• Title/Summary/Keyword: ^1H-^1H{\

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Monte Carlo Simulations and DFT Studies of the Structural Properties of Silicon Oxide Clusters Reacting with a Water Molecule

  • Jisu Lee;Gyun-Tack Bae
    • Journal of the Korean Chemical Society
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    • v.67 no.5
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    • pp.333-338
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    • 2023
  • In this study, the H2O reaction with SiO clusters was investigated using ab initio Monte Carlo simulations and density functional theory calculations. Three chemistry models, PBE1/DGDZVP (Model 1), PBE1/DGDZVP (Si atom), and aug-cc-pVDZ (O and H atoms), (Model 2) and PBE1/aug-cc-pVDZ (Model 3), were used. The average bond lengths, as well as the relative and reaction energies, were calculated using Models 1, 2, and 3. The average bond lengths of Si-O and O-H are 1.67-1.75 Å and 0.96-0.97 Å, respectively, using Models 1, 2, and 3. The most stable structures were formed by the H transfer from an H2O molecule except for Si3O3-H2O-1 cluster. The Si3O3 cluster with H2O exhibited the lowest reaction energy. In addition, the Bader charge distributions of the SinOn and (SiO)n-H2O clusters with n = 1-7 were calculated using Model 1. We determined that the reaction sites between H2O and the SiO clusters possessed the highest fraction of electrons.

Influence of Environmental Living Standards on Helicobacter pylori Infection in Korean Elementary School Children (서울 지역 초등학생의 생활환경과 Helicobacter pylori 양성률)

  • Kim, Je-Woo;Kim, Hyo-Shin;Chung, Ki-Sup
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.4 no.1
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    • pp.10-17
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    • 2001
  • Purpose: We measured anti-H. pylori IgG in Korean elementary school children living in Shinchon area of Seoul, Korea to evaluate the influence of environmental living standards on H. pylori infection. Methods: IgG antibodies to H. pylori were measured in plasma using a commercial ELISA kit (GAP IgG Helicobacter pylori, Bio-Rad Laboratories Inc., Hercules, CA, USA). Information on environmental status such as place of birth, parental income, type of housing, number of persons in the household, parents' occupation, family history of peptic ulcer disease and gastric cancer was obtained. Statistical analysis was done by Chi-square and logistic regression test using SPSS $7.0^{TM}$ for Windows. Results: Study subjects consisted of 571 children, and the age distribution ranged from 6.0 to 13.6 years with a mean of $9.6{\pm}1.8$ years. Male-to-female ratio was 1.1:1. The seropositive rates of H. pylori infection ranged from 10.4% in children aged 6 years to 30.9% in 12 year-old group, overall 16.8%. The prevalence of H. pylori infection progressively increased with age, but there was no significant difference in seropositive rates among children in different age groups (p=0.06). Seropositive rates of anti-H. pylori IgG on the basis of gender, place of birth, parental income, type of housing, parents' occupation, family history of peptic ulcer disease and gastric cancer showed no statistically significant difference. Interestingly, however, seropositive rate of anti-H. pylori IgG showed statistical significance in relation to number of persons in the household (p=0.003; Odds ratio 1.50 by logistic regression test). Conclusion: These results suggest that number of persons in the household is the most important factor among environmental living standards, and that risk of H. pylori infection increases by increment of 1.5 times as the number of persons in the household increases by one.

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Construction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cells

  • Chung, Myungguen;Cho, Soo Young;Lee, Young Seek
    • Biomolecules & Therapeutics
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    • v.26 no.3
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    • pp.290-297
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    • 2018
  • We aimed to understand the molecular changes in host cells that accompany infection by the seasonal influenza A H1N1 virus because the initial response rapidly changes owing to the fact that the virus has a robust initial propagation phase. Human epithelial alveolar A549 cells were infected and total RNA was extracted at 30 min, 1 h, 2 h, 4 h, 8 h, 24 h, and 48 h post infection (h.p.i.). The differentially expressed host genes were clustered into two distinct sets of genes as the infection progressed over time. The patterns of expression were significantly different at the early stages of infection. One of the responses showed roles similar to those associated with the enrichment gene sets to known 'gp120 pathway in HIV.' This gene set contains genes known to play roles in preventing the progress of apoptosis, which infected cells undergo as a response to viral infection. The other gene set showed enrichment of 'Drug Metabolism Enzymes (DMEs).' The identification of two distinct gene sets indicates that the virus regulates the cell's mechanisms to create a favorable environment for its stable replication and protection of gene metabolites within 8 h.

Impact of organizational influences of management on organizational performance in social enterprise (사회적기업 경영진의 조직역량이 조직성과에 미치는 영향에 관한 연구)

  • Kim, Moon-Joon;Chang, Sug-In
    • Industry Promotion Research
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    • v.3 no.2
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    • pp.9-20
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    • 2018
  • The purpose of this study is to examine the influence of orgaizational capability(Organizational management capability, marketing capability, relationship formation capability, governance capability) of management perceived by the members of the social enterprise on performance of organization(both economic and social). For such goal, empirical analysis of research hypothesis 1 (organizational competence and economic performance) and research hypothesis 2 (organizational competence and social performance) was conducted using the statistical program of IBM SPSS 24.0 for the final 195 candidates who work in social enterprise. Both hypothesis 1 and 2 were adopted, as the result of the hypothesis 1 and 2, H1-1 H2-1 (organizational management competence and economic performance and social performance), H1-2 H2-2 (marketing competence and economic performance social performance), H1-3 H2-3 (relationship formation competence, economic performance, and social performance), and H1-4 H2-4 (governance capability and economic performance and social performance) all have a significant effect on economic and social performance. Therefore, the importance of organizational capability of management, executive body of social enterprises, was emphasized for the success and strive of social enterprise and sustainable management. Therefore, it is necessary to establish an education and training system to strategically develop and strengthen the organizational capability of the management, and provide a systematic and long-termed education system and training.

Techno-economic Analysis of Glycerol Steam Reforming for H2 Production Capacity of 300 m3 h-1 (300 m3 h-1급 수소 생산을 위한 글리세롤 수증기 개질반응의 기술·경제성 분석)

  • Heo, Juheon;Lim, Hankwon
    • Applied Chemistry for Engineering
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    • v.29 no.2
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    • pp.209-214
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    • 2018
  • In this paper, the techno-economic analysis of glycerol steam reforming for $H_2$ production capacity of $300m^3\;h^{-1}$ was carried out. The process of glycerol steam reforming was constructed by using Aspen $HYSYS^{(R)}$, a commercial process simulator, and parametric studies for the effect of the operating temperature on $H_2$ production was performed. Moreover, the economic analysis was conducted through an itemized cost estimation, sensitivity analysis (SA) and cash flow diagram (CFD), and the unit $H_2$ production cost was 5.10 $ ${kgH_2}^{-1}$ through the itemized cost estimation of glycerol steam reforming for $H_2$ production capacity of $300m^3\;h^{-1}$. SA was employed to identify key economic factors and various economic indicators such as net present value (NPV), discounted payback period (DPBP), and present value ratio (PVR) were found according to $H_2$ selling price using CFD.

pH-Sensitive Release of Indomethacin from Curdlan Acetate Microspheres (Curdlan Acetate Microspheres를 이용한 Indomethacin의 pH 민감성 방출)

  • Lee Chang-Moon;Lee Young-Jin;Kim Hyung-Ju;Park Hee-Jung;Lee Ki-Young
    • KSBB Journal
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    • v.20 no.1 s.90
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    • pp.46-49
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    • 2005
  • Curdlan, a natural $\beta-1,3-glucan,$ has been studied as drug carrier due to its unique properties including its thermal gelling characters. In this study, curdlan was chemically acetylated for pH-sensitive drug delivery. Curdlan acetate microspheres(CAMs) were prepared by the solvent evaporation method. The size of the CAMs was below $200{\mu}m.$ The drug loading efficiency of microspheres was approximately $58.44\%$. In the swelling test, the CAMs showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, release rate of indomethacin(IND) at pH 7.4 from the CAMs was faster than that at pH 1.4. Therefore the CAMs have potential for the controlled release of IND over an extended period of time.

Expression and Purification of the Helicase-like Subdomains, H1 and H23, of Reverse Gyrase from A. fulgidus for Heteronuclear NMR study

  • Kwon, Mun-Young;Seo, Yeo-Jin;Lee, Yeon-Mi;Lee, Ae-Ree;Lee, Joon-Hwa
    • Journal of the Korean Magnetic Resonance Society
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    • v.19 no.2
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    • pp.95-98
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    • 2015
  • Reverse gyrase is a hyperthermophile specific protein which introduces positive supercoils into DNA molecules. Reverse gyrase consists of an N-terminal helicase-like domain and a C-terminal topoisomerase domain. The helicase-like domain shares the three-dimensional structure with two tandem RecA-folds (H1 and H2), in which the subdomain H2 is interrupted by the latch domain (H3). To understand the physical property of the hyperthermophile-specific protein, two subdomains af_H1 and af_H23 have been cloned into E. coli expression vector, pET28a. The $^{15}N$-labeled af_H1 and af_H23 proteins were expressed and purified for heteronuclear NMR study. The af_H1 protein exhibits the well-dispersion of amide signals in its $^1H/^{15}N$-HSQC spectra and thus further NMR study continues to be progressed.

Research on Relationship between Natural Vibration Periods and Structural Heights for High-rise Buildings and Its Reference Range in China

  • Xu, Peifu;Xiao, Congzhen;Li, Jianhui
    • International Journal of High-Rise Buildings
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    • v.3 no.1
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    • pp.49-64
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    • 2014
  • Natural vibration period is an important parameter for high-rise building, Based on 414 high-rise buildings completed or passed over-limit approval in China, the distribution law of natural vibration periods is analyzied. In order to satisfy the design requirements, such as global stability, story drift limit and minimum shear-gravity ratio, the reference ranges of fundamental periods $T_1$ are $0.3{\sqrt{H}}{\sim}0.4{\sqrt{H}}$ when the structural heights $H{\geq}250m$, when 150 m ${\leq}$ H < 250m, $T_1=0.25{\sqrt{H}}{\sim}0.4{\sqrt{H}}$, when 100 m ${\leq}$ H < 150 m, $T_1=0.2{\sqrt{H}}{\sim}0.35{\sqrt{H}}$, when 50 m $ {\leq}$ H < 100m, $T_1=0.15{\sqrt{H}}{\sim}0.3{\sqrt{H}}$. These can provide reference data for controlling mass and rigidity of high-rise buildings.

cDNA Sequences for Asialoglycoprotein Receptor from Human Fetal Liver

  • Lee, Dong-Gun;Lee, Sung-Gu;Kim, Kil-Lyong;Hahm, Kyung-Soo
    • BMB Reports
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    • v.30 no.4
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    • pp.299-301
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    • 1997
  • The asialoglycoprotein receptor (ASGPR) was the first described mammalian lectin that mediates the specific binding and internalization of galactose/N-acetylgalactosamine-terminating glycoproteins by hepatic parenchymal cells. H1 and H2 are known as essential subunits of the functional ASGPR. There were close similarities in ASGPR H2 subunits between cultured cell line HepG2 and normal human liver cells including identical sequences at both termini. It was therefore expected that there may be some similarities between the subunits from normal liver cells and fetal liver cells. The two subunits of human fetal liver ASGPR. designated FL-H1 and FL-H2. were cloned from cDNA library by peR and the sequences were compared with the known HI and H2 sequences of HepG2, and the H1 sequence of nornal human liver cells. The results showed that FL-H1 was identical to H1 of HepG2. Whereas FL-H2 contains a 15-bp miniexon, but missing 57-bp at the near upstream from the membrane-spanning domain compared to H2 of HepG2 and normal human liver cells indicating that FL-H2 resulted from a differential splicing compared to HepG2 and normal liver cells.

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항 Histamine제의 $H_1$-Receptor와 Muscarinic Receptor에 대한 상대적 역가

  • 이신웅;박영주
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.87-87
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    • 1993
  • 항 Histamine쟤의 효과적인 응용과 그 개발율 위한 자료를 얻고자 이들 약물의 H$_1$-receptor와 muscarinic receptor에 대한 작용의 상대적 역가를 비교하였다. 본 실험에 이용된 기니픽 회장에는 [$^3$H]QHB어 대한 단일 muscarinic receptor가 존재하였으며 [$^3$H]QNB의 affinity와 결합부위농도는 각각 54 pM 및 156 fmol/mg이었다. 항 histamine제는 muscarinic receptor에 대한 [$^3$H]QNB결합을 억제하였으며 [$^3$H]QNB 결합억제로부터 추정된 항 histamine제의 Ki치가 0.008$\mu$M-1.6$\mu$M로서 항 histamine제의 종류에 따라 현저한 차이가 있었고, 이 결과는 carbachol 반응억제로부터 추정된 각 항 histamine제의 muscarinic receptor에 대한 affinity(K$_{M}$)와 유사하였다. 한편 histamine수축반응 억제로부터 추정된 항 histamine재의 H$_1$-receptor에 대한 affinity(K$_{H}$ ) 역시 0.15nM-56.5nM로서 약물에 따라 차이가 있었고 각 약물의 $K_{M}$ /K$_{H}$ 비가 3-2300으로 H$_1$-receptor에 대한 역가와 muscarinic receptor에 대한 역가 사이에는 상관성이 없었다. 즉 유사한 항 allergy 작용을 일으킬 수 있는 치료혈중농도에서도 muscarinic receptor 차단작용이 다르며 본 실험에 사용한 13종의 기존 항 histamine제중 triprolidine이 $K_{M}$ /K$_{H}$ 비가 가장 높았고 diphenidol이 가장 낮았다. 이상의 결과로 보아 항 histamine제의 muscarinic receptor 차단작용은 이들 약물의 항 alleragy 효과에 필요한 작용이 아니며 본 실험에서 추정된 항 histamine제의 H$_1$-receptor와 muscarinic receptor에 대한 상대적 역가는 이들 약물의 선택과 평가에 중요한 지표가 될수 있을 것으로 생각된다.

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