• Childhood Kidney Diseases
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• v.4 no.1
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• pp.48-56
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• 2000

Purpose: Alport SD., the most common herectitary rephriris, is a renal disease with rapid progression. Deafness, ocular abnormalities and a specific EM finding may be associated in addition to a family history. We have aralyged retrospectively. Methods: We observed 12 children with Alport syndrome who were diagnosed at Dept. of pediatrics in Kyunghee Univ., College of Medicine, from Apr. 1991 until Jun. 1999. We used four criteria for diagnosis: renal disease, family history, deafness or eye abnormalities, and a specific finding in electron microscopy Results: 2 of 12 patients had all features of the four diagnostic criteria. We could not trace an exact family history in 3 patients, and 6 patients did not exhibit deafness or eye abnormality. One could not have renal biopsy because offer chronic renal failure. Other three criteria were observed in her. The ratio of male to female observed was 1:2 respectively and the mean age of initial renal symptom was 5.6 years. 9 of 12 patients had a family history of renal disease. In the audiogram and ocular examination for 11 of 12 cases, sensorineural hearing loss was observed in 6 and ocular abnormality in 2 cases. In electron microscopic finding, irregular thickness of the capillary basement membranes with lamination of lamina densa and foot process obliteration was noted in 9 of 11 and thin basement membrane with splitting and foot process obliteration was noted in the other 2. The mean period of follow-up was 3 6/12 years. And one patient developed the chronic renal failure until now and had kidney transplantation. Conclusion: For the diagnosis of Alport syndrome, the following four diagnostic criteria are very important : renal disease, family history, deafness or eye abnormalities, and a specific finding on electron microscopy. We expect that more patients can be detected through the analysis of these characteristics.

• The Korean Journal of Physiology
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• v.8 no.1
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• pp.27-30
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• 1974

It was planned to evaluate the influence of Panax Ginseng upon hepatic DNA synthesis in mice by observing incorporation of $[^3H]$ thymidine into the tissue cells. Thirty male mice$(body\;weight:\;18{\sim}20\;g)$ were divided equally into the ginseng and the saline groups. Each animal of the ginseng and the saline groups received every day (subcutaneously) 0.05 m1/10 g body weight of ginseng extract (4mg of ginseng alcohol extract in 1 ml of saline) and the same amount of saline, respectively, for 5 days. On the 5th experimental day, all animals received $1\;{\mu}Ci/g$ body weight of $[^3H]$ thymidine intraperitoneally 2 hours after the last medication. Five animals, at a lime, of each group were sacrificed 1, 10, and 24 hours after thymidine administration, and their hepatic radioactivity was measured autoradiographically in terms of the % number of radioactive cells in 1,000 cell counts (Radioactive Index, R.I.). Following results were obtained: 1. The hepatic radioactive indices obtained from the saline group 1, 10, and 24 hour after $[^3H]$ thymidine administration were $3.23{\pm}0.23,\;5.20{\pm}0.21,\;and\;6.00{\pm}0.30\;(mean{\pm}S.D.)$, respectively. 2. The corresponding values obtained from the ginseng group $(4.22{\pm}0.33,\;6.32{\pm}0.32,\;and\;7.42{\pm}0.35)$ were significant higher than the values of the saline group. The inference from the above results was that the ginseng facilitated hepatic DNA synthesis.

• Korean Journal of Biological Psychiatry
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• v.15 no.2
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• pp.83-91
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• 2008

Objectives : Neurological soft signs have been regarded as endophenotypes associated with the genetic basis of schizophrenia. This study was to investigate the intra-familial correlations of the neurological soft signs according to their genetic loading. Methods : Schizophrenic patients(N=14) were included, who had one parent with a family history of schizophrenia and the other without it. Genetic loading was determined by the patient's family history of schizophrenia using the Family Interview for Genetic Studies(FIGS). These parents were subdivided into two groups. The first group was designated as 'presumed carriers'(N=9) of genetic loading, who had one or more schizophreic firstor second-degree relatives. The second group was designated as 'presumed non-carriers'(N=11) of genetic loading, who had no schizophrenic first- or second-degree relatives. Normal controls(N=12) consisted of people without schizophrenic relatives. NSS were evaluated using the Neurological Evaluation Scale-Korean Version (NES-K), and the intra-familial correlations of NSS were tested using the Intra-Class Coefficients(ICC) method. Results : The scores of Motor Coordination subdimension of NES-K were significantly correlated between the patients and their presumed carriers(ICC=.804, p=.016), but not significantly correlated between the patients and their presumed noncarriers. In other subdimensions of NES-K, no significant correlation were found between the patients and their parents regardless of the genetic loading. But, there were no statistically significant differences in the scores of Motor Coordination subdimension of NES-K between the patients and controls. Conclusion : This study did not prove that the neurological soft signs might be an endophenotype of schizophrenia that cosegregate with the genetic loading. The future study using more subjects than this would be needed.

• Journal of Acupuncture Research
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• v.17 no.3
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• pp.69-74
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• 2000

이 연구는 안면마비의 재발환자에 대한 한의학적인 원인 및 발생빈도, 나이분포, 재발기간, 가족력, 당뇨와의 관계를 파악하고자 한 것이다. 안면마비는 한방병원을 찾는 환자의 주요한 질환의 하나로서 침치료에 의해 좋은 효과를 보여왔으며 이에 대한 많은 연구가 있었으나 그 재발율에 대한 구체적인 연구는 없었다. 이에 본 연구에서는 경희의료원 한방병원 침구과에 내원한 안면마비 외래환자를 대상으로 초발, 동측재발, 대측재발로 나누어 단면적 분석연구를 시행하였다. 통계처리는 SPSS 8.0를 이용하였으며 chi-square test를 시행하였다. 544명의 외래환자중 7.4%의 재발율을 나타냈으며 동측재발과 건측재발은 통계상 유의성은 없었다. 또한 재발환자의 남여비에 대한 비율은 통계상 유의성이 없었다. 재발된 환자의 평균나이는 46.8세 이었고 재발기간은 8.74년이었다. 재발된 확률은 40세에서 59세 까지 높게 나타났다. 재발된 원인으로는 과로가 가장 높은 빈도를 보였으며 풍한, 정신적인 원인, 음주순으로 나타났다. 안면마비가 재발된 환자중에 당뇨병의 기왕력이 있는 자는 22.5%였으며 안면마비의 가족력은 42.5%의 높은 비율을 나타내었다.

• Journal of Hospice and Palliative Care
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• v.14 no.1
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• pp.20-27
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• 2011

Purpose: The purpose of this study was to investigate the effects of Death Education Program which had been provided to family caregivers of disabled individuals. A single group pretest-posttest design was employed for this study, which was conducted at a community rehabilitation center located in Ulsan, South Korea. Methods: Death Education Program was conducted for 16 family caregivers of disabled individuals who agreed to participate in this study. A 2.5-hour session was conducted once a week for 10 weeks. To investigate the effects of the education program, structured questionnaires, which assessed the patients and their family member's conceptions on the meaning of life, and their resilience, burden, and attitude towards death, were administered before and after the program. Results: The subjects' conception of the meaning of life and resilience did not significantly change. The median scores for the burden of family caregivers declined, while those for the subjects' attitude towards death increased, after attending the education program. Conclusion: The findings showed that Death Education Program has an affirmative effect on the burden of family caregivers of disabled individuals and their attitude towards death.

• Childhood Kidney Diseases
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• v.5 no.1
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• pp.36-42
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• 2001

Purpose : Vesicoureteral reflux is the most commonly inherited disease detected in children with urinary tract infection. The incidence of vesicoureteral reflux among siblings of children with known vesicoureteral reflux is 8$\%$ to 45$\%$ according to different authors. Family screening of a patient with vesicoureteral reflux is important in order to prevent reflux nephropathy. The purpose of this study is to determine the incidence of vesicoureteral reflux in asymptomatic family of children with vesicoureteral reflux and the factors which influence the family history. Methods : The study group consisted of 27 families of patients with vesicoureteral reflux. The total number in the group were 79 persons. BUN, Cr, urineanalysis, voidingcystourethrography(VCUG) and 99mTc -dimercaptosuccinic acid(DMSA) renal scan were performed oil tile siblings. As for tile parents the same tests were performed except the VCUG. Results : The abnormality was detected in 7 of 27 families(25.9$\%$). Vesicoureteral reflux was detected in 5 of 20 siblings and renal scar ns detected in 3 of 32 parents. In children with vesicoureteral reflux, renal scar was detected in 24 of 32 children. Between the group with the abnormality in its family(Group A) and the group without the abnormality in its family(Group B), There was no difference of creatinine clearance between two groups. More renal scars were detected in group A according to the DMSA(A:100$\%$, B:75$\%$. t-test P<0.05). There was no difference of grade of VCUG between two groups. There was no difference between one site and both sites in two groups. In tile case of tile siblings with vesicoureteral reflux, there was high incidence of renal scar in a patient with vesicoureteral reflux according to the DMSA. Conclusion : It is important to screen vesicoureteral reflux and renal scar in case of urinary tract infection to prevent reflux nephropathy. This study implies that it is necessary to screen the family of a patient with vesicoureteral reflux especially with renal scar. (J, Korean Soc Pediatr Nephrol 5 : 36- 42, 2001)

• Korean Journal of Social Welfare
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• v.52
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• pp.63-87
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• 2003

Our society has had a growing interest in a family volunteering activity which has been proposed to be helpful to strengthen the health of the families. Thus this could be a new alternative strategy for motivating a family life as well as activating a volunteering activity which takes a major portion in the source for social welfare, as a precautionary measure against various social problems. This research therefore studied the effects of the family volunteering activity on the status of family health on the purpose for providing social work implications to activate family volunteering and to enhance the degree of family health. The study subjects were whole family members in Korea (n=494) who had participated in a family volunteering program more than 6 months (experimental group). The control subjects (n=534) were from family members without having an experience in a family volunteering program (control group). The results demonstrated that experimental group experiencing family volunteering activities represents significantly higher status of family health regarding all the study fields, e.g., family values in common, autonomy or flexibility for family, family commitment, communication within a family, family oriented problem-solving ability, compared with control group. Even the cases of control group which were regularly engaged in the social activities together, showed the lower status of family health, as compared with families having experiences in the family volunteering activity. Accordingly, family volunteering experiences has taken more favorable influences upon the status of family health than any other family activities. Therefore, the present study suggests as follows for activating family volunteering activities: 1) the development and management of programs suitable for the voluntary activities of a family unit; 2) the flexible application of the concept of family volunteering; 3) the necessity of connection between various institutions which perform family volunteering services; 4) flexible work system based on individuality getting ready for the time for the family volunteering activity; and 5) the development of the circumstances for family members who need to be taken care of.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.1
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• pp.74-80
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• 1999

A family is presented in which multiple odontogenic keratocysts have been expressed. 3 members of the two generations of family with features of multiple keratocysts, suspected basal cell nevus syndrome have been investigated. The proband, 19-year-old woman and her mother, and her brother suffered from these cysts and two female patients' disease have been recurred multiply though careful treatments. Close attention to the family and routine follow up will alert the clinician to its recurrences and genetic counseling and serial screening for the development of other symptoms, that is malignant skin carcinoma etc.

• Journal of Digital Convergence
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• v.17 no.7
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• pp.179-186
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• 2019

This study was to investigate the factors influencing colorectal cancer(CRC) screening behavior using the health belief model(HBM). It was a descriptive cross-sectional survey. A total of 148 adults aged 50 or older participants were surveyed using structured questionnaires including general characteristics,, health beliefs, and behavioral variables. The data were analyzed by descriptive statistics, t-test, chi-square test and multiple logistic regression using SPSS/WIN 25.0 program. The significant factors influecing CRC screening behavior were perceived sensitivity, spousal experience of CRC screening and family history. Therefore, in order to improve the CRC screening rate, it is necessary to increase the perceived sensitivity through systematic education about the importance of early CRC screening. In addition, it is necessary to assess the spousal screening experience and the family history of subjects and to develop the education program using the partnership of the couple.

• Journal of Families and Better Life
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• v.13 no.1
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• pp.47-57
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• 1995

본 연구는 노부모부양가족의 어려움과 요구에 적합한 프로그램을 개발하여 노부모를 부양하는 성인자녀를 실제적으로 도와주고 그들의 부양부담감을 감소시키고자 하는 데에 목적이 있다. 이러한 목적을 위해서 일차적으로 우리나라 노부모 부양가족의 요구가 고려된 실험적 노부모 부양가족 프로그램을 구상하였다. 구상된 프로그램으로 노부모가 한분이라도 생존해 계신 여덟명의 교육대상을 소규모 집단으로 모집하여 시범교육을 실시하였다. 실시과정에서 파악되는 문제점과 개선점을 검토하고 사전 검사후 사후 검사를 2회 실시하여 프로 그램의 효과를 검증평가하였다. 그 결과 본 프로그램의 참여가 프로그램의 목적과 관련된 부양에 필요한 지식정보와 자기결단 및 통제력 수준을 향상시키고, 부양자로 하여금 보다 긍정적인 노부모 부양태도나 인식을 가지게 한 것으로 나타나 프로그램의 효과성을 입증해 주었다.