• Journal of Korea Society of Waste Management
• /
• v.34 no.2
• /
• pp.205-213
• /
• 2017

The current study was performed to investigate the effect of recycling coir substrates on the growth, fruit yield, and quality of strawberry plants. Analysis of physical properties revealed that the pH of a fresh coir substrate was 5.04 while those of substrates reused for one and two years were 5.20 and 5.33, respectively. The electrical conductivity (EC) of a new substrate was as high as $4.58dS{\cdot}m^{-1}$. This can cause salt stress after transplanting. The EC tended to decrease as the substrate was recycled, and the EC of a two-year recycled substrate was $1.48dS{\cdot}m^{-1}$. The fresh substrate had lower nitrogen and calcium concentrations, but higher phosphate, potassium, and sodium concentrations than the recycled coir substrate. The coir substrates recycled for one or two years maintained better chemical properties for plant growth than the fresh substrate. Strawberry growth varied depending on the number of years that the coir substrate was recycled. In general, strawberries grown in substrates that had been reused for two years did better than those grown in substrates that had been reused once or were fresh. Ninety days after transplanting, a plant grown in a substrate that had been reused for two years contained 25 leaves, which was 3.6 more than with a fresh substrate. In addition, the plants grown in a substrate that had been reused for two years exhibited larger leaf areas than those grown in other substrates. Coir substrates that had been reused for one year increased the number and area of leaves, but not as much as the substrate that had been reused for two years. One- and two-year reused coir substrates increased the weight of strawberries produced relative to the unused substrate, but the difference was not statistically significant. The plants grown in two-year reused substrates were longer and wider, as well. Also, the number of fruits per plant was higher when substrates were reused. Specifically, the number of fruits per plant was 28.7 with a two-year reused substrate, but only 22.2 with a fresh substrate. The fruit color indices (as represented by their Hunter L, a, b values) were not considerably affected by recycling of the coir substrate. The Hunter L value, which indicates the brightness of the fruit, did not change significantly when the substrate was recycled. Neither Hunter a (red) nor b (yellow) values were changed by recycling. In addition, there were no significant changes in the hardnesses, acidities, or soluble solid-acid ratios of fruits grown in recycled substrates. Thus, it is thought that recycling the coir substrate does not affect measures of fruit quality such as color, hardness, and sugar content. Overall, reuse of coir substrates from hydroponic culture as high-bed strawberry growth substrates would solve the problems of new substrate costs and the disposal of substrates that had been used once.

• Korean Journal of Agricultural and Forest Meteorology
• /
• v.23 no.2
• /
• pp.108-121
• /
• 2021

Field studies at Suwon, Cheorwon, and Jinbu were carried out to determine the relationship between mean temperature from transplanting to heading (MT) and growth at heading stage of rice. P lant height (P H) and dry weight (DW) at heading stage were significantly correlated with MT, showing second degree polynomials. The optimal temperatures for PH and DW were 23.2 ℃ and 22.8 ℃, respectively. Little differences in rice growth among soils collected from the experimental sites and the temperature-response in a phytotron study supported that MT was the main determinant of the growth shown in the field study. Though number of days to heading increased as MT decreased, cumulative temperatures (CT) affected by sites and MT for given varieties were fairly constant. When applying specific CT for each of the varieties to the temperature in North Korea, (1) five regions (Kaesong, Haeju, Sariwon, Nampo, Pyongyang) were suitable for early to mid-maturing varieties and (2) 14 regions (Yongyon, Singye, Anju, Kusong, Sinuiju, Changjon, Wonsan, Hamhung, Pyonggang, Yangdok, Huichon, Supung, Sinpo, Kanggye) were suitable only for early-maturing varieties. In (1) regions, the similar extent of growth with that in Suwon could be achieved when mid-maturing varieties grown in Suwon are cultivated. Among (2) regions, early-maturing varieties are expected to demonstrate the similar extent of growth with that in Cheorwon in 9 regions except Hamhung, Kanggye, Pyonggang, Yangdok, and Sinpo. For Hamhung and Kanggye, the target PH was assessed as 4cm higher than that shown in Cheorwon. P lant height of 8-14cm and DW of 2-4g per hill greater than those shown in Cheorwon were the target growth for P yonggang, Yangdok, and Sinpo to attain the similar amount of growth with that in Cheorwon. It is suggested that rice varieties for North Korea could be bred by adjusting the target growth at the breeding sites in South Korea.

• Korean Journal of Food Science and Technology
• /
• v.54 no.1
• /
• pp.43-51
• /
• 2022

Regulation of the hair follicle cycle in association with dermal papilla cells is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether steam-dried Betula platyphylla extracts (BPE) promote hair growth by upregulating in vitro and in vivo responses of dermal papilla cells. The data showed that BPE3 contained high amounts of phenolic compounds with higher antioxidant effects and increased hair growth-related genes, including fibroblast growth factor7 and Wnt7b, in dermal papilla cells. Notably, BPE3 effectively enhanced the formation of hair follicles by increasing FGF7, Wnt7b, and vascular endothelial growth factor in C57BL/6N dorsal skins. Additionally, BPE3 significantly decreased the expression of inflammatory repertoires, inducible nitric oxide synthase, interleukin-6, and cyclooxygenase 2. Several small molecules, such as betulin and unsaturated fatty acids, support the pharmacological activity of BPE3. In conclusion, BPE3 effectively promoted hair growth by activating dermal papilla cells and enhancing hair follicle cycles by attenuating the inflammatory environment in the scalp.

• The Bulletin of The Korean Astronomical Society
• /
• v.45 no.1
• /
• pp.34.3-34.3
• /
• 2020

Faint z ~ 5 quasars with M1450 ~ -23 mag are known to be the potentially important contributors to the ultraviolet ionizing background in the post-reionization era. However, their number density has not been well determined, making it difficult to assess their role in the early ionization of the intergalactic medium (IGM). In this work, we present the updated results of our z ~ 5 quasar survey using the Infrared Medium-deep Survey (IMS), a near-infrared imaging survey covering an area of 85 square degrees. From our spectroscopic observations with the Gemini Multi-Object Spectrograph (GMOS) on the Gemini-South 8 m Telescope, we discovered eight new quasars at z ~ 5 with -26.1 ≤ M1450 ≤ -23.3. Combining our IMS faint quasars with the brighter Sloan Digital Sky Survey (SDSS) quasars, we derive, for the first time, the z ~ 5 quasar luminosity function (QLF) without any fixed parameters down to the magnitude limit of M1450 = -23 mag. We find that the faint-end slope of the QLF is very flat (-1.2) with a characteristic luminosity of -25.7 mag. The number density of z ~ 5 quasars from the QLF gives lower ionizing emissivity and ionizing photon density than those in previous works. These results imply that quasars are responsible for only 10-20% of the photons required to completely ionize the IGM at z ~ 5, disfavoring the idea that quasars alone could have ionized the IGM at z ~ 5.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2022.10a
• /
• pp.103-103
• /
• 2022

다복찰은 전라북도농업 기술원에서 2012~2020년에 신명흑찰과 익산488호를 교배하여 육성한 찰벼이며, 중대립, 단간, 내도복, 다수성의 특징을 보인다. 동진찰은 1998년도에 육성되었으며, 우리나라에서 가장 인기 있는 찰벼이다(재배면적 25,161ha/2021년 기준). 드문모심기 재배 기술은 2017년부터 도입되었으며, 밀파 육묘하여 재식밀도 및 재식주수를 감소함으로써 소요되는 재료비 등 경비 및 투입되는 노동력을 절감하는 경제성 있는 기술이다. 따라서 본 연구는 전라북도농업기술원에서 육성한 다복찰 보급 확대 및 가장 인기 높은 동진찰의 드문모심기 재배기술 확립 일환으로 시작되었으며, 2024년까지 3년간 실시할 계획이다. 시험은 기술원 논 포장에서 실시하였으며, 시험품종은 다복찰, 동진찰, 시험요인은 이앙시기(3처리) 및 재식밀도(4처리)를 두었다. 이앙시기별로 이앙 17일 전에 온탕소독(62℃, 10분), 종자소독(32℃, 1일), 침종(32℃, 1일), 간이출하(30℃, 3일) 과정을 거쳐 부직포 육묘(12일 정도)를 실시하였다. 5월20일(이앙520)부터 5월30일(이앙530), 6월9일(이앙609)까지 10일 간격으로 드문모심기 전용 이앙기로 이앙하였으며, 주당 본수는 5.7개 정도였다. 이앙 시기별로 시험포장을 구분하였고 포장내에 2품종, 각각 3.3m2당 80주, 60주, 50주, 37주 등 재식밀도 처리구를 두었으며, 처리구마다 3반복 조사구(10주/반복, 5본/주) 설치하였다. 10a당 9-4.5-5.7kg(N-P₂O₅-K₂O)를 밑거름(50%)-분얼거름(20)-이삭거름(30) 등 3회 거쳐 시비하였다. 중간물떼기는 이앙32일째부터 10일간 실시하였으며, 예상 출수 30일 전에 충분하게 담수하였다. 이앙20일째부터 10일 간격으로 경수, 초장, 엽색도 등 생육 조사, 그리고 출수기, 후기 생육 및 병해충을 조사하였다. 향후 수확기에 수량, 수량구성요소, 미질 및 품위를 분석할 계획이다. 시험토양은 pH 6.0~6.3, EC는0.68~0.85dS/m, 유기물함량은 52~57g/kg 수준으로 높았다. 동진찰 발아율(94.0~98.1%)이 다복찰(89.9~94.9%)보다 우수하였다(3~6%P ↑). 다복찰 묘 충실도(102~106mg/주)가 동진찰(79~101mg/주)보다 다소 좋았으며, 이앙530 묘소질이 가장 좋았다. 동진찰 초장은 다복찰에 비해 다소 길었으나 이앙시기 및 재식밀도별 초장의 변화 유형은 비슷하였다. 이앙520구의 80주에서 초장이 가장 작았고 이앙609구에서는 80주에서 다소 길었으나, 처리구간의 유의성은 없었다. 동진찰 및 다복찰 경수는 37주에서 이앙 후 40일째, 50주, 60주, 80주에서는 30일째 가장 컸다. 출수기는 다복찰에 비해 동진찰이 3~7일 정도 빨랐으며, 특히 이앙520 동진찰에서는 재식밀도가 높을수록 출수기가 빠른 경향을 보였으며, 이앙530 이후에는 재식밀도간 차이가 거의 없었다. 동진찰에 비해 다복찰 간장이 3~6cm 작았으며, 2품종 모두 이앙609구에서 가장 낮은 값을 보였다. 수장도 간장과 비슷한 경향을 보였다. 수수는 2품종 모두 이앙이 늦을수록 증가하였으며, 37주에서 가장 높았으며, 80주에 비해 다복찰, 동진찰 각각 73.8%, 77.4% 높았다. 다복찰의 경우 3.3m²당 수수는 이앙시기별과 관계없이 상대적으로 80주에서 가장 많았고 이앙520에서 재식밀도간 차이는 감소하였지만 이앙시기가 늦을수록 수수는 증가하는 경향을 보였다. 동진찰도 비슷한 경향을 보였으며, 이앙520과 이앙609 사이에 수수 차이는 적었다. 병 발생은 잎집무늬마름병, 세균성벼알마름병, 이삭누룩병이 주로 관찰되었으며, 세균성 벼알마름병은 출수기와 맞물린 이앙530에서 가장 크게 발생하였으며, 이앙520도 비슷한 경향을 보였다. 이삭누룩병 발생이 심하였는데 재식밀도간 차이보다는 이앙시기별 차이가 더 크게 발생하였으며 품종 간의 병 발생 차이는 없었다. 이상의 결과로 수수 측면에서 조기 이앙할 경우에는 50~60주, 늦은 이앙 시에는 80주가 유리할 것으로 보이며, 추후주당 립수, 등숙률, 천립중 등을 조사하고 경영비 등을 고려하여 합리적인 이앙시기 및 재식밀도를 판단할 수 있을 것으로 판단된다.

• Food Science and Preservation
• /
• v.30 no.6
• /
• pp.1056-1071
• /
• 2023

This study aimed to investigate the quality and microbial population changes for 90 days under two fermentation conditions, outdoors and indoors (35℃), with starters (single or mixed) in soybean paste. Bacillus velezensis NY12-2 (S1), Debaryomyces hansenii D5-P5 (S2), Enterococcus faecium N78-11 (S3), and their mixtures (M) were used for the makjang fermentation. The content of amino-type nitrogen among the makjang samples was highly shown in the indoors, followed by M, S3, and S2. The glutamic and aspartic acid contents in the M sample fermented in the indoors showed the highest values of 867.42±77.27 and 243.20±15.79 mg/g, respectively. By the electronic tongue analysis, the M sample fermented in the indoors exhibited lower saltiness and higher umami than the others. Consequently, we expect that using mixed strains, such as Bacillus, Debaryomyces, and Enterococcus, under constant conditions showed potential to the quality improvement of soy products.

• Korean Journal of Radiology
• /
• v.25 no.1
• /
• pp.11-23
• /
• 2024

Objective: To investigate whether reader training improves the performance and agreement of radiologists in interpreting unenhanced breast magnetic resonance imaging (MRI) scans using diffusion-weighted imaging (DWI). Materials and Methods: A study of 96 breasts (35 cancers, 24 benign, and 37 negative) in 48 asymptomatic women was performed between June 2019 and October 2020. High-resolution DWI with b-values of 0, 800, and 1200 sec/mm² was performed using a 3.0-T system. Sixteen breast radiologists independently reviewed the DWI, apparent diffusion coefficient maps, and T1-weighted MRI scans and recorded the Breast Imaging Reporting and Data System (BI-RADS) category for each breast. After a 2-h training session and a 5-month washout period, they re-evaluated the BI-RADS categories. A BI-RADS category of 4 (lesions with at least two suspicious criteria) or 5 (more than two suspicious criteria) was considered positive. The per-breast diagnostic performance of each reader was compared between the first and second reviews. Inter-reader agreement was evaluated using a multi-rater κ analysis and intraclass correlation coefficient (ICC). Results: Before training, the mean sensitivity, specificity, and accuracy of the 16 readers were 70.7% (95% confidence interval [CI]: 59.4-79.9), 90.8% (95% CI: 85.6-94.2), and 83.5% (95% CI: 78.6-87.4), respectively. After training, significant improvements in specificity (95.2%; 95% CI: 90.8-97.5; P = 0.001) and accuracy (85.9%; 95% CI: 80.9-89.8; P = 0.01) were observed, but no difference in sensitivity (69.8%; 95% CI: 58.1-79.4; P = 0.58) was observed. Regarding inter-reader agreement, the κ values were 0.57 (95% CI: 0.52-0.63) before training and 0.68 (95% CI: 0.62-0.74) after training, with a difference of 0.11 (95% CI: 0.02-0.18; P = 0.01). The ICC was 0.73 (95% CI: 0.69-0.74) before training and 0.79 (95% CI: 0.76-0.80) after training (P = 0.002). Conclusion: Brief reader training improved the performance and agreement of interpretations by breast radiologists using unenhanced MRI with DWI.

• The Korean Journal of Physiology
• /
• v.1 no.1
• /
• pp.103-120
• /
• 1967

As pointed out by many previous investigators, the cardio-pulmonary system of well trained athletes is so adapted that they can perform a given physical exercise more efficiently as compared to non-trained persons. However, the time course of the development of these cardio-pulmonary adaptations has not been extensively studied in the past. Although the development of these training effects is undoubtedly related to the magnitude of an exercise load which is repeatedly given, it would be practical if one could maintain a good physical fitness with a minimal daily exercise. Hence, the present investigation was undertaken to study the time course of the development of cardio-pulmonary adaptations while a group of non-athletes was subjected to a daily 6 to 10 minutes running exercise for a period of 4 weeks. Six healthy male medical students (22 to 24 years old) were randomly selected as experimental subjects, and were equally divided into two groups (A and B). Both groups were subjected to the same daily running exercise (approximately 1,000 kg-m). 6 days a week for 4 weeks, but the rate of exercise was such that the group A ran on treadmill with 8.6% grade for 10 min daily at a speed of 127 m/min while the group B ran for 6 min at a speed of 200 m/min. In order to assess the effects of these physical trainings on the cardio-pulmonary system, the minute volume, the $O_2$ consumption, the $CO_2$ output and the heart rate were determined weekly while the subject was engaged in a given running exercise on treadmill (8.6% grade and 127 m/min) for a period of 5 min. In addition, the arterial blood pressure, the cardiac output, the acid-base state of arterial blood and the gas composition of arterial blood were also determined every other week in 4 subjects (2 from each group) while they were engaged in exercise on a bicycle ergometer at a rate of approximately 900 kg m/min until exhaustion. The maximal work capacity was also determined by asking the subject to engage in exercise on treadmill and ergometer until exhaustion. For the measurement of minute volume, the expired gas was collected in a Douglas bag. The $O_2$ consumption and the $CO_2$ output were subsequently computed by analysing the expired gas with a Scholander micro gas analyzer. The heart rate was calculated from the R-R interval of ECG tracings recorded by an Offner RS Dynograph. A 19 gauge Cournand needle was inserted into a brachial artery, through which arterial blood samples were taken. A Statham $P_{23}AA$ pressure transducer and a PR-7 Research Recorder were used for recording instantaneous arterial pressure. The cardiac output was measured by indicator (Cardiogreen) dilution method. The results may be summarized as follows: (1) The maximal running time on treadmill increased linearly during the 4 week training period at the end of which it increased by 2.8 to 4.6 times. In general, an increase in the maximal running time was greater when the speed was fixed at a level at which the subject was trained. The mammal exercise time on bicycle ergometer also increased linearly during the training period. (2) In carrying out a given running exercise on treadmill (8.6%grade, 127 m/min), the following changes in cardio·pulmonary functions were observed during the training period: (a) The minute volume as well as the $O_2$ consumption during steady state exercise tended to decrease progressively and showed significant reductions after 3 weeks of training. (b) The $CO_2$ production during steady state exercise showed a significant reduction within 1 week of training. (c) The heart rate during steady state exercise tended to decrease progressively and showed a significant reduction after 2 weeks of training. The reduction of heart rate following a given exercise tended to become faster by training and showed a significant change after 3 weeks. Although the resting heart rate also tended to decrease by training, no significant change was observed. (3) In rallying out a given exercise (900 kg-m/min) on a bicycle ergometer, the following change in cardio-vascular functions were observed during the training period: (3) The systolic blood pressure during steady state exercise was not affected while the diastolic blood Pressure was significantly lowered after 4 weeks of training. The resting diastolic pressure was also significantly lowered by the end of 4 weeks. (b) The cardiac output and the stroke volume during steady state exercise increased maximally within 2 weeks of training. However, the resting cardiac output was not altered while the resting stroke volume tended to increase somewhat by training. (c) The total peripheral resistance during steady state exercise was greatly lowered within 2 weeks of training. The mean circulation time during exorcise was also considerably shortened while the left heart work output during exercise increased significantly within 2 weeks. However, these functions_at rest were not altered by training. (d) Although both pH, $P_{co2}\;and\;(HCO_3-)$ of arterial plasma decreased during exercise, the magnitude of reductions became less by training. On the other hand, the $O_2$ content of arterial blood decreased during exercise before training while it tended to increase slightly after training. There was no significant alteration in these values at rest. These results indicate that cardio-pulmonary adaptations to physical training can be acquired by subjecting non-athletes to brief daily exercise routine for certain period of time. Although the time of appearance of various adaptive phenomena is not identical, it may be stated that one has to engage in daily exercise routine for at least 2 weeks for the development of significant adaptive changes.

• Journal of Nutrition and Health
• /
• v.6 no.1
• /
• pp.1-9
• /
• 1973

I. Subject of the Study: Studies on the economical nutrition supplement of cereal foods for the improvement in our notional eating habits. II. Purpose and Importance of the Study: 1. Our nation is confronted with the situation that the rice, a principal food, short of some essential amino acids, lysine and threonine, leads to imbalanced meals insufficient in the nutrient of protein, to bring many difficulties in the elevation of our national physique. 2. The shortage of even the rice imperfect in the nutrient of protein makes the import of lots of foreign rice inevitable. It is considered that the protein supplement and decrease in the consumption amount, of rice, is a serious key to the solution of our food difficulty, and then a way of the proetin supplement of rice through the addition of essential amino acid is to be rarely applied in the view of the our present finance and situation. 3. In the present experiment, therefore, it aims to the suggestion of an aspect of the improvement in our national eating habits guiding in the nutrition elevation which our nation can afford economically through the development of first, a way of the protein supplement by the mixture of cereals producted plentifully in our country, and second, a way of the decrease in the consumption amount and the improvement in the nutrition of rice through the substitution of the other cereals for rice. III. Contents of Scope of the Study: 1. Objects of the study: Objects of the study are the following three items; a) The nutrition supplement of rice through the mixture of cereals. Our nation makes mainly rice as a principal food, but practically many kinds of cereal are produced in our country. They contain different levels and qualities of each nutrient and they are different from one another in the kinds of essential amino acid consisting protein. For that reason, the mutual complement efficeincy of insufficient nutrients is observed through the mixture of cereals. b) The nutrition supplement of rice through the addition of superior protein sources to rice, a principal food. The development of rice as superior foods in the sense of nutrition is conducted through the risement in protein quality by the addition of protein sources in good quality, for example, fish flour (anchovy flour), egg powder, milk powder, and so on, and through the supplement of vitamins and minerals. c) The decrease in the consumption amount of rice through the substitution of the other cereals for rice, as a principal food. The compensation for the short amount of rice is made by the reduction in the consumption of rice through the discovery of a way of substitution of the other cereals for rice, as a principal food and of the settlement of problems in nutrition and finance subsequent to this. 2. Contents of the study: a) An ideal mixture-ratio of cereals is established for rats by feeding mixed foods(rice-barely or rice-wheat) containing 5%, 15%, 25%, 35% and 45% level of either barely or wheat. b) The nutritive value is determined in the whole subsititution of other foods for rice, and then, a way of the complement of over and under nutrients is devised. c) The ideal combination is investigated for rats through feeding mixed foods of main food, rice and supplement foods of protein sources, soy bean, fish flour, egg powder and milk Powder. d) According to results from the above three experiments, the concise functional test for men and the examination of economical property are made. 3. Scope of the study: a) The observation of the effect of each diet on the growth rate for rats. The growth rate of rats was observed for 15 groups of mixed foods of a main food, rice, and wheat flour, barley powder or soy bean powder, respectively, and 12 groups of wheat flour diets supplemented with $1{\sim}3%$ milk powder, and rice or wheat flour diets supplemented with 5% of milk powder, egg powder, fish flour or soy bean powder, respectively. b) The determination of food consumption. The food consumption was determined at weekly intervals for 27 kinds of diet described in a) item. c) The determination of food efficiency rate. The food efficiency rate for each diet was determined by calculation from the gained body weight and the food consumption amount at the same intervals described in b) item. d) The determination of protein efficiency rate. The protein efficiency rate for each diet was determined by calculation form gained body weight and the protein amount of the food consumption amount at the same intervals described c) item. e) The determination of the body component. The hematocrite and hemoglobin levels in the blood, total nitrogen in the serum, blood sugar, and lipids and glycogen in the liver were determined. f) The observation of nitrogen balance. As a means of the observation of nitrogen balance, the total nitrogen in the urine was determined. g) The analysis of economical property. The economical property was analyzed as the gained body weight to the amount equivalent to one won through the conversion of the food consumption amount into money. h) The functional test for men. The concise functional test for men was made in order to establish if the best diet for experimental animals can be applied to men. IV. Results of the Study: The national food product plan, nationwide nutritive enlightment and the improvement activities in our country eating habits, especially, mixed and powder food problems are to be significantly referred, and the following results must be applied. a) In the mixed foods of cereals, the mixed food of the rice-barley containing $5{\sim}15%$ level of barley is best in terms of nutrition. b) The addition of superior protein sources, egg, Bilk, soy bean, or fish, respectively to either rice or wheat flour makes a great risement in the nutritive value. c) The animal protein is more effective in the elevation of nutritive value of cereals. d) Rice takes the most nutritive operation and has the highest preference, among rice, wheat flour and barley. e) Wheat flour is more economical than rice in evaluation of the gained body weight to the regular money, and the addition of fish or soy bean is more economical than that of any other supplement food. But the above results are true of the range of nutrition and economical property. f) The study on the nutrition composition and barley will lead to the improvement in our national eating habits as mixed food of the rice-barley containing $5{\sim}15%$ level of barley is more nutritive. g) This study on the nutrition only for the growing animal can not be considered as a perfect and entire evaluation. Consequently, the perfect data for our national nutrition can be obtained from the experiment similar to this for the much longer period examining, in details, the growth rate, change of physical strength, mental and bodily change, average life span, and resistance ability to infectious diseases.

• Nuclear Medicine and Molecular Imaging
• /
• v.41 no.1
• /
• pp.42-48
• /
• 2007

Purpose: The purpose of this study is to image metastaic lung melanoma model with optimal pre-conditions for animal handling by using $[^{18}F]FDG$ small animal PET and clinical CT. Materials and Methods: The pre-conditions for lung region tumor imaging were 16-22 h fasting and warming temperature at $30^{\circ}C$. Small animal PET image was obtained at 60 min postinjection of 7.4 MBq $[^{18}F]FDG$ and compared pattern of $[^{18}F]FDG$ uptake and glucose standard uptake value (SUVG) of lung region between Ketamine/Xylazine (Ke/Xy) and Isoflurane (Iso) anesthetized group in normal mice. Metastasis tumor mouse model to lung was established by intravenous injection of B16-F10 cells in C57BL/6 mice. In lung metastasis tumor model, $[^{18}F]FDG$ image was obtained and fused with anatomical clinical CT image. Results: Average blood glucose concentration in normal mice were $128.0{\pm}23.87$ and $86.0{\pm}21.65\;mg/dL$ in Ke/Xy group and Iso group, respectively. Ke/Xy group showed 1.5 fold higher blood glucose concentration than Iso group. Lung to Background ratio (L/B) in SUVG image was $8.6{\pm}0.48$ and $12.1{\pm}0.63$ in Ke/Xy group and Iso group, respectively. In tumor detection in lung region, $[^{18}F]FDG$ image of Iso group was better than that of Ke/Xy group, because of high L/B ratio. Metastatic tumor location in $[^{18}F]FDG$ small animal PET image was confirmed by fusion image using clinical CT. Conclusion: Tumor imaging in small animal lung region with $[^{18}F]FDG$ small animal PET should be considered pre-conditions which fasting, warming and an anesthesia during $[^{18}F]FDG$ uptake. Fused imaging with small animal PET and CT image could be useful for the detection of metastatic tumor in lung region.