• Journal of Life Science
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• v.19 no.5
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• pp.607-614
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• 2009

This study was carried out to investigate the anticarcinogenic and antioxidative activities of Hemicentrotus pulacherrimus (HP). HP was extracted with methanol (HPM), which was then further fractionated into four sub-fractions by using the solvent partition method, affording methanol (HPMM), hexane (HPMH), butanol (HPMB) and aqueous (HPMA) soluble fractions. We determined the anticarcinogenic activities of these four fractions in four kinds of cancer cell lines, such as HepG2, HT29, MCF-7 and B16-F10, by MTT assay. Among various fractions from HPM, the HPMH showed the strongest growth inhibition effect. We also determined the inductive effect on quinone reductase (QR) of HP fractions. HPMB fraction exhibited strong inductive effects in HepG2 cells at a level of 90 ${\mu}g/ml$, showing inductive indexes of 2.26 compared to the control value of 1.0. The antioxidant activities of fractions from HP were also investigated by measuring the scavenging activities of HP against reactive oxygen speicies (ROS), peroxynitrite (ONOO-) and NO. Among the various solvent fractions, HPMH fractions displayed marked antioxidative activities.

• Korean Journal of Medicinal Crop Science
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• v.10 no.2
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• pp.139-143
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• 2002

Ixeris dentate was used to extract the natural compounds with methanol and then the extracts were further fractionated using n-hexane, ethyl acetate, butanol and aqueous fraction. The methanol extract of Ixeris dentate had strong antimutagenic effect in Ames mutagenicity test. Among the extracts fractioned from the methanol extract, the butanol fraction exhibited the greatest antimutagenic effect suppressing the mutagenicity of Salmonella typhimurium TA100 with inhibition rate of 88.93%. Cancer cell lines include human lung carcinoma(A549), human breast adenocarcinoma(MCF-7) and human hepatocellular carcinoma(Hep3B). Hexane fraction showed the strongest effect against A549, MCF-7 and Hep3B at the same concentration compared to those of other fractions.

• Journal of Music and Human Behavior
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• v.9 no.2
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• pp.1-17
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• 2012

The purpose of this study was to analyze data regarding the effects of group music therapy with adolescents. 27 master's, doctorial theses and published articles between 2000 and 2012 were selected for meta analysis. Subjects, independent variables, dependent variables, and the number of session were used to compare the effectiveness of group music therapy program. 49 effect sizes using means and standard deviation from 27 studies were calculated. The results were as follows. The overall mean effect size was -0.14, which is small size effect, according to Cohen's ES interpretation criteria. The mean ES was influenced by the subjects(adolescents/maladjustment students/addictive students/students in facility), the ES of adolescents was the biggest. However there were no significant difference among subjects. During the independent variables(active music therapy/receptive music therapy/combined music therapy), combined music therapy showed the biggest efficacy. When results were sorted by the dependent variables (social/emotional/behavior/cognitive category), the ES of behavioral category was the biggest. However, there was no significant difference among them. The ES of 11~15 session was the most effective.

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2005.10a
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• pp.294-296
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• 2005

Lactobacillus 및 Streptococcus 속의 유산균을 사용하여 유산균이 가지는 항산화 효과를 측정하였다. DPPH 법을 사용하여 전자공여능을 측정한 결과, L. casei가 43.54%로 가장 높았으며 L. acidophilus는 33.43%, 그리고 S. thermophilus가 7.1%로 가장 낮은 항산화 효과를 나타내었다. 유산균 파쇄액의 SOD 유사활성은 L. acidophilus가 15.68%, L. casei는 19.86%, S. thermophilus는 49.3%로 전자공여능의 측정 결과와는 달리 S. thermophilus가 가장 뛰어난 SOD 유사활성을 나타내었다.

• Environmental and Resource Economics Review
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• v.5 no.1
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• pp.113-136
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• 1995

자원 및 환경이 경제에 미치는 영향이 큼에도 불구하고 경제-환경의 상관관계를 분석하는 방법은 아직 초보 단계에 있다. 본 연구에서는 UN, 세계은행, 멕시코 정부가 구축한 환경계정(環境計定)을 한 국가의 경제상태를 사회계정에 도입한 후, 환경(環境)-사회계정(社會計定)(ESAM) 행렬을 구축하고, Pyatt와 Round의 분할 행렬 방법에 의해서 직 간접 파급승수 효과를 측정하여, 환경관련 외생변수가 경제변수에 미치는 효과를 분석하였다. 분할 행렬 분석 결과, 농업관련 외생변수에 변화가 있으면 제조업 부문과 상업부문, 민간 서비스부문(금융, 보험, 부동산)이 가장 크게 영향을 받는 것으로 나타났다. 또한 레온티에프의 승수효과와 유사한 전이효과(轉移效果)는 순수한 간접효과인 순환효과의 상쇄로 인해 기존의 산업 연관분석에 의존한 분석은 경제와 환경의 관계를 과대추정할 수 도 있다는 것이다. 자본 투자가 5% 감소할 경우, 경제 전 부문에 상당한 영향을 준 것으로 나타났으며 생산부문에서는 임업, 건설업이 가장 영향을 받으며, 환경부문에서는 토양의 침식으로 인한 환경서비스의 감소가 가장 크게 영향을 받는 것으로 추정되었고 수산자원 또한 많은 영향을 받는 것으로 나타났다.

• The Korean Journal of Applied Statistics
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• v.15 no.2
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• pp.269-279
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• 2002

We considered the problem for confirmation of multiple outliers and leverage points. Identification of multiple outliers and leverage points is difficult because of the masking effect and swamping effect. Rousseeuw and van Zomeren(1990) identified multiple outliers and leverage points by using the Least Median of Squares and Minimum Value of Ellipsoids which are high-breakdown robust estimators. But their methods tend to declare too many observations as extremes. Atkinson(1987) suggested a method for confirming of outliers and Fung(1993) pointed out Atkinson method's limitation and proposed another method by using the add-back model. But we analyzed that Fung's method is affected by adjacent effect. In this thesis, we proposed one procedure for confirmation of outliers and leverage points and compared three example with Fung's method.

• Journal of Life Science
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• v.17 no.10
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• pp.1368-1373
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• 2007

Inhibitory effects of several solvent fractions from soybean on mutagenicity using Salmonella typhimurium TA 100 in Ames test and growth of human cancer cells (AGS gastric adenocarcinoma, Hep 3B hepatocellular cancinoma and HT-29 colon cancer cells) were studied. The treatment of dichloromethane and ethylacetate fractions (2.5 mg/assay) extracted from soybean to Ames test system inhibited aflatoxin $B_1\;(AFB_1)$ induced mutagenicity by 83%, respectively, and showed a higher antimutagenic effect than other solvent fractions. In case of N-methyl-N#-nitro-N-nitrosoguamidine (MNNG) induced mutagenicity, the ethylacetate fraction showed the highest inhibitory effect (by 67%) among solvent extracts, although the inhibitory effect was not stronger compared with $AFB_1$ induced mutagenicity. In sulforhodamine B (SRB) assay, the treatment of ethylacetate fraction (2 mg/assay) significantly inhibited the growth of AGS, Hep 3B and HT-29 cancer cells by 66%, 73% and 77%, respectively, followed with the intermediate and dichloromethane fractions. These results indicated that soybean fraction extracted with ethylacetate had higher inhibitory effects on $AFB_1$ and MNNG in Ames test and growth inhibition activity to human cancer cells was appeared, suggesting that soybean fraction extracted with ethylacetate may contain the biologically active compounds.

• Journal of Life Science
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• v.18 no.4
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• pp.467-473
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• 2008

This study was performed to investigate the antioxidant effect of 80% ethanol extracts from Pimpinella brachycarpa in vitro. The extraction yields of 80% ethanol extract was 9.23 g/100 g. The extract was further fractionated subsequently by n-hexane, chloroform, ethylacetate, n-butanol and water. Water fraction showed the highest extraction yield among fractions. Antioxidative activities of different fractions were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical generation, Rancimat test, thiobarbituric acid (TBA) value, nitrite scavenging activity, inhibition of lipid peroxidation and peroxide value in linoleic acid in comparison with the commercial antioxidant butylated hydroxytoluene (BHT). Antioxidant activities of n-hexane fraction of Pimpinella brachycarpa ethanol extract were the highest among fractions. Furthermore, the antioxidative capacity of the n-hexane fraction was similar to that of BHT.

• The Korean Journal of Food And Nutrition
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• v.13 no.3
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• pp.249-254
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• 2000

산초종피 메탄올 추출물과 heperoside의 사전투여가 사염화탄소에 의해 예상되는 혈청지질설분의 농도 변화에 미치는 효과를 밝히기 위해 ICR계 mouse를 대상으로 실험한 결과는 다음과 같다. 사엽화탄소로 혈청 총콜레스테롤 농도가 유의적으로 증가되었으나, 산초 메탄올 추출물과 hyperoside의 사전투여는 사염화탄소에 의한 이의 증가를 유의적으로 억게시켰으며, 20mg/kg hyperoside투여군에서 그 효과가 가장 높았다. 사염화탄소로 혈청 HDL-cholesterol농도가 유의적으로 감소되었으나, 산초 메탄올 추출물과 hy-peroside의 사전투여는 사염화탄소에 의한 이의 감소를 유의적으로 억제시켰으며, 20mg/kg hyperoside투여군에서 그 효과가 가장 높았다. 사염화탄소로 혈청 LDL-cholesterol농도가 유의적으로 증가되었으나, 산초 메탄올 추출물과 hyperoside의 사전투여는 사염화탄소에 의한 이의 증가를 유의적으로 억제시켰으며, 20mg/kg hyperoside 투여군에서 그 효과가 가장 높았다. 사염화탄소로 혈청 triglyceride 농도가 유의적으로 증가되었으나, 산초 메탄올 추출물과 hyperoside의 사전투여는 사염화탄소에 의한 이의 증가를 유의적으로 억제시켰다.

• Korean Journal of Food Science and Technology
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• v.19 no.6
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• pp.556-560
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• 1987

In this study, silicone oil was added into soybean oil in order to investigate its effect on acid value (AV), carbonyl value (COV), TBA value, fatty acid composition and color intensity of soybean oil during frying at $170^{\circ}C$. It was found that the AV, COV and TBA value were significantly decreased as the concentration of silicone oil increased from 0 to 5 ppm in soybean oil after frying for 7 hours. The color intensity was also decreased by 26% of color of 7 hours-heated soybean oil without silicone oil addition. Little changes in fatty arid composition was measured between the samples after 7 hours frying. From the overall result of this study, addition of silicone oil by 1 ppm was recommended for effective reduction of rancidity development of soybean oil ing frying.