• 대한한방부인과학회지
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• 제22권4호
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• pp.149-156
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• 2009

Purpose: To evaluate the association of sasang constitution with bone mineral density (BMD) in postmenopausal Korean women. Methods: Sasang constitution was analyzed by Phonetic System for Sasang Constitution in 92 postmenopausal Korean. The BMD was checked using dual-energy x-ray absorptiometer(DEXA) at lumbar spine, femur neck. Results: Bone mineral density of lumbar spine(T-score) according to Sasang constitution was Taeumin($-1.12{\pm}1.26$), Soyangin($-1.30{\pm}1.06$), Soeumin($-1.51{\pm}1.21$). Bone mineral density of femur neck(T-score) according to Sasang constitution was Taeumin($-0.76{\pm}1.07$), Soyangin($-0.92{\pm}0.81$), Soeumin($-0.84{\pm}0.86$). Conclusion: There was significant relationship between sasang constitution and BMD of femur neck. There was no significant relationship between sasang constitution and BMD of lumbar spine.

• 대한한방부인과학회지
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• 제22권1호
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• pp.31-40
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• 2009

Purpose: This study was carried out to investigate the anti-tumor metastasis effect and activation of innate immunity by extracts of Mori radicis cortex. Methods: Anti-tumor metastatic experiment was conducted in vitro and in vivo by using colon 26-M3.1 carcinoma cell, L5178Y-R lymphoma cell and HeLa cell. To observe the activation of innate immunity by extracts of Mori radicis cortex, we estimated IL-6, IL-10, IL-12, TNF-${\alpha}$ from peritoneal macrophages. And we evaluated the activation of NK cell by using anti-asialo-GM1 serum. Results: We found that the administration of Mori radicis cortex extracts significantly inhibited tumor metastasis. In an in vitro cytotoxicity analysis, Mori radicis cortex affected tumor cell growth above specific concentration. Mori radicis cortex also stimulated peritoneal macrophage, which was followed by the production of various cytokines such as IL-6, IL-10, IL-12, TNF-${\alpha}$. The depletion of NK cells by anti-asialo GM1 serum partly abolished the inhibitory effect of Mori radicis cortex on tumor metastasis. Conclusion: Mori radicis cortex appears to have considerable activity on the anti-metastasis by activation of innate immunity.

• 대한한방부인과학회지
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• 제22권2호
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• pp.151-162
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• 2009

Purpose: The purpose of this study is to analyze the perception that gynecological surgery patients have on Traditional Korean Medicine(TKM) treatment. Methods: We studied the perception of TKM treatment by questionnaire from August, 2008 to Febrary, 2009 in Kyung-Hee University East-West Neo medical center. A questionnaire was given to 180 women and 150 women answered. Results: Out of 150 women, 93 women(62%) had been given TKM treatment during the last 3 years, while 57 women(32%) hadn't. 53 women(35.5%) had taken herbal medicine within the last 2 weeks, while 97 women(64.7%) hadn't. 71 women(47.3%) reported that they had been given TKM treatment related to the causative disease for the operation, while 22 women(14.7%) hadn't. And 97 women(64.7%) indicated that they were willing to use TKM as a part of their postoperative medical care, 53 women(35.3%) indicated that they weren't. Conclusion: Many patients are willing to take TKM treatment as postoperative care. We need more accumulation of data for demonstrating the efficacy and safety of TKM treatment.

• 대한한방부인과학회지
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• 제22권4호
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• pp.109-121
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• 2009

Purpose: The purpose of this study was to find out the correlation among body mass index (BMI), dysmenorrhea and digestion function. Methods: We conducted a questionnaire survey of 307 high school girls about their menstruation and digestion function from one high school located in Seoul from Mar. 23 to Mar. 28 in 2009. And the we measured their height and weight to calculate their BMI. Using one way ANOVA, chi-square test and pearson correlation, statistical analysis was made by SPSS 12.0. We significance level p-value was determined as 0.05. Results: 1. There was no significant correlation between BMI and the severity of dysmenorrhea. 2. There was no significant correlation between BMI and digestion power. 3. There was statistically mild correlation between dyspepsia and the severity of menstrual pains. Conclusion: From above results, we could conclude that dyspepsia had mild relation to menstrual pains.

• 대한한방부인과학회지
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• 제21권3호
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• pp.179-199
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• 2008

Purpose: To clarify the influence of "Dongeuibogam" on three important medical books "Euimunbogam", "Jaejungshinpyeon" and "Bangyakhabpyeon", in Chosun Dynasty. Methods: To examine and compare the three medical books, with "Uterus" and "Gynecology" part in "Dongeuibogam" to investigate effects of theories and prescriptions of "Dongeuibogam" upon gynecology. Results: Firstly, "Dongeuibogam" positively and practically reestablished the medical books existing at that time and made the high use of them in practice. Secondly, the three medical books mostly follows the formation of "Pomun" and "Buinmum" in "Dongeuibogam". thirdly, the three medical books inclusively accepted the theory and prescriptions of "Dongeuibogam" and made use of them actively in practice. Furthermore they developed other points of view in 'disease pattern identification and treatment'(辨證施治). Conclusion: "Dongeuibogam" had great influence upon gynecology in the medical books at the latter term of Chosun dynasty. "Dongeuibogam" also have had huge influence upon the clinical practice in gynecology until now by making the foundation of gynecology in traditional Korean medicine.

• 대한한방부인과학회지
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• 제36권1호
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• pp.23-34
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• 2023

Objectives: This study was conducted to confirm the anticancer effect of Torilis Japonica (TJ) on cervical cancer and to determine whether the effect was apoptosis. Methods: In this study, the effect of TJ extract on toxicity, mitochondrial morphology, nuclear morphological changes, Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in HeLa cell, human cervical cancer cell. Results: The cytotoxicity, ratio of cells with nuclear changes to the total number of cells, and P38 phosphorylation increased in a concentration-dependent manner after administration of TJ extract. The length of mitochondria and ERK phosphorylation in HeLa cells decreased in a concentration-dependent manner after administration of TJ extract. Conclusions: TJ extract has an anticancer effect on cervical cancer cells, which is presumed to be due to apoptosis, and showed potential as a future cervical cancer treatment.

• 대한한방부인과학회지
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• 제22권3호
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• pp.25-35
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• 2009

Purpose: The purpose of this study is to investigate the effect of Boheo-tang (B) and Boheo-tang plus cervi pantotrichum cornu (B+CP) on immune response in postpartum C57BL/6N mice. Methods: Normal saline(control), B and B+CP (8${\mu}{\ell}$/g) were administerd p.o. twice a day for 20 days. Subpopulation of T and B lymphocyte were accessed by flow cytometric analysis. Results: Splenic T and B lymphocytes were increased by the treatment of B. Subpopulation of cytotoxic T lymphocytes in the spleen, were significantly increased by both treatment of B and B+CP. Subpopulation of cytotoxic T lymphcytes in the thymus, were significantly increased by both treatment of B and B+CP. IL-4 production was significantly increased by the treatment of B+CP. Conclusion: This study shows that treatment of Boheo-tang and Boheo-tang plus cervi pantotrichum cornu can improve postpartum immune response in C57BL/6N mice.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 봄 학술발표논문집 Vol.31 No.1 (A)
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• pp.217-219
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• 2004

전자문서교환(EDI, Electronic Data Interchange)은 기업과 기업 간에 컴퓨터와 컴퓨터의 통신을 통하여 필요한 거래문서를 구조화된 형식으로 교환하여 업무를 처리하는 방식을 말한다. 이러한 전자문서의 유통은 절러 위험요소로부터 완전히 해방되지는 못한다. 본 연구에서는 향후 국내에서 발생 될 위협요소 중 우선적인 보호가 요구되는 것으로 메시지 노출로 인한 프라이버시 침해 및 중요 내용의 노출문제와 메시지 수정 문제 및 발신처 인증 문제. 그리고 수신자의 수신사실에 대한 부인을 위험요소로 선정하였다. 또한, 이를 막기 위한 보안서비스를 메시지 비밀보장. 무결성, 메시지 발신처 인증 및 수신내용 부인불능 등을 선정하여 이들의 구현방안을 제시하였다.

• 한국데이터정보과학회:학술대회논문집
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• 한국데이터정보과학회 2006년도 PROCEEDINGS OF JOINT CONFERENCEOF KDISS AND KDAS
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• pp.235-240
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• 2006

자궁근종은 부인과 질환 중 자궁 및 여성 골반내에서 발생하는 양성종양 중 발생빈도가 가장 높은 것으로 특히 30세이후에 발생빈도가 높아지는 질환으로 알려져 있다. 최근, D대학 한방부인과에서는 실제 자궁근종환자가 가지고 있는 증상에 대한 분석을 수행한 바 있으며, 이를 좀더 발전시켜 자궁근종 증상지표를 개발하는 연구를 시행하였다. 본 연구에서는 자궁근종 발생여부와 환자들이 가지고 있는 병기 점수간의 연관성을 파악하여 자궁근종과 관련되는 주 병기 변수를 확인함으로써 이를 통한 자궁질환 연구에 기초를 제시하고자 한다.

• 대한한방부인과학회지
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• 제32권4호
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• pp.1-13
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• 2019

Objective: This study is aimed to investigate the anti-tumor metastasis by innate immunomodulating effects of crude polysaccharide isolated from Polygonati Rhizoma (CP-PR) on 4T1 breast cancer cells. Methods: CP-PR was isolated from Polygonati Rhizoma. Antimetastatic experiments were conducted in vivo mouse model by using 4T1 breast cancer cells. The cell viability of CP-PR was tested with normal spleen and 4T1 breast cancer cells. To observe the activation of macrophages with/without 4T1 breast cancer cells, production of tumor necrosis factor-${\alpha}$ ($TNF-{\alpha}$), interleukin-6 (IL-6), IL-10 and IL-12 were measured with enzyme-linked immunosorbent assay (ELISA), respectively. In addition, the lysis of YAC-1 cells and the production of granzymes were measured to observe the activation of natural killer (NK) cell. Results: Intravenous administration of CP-PR significantly inhibited metastasis of 4T1 breast cancer cells. In an in vitro cytotoxicity analysis, CP-PR affected the growth of normal spleen and 4T1 breast cancer cells above specific concentration. The production of $TNF-{\alpha}$, IL-6, IL-10 and IL-12 were significantly increased in macrophages with CP-PR. As compared with control, CP-PR showed significantly higher production of $TNF-{\alpha}$, IL-10 and IL-12 in macrophages co-cultured with 4T1 breast cancer cells. The lysis of YAC-1 cells and the production of granzymes were significantly up regulated by CP-PR. Conclusion: CP-PR appears to have considerable activity on the anti-metastasis by activation of innate immune system.