• Korean Journal of Social Welfare Studies
• /
• v.48 no.4
• /
• pp.91-120
• /
• 2017

This study aimed (a) to examine the association between chronic illness and multidimensional disability(i.e., psychological/emotional functions, activity capacity, and participation frequency) among older adults with disabilities, (b) to investigate the effect of formal and informal supports on multidimensional disability, and (c) to analyze the moderating effects of formal and informal supports on the association between chronic illness and multidimensional disability. This study used 2014 Korea Welfare Panel Study(the 9th wave) data and 450 older adults with disabilities aged 50 and over were selected as the study target. The research model was analyzed by structural equation modeling using IBM AMOS 22.0. Based on the ICF framework developed by WHO, health condition was measured by the level of chronic illness; psychological/emotional functions were measured by health satisfaction, self-esteem, and depression; activity capacity was measured by ADLs and IADLs; participation frequency was measured by the total number of social activities joined; formal support was measured by the total number of formal welfare services for people with disabilities utilized; informal support was measured by perceived social support. The findings showed that the level of chronic illness was negatively associated with psychological/emotional functions among the older adults with disabilities. The informal support positively affected psychological/emotional functions and activity capacity, whereas the formal support showed the opposite result. That is, the formal support negatively influenced activity capacity and showed a moderating effect on the association between the level of chronic illness and the psychological/emotional functions in a reverse way. Based on the results, practice and policy implications for alleviating disability level among the older adults with disabilities were discussed.

• 한국노년학
• /
• v.41 no.1
• /
• pp.149-168
• /
• 2021

This study was to develop the Medication Adherence Scale in Elderly (MAS-E) with chronic disease and verify its reliability and validity. The MAS-E was developed in 5 steps: Configuration of conceptual frame by content analysis, preliminary items, pilot study, reliability and validity test, and development of final MAS-E with chronic disease. The questionnaires were collected from 345 adults with one-to-one interviews. Verification of its reliability and validity was divided into two phases. Reliability was tested using Cronbach's alpha, split-halves reliability, and test-retest. For validity tests, item analysis, factor analysis, total score-factor score correlation analysis, and criterion related validity were used. The developed scale consisted of 18 items and 4 factors - remember of taking medication (2 items), expectations for drug effects (5 items), practice taking medication according to instructions (8 items), communicating with health professionals (3 items), and explained 69.7% of total variance. The scale had significantly positive correlation (r = .72, p <.001) with the Morisky Medication Adherence Scale (MMAS-8). Cronbach's alpha was .91, Guttman split half coefficient was .80, and test-retest reliability was .912. Finding suggest that the MAS-E is a suitable scale to assess the status of medication adherence in elderly with chronic disease.

• Journal of Life Science
• /
• v.32 no.6
• /
• pp.476-481
• /
• 2022

Ubiquitin signaling regulates virtually all aspects of eukaryotic biology and dynamic processes in which protein substrates are modified by ubiquitin. To regulate these processes, deubiquitinating enzymes (DUBs) cleave ubiquitin or ubiquitin-like proteins from these substrates. DUBs have been implicated in the pathogenesis of cancer, leading to the development of increasing numbers of small-molecule DUB inhibitors. On the other hand, recent studies have focused on the function of DUBs in metabolic diseases such as obesity, diabetes, and fatty liver diseases. DUBs play a positive or negative role in the progression and development of metabolic diseases. Their involvement in cell pathology and regulation of major transcription factors in metabolic syndrome has been examined in vitro and in animal and human biopsies. UCH, USP7, and USP19 were linked to adipocyte differentiation, body weight gain, and insulin resistance in genetic or diet-induced obesity. CYLD, USP4, and USP18 were found to be closely associated with fatty liver diseases. In addition, these liver diseases were accompanied by body weight change in certain cases. Collectively, in this review, we discuss the current understanding of DUBs in metabolic diseases with a particular focus on obesity. We also provide basic knowledge and regulatory mechanisms of DUBs and suggest these enzymes as therapeutic targets for metabolic diseases.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.12 no.1
• /
• pp.16-22
• /
• 2009

Purpose: To update the epidemiologic information of hepatobiliary diseases in pediatric inpatients using cross-sectional survey data throughout the Republic of Korea. Methods: Nationwide cross-sectional survey was obtained from the 85 residency training hospitals in Korea to gather the final diagnosis on discharge. The surveyed periods were from 2004 to 2006. All the reports regarding the diagnosis were based on ICD-10 system. In this study, we focused on hepatobiliary diseases. Results: A total of 826,896 cases with discharge data were collected, of which 4,151 (5.0%) hepatobiliary cases were identified; 2,385 cases (57.4%) of hepatobiliary disease were hepatitis, which was the most common hepatobiliary disease. Other diseases included congenital hepatobiliary diseases (524 cases [12.6%]) and biliary diseases (315 cases [7.6%]). The prevalence of hepatobiliary disease according to age differed. Biliary atresia was the most common hepatobiliary disease in the neonatal period, whereas the prevalence of hepatitis increased in adolescents. The total number of hepatobiliary operations was 416 cases. With the comparison of annual data, there was no definite difference in the total number of hepatobiliary cases. The average duration of hospital stay appeared to decrease gradually. Conclusion: In this study, we have summarized the recent epidemiology of hepatobiliary disorders in Korean children based on discharge data. Hepatobiliary disorders in pediatric inpatient units consisted of diverse disorders with a low prevalence, so multi-center approaches should be considered to enhance the clinical and public health outcomes. To improve this nationwide survey, a new data collecting system should be developed.

• Journal of the Korea Convergence Society
• /
• v.10 no.2
• /
• pp.339-347
• /
• 2019

This study was conducted from November 1, 2017 to November 30, 2017 in 268 women in late postmenopausal period in D and S shipyards located in G city. The subjects were divided into two groups according to the risk factors of cerebrovascular disease according to the presence or absence of risk factors of cerebrovascular disease. The subjects were divided into two groups according to their general characteristics, cerebrovascular disease prevention knowledge, attitude and health behavior. The variables that had statistically significant difference in health group and risk group were age (F=92.239, p<.001), cohabitation type ($x^2=20.056$, p<.001), income level ($x^2=39.023$, p<.001), the number of working hours per week (F=32.217, p<.001), the number of working years (F=12.310, p=.001), family history of cardiovascular disease ($x^2=233.442$, p<.001), subjective health status($x^2=19.058$, p=.001). There was a significant difference between the two groups in the degree of knowledge related to prevention of cardiovascular disease (F=2.679, p=.008) and health behavior fulfillment (F=4.339, p<.001). (r=.348, p<.001), the risk group had a higher knowledge (r=.279, p=.002), and the other group Attitude (r=.194, p=.030) showed a statistically significant correlation. Based on this, it is necessary to develop and apply an intervention program considering the characteristics of vulnerable group of cerebrovascular disease.

• Journal of Life Science
• /
• v.19 no.12
• /
• pp.1750-1757
• /
• 2009

The purpose of this study was to investigate the effects of regular walking exercise on health-related parameters in the elderly with chronic diseases - apoplexy, overweight, impaired fasting glucose, and overweight + impaired fasting glucose. A total of 85 subjects, 27, 17, 21 and 20 in apoplexy (A), overweight (O), impaired fasting glucose (IFG), overweight + impaired fasting glucose group (O_IFG), respectively, completed a 12-week walking exercise. The health-related parameters were measured before and at the completion of the exercise program including anthropometric measurements, functional physical fitness levels, blood pressure, fasting glucose, blood lipid profiles and chronic inflammatory markers (CRPs). Significant improvements in body weight, BMI, %body fat, blood pressure, all blood lipid measurements and all measured physical fitness items were shown in A; those in %body fat, TC, HDL-C and LDL-C in O; those in body weight, BMI, %body fat, fasting glucose, TC, TG and HDL-C in IFG; and those in body weight, HDL-C and LDL-C in O_IFG (p<0.05). The results of the present study demonstrated that a 12-week walking exercise brought positive effects on body weight, bloody lipid profiles, fasting glucose and functional physical fitness levels in the elderly with chronic diseases. In conclusion, this study suggested that walking regularly is very effective in lowering the risks of developing chronic diseases.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1995.04a
• /
• pp.105-105
• /
• 1995

새로운 간장질환 치료제로 개발중인 YH439가 orotic acid, nicotinamide 및 ethionine에 의해 유발되는 지방간에 대한보호 및 치료효과를 관찰하였다. 웅성 SD계 rat에 orotic acid(1%) 또는 nicotinamide(2%)가 첨가된 사료를2주간 섭취시켜 유발된 지방간에 대한 YH439의 보호 및 치료효과와 ethionine(100mg/kg, i.p.)투여로 유도되는 지방간에 대한 YM439의 보호효과를 관찰하기 위하여 간 조직 중 triglyceride, cholesterol 및 phospholipid의 함량을 측정하여 비교하였다. 그 결과, erotic acid 또는 nicotinamide의 섭취로 인해 랫드의 간 조직 중 triglyceride, cholesterol 및 phospholipid의 함량은 1.5-3배정도 증가하였으며, 이 증가된 지질들은 YH439 100, 200mg/kg 투여에 의해 유의성 있게 억제되었다. 또한 ethionine투여에 의해서도 랫드의 간 조직 중 triglyceride, cholesterol 및 phospholipid의 함량은 약 2배정도 증가되었으며, YH439 전저치에 의해 이 현상들이 억제되는 효과를 나타내었다.

• The Korean Journal of Nuclear Medicine
• /
• v.29 no.4
• /
• pp.492-496
• /
• 1995

To evaluate the usefulness of hepatic uptake in neonatal jaundice, Tc-99m-DISIDA cholescintigraphy was reviewed for 13 infants with prolonged mired jaundice and no demonstrable excretion into bowel,even after 24hr. Five patients proved to have biliary atresia. The remainder had neonatal hepatitis. There was no distinct differentiation of the hepatic uptake of tracer at 5 and 10 minutes between biliary atresia and neonatal hepatitis. The consideration of hepatic uptake rate of the tracer is not useful in differentiating neonatal hepatitis from biliary atresia.

• 발명특허
• /
• v.31 no.4 s.358
• /
• pp.54-56
• /
• 2006

현재 병원 및 의원에서는 GOT, GPT 등의 간 질환 진단시약을 사용하고 있다. 하지만 이것들은 특이성이 떨어진다는 문제점을 가지고 있다. 또한 초기 염증 및 급성간염 진단에 있어서는 유용할 지 모르나 만성간염, 간경변, 간암에 있어서는 수치가 정상으로 나타나는 경우도 있어 오진 및 의료분쟁의 원인이 되기도 하 는 등의 치명적인 오류를 안고 있다. 이렇듯 간의 초기 염증 및 급성간염 진단만 가능하던 현재의 간질환 진단시약이 가지고 있는 문제점을 해결하여 만성간염, 간경변, 간암 등까지도 확실하게 구별할 수 있음은 물론 간질환의 진행상태까지도 판단할 수 있는 세계 유일의 제품을 개발하게 되었다. 이는 간경변, 간암의 경우 9 6 %의 높은 판정비율을 나타낸다.

• Proceedings of the Optical Society of Korea Conference
• /
• 2001.02a
• /
• pp.270-271
• /
• 2001

안과 실명 질환의 가장 많은 부분을 차지하는 안구 망막의 실시간 3차원 계측기술은 아직 초보단계에 머물고 있다. 다른 장기나 조직에 비해 3차원계측기술이 늦어진 몇 가지 이유를 들면 다음과 같다. 첫째, 망막이 150$\mu$에서 400$\mu$의 얇은 막이어서 기존의 초음파(ultrasonography), CT(computerized tomography)나 MRI(magnetic resonance image)의 해상력으로는 영상화되지 않는다. 둘째로는 망막이 안구내의 뒤쪽에 위치하여 오직 동공을 통해서만 관찰 가능하여 3차원이 영상화가 어렵다. (중략)