• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3897-3901
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• 2013

Background: Optimal treatment for prostate cancer remains a challenge worldwide. Recently, T cell immunoglobulin mucin-3 (TIM-3) has been implicated in tumor biology but its contribution prostate cancer remains unclear. The aim of this study was to investigate the role of TIM-3 as a prognostic marker in patients with prostate cancer. Methods: TIM-3 protein expression was determined by immunohistochemistry and Western blotting in 137 prostate cancer tumor samples and paired adjacent benign tissue. We also performed cell proliferation assays using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl- 2H tetrazolium bromide (MTT) and cell invasion assays. The effects of small interfering RNA (siRNA)-mediated knockdown of TIM-3 (TIM-3 siRNA) in two human prostate cancer cell lines were also evaluated. Results: TIM-3 expression was higher in prostate cancer tissue than in the adjacent benign tissue (P<0.001). High TIM-3 expression was an independent predictor of both recurrence-free survival and progression-free survival. TIM-3 protein was expressed in both prostate cancer cell lines and knockdown suppressed their proliferation and invasion capacity. Conclusions: TIM-3 expression is associated with a poor prognosis in prostate cancer. Taken together, our resutlts indicate that TIM-3 is a potential prognostic marker in prostate cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4151-4155
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• 2013

Background: To compare response evaluation criteria in solid tumours (RECIST) and volumetric evaluation (VE) for colorectal cancer with liver-limited metastasis. Patients and Methods: VE of liver metastases was performed by manual contouring before and after chemotherapy on 45 pairs of computed tomography (CT) images in 36 patients who suffered from metastatic colorectal cancer (mCRC) with liver metastasis only. Cohen kappa was used to compare the agreement between VE and RECIST. Pearson correlation was performed for their comparison after cubic root transformation of the aggregate tumor volumes. Logistic regression was done to identify clinical and radiographic factors to account for the difference which may be predictive in overall response (OR). Results: There were 16 partial response (PR), 23 stable disease (SD) and 6 progressive disease (PD) cases with VE, and 14 PR, 23 SD and 8 PD with RECIST. VE demonstrated good agreement with RECIST (${\chi}$=0.779). Discordant objective responses were noted in 6 pairs of comparisons (13.3%). Pearson correlation also showed excellent correlation between VE and RECIST ($r^2$=0.966, p<0.001). Subgroup analysis showed that VE was in slightly better agreement with RECIST for enlarging lesions than for shrinking lesions ($r^2$=0.935 and $r^2$=0.780 respectively). No factor was found predictive of the difference in OR between VE and RECIST. Conclusions: VE exhibited good agreement with RECIST. It might be more useful than RECIST in evaluation shrinking lesions in cases of numerous and conglomerate liver metastases.

• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1080-1085
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• 2006

A series of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-one derivatives were synthesized using 7-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and the subcutaneous pentylenetetrazole test (sc-PTZ), and their neurotoxicities were measured by the rotarod neurotoxicity test (Tox). The tests demonstrated that 8-hexyloxy-4,5-dihydro-[1.2.4]triazole[4.3-a]quinoline-1-one (4e) and 8-heptyloxy-4,5-dihydro-[1,2,4]triazole[4, 3-a]quinoline-1-one (4f) were the most potent anticonvulsants, with 4e having $ED_{50}$ values of 17.17 mg/kg and 24.55 mg/kg and protective index ($PI=TD_{50}/ED_{50}$) values of 41.9 and 29.3 in the MES and sc-PTZ tests, respectively, and 4f having $ED_{50}$ values of 19.7 mg/kg and 21.2 mg/kg and PI values of 36.5 and 33.9 in the MES and sc-PTZ tests, respectively. The PI values of 4e and 4f were many fold better than that of the marketed drugs phenytoin, carbamazepine, phenobarbital and valproate, which have PI values in the range of 1.6-8.1 in the MES test and <0.22-5.2 in the sc-PTZ test. Structure-activity relationships were also discussed.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5983-5987
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• 2013

Radix Tetrastigma Hemsleyani Flavone (RTHF) is widely used as a traditional herb for its detoxification and anti-inflammation activity. Recently, several studies have shown that RTHF can inhibit growth and induce apoptosis in human cancer cell lines. However, the mechanisms are not completely understood yet. In this study we investigated the potential effects of RTHF on growth and apoptosis in human lung adenocarcinoma A549 cells as well as its mechanisms. A549 cells were treated with RTHF at various concentrations for different times. In vitro the MTT assay showed that RTHF had obvious anti-proliferation effects on A549 cells in a dose- and time-dependent manner. Cell morphological changes observed by inverted microscope and Hoechst33258 methods were compared with apoptotic changes observed by fluorescence microscope. Cell apoptosis inspected by flow cytometry showed significant increase in the treatment group over the control group (P<0.01). Expression of apoptosis related Bax/Bcl-2, caspases and MAPK pathway proteins were detected by Western blotting. The results showed that RTHF up-regulated the Bax/Bcl-2 ratio and cle-caspase3/9, cle-PARP expression in a dose-dependent manner. Expression of p-p38 increased, p-ERK decreased significantly and that of p-JNK was little changed in the RTHF group when compared with the control group. These results suggest that RTHF might exert anti-growth and apoptosis activity against lung cancer A549 cells through activation of caspases and Bcl-2 family proteins and the MAPK pathway, therefore presenting as a promising therapeutic agent for the treatment of lung cancer.

• Food Science and Biotechnology
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• v.15 no.5
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• pp.814-816
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• 2006

Monacolin K (MK) was produced on soybean using Monascus ruber GM011 by a two-stage-fermentation process. The optimal temperature was identified as $28^{\circ}C$. Higher yield was obtained by multiple-level-temperature cultivation than by single-level-temperature cultivation. The highest yield of total MK, 4.810 mg/g dry soybean product, was attained after 30 days of solid-state fermentation. No citrinin could be detected in the fermented soybean.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2528-2533
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• 2007

Thermoforming is one of the most versatile and economical processes available for the manufacturing polymer products. The drawback of thermoforming is difficult to get uniform thickness of final products. For the distribution of thickness strongly depends on the temperature distribution of sheet, the adjustment of heater power is very important In this paper, an optimization study for getting uniform temperature distribution was carried out using dual optimization steps. At first, the steady state optimal distribution of heater power is searched by numerical optimization to get uniform temperature of sheet surface. In the second step, time-dependent optimal heater inputs have been found out to decrease the temperature difference through the direction of thickness using Rseponse Surface Method and D-optimal method. The optimization results show that the time-dependent optimal heater power distribution gives acceptable uniform sheet temperature in the field of forming temperature..

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2757-2762
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• 2007

A cyclone design concept named Convex cyclone was developed to reduce pressure losses. Contrary to conventional cylinder-on-con type cyclone, inner wall of Convex cyclone are defined with a continuous curve and it has convex shape body. The discontinuity of inner diameter variation rate of cylinder-on-con type cyclone cause additional pressure loss. Continuous wall of Convex cyclone prevent additional pressure loss. In order to verify Convex cyclone design concept, we make a comparative experiments between Stairmand HE and Convex cyclone. Experimental Convex cyclone designed based on Stairmand HE model, and inner wall are defined with circular arch. The experimental result clearly shows that Convex cyclone can achieve maximum 50% pressure loss reduction with a few percent of collection efficiency drop. In addition, the experimental results indicated the existence of optimum convexity, minimum pressure loss, of cyclone wall.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 1998.08a
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• pp.91-94
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• 1998

Preparing food is a universal activity of families and households around the world. The kitchen is the site of these activities and is often considered the center of the home. This symposium examines housing and kitchens in Eastern and Western countries through an exploration of cultural history and lifestyles throughout the centuries. Korea and the United States were selected as the original countries for comparison and study. China and Japan were included to provide a more comprehensive Oriental perspective, while England and Italy were included to expand on the European heritage prevalent in the history of the United States.

• Journal of Power Electronics
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• v.12 no.1
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• pp.181-192
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• 2012

The increased penetration of Distributed Energy Resources (DER) is challenging the entire architecture of conventional electrical power system. Microgrid paradigm, featuring higher flexibility and reliability, becomes an attractive candidate for the future power grid. In this paper, an overview of microgrid configurations is given. Then, possible structure options and control methods of DER units are presented, which is followed by the descriptions of system controls and power management strategies for AC microgrids. Finally, future trends of microgrids are discussed pointing out how this concept can be a key to achieve a more intelligent and flexible power system.

• ETRI Journal
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• v.37 no.2
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• pp.338-347
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• 2015

The multi-carrier transmission signal in Multi-Carrier Code Division Multiple Access (MC-CDMA) has a high peak-to-average power ratio (PAPR), which results in nonlinear distortion and deteriorative system performance. An n-tuple selective mapping method is proposed to reduce the PAPR, in this paper. This method generates $2^n$ sequences of an original data sequence by adding n-tuple of n PAPR control bits to it followed by an interleaver and error-control code (ECC) to reduce its PAPR. The convolutional, Golay, and Hamming codes are used as ECCs in the proposed scheme. The proposed method uses different numbers of the n PAPR control bits to accomplish a noteworthy PAPR reduction and also avoids the need for a side-information transmission. The simulation results authenticate the effectiveness of the proposed method.