• 제목/요약/키워드: [4+2]-Cycloaddition

검색결과 97건 처리시간 0.022초

입체선택적인 분자내 [2+2] 환화반응을 이용한 광학활성 Bicyclo[4.2.0.]octanone의 합성 (Synthesis of The Optically Active Bicyclo [4.2.0. ] octanone by Stereoselective Intramolecular [2+2] Cycloaddition)

  • 심필종;김희두
    • 약학회지
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    • 제41권6호
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    • pp.714-717
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    • 1997
  • Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.

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Cycloadditiona reaction of 5-(2-thienyl)methylene derivatives of thiazolidinone-4-thiones and their antimicrobial activities

  • Ead, Hamed A.;Metwalli, Nadia H.;Morsi, Nagwa M.
    • Archives of Pharmacal Research
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    • 제13권1호
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    • pp.5-8
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    • 1990
  • The cycloaddition of the newely synthesized 5-(2-thienyl)methylene derivatives of thiazolidinone-4-thiones, 2a-c to acrylonitrile (3a), ethylacrylate (3b), N-phenylmaleimide (6) and dimethyl fumarate (8) has been evaluated. Under thermal reaction conditions [4 +2] cycloaddition proceeds with complete site and regioselectivity to yield the cycloadduct, 4, 5, 7 and 9, respectively. The antimicrobial activities of some of the new products were tested.

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Control over [2+2+2] and Carbonylative [4+2] Cycloaddition by CO Pressure in Co-Catalyzed Cycloaddition between Internal Diynes and Cyclopentadiene

  • Kim, Do-Han;Chung, Young-Keun;Han, Jin-Wook
    • Bulletin of the Korean Chemical Society
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    • 제29권6호
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    • pp.1224-1228
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    • 2008
  • The reaction of internal diynes and cyclopentadiene in the presence of 5 mol % of cobalt catalysts proceeded under 5 atm of carbon monoxide pressure to give a high yield of the corresponding [2+2+2] cycloaddition product. By lowering carbon monoxide pressure from 30 atm to 5atm, cyclopentadiene can be used as a dienophile in the cobalt carbonyl-catalyzed [2+2+2] cycloaddition reaction between internal diynes and cyclopentadiene.

Density Functional Study on [3+2]-Dipolar Cycloaddition Reaction of the N-heterocyclic Carbene Boryl Azide with Olefins

  • Zhang, Xing-Hui;Wang, Ke-Tai;Niu, Teng;Li, Shan-Shan
    • Bulletin of the Korean Chemical Society
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    • 제35권5호
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    • pp.1403-1408
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    • 2014
  • The cycloaddition reactions of the N-heterocyclic carbene boryl azide with methyl acrylate, butenone, and hexafluoropropene have been investigated theoretically. Solvent effects on these reactions have been explored by calculation that included a polarizable continuum model (PCM) for the solvent (C6H6). The title reaction could produce 4- and 5-substituted 1,2,3-triazolines, respectively. The reaction systems have the higher chemical reactivity with the low barriers and could be favored. Yet the smaller differences have been found to occur in energetics, and the cycloaddition reactions occur for s-trans conformations over s-cis conformations. The calculations indicated that the cycloaddition reaction of the alkenes have certain regioselectivity.

Fe(0) 촉매를 이용한 Acetylenic Dienes 의 분자내 [4+2] 고리화 첨가반응에 관한 연구 (Studies Towards Intramolecular Formal Iron-Catalyzed [4+2] Cycloaddition of Acetylenic Dienes)

  • 변상용
    • 대한화학회지
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    • 제38권1호
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    • pp.61-68
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    • 1994
  • Fe(0)촉매하에서 이중고리 생성물이 얻어지는 acetylenic diene을 반응시켜 분자내 [4+2]고리화 첨가반응을 조사하였다. 위 반응은 이분자 첨가반응과 분자내 탄소 고리화 반응이 경쟁적으로 진행된다고 알려져 있다. 그러나 Fe(0)촉매하에서 4,4-dimethyl-3-(tert-butyldimethylsiloxy)-1-phenyl-6,8-decadien-1-yne(11)의 고리화 반응은 단지 이중고리 생성물만이 얻어졌다(수득율 78.1%). 이 결과에서 dienyne의 4,4-위치에 치환된 dimethyl기가 Fe(0)촉매하의 고리화 반응조건에 안정함으로 인하여 분자내 고리화 반응이 촉진되는 것으로 생각된다.

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AgBF4/[Bmim]BF4-Catalyzed [3+2] Cycloaddition of Cyclic Diazodicarbonyl Compounds: Efficient Synthesis of 2,3-Dihydrofurans and Conversion to 3-Acylfurans

  • Xia, Likai;Lee, Yong-Rok;Kim, Sung-Hong;Lyoo, Won-Seok
    • Bulletin of the Korean Chemical Society
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    • 제32권5호
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    • pp.1554-1558
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    • 2011
  • A novel and efficient method for the synthesis of 2,3-dihydrofurans bearing a variety of substituents on the dihydrofuran ring was achieved by the reaction of cyclic diazodicarbonyl compounds with styrene and vinyl acetate. The key strategy was AgBF$_4$/[Bmim]BF$_4$-catalyzed [3+2] cycloaddition. The synthesized dihydrofurans with an acetate group were further converted to the corresponding 3-acylfurans.

Regioselective 1,3-Dipolar Cycloaddition and 1,2-Addition between Benzaldoxime NH-nitrone and Perfluoro-2-methyl-2-pentene

  • Lee, Chan-Woo;Park, Joo-Yuen;Kim, Hyun-Uk;Chi, Ki-Whan
    • Bulletin of the Korean Chemical Society
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    • 제31권5호
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    • pp.1172-1176
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    • 2010
  • Regioselective perfluorinated [3+2] cycloadducts and 1,2-adducts have been prepared by 1,3-dipolar cycloaddition between benzaldoxime NH-nitrone and perfluorinated alkene, perfluoro-2-methyl-2-pentene. Although the cycloaddition reaction is carried out at room temperature, the corresponding perfluorinated compounds are effectively produced in a high yield. In particular, the methoxy-substituted adducts (4 and 7a) show the self-assembled structure by intermolecular interactions. These derivatives were characterized by IR, $^1H$ and $^{19}F$ NMR, and the absolute structure of perfluorinated adducts was confirmed by X-ray crystallography.

Regio- and Diastereoselective 1,3-Dipolar Cycloaddition between Perfluoro-2-methyl-2-pentene and Nitrones: A Facile Approach to Partially-Fluorinated Isoxazolidines

  • Moon, Mi-Eun;Park, Joo-Yeon;Jeong, Eun-Ha;Vajpayee, Vaishali;Kim, Hyun-Uk;Chi, Ki-Whan
    • Bulletin of the Korean Chemical Society
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    • 제31권6호
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    • pp.1515-1518
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    • 2010
  • Regio- and diastereoselective 1,3-dipolar cycloaddition reactions of nitrones {(Z)-${\alpha}$-phenyl-N-methylnitrone (1a) and (Z)-${\alpha}$-propyl-N-butylnitrone (1b)} with electron-deficient perfluoro-2-methyl-2-pentene (2) lead to novel isoxazolidines {5-fluoro-5-pentafluoroethyl-4,4-bis-trifluoromethyl-2-methyl-3-phenyl-isoxazolidine (3a) and 2-butyl-5-fluoro-5-pentafluoroethyl-4,4-bis-trifluoromethyl-3-propyl-isoxazolidines (3b) respectively} as major constituents. These derivatives were characterized by IR, $^1H$ and $^{19}F$ NMR, GC-MS and NOE measurements, and the absolute structure of 3a was confirmed by X-ray crystallography.