korea Central Cancer Registry reported in 2011 that the prevalence rate of thyroid cancer was about 19.6% (the highest) in both men and women. The ratio of thyroid cancer, among cancers that women suffer from, was about 31.1%, the highest among female cancers and about five times more than men. Regarding the incidence of thyroid cancer by age group, the crude rate was highest in women and men aged 15~34. From these figures it can be inferred that there is a greater relationship between thyroid cancer and hormones compared with other cancers. Therefore, young women aged 20~25, even if they are in full health, should undergo a medical examination. This study is aimed at examining changes in thyroid gland detected through self evaluation tests and the analysis of ultrasound screening images in persons aged 20~25. According to the study, 213 persons (about 46.6%) out of 457 people who took part in the study had abnormal echo patterns. With regard to women's abnormal patterns, about 73.4% of them were found to have calcified cystic, 11.8% diffuse-type low-echo and 7.3% cystic echo. With regard to male participants, about 61.1% were found to have calcified cystic, followed by 19.4% with the size of the isthmus increased and 13.9% with diffuse-type low-echo. According to the outcomes of an analysis regarding self-testing for hyperthyroidism, the average points of participants who were found to have abnormal echo patterns in ultrasound tests were 6.85 and the figure was 5.88 in persons with normal patterns. The figure was about 15% higher in abnormal respondents.