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pH-Sensitive Release of Indomethacin from Curdlan Acetate Microspheres  

Lee Chang-Moon (Interdisciplinary Program of Biomedical Engineering, Chonnam National University)
Lee Young-Jin (Department of Material Chemical and Biochemical Engineering, Chonnam National University)
Kim Hyung-Ju (Interdisciplinary Program of Biomedical Engineering, Chonnam National University)
Park Hee-Jung (Department of Material Chemical and Biochemical Engineering, Chonnam National University)
Lee Ki-Young (Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)
Publication Information
KSBB Journal / v.20, no.1, 2005 , pp. 46-49 More about this Journal
Abstract
Curdlan, a natural $\beta-1,3-glucan,$ has been studied as drug carrier due to its unique properties including its thermal gelling characters. In this study, curdlan was chemically acetylated for pH-sensitive drug delivery. Curdlan acetate microspheres(CAMs) were prepared by the solvent evaporation method. The size of the CAMs was below $200{\mu}m.$ The drug loading efficiency of microspheres was approximately $58.44\%$. In the swelling test, the CAMs showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, release rate of indomethacin(IND) at pH 7.4 from the CAMs was faster than that at pH 1.4. Therefore the CAMs have potential for the controlled release of IND over an extended period of time.
Keywords
Curdlan; indomethacin; pH-sensitive; microsphere;
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