• Title/Summary/Keyword: 가소제

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Residue levels of phthalic acid esters (PAEs) and diethylhexyl adipate(DEHA) in various industrial wastewaters (업종별 산업폐수 중 프탈산에스테르와 디에틸헥실아디페이트의 잔류수준)

  • Kim, Hyesung;Park, Sangah;Lee, Hyeri;Lee, Jinseon;Lee, Suyeong;Kim, Jaehoon;Im, Jongkwon;Choi, Jongwoo;Lee, Wonseok
    • Analytical Science and Technology
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    • v.29 no.2
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    • pp.57-64
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    • 2016
  • Many phthalic acid esters (PAEs), including DMP, DEP, DBP, BBP, and DEHP, as well as DEHA are widely used as plasticizers in plastics. An analytical method was developed and used to analyze these compounds at 41 industrial facilities. The coefficient of determination (R2) for each constructed curve was higher than 0.98. The method detection limit (MDL) values were 0.4–0.7 μg/L for PAEs and 0.6 μg/L for DEHA. In addition, the recovery rate was shown to be 77.0–92.3%, while the relative standard deviation was shown to be in the range of 5.8-10.5%. DMP (n = 3), DEP (n = 2), DBP (n = 2), BBP (n = 2), and DEHA (n = 3) were detected in the range of 2.2-11.1% in the influent. DEHP was a predominant compound and was detected at > MDL in both the influent (n = 16, 35.6%) and the effluent (n = 4, 10.0%) at a high removal efficiency (92–100%). The highest levels of residue in industrial wastewater influent were 137.4 μg/L of DEHP at plastic products manufacturing facility, 12.5 μg/L of DEHA at a chemical manufacturing facility, and 14.0 μg/L of DEP at an electronics facility. The highest concentration of effluent was 12.5 μg/L of DEHP at a chemical manufacturing facility, which indicated that the effluent was below the allowable concentration (800 μg/L). Therefore, the levels of PAEs and DEHA that are discharged into nearby streams could not influence the health of the ecosystem.

Effects of Endocrine Disruptors on the Expression of Estrogen Receptors in Ovary and Uterus from Immature Rats (내분비계 장애물질이 미성숙한 흰쥐의 난소와 자궁에서의 에스트로겐 수용체 발현에 미치는 효과)

  • Lee, Kyeung-Yeup;Lee, Sung-Ho
    • Development and Reproduction
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    • v.10 no.4
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    • pp.255-261
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    • 2006
  • Although some phytoes rogens might have beneficiary rather than adverse effects, most endocrine disrupting compounds(EDCs) are considered to be harmful to human and wildlife health through interfering the endocrine system. Previously we found that prepubertal exposure to genistein(GS), a well-known isoflavone phytoestrogen, could activate the reproductive system of immature female rats resulting precocious puberty. Interestingly, di(2-ethyl hexyl) phthalate(DEHP) exposure brought inverse result, a delayed puberty, in the same experimental regimen. In this study, we examined whether prepubertal exposure to GS or DEHP affect the gene expressions of estrogen receptors($ER\;{\alpha}$ and $ER\;{\beta}$) and LH receptor(LHR) which represent the maturational status of ovary and uterus in immature rats. GS (100 mg/kg/day) was administered daily from postnatal day 25 to the day when the first vaginal opening(VO) was observed, and the animals were sacrificed on the next day(day 32). Similarly, DEHP(l00 mg/kg/day) was administered daily from postnatal day 25 through the day when the first V.O. in control group was observed, and the animals were sacrificed on the next day(day 36). To determine the transcriptional changes in the hormone receptors, total RNAs were extracted from ovary and uterus and were applied to semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). In the GS group, the transcriptional activities of $ER\;{\alpha}$, $ER\;{\beta}$ and LHR in uterus and LHR in ovary were significantly increased when compared to those of control group. In the DEHP group, the transcriptional activities of all the hormone receptors measured were significantly lowered when compared to those of control group. These alteration of the reproductive hormone receptor expressions in ovary and uterus might be represent the phenotypic aspects(secondary sexual characteristics) such as tissue weights and reproductive hormone levels during perinatal period in immature female rats.

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Effect of Prepubertal Exposure to Di(2-ethylhexyl)phthalate on the Maturation of Rat Seminal Vesicles and Prostate Glands (사춘기 전 수컷 흰쥐의 저정낭과 전립선의 성숙에 미치는 Di(2-ethylhexyl) phthalate(DEHP)의 영향)

  • Heo, Hyun-Jin;Lee, Won-Yong;Yoon, Yong-Dal;Choi, Donchan;Lee, Sung-Ho
    • Development and Reproduction
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    • v.12 no.3
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    • pp.251-259
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    • 2008
  • The plasticizer di(2-ethylhexyl)phthalate(DEHP) is one of the most well known endocrine disrupting chemicals (EDCs) because of its strong anti-androgenic effects on the reproductive and developmental process in male rodents and human. The present study was performed to examine whether prepubertal exposure to DEHP can make any alteration during the maturation of accessory sex organs in male rats. As a result, there was no significant change in body weights, serum T levels and tissue weights except of seminal vesicle and ventral prostate in DEHP-treated animals compared to vehicle-treated ones. The seminal vesicle weights in high-dose group (200 mg/kg) were significantly lower than those from the control group (p<0.05), and ventral prostate weights were significantly lower than those from the control group (p<0.05) in both low-dose (20 mg/kg) and high-dose group. Histological studies revealed that the seminal vesicles from DEHP-treated groups showed reduced areas of mucosal folds. Pseudostratified columnar epithelia were observed in the ventral prostates of DEHP-treated samples while cuboidal epithelia were found in the control group. The transcriptional activities of ER-$\alpha$ in seminal vesicle from high-dose group (p<0.05) were significantly higher than those from the control group, and ER-$\beta$ expression was significantly decreased in low-dose group (p<0.05) compared to the control. In ventral prostate, ER-$\beta$ mRNA levels from low-dose group (p<0.05) were significantly lower than those from the control group, and significantly increased in high-dose group (p<0.01). AR expressions, however, were not significantly different in all experimental groups of both seminal vesicle and ventral prostate. In conclusion, the present study demonstrated that (i) adverse effect (s) of DEHP on sexual maturation during prepubertal period could be limited, (ii) seminal vesicle and prostate gland were sensitive targets to DEHP in prepubertal rats and (iii) the deleterious effects of DEHP might be mediated through ER-associated mechanism.

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Role of Tumor-associated Macrophage in Tumor Microenvironment (암미세환경에서 종양관련대식세포의 역할)

  • Min, Do Sik
    • Journal of Life Science
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    • v.28 no.8
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    • pp.992-998
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    • 2018
  • Cancer cells grow in an environment composed of various components that supports tumor growth. Major cell types in the tumor microenvironment are fibroblast, endothelial cells and immune cells. All of these cells communicate with cancer cells. Among infiltrating immune cells as an abundant component of solid tumors, macrophages are a major component of the tumor microenvironment and orchestrates various aspects of immunity. The complex balance between pro-tumoral and anti-tumoral effects of immune cell infiltration can create a chronic inflammatory microenvironment essential for tumor growth and progression. Macrophages express different functional programs in response to microenvironmental signals, defined as M1 and M2 polarization. Tumor-associated macrophages (TAM) secret many cytokines, chemokines and proteases, which also promote tumor angiogenesis, growth, metastasis and immunosuppression. TAM have multifaceted roles in the development of many tumor types. TAM also interact with cancer stem cells. This interaction leads to tumorigenesis, metastasis, and drug resistance. TAM obtain various immunosuppressive functions to maintain the tumor microenvironment. TAM are characterized by their heterogeneity and plasticity, as they can be functionally reprogrammed to polarized phenotypes by exposure to cancer-related factors, stromal factors, infections, or even drug interventions. Because TAMs produce tumor-specific chemokines by the stimulation of stromal factors, chemokines might serve as biomarkers that reflect disease activity. The evidence has shown that cancer tissues with high infiltration of TAM are associated with poor patient prognosis and resistance to therapies. Targeting of TAM in tumors is considered a promising therapeutic strategy for anti-cancer treatment.

Preparation of Asymmetric Folyethersulfone Hollow Fiber Membranes for Flue Gas Separation (온실기체 분리용 폴리이서설폰 비대칭 중공사 막의 제조)

  • Kim Jeong-Hoon;Sohn Woo-Ik;Choi Seung-Hak;Lee Soo-Bok
    • Membrane Journal
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    • v.15 no.2
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    • pp.147-156
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    • 2005
  • It is well-known that polyethersulfone (PES) has high $CO_2$ selectivity over $N_2\;(or\;CH_4)$ and excellent pressure resistance of $CO_2$ plasticization among muy commercialized engineering plastics[1-4]. Asymmetric PES hollow fiber membranes for flue gas separation were developed by dry-wet spinning technique. The dope solution consists of PES, NMP and acetone. Water and water/NMP mixtures are used in outer and inner coagulants, respectively. Gas permeation rate (i.e., permeance) and $CO_2/N_2$ selectivity were measured with pure gas, respectively and the micro-structure of hollow fiber membranes was characterized by scanning electron microscopy. The effects of polymer concentration, ratio of NMP to acetone, length of air gap, evaporation condition and silicone coating were investigated on the $CO_2/N_2$ separation properties of the hollow fibers. Optimized PES hollow fiber membranes exhibited high permeance of $25\~50$ GPU and $CO_2/N_2$ selectivity of $30\~40$ at room temperature and have the apparent skin layer thickness of about $0.1\;{\mu}m$. The developed PES hollow fiber membranes, would be a good candidate suitable for the flue gas separation process.

Pervaporation Separation of Ethanol Aqueous Solution through Carbonate-type Polyurethane Membrane III. The Effect of Zwitterionic Group (카보네이트형 폴리우레탄막을 이용한 에탄올 수용액의 투과증발분리 III. 양쪽이온성기에 의한 영향)

  • Oh, Boo Keun;Lee, Young Moo;Noh, Si Tae
    • Applied Chemistry for Engineering
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    • v.3 no.4
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    • pp.605-613
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    • 1992
  • NCO-terminated prepolymers were synthesized by reacting carbonate-type polyol(PTMCG)($M_w=1,000$ and 2,000) with MDI and N-methyldiethanolamine, as a chain extender. Carbonate-type polyurethane containg zwitterionic group was prepared by reacting the prepolymer with 1,3-propane sultone. From the IR and NMR spectra of model reactions, it was known that the ionization occurred under the same condition. The structure of zwitterionic carbonate-type polyurethane(ZPU) therefore could be confirmed from the model reactions. Glass transition temperature(Tg) ranged between $-15{\sim}-30^{\circ}C$ from the thermal data. Tg was between $-15{\sim}-18^{\circ}C$ for a series of ZPU10 samples and between $-25{\sim}-26^{\circ}C$ for a series of ZPU20 polymers. Tensile strength increased with mole ratio of ionic content. On the contrary, elongation was rather dropped with mole ratio of ionic content. ZPU10-30 having better tensile strength and less elongation was selected as a membrane for the concentration of ethanol aqueous solution through pervaporation. To obtain the better selectivity, it was crosslinked with HMDI. In the swelling test, it showed the higher swelling degree at around 50wt% ethanol concentration due to the plastization effect of ethanol. To optimize the separation capacity, two operating factors-feed concentration and temperature-were considered. The overall separation capacity was as follows : separation factor, 2~83.2 ; the flux, $25.4{\sim}58.8g/m^2hr$.

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Studies on the N , $P_2O_5$ and $K_2O$-Application in the Mixed Sward of Alfalfa-Grass I. Effect of nitrogen fertilization on dry mixed sward of alfalfa-grasses (Alfalfa-Grass 혼파초지에 대한 3요소 시비 연구 I. 질소질비료의 시용수준이 alfalfa-grass 혼파초지의 건물 및 양분수량에 미치는 영향)

  • 박근제;최기준;이필상;김영진
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.15 no.3
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    • pp.169-174
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    • 1995
  • To investigate the effects of nitrogen(N) fertilization levels on the dry matter(DM) yield, nutrition yield, and N efficiency of forages in mixed sward of alfalfa-grasses, a field experiment arranged by randomized complete block design with five treatments(0, 70, 140, 210 and 280kg N/ha) was conducted at Livestock Experiment Station in Suwon, September, 1990 to February, 1993. During two years, average DM yields of forage increased as N fertilization level was increased, but no significant difference was found between DM 10,266kg of N 210kgha and DM 10,845kg of N 280kgha. Crude protein and energy productivity of forages increased as N fertilization level was increased, and the increasing degree was highest between N 140kg and 210kg/ha fertilization. With increasing N fertilization, mineral contents tended to decrease in P and K/Ca+ Mg equivalent ratios, to increase in Mg, but not to be regular in the other elements. Efficiency of N was highest at N 210kg/ha fertilization, which produced DM 21.6kg, net energy lactation 129.3 MJ, starch equivalent 12.3kStE and total digestible nutrients 14.5kg per Ikg N.

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Effects of Solvent Mixtures on Dispersion and Rheology of Alumina/zirconia Tape Casting Slurries (알루미나/지르코니아 테이프 케스팅 슬러리의 분산과 레올로지에 미치는 용매혼합의 영향)

  • Kim, Ji-Hyeon;Yang, Tae-Yeong;Lee, Yun-Bok;Yun, Seok-Yeong;Park, Heung-Chae
    • Korean Journal of Materials Research
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    • v.11 no.6
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    • pp.519-526
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    • 2001
  • The effects of methyl isobutyl ketone(MIBK)/ethanol(EtOH) solvent mixtures on the dispension, particle size distribution and rheology of $Al_2$O$_3$/ZrO$_2$ nonaqueous suspensions were investigated by measuring sedimentation density and viscosity. The sedimentation density of $Al_2$O$_3$ and ZrO$_2$ particles increased in MIBK-rich($\geq$60 vol%) solvents with 'Hypermer' KD-1 as a dispersant. The ball-milled suspensions in 80MIBK/20EtOH(vol%) solvent exhibited the narrow and unimodal particle size distribution. Although all Suspensions exhibited the Pseduo-Plastic flow(Shear thinning) the shear thinning behavior was somewhat different depending on the mixture ratio of $Al_2$O$_3$/ZrO$_2$ and MIBK/EtOH. Under a given shear rate( <300 s$^{-1}$ for $Al_2$O$_3$; <3000 s$^{-1}$ for ZrO$_2$) the strongest shear thinning appeared in the $Al_2$O$_3$ and ZrO$_2$ suspensions with pure MIBK solvent. The shear thinning was nearly independable on the mixture ratio of $Al_2$O$_3$/ZrO$_2$ in case of using the identical solvent(80MIBK/20EtOH, vol%).

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Vitrification of Highly Active Liquid Waste(II) (The thermal decomposition of HARVEST feed slurries and the characterization of the product)

  • Chun, K.S.;Morris, J.B.
    • Nuclear Engineering and Technology
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    • v.11 no.3
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    • pp.203-212
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    • 1979
  • The thermal decomposition of simulated Magnox highly active waste and of HARVEST feed slurries (SW and SG) which include tile glass forming chemicals has been studied. The waste and the slurries are almost completely calcined by 500-55$0^{\circ}C$. The colour of the solids from the slurries varies little until about 90$0^{\circ}C$ when it darkens considerably. The slurries begin to vitrify at this temperature and are completely vitrified at 1000-105$0^{\circ}C$. On the other hand. the sulphate impurity in SN slurry causes a yellow phase to separate above 75$0^{\circ}C$. The density of the intermediate solids is fairly low until 650$^{\circ}$-$700^{\circ}C$ is reached. This temperature seems to mark the onset of fluxing as tile density rises quickly to 2g/㎤ at 700$^{\circ}$ -80$0^{\circ}C$. The strengh of the solids decreases with temperature up to 50$0^{\circ}C$, and then rises as the solids begin to sinter. Below 50$0^{\circ}C$ the SN solids are the stronger. suggesting that the impurity renders this silica more reactive.

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A Study on Jurisdiction under the International Aviation Terrorism Conventions (국제항공테러협약의 관할권 연구)

  • Kim, Han-Taek
    • The Korean Journal of Air & Space Law and Policy
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    • v.24 no.1
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    • pp.59-89
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    • 2009
  • The objectives of the 1963 Tokyo Convention cover a variety of subjects, with the intention of providing safety in aircraft, protection of life and property on board, and promoting the security of civil aviation. These objectives will be treated as follows: first, the unification of rules on jurisdiction; second, the question of filling the gap in jurisdiction; third, the scheme of maintaining law and order on board aircraft; fourth, the protection of persons acting in accordance with the Convention; fifth, the protection of the interests of disembarked persons; sixth, the question of hijacking of aircraft; and finally some general remarks on the objectives of the Convention. The Tokyo Convention mainly deals with general crimes such as murder, violence, robbery on board aircraft rather than aviation terrorism. The Article 11 of the Convention deals with hijacking in a simple way. As far as aviation terrorism is concerned 1970 Hague Convention and 1971 Montreal Convention cover the hijacking and sabotage respectively. The Problem of national jurisdiction over the offence and the offender was as tangled at the Hague and Montreal Convention, as under the Tokyo Convention. Under the Tokyo Convention the prime base of jurisdiction is the law of the flag (Article 3), but concurrent jurisdiction is also allowed on grounds of: territorial principle, active nationality and passive personality principle, security of the state, breach of flight rules, and exercise of jurisdiction necessary for the performance of obligations under multilateral agreements (Article 4). No Criminal jurisdiction exercised in accordance with national law is excluded [Article 3(2)]. However, Article 4 of the Hague Convention(hereafter Hague Article 4) and Article 5 of the Montreal Convention(hereafter Montreal Article 5), dealing with jurisdiction have moved a step further, inasmuch as the opening part of both paragraphs 1 and 2 of the Hague Article 4 and the Montreal Article 5 impose an obligation on all contracting states to take measures to establish jurisdiction over the offence (i.e., to ensure that their law is such that their courts will have jurisdiction to try offender in all the circumstances covered by Hague Article 4 and Montreal Article 5). The state of registration and the state where the aircraft lands with the hijacker still on board will have the most interest, and would be in the best position to prosecute him; the paragraphs 1(a) and (b) of the Hague Article 4 and paragraphs 1(b) and (c) of the Montreal Article 5 deal with it, respectively. However, paragraph 1(b) of the Hague Article 4 and paragraph 1(c) of the Montreal Article 5 do not specify if the aircraft is still under the control of the hijacker or if the hijacker has been overpowered by the aircraft commander, or if the offence has at all occurred in the airspace of the state of landing. The language of the paragraph would probably cover all these cases. The weaknesses of Hague Article 4 and Montreal Article 5 are however, patent. The Jurisdictions of the state of registration, the state of landing, the state of the lessee and the state where the offender is present, are concurrent. No priorities have been fixed despite a proposal to this effect in the Legal Committee and the Diplomatic Conference, and despite the fact that it was pointed out that the difficulty in accepting the Tokyo Convention has been the question of multiple jurisdiction, for the reason that it would be too difficult to determine the priorities. Disputes over the exercise of jurisdiction can be endemic, more so when Article 8(4) of the Hague Convention and the Montreal Convention give every state mentioned in Hague Article 4(1) and Montreal Article 5(1) the right to seek extradition of the offender. A solution to the problem should not have been given up only because it was difficult. Hague Article 4(3) and Montreal Article 5(3) provide that they do not exclude any criminal jurisdiction exercised in accordance with national law. Thus the provisions of the two Conventions create additional obligations on the state, and do not exclude those already existing under national laws. Although the two Conventions do not require a state to establish jurisdiction over, for example, hijacking or sabotage committed by its own nationals in a foreign aircraft anywhere in the world, they do not preclude any contracting state from doing so. However, it has be noted that any jurisdiction established merely under the national law would not make the offence an extraditable one under Article 8 of the Hague and Montreal Convention. As far as international aviation terrorism is concerned 1988 Montreal Protocol and 1991 Convention on Marking of Plastic Explosives for the Purpose of Detention are added. The former deals with airport terrorism and the latter plastic explosives. Compared to the other International Terrorism Conventions, the International Aviation Terrorism Conventions do not have clauses of the passive personality principle. If the International Aviation Terrorism Conventions need to be revised in the future, those clauses containing the passive personality principle have to be inserted for the suppression of the international aviation terrorism more effectively. Article 3 of the 1973 Convention on the Prevention and Punishment of Crimes Against Internationally Protected Persons, Including Diplomatic Agents, Article 5 of the 1979 International Convention against the Taking of Hostages and Article 6 of the 1988 Convention for the Suppression of Unlawful Acts Against the Safety of Maritime Navigation would be models that the revised International Aviation Terrorism Conventions could follow in the future.

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