• Nutrition Research and Practice
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• 제13권3호
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• pp.263-267
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• 2019

BACKGROUD/OBJECTIVES: Obesity is globally a major public health issue. Evidence suggests that elevated ferritin levels are associated with obesity, dyslipidemia, insulin resistance, and metabolic syndrome. This study was undertaken to examine the relationship between the serum ferritin level and depression in Korean male adults with respect to classification of the prevailing obesity. SUBJECTS/METHODS: This was a case-control study; subjects were classified into obese group (${\geq}25.0kg/m^2$, 28 subjects) and normal group ($18.5-22.9kg/m^2$, 27 subjects). A survey was conducted to assess the depression levels as per the guidelines suggested by the Center program for Epidemiological Studies-Depression (CES-D). Blood was collected from each group for assessing biomarkers, and isolated plasma was evaluated for fasting glucose, insulin, quantitative insulin sensitivity check index, and ferritin levels. Data were analyzed, and groups were compared with respect to Body Mass Index (BMI), depression scale and biomarkers. RESULTS: The average depression score of the obesity group was 16.86, which was higher than the normal group (12.56). Subjects scoring more than 16 points comprised 53.6% of the population in the obese group, which was more than double that in the normal group, as assessed by the CES-D program. Furthermore, the serum ferritin level of the obesity group was 207.12 ng/mL, which was higher than that of the normal group (132.66 ng/mL). Lastly, the BMI appeared to be significantly correlated with both depression (r = 0.320, P = 0.017) and elevated ferritin levels (r = 0.352, P = 0.008). CONCLUSION: This study provides evidence of existing correlation between ferritin and depression with obesity.

• Smart Structures and Systems
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• 제29권1호
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• pp.29-39
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• 2022

Crack detection plays an important role in the maintenance and protection of steel box girder of bridges. However, since the cracks only occupy an extremely small region of the high-resolution images captured from actual conditions, the existing methods cannot deal with this kind of image effectively. To solve this problem, this paper proposed a novel three-stage method based on deep learning technology and morphology operations. The training set and test set used in this paper are composed of 360 images (4928 × 3264 pixels) in steel girder box. The first stage of the proposed model converted high-resolution images into sub-images by using patch-based method and located the region of cracks by CBAM ResNet-50 model. The Recall reaches 0.95 on the test set. The second stage of our method uses the Attention U-Net model to get the accurate geometric edges of cracks based on results in the first stage. The IoU of the segmentation model implemented in this stage attains 0.48. In the third stage of the model, we remove the wrong-predicted isolated points in the predicted results through dilate operation and outlier elimination algorithm. The IoU of test set ascends to 0.70 after this stage. Ablation experiments are conducted to optimize the parameters and further promote the accuracy of the proposed method. The result shows that: (1) the best patch size of sub-images is 1024 × 1024. (2) the CBAM ResNet-50 and the Attention U-Net achieved the best results in the first and the second stage, respectively. (3) Pre-training the model of the first two stages can improve the IoU by 2.9%. In general, our method is of great significance for crack detection.

• 한국음향학회지
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• 제26권4호
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• pp.144-152
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• 2007

기존의 심음분류를 위한 연구들은 인공신경망을 이용하여 주로 이루어졌다. 그러나 심음신호의 통계적 특성을 분석 한 결과 HMM의 의한 신호모델링이 적합한 것으로 나타났다. 본 연구에서는 다양한 질병을 나타내는 심음신호를 HMM을 이용하여 모델링 하고 인식성능이 심음신호의 클러스터링에 따라서 많이 좌우되는 것을 알 수 있었다. 또한 실제 환경에서의 심음신호는 그 시작과 끝나는 시점이 정해지지 않은 연속신호이다. 따라서 HMM을 이용한 심음분류를 위해서는 연속적인 심음신호로부터 한 사이클의 분할된 심음을 추출할 필요성이 있다. 일반적으로 수동분할은 분할오류를 발생시키며 실시간 심음인식에 적합하지 않으므로 분할과정이 필요치 않는 ergodic형 HMM을 변형하여 사용할 것을 제안하였다. 그리고 제안된 HMM은 연속심음을 이용한 분류실험에서 매우 높은 성능을 보임을 알 수 있었다.

• 한국조경학회지
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• 제36권3호
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• pp.75-84
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• 2008

본 연구는 경관이 발생하는 조망점에서 체험되는 시각특성과 그 조망점에서의 경관체헝을 극적으로 이끄는 지리 구조를 양산시에 소재하고 있는 산지 경관의 사례 연구를 통하여 밝현 것이며, 그 결과는 다음과 같다. 양산시 소재 6개의 산을 대상으로 그 산을 체험할 수 있는 조망점을 40개소 선정하였다. 이들 조망점에서 파악된 산지경관 조망점에서 조망대상이 중거리역에 주로 분포하고 있으며, 시각크기는 산과 대변하는 느낌을 주는 앙각 11${\sim}13^{\circ}$, 시야 전체를 차지하고 광대한 인상을 주는 수평각 50${\sim}90^{\circ}$라는 것을 알 수 있었다. 양산시에서는 도시민이 산의 느낄 수 있는 거리대에서 대면적 관계로 산지경관을 지각하고 있다. 이어서 인상적인 경관체험을 유발하는 조망점의 지리 구조를 8개 의 유형으로 분류하였으며, 그 특성을 고찰하였다. 산이 건물이나 길가의 수목 등의 주변 환경이 만들어낸 좁고 긴 선형의 공간을 형성하는 회랑형이 7개소, 또 산을 교량 또는 고가도로의 하부나 터널을 지날 때 가려졌던 시야와 빛이 열리면서 체험하게 되는 터널형이 2개 소, 산세를 따라 굽이지는 길의 마지막에 나타나는 미로형이 4개소, 교차로에서 방향을 전환하거나 건물이나 산자락을 끼고 돌 때 동선방향이 바뀌는 순간 나타나는 모롱이형이 8개소, 오르막 경사의 마루에서 나타나는 고개마루형이 3개소, 산이 관찰자와 같은 진행방향으로 길게 누워져 있을 때 차창에 지속적으로 나타나는 평행형이 4개소, 고립되어 있는 산파 형태인 대변형이 5개소, 마을, 도시 등의 지역 경제나 교량, 광장과 같은 주요 지점을 지날 때 나타났다. 산지 경관이 인상적으로 체험되기 위해서는 조망점뿐 아니라 그곳으로 다가가는 지리구조도 아울러 중요하다는 것을 확인하였다. 본 연구의 성과는 산지경관의 관리 및 보존과 경관자원도 등 경관영향평가의 기초자료를 수집하는 기초 자료가 될 것이다. 또 경관도로의 정비 등에도 응용할 수 있을 것으로 기대한다.

• 한국균학회지
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• 제26권2호통권85호
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• pp.265-274
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• 1998

목질진흙버섯(Phellinus sp.) 자실체의 인공재배를 위한 기초자료마련의 일환으로 자실체로부터 순수분리한 상황속의 한 균주를 이용하여 참나무 (Quercus aliena), 뽕나무(Morus alba) 및 오리나무(Alnus japonica)의 3종 톱밥기질에 따른 균사생육의 최적조건을 반응표면분석방법으로 조사하였다. 균사생육에 영향을 미치는 3종의 독립변수(쌀겨첨가량, 배지의 초기 pH 및 수분함량)와 그 최적값을 검토한 결과, 쌀겨첨가량은 3종의 톱밥배지 모두에서 약 30%(w/w) 첨가시에 가장 좋았으며, 수분함량은 $65{\sim}70%(w/v)$ 범위 에서 좋았다. 배지의 초기 pH는 참나무와 뽕나무에서는 $pH\;5{\sim}6$, 오리나무 톱밥배지의 경우는 pH 6에서 가장 좋았다. 균사의 생육온도는 모든 톱밥배지에서 $25{\sim}30^{\circ}C$의 온도범위에서 좋았으나, 톱밥수종에 따른 차이를 보였다. 균사생육에 영향을 미치는 쌀겨첨가량$(X_1)$, 배지의 초기 $pH(X_2)$ 및 수분함량 $(X_3)$을 각각 종속변수로 하고, 균사의 생육길이를 독립변수(Y)로 하여 반응 표면분석한 결과, 참나무 톱밥의 경우, 쌀겨첨가량 31.01%(w/w), 배지의 PH 5.31, 그리고 수분함량 69.03%(w/v)에서 얻어졌으며, 이때 기대되는 균사의 생육길이는 8.32cm이었다. 특히, 쌀겨 첨가량$(X_1)$과 수분함량$(X_3)$)의 회귀계수가 높아, 이 변수들이 균사생육에 큰 영향을 미침을 알 수 있었다. 뽕나무 톱밥배지의 경우, 쌀겨첨가량, 배지의 초기 pH 및 수분함량의 정상점은 각각 28.77%(w/w), 5.28및 69.8%(w/v)로, 예측되는 균사의 생육길이는 7.60 cm이었다. 오리나무 톱밥 배지의 정상점은 쌀겨첨가량 28.74%(w/w), 배지의 pH 6.04및 수분함량 66.96%(w/v)으로, 이때, 예상되는 균사의 생육길이는 5.38cm이었다. 이상의 결과로부터 목질진흙버섯의 균사 생육과 독립변수들 사이에는 상관관계가 높았고, 쌀겨첨가량과 배지의 초기 pH가 수분함량보다 균사생육에 더 큰 영향을 미쳤으며, 목질진흙버섯의 균사 생육을 위한 최적의 톱밥 수종은 참나무(Quercus aliena)>뽕나무(Morus alba)>오리나무(Alnus japonica)의 순이었다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권4호
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• pp.491-500
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• 2010

Three experiments were conducted to investigate the effects of polyurethane coated urea on in vitro ruminal fermentation, ammonia release dynamics and lactating performance of Holstein dairy cows fed a steam-flaked corn-based diet. In Exp. 1, a dual-flow continuous culture was run to investigate the effect of polyurethane coated urea on nutrient digestibility, rumen fermentation parameters and microbial efficiency. Three treatment diets with isonitrogenous contents (13.0% CP) were prepared: i) feedgrade urea (FGU) diet; ii) polyurethane coated urea (PCU) diet; and iii) isolated soy protein (ISP) diet. Each of the diets consisted of 40% steam-flaked corn meal, 58.5% forages and 1.5% different sources of nitrogen. PCU and FGU diets had significantly lower digestibility of NDF and ADF (p<0.01) than the ISP diet. Nitrogen source had no significant effect (p = 0.62) on CP digestibility. The microbial efficiency (expressed as grams of microbial N/kg organic matter truly digested (OMTD)) in vitro of the PCU diet (13.0 g N/kg OMTD) was significantly higher than the FGU diet (11.3 g N/kg OMTD), but comparable with the ISP diet (14.7 g N/kg OMTD). Exp. 2, an in vitro ruminal fermentation experiment, was conducted to determine the ammonia release dynamics during an 8 h ruminal fermentation. Three treatment diets were based on steam-flaked corn diets commonly fed to lactating cows in China, in which FGU, PCU or soybean meal (SBM) was added to provide 10% of total dietary N. In vitro $NH_3-N$ concentrations were lower (p<0.05) for the PCU diet than the FGU diet, but similar to that for the SBM diet at all time points. In Exp. 3, a lactation trial was performed using 24 lactating Holstein cows to compare the lactating performance and blood urea nitrogen (BUN) concentrations when cows were fed PCU, FGU and SBM diets. Cows consuming the PCU diet had approximately 12.8% more (p = 0.02) dietary dry matter intake than those consuming the FGU diet. Cows fed the PCU diet had higher milk protein content (3.16% vs. 2.94%) and lower milk urea nitrogen (MUN) concentration (13.0 mg/dl vs. 14.4 mg/dl) than those fed the FGU diet. Blood urea nitrogen (BUN) concentration was significantly lower for cows fed the PCU (16.7 mg/dl) and SBM (16.4 mg/dl) diets than the FGU (18.7 mg/dl) diet. Cows fed the PCU diet had less surplus ruminal N than those fed the FGU diet and produced a comparable lactation performance to the SBM diet, suggesting that polyurethane coated urea can partially substitute soybean meal in the dairy cow diet without impairing lactation performance.

• Biomolecules & Therapeutics
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• 제26권6호
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• pp.608-615
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• 2018

Benzalkonium chloride, diazolidinyl urea, and imidazolidinyl urea are commonly used preservatives in cosmetics. Recent reports suggested that these compounds may have cellular and systemic toxicity in high concentration. In addition, diazolidinyl urea and imidazolidinyl urea are known formaldehyde (FA) releasers, raising concerns for these cosmetic preservatives. In this study, we investigated the effects of benzalkonium chloride, diazolidinyl urea, and imidazolidinyl urea on ROS-dependent apoptosis of rat neural progenitor cells (NPCs) in vitro. Cells were isolated and cultured from embryonic day 14 rat cortices. Cultured cells were treated with 1-1,000 nM benzalkonium chloride, and $1-50{\mu}M$ diazolidinyl urea or imidazolidinyl urea at various time points to measure the reactive oxygen species (ROS). PI staining, MTT assay, and live-cell imaging were used for cell viability measurements. Western blot was carried out for cleaved caspase-3 and cleaved caspase-8 as apoptotic protein markers. In rat NPCs, ROS production and cleaved caspase-8 expression were increased while the cell viability was decreased in high concentrations of these substances. These results suggest that several cosmetic preservatives at high concentrations can induce neural toxicity in rat brains through ROS induction and apoptosis.

• 한국연초학회지
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• 제13권2호
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• pp.5-20
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• 1991

For the quality enhancement of harvested-year leaf tobacco to the quality of 2-year naturally aged leaf tobacco, cellulose and nicotine degradative bacteria were isolated and identified. Effects of artificial fermentation treated cellulase and nicotine degradative bacteria on the quality of leaf tobacco were investigated from the chemical and sensory points of view. 1, Changes in chemical composition of leaf tobacco resulted from the addition of cellulase extracted from Cellulomonas sp. [3ml(${\mu}{\textrm}{m}$ D-glucose/ml. mil-1) of enzymes solution 11009 of leaf tobacco] and nicotine degradative bacteria, Pseudomonas sp. 2ml(IX109 cells$\div$ 100g of leaf tobacco), and subsequently fermented at 40${\mu}{\textrm}{m}$$^{\circ}C$, 65% R. H. for 40 days are as follows : 1) Content of crude fiber decreased 12% It took 9 min, 53 sec. to reach full combustion in control group but took only 7 min. 47 sec. in the treated group, taking almost equal time to 2-year naturally aged leaf tobacco(7 min. 35sec.). 2) Light intensity of control group was 60.96% with bright lemon color but that of treated leaf tobacco accounted for 47.69 with orange to dark brown color series, which was almost equal to the value, 45.69, of 2-year naturally aged leaf tobacco. 3) Linoleic acid, serving mild taste among organic acids, amounted to 1.llmg/g in control group but increased to 1.35m9/9 in the treated leaf tobacco, identical to the content(1.35mg/g) of 2-year naturally aged leaf tobacco. 4) Content of solanone, on of the typical leaf tobacco flavor compounds, accounted for 2.95% in control group but increased to 2.87% in treated group. 5) Methyl furan, useful flavor compound in smoke composition, accounted for 17.6$\mu\textrm{g}$/cig. in control group but increased to 25.9$\mu\textrm{g}$/cig. in treated group. However, acroleine decreased from 69.3$\mu\textrm{g}$/cig. in control group to 58.6$\mu\textrm{g}$/cig. in treated group 2. In sonsory test, mild taste evaluation of control group scored 5.47 and treated group 7.93 which was evaluted almost equal to the value(8.00) of 2-year naturally aged leaf tobacco. Aroma evaluation of control group scored 5.60, treated group 8.20, and 2-year naturally aged leaf tobacco 8.33. In addition, total harmony taste of control group showed 5.67, treated group 8.07 (p<0.01), and 2-year naturally aged leaf tobacco 8.00. From these results, it can be said that quality of treated leaf tobacco is not inferior to that 2-year naturally aged leaf tobacco.

• 한국콘텐츠학회논문지
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• 제16권11호
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• pp.742-753
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• 2016

안의삼동은 19세기 영남 지방 최고의 명승으로 각광받던 곳이었으나 오늘날에는 각 경관요소가 산재되어 전해오고 있다. 본 연구는 안의삼동의 경관구조 재현 및 명승적 가치 제고를 위해 관찬지리지에 수록된 주요지점을 추출하고 경관구조를 살펴본 결과 다음과 같은 결론을 도출하였다. 관찬지리지에 나타나는 안의삼동의 명승적 가치를 지닌 주요지점을 추출한 결과 화림동은 6개소, 심진동은 9개소, 원학동은 25개소로 확인되었다. 화림동은 누정과 형승이 각각 3개소로 나타났으며, 심진동의 주요지점은 모두 형승에 해당하는 자연물에 해당하였다. 원학동은 안의삼동 동천 중 가장 많은 요소들이 수록되었다. 화림동은 정자 중심의 경구집합형, 심진동은 계곡을 따라 분포하는 경점연속형, 원학동은 경구집합형과 경점연속형이 동시에 나타나는 복합형의 개별 분포 구조를 지니고 있었으며 각 동천의 집합적 의미구조를 살펴본 결과 지형에 따라 시각적 거리적 격리를 통해 주변과의 영역성을 달리하고 있으며, 좁은 입구와 위요된 지형은 동천이 무릉도원의 공간으로 인식되는 구조를 지니고 있었다. 또한 19세기 유람문화의 성행과 함께 효율적인 경로 모색에 의한 각 주요지점의 연계는 이전시기 개별 동천으로 인식되던 경관구조가 통합된 하나의 동천으로 확대되었으며, 이는 동일한 시점과 종점, 유람경로를 지니는 일반적인 동천의 경관전개와는 차별성을 지닌다.

• Genomics & Informatics
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• 제15권1호
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• pp.2-10
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• 2017

Early detection and proper management of kidney rejection are crucial for the long-term health of a transplant recipient. Recipients are normally monitored by serum creatinine measurement and sometimes with graft biopsies. Donor-derived cell-free deoxyribonucleic acid (cfDNA) in the recipient's plasma and/or urine may be a better indicator of acute rejection. We evaluated digital PCR (dPCR) as a system for monitoring graft status using single nucleotide polymorphism (SNP)-based detection of donor DNA in plasma or urine. We compared the detection abilities of the QX200, RainDrop, and QuantStudio 3D dPCR systems. The QX200 was the most accurate and sensitive. Plasma and/or urine samples were isolated from 34 kidney recipients at multiple time points after transplantation, and analyzed by dPCR using the QX200. We found that donor DNA was almost undetectable in plasma DNA samples, whereas a high percentage of donor DNA was measured in urine DNA samples, indicating that urine is a good source of cfDNA for patient monitoring. We found that at least 24% of the highly polymorphic SNPs used to identify individuals could also identify donor cfDNA in transplant patient samples. Our results further showed that autosomal, sex-specific, and mitochondrial SNPs were suitable markers for identifying donor cfDNA. Finally, we found that donor-derived cfDNA measurement by dPCR was not sufficient to predict a patient's clinical condition. Our results indicate that donor-derived cfDNA is not an accurate predictor of kidney status in kidney transplant patients.