• The Monthly Diabetes
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• s.214
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• pp.35-37
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• 2007

당뇨병환자에서 발생하는 가장 중요한 급성 합병증인 당뇨병성 케톤산증이나 고삼투성 비케톤성 혼수는 인슐린의 투여를 중단하였거나 감염, 외상 등의 신체적 손상이나 정신적 스트레스에 의하여 인슐린에 대한 길항 호르몬들이 과분비돼 발생한다. 일반적으로 당뇨병성 케톤산증은 인슐린 의존형 당뇨병환자 중 주로 젊은 층에서 자주 나타나며 병의 경과가 빠르게 진행되기 때문에 고삼투압 상태보다는 케톤산혈증이 주요 문제가 된다. 반면에 고삼투압성 비케톤성 혼수는 인슐린 비의존형 당뇨병환자 중 주로 노인층에서 호발하며 병의 경과가 서서히 진행하기 때문에 심한 고혈당 상태로 인한 고삼투압 상태가 주요 문제가 된다. 이와같은 당뇨병의 급성 대사성 합병증들은 치료가 지연되거나 적절한 치료가 행해지지 못했을 때는 예후가 극히 불량하며 사망률 또한 높은 것으로 보고되고 있다. 이에 급성 대사성 합병증 중 당뇨병성 케톤산증의 병인, 진단 및 치료 등을 알아보기로 한다.

• The Monthly Diabetes
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• s.207
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• pp.11-13
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• 2007

혈당이 잘 조절이 되지 않는 당뇨병환자에서 특히 발생하는 치과질환으로는 구강건조증, 치주질환의 증가, 치아우식증의 증가, 여러 종류의 미생물에 의한 감염, 상처치유의 지연 등이 있다. 당뇨병환자의 이러한 구강 내 합병증은 과도한 소변의 배설로 인한 체액의 소실, 감염에 대한 취약성, 소혈관의 변화 그리고 타액내 포도당 농도의 증가와 관련이 깊은 것으로 알려져 있다.

• Journal of the Korean Orthopaedic Association
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• v.54 no.1
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• pp.67-71
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• 2019

Klebsiella pneumoniae causes that liver abscess mostly, also spread to pneumonia, meningitis, urinary tract infections. Septic arthritis caused by K. pneumoniae is a quite rare and has not been reported in Korea. Therefore, the authors report a case of the septic arthritis in the knee joint caused by K. pneumoniae in a patient with type 2 diabetes mellitus and osteoarthritis of the knee that successfully treated by early detection and arthroscopic synovectomy.

• Clinical and Experimental Pediatrics
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• v.50 no.12
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• pp.1217-1224
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• 2007

Purpose : Due to its high potency against leukemic blasts, our institution has opted for the use of dexamethasone during acute lymphoblastic leukemia (ALL) remission induction, but in our most recent treatment protocol, CMCPL-2005, we shortened the length of steroid treatment from 4 to 3 weeks. We compared both the rates of remission induction and significant complications observed during induction with CMCPL-2005, with those noted for our previous protocol, CMCPL-2001. Methods : We retrospectively reviewed the records of patients diagnosed with ALL from January, 2001 to December, 2006 at the Department of Pediatrics, St. Mary's Hospital, the Catholic University of Korea. Data concerning age, sex, WBC count at diagnosis, immunophenotype, cytogenetic traits, and risk group were collected for each patient. Results of remission induction treatment were compared between the two patient groups. Infection and other major complications resulting from treatment were investigated according to NCI toxicity criteria. Results : A total of 141 and 88 patients received remission induction under CMCPL-2001 and CMCPL-2005 respectively. In the CMCPL-2001 group, 136 (96%) achieved complete remission while 82 (93%) achieved CR in the CMCPL-2005 group. Patients in the CMCPL-2005 group were more likely to undergo remission induction without experiencing major complications. However, with regards to steroid related toxicities such as infection, no significant differences were noted. Conclusion : We shortened the length of steroid administration from four to three weeks, yet found the remission induction rate to be comparable to that of our previous regimen. However, rates of steroid related toxicities such as infectious complications remain unchanged despite shortened exposure to dexamethasone.

• Food Science and Industry
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• v.44 no.1
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• pp.59-62
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• 2011

전세계적으로 감염성 질환은 주요한 건강 문제이다. 장내 미생물 균총은 해로운 미생물로부터 숙주를 보호할 뿐 아니라 면역계에 있어서 매우 중요한 역할을 한다. 이점이 바로 프로바이오틱스 즉, 건강에 도움을 주며 살아있는 미생물로 정의되는 기본 개념을 탄생시켰다. Lactobacillus rhamnosus GG(이하 LGG) 균은 세계적으로 가장 많이 연구된 프로바이오틱스 균종 중 하나로서, 확인된 효능의 대부분은 주로 위장관 질환에 관한 것이다. 몇몇 연구를 통해 급성 수양성 설사의 치료, 항생제 관련 증상의 예방, 그리고 여행자 설사에 대한 LGG균의 효과가 밝혀졌다. LGG균은 소아에서 호흡기 감염의 발생을 줄이거나 그 합병증을 감소시키는 것으로 보인다. 많은 연구를 통해 LGG 균, LC705, 그리고 프로피오니박테리움 PJS균을 모두 포함한 복합 유산균 제제인 $LGG^{(R)}$ Extra가 위장관 불편감을 줄이고 삶의 질을 향상시키는 것으로 나타났다. 따라서 LGG균의 사용은 감염성 질병의 관리와 위장관 건강을 얻는데 있어 안전하고 쉬운 방법이라 하겠다.

• Clinical and Experimental Pediatrics
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• v.51 no.5
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• pp.533-537
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• 2008

Mycoplasma pneumoniae (M. pneumoniae) infection causes a wide variety of clinical manifestations in children and young adults, the main one being pneumonia. M. pneumoniae is transmitted from person to person by infected respiratory droplets. Symptoms caused by M. pneumoniae infection can be divided into those involving the respiratory tract, and those caused by extrapulmonary disease. M. pneumoniae infections may cause central nervous system (CNS) complications-with encephalitis being the most frequent-and stroke being a rare complication. The pathogenesis of the CNS disease is unclear; possibilities include direct infection and an immune-mediated reaction. We present two cases of CNS complications subsequent to infection with M. pneumoniae; both cases had convincing evidence of preceding M. pneumoniae respiratory disease with no evidence of viable M. pneumoniae in the cerebrospinal fluid. We report cases of encephalitis and stroke following a recent M. pneumoniae infection.

• Journal of Chest Surgery
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• v.34 no.6
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• pp.485-489
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• 2001

Background: The most important factor in preventing sternal complications is stable sternal approximation. We have tried to find the most effective sternal closure method by examining the incidence of sternal dehiscence with or without infection in patients with cardiac surgery through median sternotomy. Material and Method: This study was performed in 489 patients over 45 years of age with median sternotomy for open cardiac surgery. Simple closure with interrupted 6 wires was performed in 159 patients, figure-of-8 closure technique in 119, overlapping interrupted closure using 10 wires in 150, and combined closure technique of interrupted simple closure and figure-of-8 suture closure in 61. Two hundred thirty-four patients underwent valve and aortic operations and 213 patients coronary artery bypass surgery. Result: Sternal dehiscence with or without infection occurred in 12 (2.5 %) patients. The complication developed in 5 of 159 patients (3.1%) with six interrupted simple closure, in 4 of 119 patients (3.4%) with figure-of-8 closure, and in 3 of 150 patients (2.0%) with overlapping interrupted closure using 10 wires, but there was no complication in 61 patients with combined closure technique (relative risk for other closure techniques, p<0.05). There was no significant difference in the incidence of the sternal complication between valve and aortic operation group and coronary artery bypass group (3.0% vs 2.3%, not significant), but diabetes mellitus was a significant independent risk factor (odds ratio and multivariate analysis, p<0.05). Conclusion: The sternal closure technique that combines simple interrupted suture closure and figure-of-8 suture closure may be a more useful technique to enhance sternal stabilization compared to other closure techniques, such as simple interrupted closure, 8-figure closure, and overlapping interrupted closure.

• Journal of Hospice and Palliative Care
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• v.13 no.1
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• pp.24-31
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• 2010

Purpose: A central venous catheterization (CVC) is frequently used for delivering anti-cancer chemotherapeutic agents, blood products, parenteral nutrition, and other intravenous therapy in patients with cancer. Major complications of CVC use are thrombosis, infection, and mechanical complications. The aim of this study was to evaluate the frequency of CVC complications and related factors. Methods: The records of cancer patients who received a CVC at our university hospital from March 2001 to October 2006 were retrospectively investigated. Chi square test was used to determine whether there was a related factor for thrombosis or infection, and Kaplan-Meier analysis for univariate analysis, or Cox-regression analysis for multivariate analysis was used for catheter life span. Results: Three hundred and ten CVCs (235 nontunneled, 75 tunneled) were inserted in 310 patients (157 males, 153 females). Among them, 104 had hematologic cancers and 206 had solid cancers. The mean age of the patients was 52 years (range, 19~82 years). CVC complications occurred in 60 cases (19%). CVC-related thrombosis occurred frequently in patients with infection (P=0.003), whereas diagnosis, catheter type, transfusion, and TPN history did not affect infection or thrombosis. The mean duration of the catheter was 102 days (range, 2~1,330 days), and the duration was prolonged in patients with tunneled catheters (P=0.000), or without transfusion through CVC (P=0.030). Conclusion: The major complications for long-term use of a CVC were infectionand thrombosis. Tunneled catheter was effective tool for long term use, especially in cases without transfusion through CVC. The studies on the prevention or treatment ofthrombosis and infection are, therefore, warranted by using CVC for an extended period of time.

• Clinics in Shoulder and Elbow
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• v.13 no.1
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• pp.106-110
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• 2010

Purpose: We report a case of pyogenic arthritis of the shoulder secondary to infective endocarditis. Materials and Methods: A 70 year-old male who had suffered from pyogenic arthritis of the left shoulder secondary to infective endocarditis was treated with artificial valvuloplasty, arthroscopic synovectomy and drainage. Results: Infection was cured and the patient achieved a good functional outcome. Conclusion: Pyogenic arthritis of the shoulder is rarely associated with infective endocarditis. However, if the symptoms are misdiagnosed as musculoskeletal symptoms associated with infective endocarditis, serious complications may arise. As such, musculoskeletal symptoms associated with infective endocarditis should be paid careful attention.

• Clinics in Shoulder and Elbow
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• v.14 no.1
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• pp.146-152
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• 2011

Purpose: To describe the recent clinical results and complications of total elbow arthroplasty based on the literature review. Materials and Methods: The indications of total elbow arthroplasty include rheumatoid or inflammatory arthritis, posttraumatic arthritis, anklylosed elbow, tumor resection which cannot recover elbow function by other reconstructive procedures, and comminuted distal humerus fracture in elderly patients. Complications are aspetic loosening, infection, prosthesis fracture, periprosthetic fracture, ulnar neuropathy, ectopic ossification, triceps insufficiency, dislocation, and bushing wear. Results and Conclusion: Mean 10 year survival rate following total elbow arthroplasty has been reported 85% on the basis of revision. The prognosis in patients with an inflammatory arthritis is reported to be best, and loosening rate in patients with a posttraumatic arthritis tends to be high. Complication rate is known to be higher than that of other joint arthroplasty. In particular, deep infection occurs in 3~5% of the patients. Total elbow arthroplasty provide satisfactory results when it is performed properly in selected patients who have an elbow joint with irreversible dysfunction and low level activities.