• The Journal of the Korea Contents Association
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• v.17 no.7
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• pp.253-264
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• 2017

The purpose of this study was to investigate role perception, knowledge, self-confidence of practice, and educational needs of child daycare teachers' infectious disease management and to identify their relationship. A correlation study was conducted. Participants were 180 child daycare teachers. Almost eighty percent(78.9%) of participants did not received infectious disease management education. The mean percent of correct answers for infectious disease management knowledge of participants was 52.3% and their self-confidence of practice of infectious disease management was low. However, their role perception of infectious disease management and educational needs were high. Educational needs on 'hand washing and hygiene to prevent infectious diseases', 'blocking transmission of infectious diseases', 'infectious disease specific management and care', and 'infectious disease specific symptoms' were high. Child daycare teachers' role perception of infectious disease was positively correlated with their knowledge and educational needs. Development and evaluation of educational interventions to improve child daycare teachers' infectious disease prevention and management are recommended. Particularly, efforts are needed to improve child daycare teachers role perceptions as infectious disease manager.

• The Korean Journal of Pharmacology
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• v.31 no.3
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• pp.323-331
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• 1995

Monocyte/macrophage infiltration is the well known initial features associated with the development of glomerular disease including non-immune mediated nephropathy. Tumor necrosis factor ${\alpha}(TNF{\alpha})$, a cytokine produced primarily by monocyte/macrophage, exhibits similar effects as observed at the initial stages and during the progression of glomerular injury. Because the mesangial cells are target cells for glomerular injury, the present study examined the effect of $TNF{\alpha}$ on glomerular mesangial cell membrane lipid peroxidation as an index of cytotoxicity attributing to $TNF{\alpha}$. Primary culture of rat mesangial cell was established by incubation of glomeruli isolated from male Sprague-Dawley rat kidneys utilizing a standard sieving method. The levels of lipid peroxides in the mesangial cells were quantitated by malondialdehyde- thiobarbituric acid adduct formation. During an 8 hour incubation at $37^{\circ}C$, $TNF{\alpha}$ at 10 to 10,000 units/ml increased the levels of lipid peroxides dose dependently. Western blot analysis demonstrated that a short thermal stress induced heat shock response and the synthesis of heat shock protein 70(hsp70) in this mesangial cells. Further, this induction of hsp 70 prevented increase of lipid peroxides in the mesangial cells exposed to $TNF{\alpha}$. These data suggest that $TNF{\alpha}-induced$ lipid peroxidation in the mesangial cells may have pathophysiological relevance to glomerular injury and prior induction of heat shock response may play a role in the cellular resistance against $TNF{\alpha}-induced$ glomerular injury.

• Journal of the Korean Orthopaedic Association
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• v.54 no.3
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• pp.203-210
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• 2019

The aim of this review was to evaluate minimally invasive lateral lumbar interbody fusion on the latest update. Lumbar interbody fusion was introduced recently. This study performed, a literature review of the indications, clinical outcomes, fusion rate, and complications regarding recently highlighted minimally invasive lateral lumbar interbody fusion. The indications of lateral lumbar interbody fusion are similar to the conventional anterior and posterior interbody fusion in degenerative lumbar diseases. In particular, lateral lumbar interbody fusion is an effective minimally invasive surgery in spinal stenosis, degenerative spondylolisthesis, degenerative adult deformity, degenerative disc disease and adjacent segment disease. In addition, the clinical outcomes and fusion rates of lateral lumbar interbody fusion are similar compared to conventional lumbar fusion. On the other hand, non-specific complications including hip flexor weakness, nerve injury, vascular injury, visceral injury, cage subsidence and pseudohernia have been reported. Lateral lumbar interbody fusion is a very useful minimally invasive surgery because it has advantages over conventional anterior and posterior interbody fusion without many of the disadvantages. Nevertheless, nonspecific complications during lateral lumbar interbody fusion procedure remain a challenge to be improved.

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.25-34
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• 2001

복부의 자기공명영상(Magnetic resonance imaging； MRI)은 주로 간 질환의 검사에서 다른 영상검사로 해결되지 않은 궁금점을 풀기 위한 보조적인 검사로 주로 사용하였으나, 최근 들어서는 병변의 발견 및 감별진단에 직접적인 검사로도 자주 이용하고 있으며, 담췌관 질환이나 위장관 검사 등에도 적용범위가 넓어지고 있다. 이는 그간의 하드웨어 및 소프트웨어상의 발달로 인해, 위장관 연동운동이나 호흡에 따른 인공물을 억제하면서도 해부학적인 세부구조는 자세하게 나타낼 수 있는 우수한 영상을 얻을 수 있음으로써 가능하게 되었다. 고속영상은 영상의 질을 우수하게 할 뿐 아니라, 검사시간을 단축시켜서 더 많은 환자를 검사할 수 있게 하고, 한자가 검사에 더 잘 적응할 수 있게 하여준다. 단발(single-shot)기법의 고속 T2강조영상은 담췌관이나 위장관등 그간 MRI를 적용하기 어려웠던 부위에 대한 검사가 가능하게 하였으며, 고속의 3차원 T1강조 펄스대열(pulse sequence)은 단면에 따른 오기록(misregistration)이나 운동인공물이 적으면서도, 향상된 다평면적인 영상구성을 얻을 수 있게 하였다. ［l］. 본 강좌에서는 최근 수년간 복부 MRI의 응용을 증가할 수 있게 한 영상장치 및 펄스대열의 발전과 최근 국내에 시판이 허용되어 사용이 증가되고 있는 새로운 간자기공명조영제에 관해서 살펴보고자 한다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.158-158
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• 1993

노화현상에 따른 여러 가지 병태생리조건의 형성과 난치성 성인병질환의 발병 및 진행과정에 활성산소류들과 이들에 의해 유도되어지는 free radical이 관여하고 있다는 증거가 여러연구진에 의해서 보고되어지고 있다. 산소를 이용하여 생명현상을 이어가는 생물체들은 필연적으로 활성산소들을 생성하는 생화학적 산화반응기구를 효율적으로 활용하면서 항상성을 유지시키고 있다. 그러므로 활성산소의 생성과 분해과정의 평형유지는 생물학적으로 대단히 중요한 의미를 갖고 있다. 임상적으로 alcohol은 질병의 악화 내지는 질환의 발병조건을 조성하는 병태생리기구에 기여할 것으로 생각되어 대부분의 환자에게 금주시키고 있으나 그 작용기전에 대해서는 충분히 설명되지 못하고 있다. 본 연구에서는 alcohol을 급ㆍ만성으로 실험동물에 투여하고 생체에서 활성산소 생성에 중요한 역할을 하는 xanthine oxidase와 aldehyde oxidase의 활성변화를 관찰하면서 전자의 형전환속도와 과산화지질 생성속도와의 상관성을 중점 비교 관찰하므로서 alcohol성 간손상 실험 model을 계획하였다. 간 및 신장조직에서 alcohol에 유래되는 활성산소의 생성계에 관여하는 효소 활성의 변화와 조직의 과산화지질 생성반응 속도는 alcohol의 투여방법, 기간, 시간(diurnal variation), 나이 및 암수에 따라 다르게 나타남을 관찰할 수 있었다.

• Proceedings of the Korea Information Processing Society Conference
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• 2011.11a
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• pp.1055-1058
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• 2011

본 논문은 IT분야의 다양한 융합 기술 분야 중에서 언제 어디서나 사용자의 건강상태를 실시간으로 확인 할 수 있는 u-Health 시스템(Ubiquitous Health System)을 구현하였다. 현재 서비스되고 있는 u-Health 시스템은 초기 단계로 사용자의 상태를 확인하는 센서 기기에 의존하여 센서로부터 측정된 데이터를 가족 및 의료기관 등이 직접 분석하여 대처 하는 방법을 사용하고 있다. 그러나 기존에 개발된 u-Health 시스템은 센서 기기에 대한 오동작과 응급상황 발생 시 정확하고 신속한 대처를 할 수 없다는 단점을 가지고 있다. 따라서 본 논문에서는 u-Health 시스템의 단점을 보완하고자 기존 u-Health 시스템에 질환판별 알고리즘을 적용하여 사용자의 상태를 진단하고 이상 징후나 응급상황을 판단 할 수 있도록 하여 신뢰성을 높인다. 또한 질환판별 결과가 응급상황으로 판정될 시 가족 및 의료기관에 실시간으로 문자 메시지를 전송하여 알림 역할을 하고, 스마트폰과 웹페이지를 이용하여 실시간으로 사용자의 상태를 확인할 수 있도록 하여 신속성을 높이는데 목적이 있다.

• The Monthly Diabetes
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• s.257
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• pp.34-35
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• 2011

당뇨병과 간은 상관관계가 없는 것 같지만 그동안 당뇨병과 간에 대한 연구가 여러 차례 진행돼 왔다. 우리나라에서 2001년 연구한 바에 따르면 제 2형 당뇨병에서 C형 간염의 발생률이 높은 것으로 나타났다. 뿐만 아니라 당뇨병환자에서 비알콜성 지방간이 흔하게 관찰되는 것으로 보고되고 있다. 반면 간 질환자에서 당뇨병 발생빈도가 10~30%로 매우 높게 나타나 당뇨병과 간이 밀접한 연관성이 있음을 짐직할 수 있다.

• Journal of the Korean Society of Radiology
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• v.10 no.2
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• pp.81-87
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• 2016

In this study we proposed a texture feature analysis algorithm that distinguishes between a normal image and a diseased image using CT images of some fatty liver patients, and generates both Eigen images and test images which can be applied to the proposed computer aided diagnosis system in order to perform a quantitative analysis for 6 parameters. And through the analysis, we derived and evaluated the recognition rate of CT images of fatty liver. As the results of examining over 30 example CT images of fatty liver, the recognition rates representing a specific texture feature-value are as follows: some appeared to be as high as 100% including Average Gray Level, Entropy 96.67%, Skewness 93.33%, and Smoothness while others showed a little low disease recognition rate: 83.33% for Uniformity 86.67% and for Average Contrast 80%. Consequently, based on this research result, if a software that enables a computer aided diagnosis system for medical images is developed, it will lead to the availability for the automatic detection of a diseased spot in CT images of fatty liver and quantitative analysis. And they can be used as computer aided diagnosis data, resulting in the increased accuracy and the shortened time in the stage of final reading.

• Journal of Digital Convergence
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• v.14 no.2
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• pp.501-507
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• 2016

We obtained medical test data of 150 male from National Health Insurance Corporation, that included physique, blood chemistry, and lifestyle. ${\chi}^2-test$ and logistic regression, and multiple regression were done to verify how CAD risks and/or lifestyle are different between obese and non-obese person. SPSS(version 18) was used for statistical procedures and p-value of .05 was regarded as good through. ${\chi}^2-test$ showed the frequency of hypertension, htperglycemia, hyperlipidemia were higher in obese person than in non-obese This result told us that lifestyle modification could be a key to prevent cardiovascular disease by controlling and managing body composition, especially abdominal obesity.

• Korean Journal of Social Welfare Studies
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• v.42 no.2
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• pp.303-322
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• 2011

The increased needs for medical cost containment and the quality of life improvement for the low-income elderly with chronic disease require the complementary relationship between hospital care and community health services. This study investigated the current status of the linkage between Korean hospital care and community services using Seoul Welfare Panel Study(SWPS) data. Logistic regression analysis was used to examine the effects of experiences of hospitalization and outpatient health services on use and needs of community health services. The analysis results indicated that the elderly with chronic disease who have not experienced outpatient health services were unlikely to receive health and social services in the community. Even those who have experienced hospitalization were not provided complementary health services in the community despite the increasing demand.