• Herbal Formula Science
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• v.26 no.3
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• pp.207-221
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• 2018

Objectives : Present study investigated hepatoprotective effect of Haegan-jeon extract (HE) and tried to elucidate molecular mechanism involved. According to molecular mechanism, present study optimized herbal composition of HE (op-HE) and compared in vitro and in vivo hepatoprotective effects of op-HE to HE. Methods : For in vitro experiments, HepG2 cells were exposed to arachidonic acid (AA, $10{\mu}M$) and iron ($5{\mu}M$) for inducing oxidative stress. Cell viability, GSH contents, $H_2O_2$ production, mitochondrial membrane potential, immunoblot and reporter gene assay were performed to investigate cytoprotective effects and responsible molecular mechanisms. For in vivo experiments, hepatoprotective effect of HE and op-HE were assessed on $CCl_4-induced$ liver injury mice model. Results : HE pretreatment prevented AA+iron-mediated hepatocytes apoptosis. In addition, AA+iron-induced mitochondrial dysfunction, $H_2O_2$ production, glutathione depletion were reduced by HE pretreatment. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation, antioxidant response element (ARE)-driven reporter gene activity, and antioxidant genes expression were increased by HE. Based on reporter gene and MTT assays, we found that op-HE consisting three medicinal herbs also significantly increased transactivation of Nrf2 and reduced the AA+iron-mediated cytotoxicity. Moreover, in $CCl_4-induced$ liver injury mice model, HE-op had an ability to ameliorate $CCl_4-mediated$ increases in serum alanine transferase and aspartate aminotransferase activity, hepatic degeneration, inflammatory cell infiltration, and collagen deposition. Hepatoprotective effects of op-HE were comparable to those of HE. Conclusions : Present study suggests that op-HE as well as HE exhibit hepatoprotective effect against oxidative stress-mediated liver injury via Nrf2 activation.

• Tuberculosis and Respiratory Diseases
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• v.43 no.4
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• pp.527-535
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• 1996

Background : Cell adhesion molecules knave been Implicated In the various stages of tumor progression and metastasis. ICAM-1 plays a important roles in cell-cell interactions in inflammatory and immune response of several diseases. Recently, elevated levels of sICAM-1 in circulation was reported as association with liver metastasis in gastric, Colonic, gall bladder and pancreatic cancer, with reduced survival in malignant melanoma. This study was performed to measure the sICAM-1 in patients with lung cancer and to evaluate the relations between staging of lung cancer and level of sICAM-1. Methods : Serum sICAM-1 was measured in 36 patients with lung cancer according to the pathologic types and clinical staging before therapy and in 8 controls with ICAM-1 ELISA kit. Results : Serum sICAM-1 levels were elevated in patients with lung cancer except small cell type. Also progression and metastasis of lung cancer associated with elevation of sICAM-1 levels. Conclusion : These results suggest that higher levels of serum ICAM-1 reflect the progression and metastasis of lung cancer and it may be used as a marker with diagnostic and prognostic significance.

• Journal of Gastric Cancer
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• v.3 no.4
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• pp.191-194
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• 2003

Purpose: Neuroendocrine carcinomas of the stomach account for only about $0.3\%$ of all gastric tumors. The prognosis of this disease is very poor compared with the common type of gastric adenocarcinoma. The purpose of this retrospective study was to review the clinicopathologic features of 18 cases of this unusual gastric tumor and to establish a treatment strategy for this tumor. Materials and Methods: Excluding 2 cases of non-curative resection and 1 case of operative mortality, 18 cases of typical neuroendocrine carcinoma who had curative resection from January 1991 to December 2000 at Asan Medical Center were analyzed; 6841 gastric cancer patient were treated surgically during the same period. Results: The mean age at the time of diagnosis was 58.6 years (range: $35\∼75$ yr). Sixteen patients were male, and two were female. Eleven tumors ($61.1\%$) developed in the lower part of the stomach, three ($16.7\%$) in the middle part, and three ($16.7\%$) in the upper part. One tumor involved the entire stomach. Eight cases ($44.4\%$) were Borrmann type 2, and six case ($33.3\%$) were Borrmann type 3. The mean tumor size was 6.94 cm (range: $0.6\∼15$ cm). Nine cases ($50\%$) showed recurrence of the disease, and eight of them died within 20 months. Of the nine recurred cases, 7 cases ($77.8\%$) showed liver metastasis. The mean disease-free interval was 6.8 months (range: $2.5\∼11$ months) after surgical resection, and the mean survival was 17.9 months (range: $8\∼40$ months) for recurrence cases. One patient with liver metastasis was treated with a liver-wedge resection just after diagnosis and was still alive for 37.5 months postoperatively. There were 9 deaths after the median follow- up period of 40 months (range: $8\∼72$ months). Conclusion: Gastric neuroendocrine carcinomas frequently recur at the liver, even in early stage cancer, and have a poor prognosis. We experienced a case of successful control of hepatic metastasis by surgical resection and a case of a small cell carcinoma which was successfully controlled with systemic chemotherapy.

• Journal of Gastric Cancer
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• v.8 no.4
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• pp.204-209
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• 2008

Purpose: The goal of this study was to review the clinicopathologic characteristics of neuroendocrine tumor (NET) of the stomach. Materials and Methods: We retrospectively reviewed the medical records of 13 patients who were diagnosed with neuroendocrine tumor from January 1999 to August 2007 at Kosin Medical Center; 4,159 gastric cancer patients were treated surgically during the same time. The average follow up period was 14.3 months. Results: The majority of 13 patients were men (male-female ratio: 11:2) and the average age of patients with NET was 59.4 years (range: 42~72 years). The presenting symptoms were mostly epigastric pain and soreness. The tumor was limited to the mucosa or submucosa in two cases, and the tumor extended beyond the muscle layer in 11 cases. The mean size of the tumor was 7.0 cm, ranging from 0.7 cm to 15 cm. The type of the NEC (according to the WHO classification) was type 3 for eight patients, type 4 for four patients and type 1 for one patient. Regional lymph node metastasis was noted in 11 patients. Four cases showed recurrence of disease and the site of recurrence included liver in two patients, multiple organs (including the peritoneum and lung) in one patient and multiple organs (including liver, pancreas and duodenum) in one patient. The recurrent cases were type 3 and type 4 and the average survival period of the recurrent patients was 12.8 months. Conclusion: The majority of neuroendocrine tumors of the stomach were at an advanced stage at the time of diagnosis. These tumors frequently recurred in the liver and they have a poor prognosis.

• Journal of the Korean Society of Radiology
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• v.85 no.2
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• pp.421-427
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• 2024

Ectopic breast tissue can develop along the mammary ridge from the axilla to the groin, and the most common site is the axillae. Primary carcinoma of ectopic breast tissue is extremely rare. We report a rare case of a 61-year-old woman with a palpable mass in her left axilla who had a history of surgical excision of accessory breast tissue in the same area. Mammography (MMG), including axillary tail view, ultrasound (US), and breast MRI were performed. We evaluated the extent and characteristics of the microcalcifications in the axillary tail view. A US-guided biopsy was done, and histopathology revealed an invasive ductal carcinoma. Enhanced abdominal CT revealed multiple hepatic masses consistent with metastases, and the patient received palliative chemotherapy. Herein, we present a rare case of breast cancer arising from accessory breast tissue in the axilla, best appreciated on the axillary tail view of the patient's MMG.

• Proceedings of the KIEE Conference
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• 2005.11b
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• pp.162-164
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• 2005

This paper presents an hour-ahead System Marginal Price (SMP) forecasting framework based on a neural network. Recently, the deregulation in power industries has impacted on the power system operational problems. The bidding strategy of market participants in energy market is highly dependent on the short-term price levels. Therefore, short-term SMP forecasting is a very important issue to market participants to maximize their profits. and to market operator who may wish to operate the electricity market in a stable sense. The proposed hybrid neural network is composed of tow parts. First part of this scheme is pattern classification to input data using Kohonen Self-Organizing Map (SOM) and the second part is SMP forecasting using back-propagation neural network that has three layers. This paper compares the forecasting results using classified input data and unclassified input data. The proposed technique is trained, validated and tested with historical date of Korea Power Exchange (KPX) in 2002.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2008.10b
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• pp.656-663
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• 2008

XML 기술의 발전에 따라 확장성 있는 ebXML(Electronic Business eXtensible Markup Language) 기반의 스키마 사용이 확장되면서 점차 기존 EDI 전자문서나 DTD(Document Type Definition) 구조로 되어 있는 전자문서를 XML 스키마 형태로 변환하거나 새롭게 개발해고 있는 추세이다. 한국전자거래진흥원에서는 XML 전자운세 개발 지침과 함께 XML 라이브러리를 개발하여 제시함으로써 표준 XML 전자문서의 개발을 지원하고 있다. XML 전자문서 개발 지침은 ebXML CCTS 기술규격에서 제시하고 있는 방법론을 준용하고, UN/CEFACT ATG 그룹에서 개발한 XML Naming & Design Rule 규격을 국내에 맞게 수정하여 적용하고 있다. 또한 XML 라이브러리는 전자문서 개발지침에 따라 사전에 정의하고 개발해 놓은 핵심 컴포넌트와 비즈니스 정보 개체들로 구성되어 있다. 하지만 전자문서개발 지침상의 일부 규칙들이 의미상 명확하지 않은 상태에서 개발자의 임의적 선택의 폭을 허용하거나 개체의 명명에 대한 뚜렷한 기준을 제시하지 못함으로써 핵심 컴포넌트와 비즈니스 정보 개체의 검색 및 재사용을 제한하고 라이브러리 유지보수를 어렵게 하고 있는 실정이다. 본 연구에서는 XML 전자문서 개발지침 상의 일부 규칙에 대한 문제점을 분석, 규칙을 구제화함으로써 개발자 중립적인 핵심 컴포넌트와 비즈니스 정보 개체의 개발을 지원하고 라이브러리 관리를 효율적으로 수행할 수 있는 방안을 제시하고자 한다.

• The Journal of Dong Guk Oriental Medicine
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• v.4
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• pp.327-338
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• 1995

The purpose of this study is to observe the effect of Nanganjeon on serum reaction in $CCl_4$ treated rats. In this study, the experimental rats divided four group(Control group, $CCl_4$ group, Haeganjeon group, and Sample group) : Under the same condition, control group were administered water, sample group were administered Nanganjeon for 7days. And then, both $CCl_4$ group and sample group were injected to abdomen with $CCl_4$ for 1days. The change of GOT, GPT, ALP, LDH, and bile acid activity in blood serum. The obtained results are summarised as follows : 1. In the change of SGOT, SGPT contents, as compared with control group, sample group was significantly decreased. 2. In the change of serum ALP contents, as compared with control group, sample group was significantly decreased. 3. In the change of serum bile acid contents, as compared with control group, sample group was significantly decreased. 4. In the change of serum LDH contents, as compared with control group, sample group was significantly decreased.

• The Journal of Dong Guk Oriental Medicine
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• v.4
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• pp.313-325
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• 1995

The purpose of this study is to observe the effect of Whaganjeon on serum reaction in $CCl_4$ treated rats. In this study, the experimental rats divided four group(Control group, $CCl_4$ group, Whaganjeon group, and Sample group) : Under the same condition, control group were administered water, sample group were administered Whaganjeon for 7days. And then, both $CCl_4$ group and sample group were injected to abdomen with $CCl_4$ for 1days. The change of GOT, GPT, ALP, LDH, and bile acid activity in blood serum. The obtained results are summarised as follows : 1. In the change of SGOT, SGPT contents, as compared with control group, sample group was significantly decreased. 2. In the change of serum ALP contents, as compared with control group, sample group was significantly decreased. 3. In the change of serum bile acid contents, as compared with control group, sample group was significantly decreased. 4. In the change of serum LDH contents, as compared with control group, sample group was significantly decreased.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.4
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• pp.78-85
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• 2006

A person's body resistance in the waterpark, public bath and similar places is much lower than any other places due to effect of water. So low voltage may create a shock hazard for the human body in case of leakage or fault currents from lighting unit etc. We researched the related regulations which are internal standards, NEC, IEC and investigated the actual conditions for the prevention of electric shock due to lighting units in the waterpark, public bath and similar places. As a results internal standard is obscure as compared with NEC, IEC which is the limit of application and distinction of environment condition. And then internal standard's using voltage is higher than NEC, IEC in filed of water. Studies show that internal standard should be revision that raise the installation height of lighting unit, mark IP level surface of lighting unit and limit using voltage to line-to-line voltage