• 한국독어학회지:독어학
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• 제10집
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• pp.1-24
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• 2004

Wir leben heute in der sosenannten Wissensgesellschaft. Diese Geseilschaft kann durch den Zugang zu immensen Wissens- und Informationsbestanden sowie durch einen fruher nicht denkbaren Grad an $Akualit\"{a}t$ dieser Informationen gekennzeichnet werden Deutsche Unternehmen haben bereits erkannt, dass das Wissen ihrer Mitarbeiter den Wert eines Unternehmens $ma{\ss}geblich$ bestimmt. Deshalb fordern sie von ihren Mitarbeitern, sich immer speziellere, immer neuere Wissensinhaite bzw. Informationen immer schneller anzueignen. Dies gilt auch $f\"{u}r$ Fremdsprachen, deren Kenntnis im Prozess der weit vorangeschrittenen Internationalisierung und Globalisierung als ein wesentliches Instrument vorausgesetzt wird. Der Hangel an fremdsprachlichen $F\"{a}higkeiten$ in Betrieben wirkt sick vol allem auf ihre Kompetenz im Umgang mil einer steigenden Anzahl von $Gesch\"{a}ftskontakten$ und ihre $ausl\"{a}ndischen$ $M\"{a}rkte$ aus. D. h. er bedeutet in einer durch zunehmenden Wettbewerb bestimmten Weit Marktverluste. Unternehmen sollen Herausforderungen $bew\"{a}ltigen$, die $gro{\ss}e$ interaktive und kommunikative $F\"{a}higkeit$ erfordern, $Ver\"{a}nderungen$ zu begreifen, sich ihnen zu stollen und sie zu $\"{u}berwinden$, um erfolgreich einen $gr\"{o}{\ss}eren$ Wirkungskreis auf den $Weltm\"{a}rkten$ zv erreichen. Deutsche Unternehmen erkennen inzwischen die besondere Bedeutung von $Fremdsprachenf\"{a}higkeiten$ ihrer Mitarbeiter $f\"{u}r$ Erfdlgssicherung und -ausbau. Diese Erkenntnisse ergeben sich auch aufgrund von Unternehmensbefragungen (z.B. vom Institut der deutschen Wirtschafi, $K\"{o}ln$). In fast allen Unternehmen ist Englisch die Fremdsprache Nummer Eins. Sie brauchen allerdings mehr als eine Fremdsprache. In der Regel werden zwei bis drei Fremdsprachen pro Betrieb $ben\"{o}tigt$. Wie $gro{\ss}$ der Fremdsprachenbedarf ist, $h\"{a}ngt$ von verschiedenen Faktoren ab: 1) Je $gr\"{o}{\ss}er$ ein Betrieb ist, desto wichtiger werden die fremdsprachlichen $F\"{a}higkeiten$ seiner Mitarbeiter. 2) In Firmen mit Auslandsverbindung und Unternehmen, die Teil eines $ausl\"{a}ndischen $Betriebes sind bzw $ausl\"{a}indische$ Niederlassungen haben, ist der Fremdsprachenbedarf von $gro{\ss}er$ Bedeutung. 3) Nach Branchen ist der Fremdsprachenbedarf differenziert. Fremdsprachenkenntnisse sind im exportorientierten produzierenden Gewerbe unverzichtbar. 4) In den verschiedenen Unternehmensbereichen werden Fremdsprachenkenntnisse differenziert $ben\"{o}tigt$. Funktionsbereiche wie Verkauf und Kundenbetreuung haben den $st\"{a}rksten$ Fremdsprachenbedarf, Kommunikation ist eine wesentliche Voraussetzung $f\"{u}r$ erfolgreiche Verhandlungen. Je $gr\"{o}{\ss}er$ die sprachliche $F\"{a}higkeiten$ und das Geschick der Mitarbeiter sind, umso besser laufen die $Gesch\"{a}ftsverhandlungen$. Damit wird klar, weshalb sich viele deutsche Unternehmen beim Fremdsprachenlernen, bzw. bei der Fort- und Weiterbildung von Fremdsprachenkenntnissen ihrer Mitarbeiter spendabel zeigen.

• 환경정책연구
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• 제11권3호
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• pp.49-65
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• 2012

도로교통소음은 자동차의 이동 즉 교통량과 통행속도등 도로교통환경과 밀접하게 관련되는바 본 논문에서는 교통류특성과 도로교통소음과의 관계를 분석하고자 몇 가지 문제를 제기하였다 첫째는 "최대 소음이 언제 발생하는가?"라는 문제로 교통량이 많은 첨두시간대에 과연 최대소음이 발생할 것인지를 교통류측면에서 검토하고자 하였다. KHTN 모델을 통해서 LOS를 분석한 결과 실제 최대 소음은 용량상태인 LOSE가 아닌 LOSD에서 발생하는 것으로 나타났다. 이는 실제 첨두시간대에는 교통량은 많지만 통행속도가 낮기 때문에 오히려 첨두시간을 전후하여 최대소음이 발생할 가능성이 높다는 것을 보여준다. 둘째는 교통소음예측에 이용되는 차종별 통행속도 추정에 관한 것으로, 보다 쉬우면서도 정확성을 지닌 통행속도추정기법을 찾고자 하였다. 이를 위해 스케치 플래닝 기법으로 도로용량편람의 '고속도로 기본구간의 속도 교통량 곡선과 서비스수준' 그래프를 이용하는 방법을 제시하였다. 각 설계속도별 추세선 모형식 산정결과 최적의 함수유형은 2차 다항식이며 각각 $R^2$가 0.96이상의 값을 가지고 있어 적합한 모형으로 판단된다.

• Journal of Gastric Cancer
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• 제18권1호
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• pp.69-81
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• 2018

Purpose: It has been reported that the survival of patients with locally advanced gastric cancer (LAGC) is better in East Asia countries than in developed western countries; however, the prognosis of LAGC remains poor. This study aimed to evaluate the effects of perioperative chemotherapy on the long-term survival of East Asia patients with LAGC. Materials and Methods: From October 2006 through August 2008, 43 patients with LAGC received perioperative S-1 combined with weekly docetaxel in a phase II study (neoadjuvant group). These patients were matched using propensity scores to patients who underwent surgery without neoadjuvant chemotherapy during the same period (surgery group). The surgical outcomes and long-term survivals were compared between the 2 groups. Results: After matching, 43 and 86 patients were included in the neoadjuvant and surgery groups, respectively, and there was no significant difference in their baseline characteristics. Although the operating time was longer in the neoadjuvant group, there was no significant difference in postoperative complications between the 2 groups. The neoadjuvant group had a significantly higher 5-year overall survival (OS) rate (73.3% vs. 51.1%, P=0.005) and a trend towards higher 5-year progression-free survival (PFS) (62.8% vs. 49.9%, P=0.145). In the multivariate analysis, perioperative chemotherapy was an independent factor for OS, with a hazard ratio of 0.4 (P=0.005) and a marginal effect on the PFS (P=0.054). Conclusions: Perioperative chemotherapy was associated with better long-term survival without increasing postoperative complications in the setting of D2 surgery for patients with LAGC, suggesting that perioperative chemotherapy can be a therapeutic option in East Asia countries.

• Asian-Australasian Journal of Animal Sciences
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• 제27권10호
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• pp.1461-1468
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• 2014

This study was aimed to examine the antibacterial and antioxidative properties of seven edible plants from Thailand to develop alternative antibiotics as feed additives. The plants include Citrus aurantifolia Swingle (Lime) fruits and its leaves, Sesbania grandiflora L. (Agati sesbania) leaves, Piper sarmentosum Roxb (Wild betal) leaves, Curcuma domestica Valeton (Turmeric) roots, Morinda citrifolia L. (Beach mulberry) leaves, Cassia siamea britt (Siamea cassia) leaves, and Cocos nucifera L. (Coconut) peels. The plants were extracted by methanol, n-hexane, chloroform, ethyl acetate, butanol and water. Antibacterial activities with minimum inhibitory concentration (MIC) were determined by agar diffusion assay against Escherichia coli, Burkholderia sp., Haemopilus somnus, Haemopilus parasuis, and Clostridium perfringens that were considered pathogenic strains in livestock infection. Methanol extracts of C. aurantifolia Swingle fruits and leaves showed the broadest spectrum of antibacterial activities except for C. perfringens. Butanol extract of S. grandiflora L. leaves showed the strongest activity against Burkholderia sp. with MIC, $135{\mu}g/mL$. P. sarmentosum Roxb leaves showed antibacterial activities against E. coli, Burkholderia sp. and H. parasuis. Ethyl acetate and water extracts from C. domesitca Valeton roots showed MIC of $306{\mu}g/mL$ and $183{\mu}g/mL$, respectively against only C. perfringens. Antioxidative activity was determined by 2-diphenyl-2-picryl hydrazyl photometric assay. The methanol extracts of C. aurantifolia Swingle fruits and P. sarmentosum Roxb leaves showed the highest antioxidant activity among all the extracts with 3.46 mg/mL and 2.70 mg/mL effective concentration 50% ($EC_{50}$) values, respectively. Total contents of phenolics and flavonoids were measured from the plant extracts. Methanol extracts of S. grandiflora L. and chloroform extracts of C. domestica Valeton were found to have the highest amount of total phenolics, 41.7 and $47.8{\mu}g/mL$, respectively. Flavonoid content of methanol extracts in S. grandiflora L. T was $22.5{\mu}g/mL$ and the highest among plant extracts tested. These results indicated that C. aurantifolia Swingle, S. grandiflora L., P. sarmentosum Roxb, and C. domestica Valeton have antibacterial and antioxidant activities and can be used as alternative antibiotics or potential feed additives for the control of animal pathogenic bacteria.

• Asian-Australasian Journal of Animal Sciences
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• 제26권5호
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• pp.638-645
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• 2013

Interferon-tau (IFNT) is thought to be the conceptus protein that signals maternal recognition of pregnancy in ruminants. We and others have observed that OCT4 expression persists in the trophectoderm of ruminants; thus, both CDX2 and OCT4 coexist during the early stages of conceptus development. The aim of this study was to examine the effect of CDX2 and OCT4 on IFNT gene transcription when evaluated with other transcription factors. Human choriocarcinoma JEG-3 cells were cotransfected with an ovine IFNT (-654-bp)-luciferase reporter (-654-IFNT-Luc) construct and several transcription factor expression plasmids. Cotransfection of the reporter construct with Cdx2, Ets2 and Jun increased transcription of -654-IFNT-Luc by about 12-fold compared with transfection of the construct alone. When cells were initially transfected with Oct4 (0 h) followed by transfection with Cdx2, Ets2 and/or Jun 24 h later, the expression of -654-IFNT-Luc was reduced to control levels. OCT4 also inhibited the stimulatory activity of CDX2 alone, but not when CDX2 was combined with JUN and/or ETS2. Thus, when combined with the other transcription factors, OCT4 exhibited little inhibitory activity towards CDX2. An inhibitor of the transcriptional coactivator CREB binding protein (CREBBP), 12S E1A, reduced CDX2/ETS2/JUN stimulated -654-IFNT-Luc expression by about 40%, indicating that the formation of an appropriate transcription factor complex is required for maximum expression. In conclusion, the presence of OCT4 may initially minimize IFNT expression; however, as elongation proceeds, the increasing expression of CDX2 and formation of the transcription complex leads to greatly increased IFNT expression, resulting in pregnancy establishment in ruminants.

• Asian-Australasian Journal of Animal Sciences
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• 제30권5호
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• pp.672-682
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• 2017

Objective: This study was conducted to investigate the effects of probiotic, prebiotic and synbiotic with and without feed restriction on broilers performance, blood parameters, carcass characteristics, and feed cost of production from 1 to 56 days of age. Methods: Two hundred and forty unsexed one day-old chicks of Arbor Acres breed were used. Two trials, I and II, were conducted, with 120 birds in both. Each trial was divided into 4 equal groups. The birds in trial I were fed ad libitum throughout the experiment, while the chicks in trial II were fed ad libitum during the first week of age, then subjected to 5 hours/d of feed restriction from the beginning of the second week up to the end of the experiment. In both trials, the birds in group 1 were fed on a control diet while the other groups were given the same control diet supplemented either with a probiotic in group 2, prebiotic in group 3, or synbiotic in group 4. Results: It was found that chicks fed diets supplemented with probiotic, prebiotic and synbiotic (with and without feed restriction) exhibited higher body weight and feed efficiency than chicks fed the control diets. The feed additives in both trials did not affect hemoglobin, serum total protein, albumin, globulin, glucose, and total cholesterol, except the packed cell volume which was increased in the additive treatments with restriction at the end of the experiment. Moreover, the dietary treatments did not influence the carcass yield. However, the relative weights of liver, gizzard and proventriculus, small intestine and bursa of fabricius were found to be increased. The additives decreased the visible fat in the carcass, with more decreasing effect in the additive groups with restriction. The lowest feed cost per kg of weight gain was observed in the birds fed diets supplemented with synbiotic, probiotic and prebiotic. Feed restriction improved the feed conversion ratio, economic return, but decreased the feed intake, serum total cholesterol and visible fat in comparison with non-restricted groups. Conclusion: The biological feed additives could be routinely added to broiler diets, especially when a feed restriction program is followed. Finally, it can be recommended to restrict feed, and add probiotic or synbiotic to increase weight, improve feed conversion rate and reduce feed cost of production.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.197-200
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• 2016

Background: Wedge filters are commonly used in radiation oncology for eliminating hot spots and creating a uniform dose distribution in optimizing isodose curves in the target volume for clinical aspects. These are some limited standard physical wedges ($15^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$),or creating an arbitrary wedge angle, like motorized wedge or dynamic wedge,${\ldots}$ The new formulation is presented by the combination of wedge fields for determining an arbitrary effective wedge angles. The isodose curves also are derived for these wedges. Materials and Methods: we performed the dosimetry of Varian Clinac 2100C/D with Scanditronix Wellhofer water blue phantom, CU500E, OmniPro - Accept software and 0.13cc ionization chamber for 6Mv photon beam in depth of 10cm (reference depth) for universal physical wedges ($15^{\circ}$, $30^{\circ}$, $45^{\circ}$, and $60^{\circ}$) and reference field $10.10cm^2$. By combining the isodose curve standard wedge fields with compatible weighting dose for each field, the effective isodose curve is calculated for any wedge angle. Results: The relation between a given effective wedge angle and the weighting of each combining wedge fields was derived. A good agreement was found between the measured and calculated wedge angles and the maximum deviation did not exceed $3^{\circ}$. The difference between the measured and calculated data decreased when the combined wedge angles were closer. The results are in agreement with the motorized single wedge appliance in the literature. Conclusions: This technique showed that the effective wedge angle that is obtained from this method is adequate for clinical applications and the motorized wedge formalism is a special case of this consideration.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2005년도 제30회 춘계학술대회
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• pp.59-63
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• 2005

호흡 움직임은 종양에 대한 방사선치료의 부정확한 방사선조사가 유도되도록 복부 및 흉부에서 움직임을 야기한다. 그러므로 치료시 이러한 움직임에 대한 정확한 계산은 정상조직에는 저 선량을 조사되도록 CTV의 마진을 줄일 수 있고 방사선치료에 발생되는 부작용을 줄일 수 있다. Intrafraction motion을 고려하는 기술로는 호흡 멈춤, 호흡동조, 4차원 또는 종양추적 기술이 있다. 호흡동조 방법은 환자의 호흡 신호가 호흡주기의 일정한 범위에 위치할 때 주기적으로 빔을 조사하고 그 범위를 벗어날 때는 빔을 조사하지 않는 방법이다. 이러한 기술은 내부장기 움직임과 상관관계가 있는 호흡 움직임 신호의 획득이 요구된다. 호흡동조 방사선치료를 위한 예비연구로 본 연구자들은 호흡 움직임 신호 측정을 수행하였다. 환자의 호흡 움직임 신호 측정을 위해서, 호흡측정시스템을 3 가지 센서, 4 채널 데이터 획득 시스템, 신호처리용 컴퓨터로 구성하였다. 2명의 환자를 대상으로 본 연구자들은 호흡측정시스템을 가지고 호흡주기 및 파형을 평가하였다. 그 결과 호흡주기는 시간의 함수에 따라 일반적으로 정확한 대칭 형태는 아니지만 주기적인 형태로 측정되었다. 호흡측정 시스템은 기대했던 만큼 환자의 호흡을 잘 추적하였으며 실험에 적용하기 위해 쉽게 컨트롤 할 수 있었다.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 1999년도 추계학술발표회 초록집
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• pp.15-15
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• 1999

In chip plating, several parameters must be taken into consideration. Current density, solution concentration, pH, solution temperature, components volume, chip and media ratio, barrel geometrical shape were most likely found to have an effect to the process yields. The 3 types of barrels utilized in chip plating industry are the conventional rotating barrel. vibrational barrel (vibarrel), and the centrifugal type. Conventional rotating barrel is a close type and is commonly used. The components inside the barrel are circulated by the barrel's rotation at a horizontal axis. Process yield has known to have higher thickness deviation. The vibrational barrel is an open type which offers a wide exposure to electrolyte resulting to a stable thickness deviation. It rotates in a vertical axis coupled with multi-vibration action to facilitate mixed up and easy transportation of components, The centrifugal barrel has its plated work centrifugally compacted against the cathode ring for superior electrical contact with simultaneous rotary motion. This experiment has determined the effect of barrel vibration intensity to the plating thickness distribution. The procedures carried out in the experiment involved the overall plating process., cleaning, rinse, Nickel plating, Tin-Lead plating. Plating time was adjusted to meet the required specification. All other parameters were maintained constant. Two trials were performed to confirm the consistency of the result. The thickness data of the experiment conducted showed that the average mean value obtained from higher vibrational intensity is nearer to the standard mean. The distribution curve shown has a narrower specification limits and it has a reduced variation around the target value, Generally, intensity control in vi-barrel facilitates mixed up and easy transportation of components, However, it is desirable to maintain an optimum vibration intensity to prevent solution intrusion into the chips' internal electrode. A cathodic reaction can occur in the interface of the external and internal electrode. $2HD{\;}+{\;}e{\;}{\rightarrow}20H{\;}+{\;}H_2$ Hydrogen can penetrate into the body and create pressure which can cause cracks. At high intensity, the chip's motion becomes stronger, its contact between each other is delayed and so plating action is being controlled. However, the strong impact created by its collision can damage the external electrode's structure thereby resulting to bad plating condition. 1 lot of chip was divided into two equal partion. Each portion was loaded to the same barrel one after the other. Nickel plating and tin-lead plating was performed in the same station. Portion A maintained the normal barrel vibration intensity and portion B vibration intensity was increased two steps higher. All other parameters, current, solution condition were maintained constant. Generally, plating method find procedures were carried out in a best way to maintained the best plating condition. After plating, samples were taken out from each portion. molded and polished. Plating thickness was investigated for both. To check consistency of results. 2nd trial was done now using different lot of another characteristics.

• 한국제4기학회지
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• 제9권1호
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• pp.33-42
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• 1995

우리나라의 서해(West Sea)는 일명 황해(Yellow Sea)라고 일컬어지는 약 40여 m의 평균 수심을 갖는 대륙붕 해저지형 분지에 의하여 지배되는 전형적 육연해이다, 그런데 이 바다는 중심부(황해의 중심부)를 기준으로 하여 중국 대륙의 산동반도에서 양가강 하구에 이르는 서부 해안을 가지며 북부에는 발해만의 해안이 있고 동부에는 서해(황해) 특유의 넓 은 조수환경(tidal environment)과 조수해안이 발달한다. 그러나 남쪽으로는 북서태평양과 연결된다. 한국 서해안이 평균 4m 이상의 조차(tidal range)를 나타내는 조간대 조수환경이 며 조간대 해저지형(intertidal morphology)이 전형적인 퇴적층(체)에 의하여 지배되는 여러 가지 특징을 나타낸다. 서해안 조수환경은 네델란드, 독일 또는 지배되는 여러 가지 특징을 나타낸다. 서해안 조수환경은 네델란드 독일 또는 미국의 경우와 같이 연구가 잘되어 세계 적으로 널리 알려진 소위 barrier island system and tidal depositional environments와는 크 게 다른 퇴적과정과 환경이다. 경기도 남양만의 조수 환경의 경우, 조간대 해저지형 요소인 조류로(tidal channel)와 조간대 정규해저(intertidal zone proper)에 관한 동력적 퇴적과정 연 구결과 조간대 특유의 lateral sedimentation 과 vertical sedimentation 2가지 퇴적과정중 후 자의 퇴적과정이 우세한 것으로 밝혀졌고 이러한 퇴적과정의 진행이 매우 안정한 지속성을 가지는 것이 특징이다, 이러한 퇴적과정의 조간대 퇴적물의 쇄설 입자는 약 20% 미만의 모 래(sand) 입자 50~70%의 실트(silt) 와 점토(clay) 입자가 20~30%에 달하는 입자조직 (grain texture)의 퇴적상을 나타낸다. 결과적으로 조간대의 동력적인 조수수괴의 수위(level of tidal water)는 평균 만조선과 평균 저조선으로 한정되며 이것은 퇴적과정과 퇴적작용의 조정(control) 요인으로 조간대 퇴적상의 발달과 분포에 큰 영향을 미친다, 예를들면 남양만 등의 대부분의 서해안 조간대 표층 퇴적상(녁\ulcorner미 sedimentary faci-es)은 만조선에서 간조 선에 가까울수록 조립화현상(coarsening trend)을 나타낸다. 이러한 퇴적상 변화는 저조선에 서 만조선으로의 조간대 지형과 주조수로의 지형.수력학적 특성이 다음과 같기 때문이다. a) a general decrease in width b) a general decrease in depth c) a general decrease in maximum and average current velocities d) a general increase in contents of suspended mud e) a general decrease in grain size of the bottom sand and an increasing abundance of muddy deposits. 우리나라 서해안 조간대 퇴적층(체)의 수직 층서(vertical stratigraphy)는 지난 3여년동안의 수십개의 vibracoring(주상시추)에 의하여 매우 흥미롭고 중요하게 밝혀지고 있는바 이것은 현세(Holocene)와 선현세(preHolocene: 11000 years BP)의 오랜시간 경과에 따른 조수환경 변화의 수직퇴적 과정과 기후 해수면 변화의 현상에 원인이 있다고 해석된다.(박용안 외, 1992-1995)결과적으로 서해안 조수퇴적체(층)의 분지주변(basim margin)진화과정이 밝혀지 고 있다.