• Molecules and Cells
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• v.25 no.2
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• pp.305-311
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• 2008

After successful clinical application, arginine deiminase (ADI) has been proposed to be a new cancer therapeutic. In the present study, we examined the effect of ADI in combination with ionizing radiation (IR) on MCF-7 cell growth and clonogenic cell death. Cell growth was inhibited by IR in a dose-dependent manner and ADI enhanced the radiosensitivity. ADI itself did not suppress the growth of MCF-7 cells due to the high level of expression of argininosuccinate synthetase (ASS), which convert citrulline, a product of arginine degradation by ADI, to arginine. Previously, it was suggested that ammonia, another product of arginine degradation by ADI, is the main cause of the growth inhibition of irradiated hepatoma cells contaminated with ADI-expressing mycoplasma [van Rijn et al. (2003)]. However, we found that ammonia is not the only factor that enhances radiosensitivity, as enhancement was also observed in the absence of ammonia. In order to identify the enhancing effect, levels of ASS and proteins related to the cell cycle were examined. ASS was unchanged by ADI plus IR, but p21 (a CDK inhibitor) was upregulated and c-Myc downregulated. These findings indicate that changes in the expressions of cell cycle proteins are involved in the enhancement of radiosensitivity by ADI. We suggest that ADI is a potential adjunct to cancer therapy.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.4 no.2
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• pp.108-120
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• 1992

An ADI model for linearized shallow water equation is modified using the method of factorization. In order to show its validity. the computational results are compared both with the analytical solution and with those from existing models, for a rectangualr domain with constant and varying amplitudes at the open boundary. It is shown the accuracy of numerical solutions depends on the size of time step. depth and bottom friction. The modified ADI model is shown to be superior to the existing models such as Leendertse (1971). Butler (1980) and Sheng (1983).

• The Korean Journal of Pesticide Science
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• v.11 no.4
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• pp.289-298
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• 2007

In order to set ADIs for pesticides registered for use in Korea, an analysis of guidelines on setting ADIs and ADIs established by international bodies and advanced countries was conducted General guidelines on the derivation ADIs are very similar among regulatory authorities. However, there were large differences in the ADIs' setting status and ADI values set for some individual pesticides. ADIs were established for 213 pesticides in UN, 332 in USA, 230 in Japan, 219 in UK and 435 in EU and Australia. Of the established ADIs in other countries, 87 to 252 pesticides were the pesticides registered in Korea depending countries. The number of lowest ADIs depending countries was 32 in USA, 23 in Japan, 6 in EU and Australia. The key target organs and endpoints used for setting ADIs were in the order of enzyme inhibition, body weight change and adverse effect on liver. The number of ADIs used for setting MRLs in Korea was high in the order of JMPR, Japan and USA. ADIs of EU and JMPR had highest similarity among bodies investigated. By referring to the guidances investigated at this study, guideline for setting ADI and ADIs for 64 pesticides registered in Korea were proposed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.3
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• pp.119-127
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• 1993

Recently, ADI scheme has been a most common tool for solving shallow water equation numerically. But ADI models of tidal flow is likely to cause so called ADI effect in such a region of the Yellow Sea which shows complex topography and has submarine canyons especially. To overcome this, a finite difference algorithm is developed which adopts fully implicit method and preconditioned conjugate gradient squared method. Applying the algorithm including simulation of intertidal zone to Sae-Man-Keum. velocity fields and flooding/drying phenomena are simulated well in spite of complex topography.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.7
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• pp.36-44
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• 1996

Drilling tests were carried out austempered ductile cast iron(ADI) to clarify the factors influencing the drilling characteristics of ADI material. The machinability of material was evaluated using high speed steel drill and cobalt contained drill of 6mm diameter. The spheroidal graphite cast iron materials were austemized at 900 .deg. C for 1 hour and then wear was kept at 375 .deg. C for 2 hours. Austempered ductile cast iron contains a great deal of retained austenite which contribustes to an improvement of impact strength. In this paper, machinability of ADI was invastigated by drilling experimentation. The results obtained are as follows:a) Flank wear incresses logarithmically with the increases of cutting time and proportionally with the increases of cutting force. b) Drilling hole number of about 2 times can be educed more step feed than ordinary feed due to the high hardness of ADI material and hardness increasing ascribed to the martensite of retained austenite.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.3 no.2
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• pp.1-4
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• 1999

The Helmholtz equation is very important in physics and engineering. However, solution of the Helmholtz equation is in general known as a very difficult phenomenon. For if the ${\omega}$ is negative, the FDM discretized linear system becomes indefinite, whose solution by iterative method requires a very clever preconditioner. In this paper we assume that ${\omega}$ is nonnegative, and determine the optimal ${\rho}$ parameter for the three dimensional ADI iteration for the Helmholtz equation. The ADI(Alternating Direction Implicit) method is also getting new attentions due to the fact that it is very suitable to the vector/parallel computers, for example, as a preconditioner to the Krylov subspace methods. However, classical ADI was developed for two dimensions, and for three dimensions it is known that its convergence behaviour is quite different from that in two dimensions. So far, in three dimensions the so-called Douglas-Rachford form of ADI was developed. It is known to converge for a relatively wide range of ${\rho}$ values but its convergence is very slow. In this paper we determine the necessary conditions of the ${\rho}$ parameter for the convergence and optimal ${\rho}$ for the three dimensional ADI iteration of the Peaceman-Rachford form for the real Helmholtz equation with nonnegative ${\omega}$. Also, we conducted some experiments which is in close agreement with our theory. This straightforward extension of Peaceman-rachford ADI into three dimensions will be useful as an iterative solver itself or as a preconditioner to the the Krylov subspace methods, such as CG(Conjugate Gradient) method or GMRES(m).

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.5 no.2
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• pp.46-56
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• 1996

Drilling tests were carried out austempered ductile castiron(ADI) to clarify the factors influencing the drilling characteristics of ADI material. The machinability of material was evaluated using high speed steel drill and cobalt contained drill of 6mm diameter. The spheroidal graphite cast iron materials were austenized at 90$0^{\circ}C$ for 1 hour and then wear was kept at 375$^{\circ}C$ for 2 hours. Austempered ductile cast iron contains a great deal of retaine austenite which contributes to an improvement of impact strength, In this paper, machinability of ADI was investigated by drilling experimentation. The results obtained are as follows: a)Flank wear increases logarithmically with the increases of cutting time. b) Relation of flank wear and cutting force can be appiled to $F_z$ = 925VB + 820 for the cutting suggested condition. c) Drilling hole number of about 2 times can be reduced more step feed than ordinary feed due to the high hardness of ADI material and hardness increasing ascribed to the martensite of retained austenite.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.8 no.1
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• pp.81-88
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• 1999

This paper was carried out to know the influence of advanced austempered ductile cast iron (ADI) on the tool life and mechanical properties of drilling machinability. For manufactured method of ADI, the spheroidal graphite cast iron were austenized at 90$0^{\circ}C$ for 1 hour and then austempered for 2 hour at 37$0^{\circ}C$ in the salt bath. And interrelationship has been investigated between tool life and mechanical characteristics of specimen material on drilling condition when the ordinary and step-feed drilling are carried out to drill holes of specimens. Tensile strength and hardness of ADI decrease and elongation of ADI increases with the increase austempered temperature. It is known that about 2 times of tool life in the case of step-feed decreases compared with ordinary feed due to the high hardness of ADI and hardness ascribed to the fact that retained austenite became to martensite state due to cutting heat in drilling. Under the constant feed rate 0.1mm/rev relation between hardness and length of end tip after drilling can be formularized to Hv=$788.46L^{-0.096}$ for the cutting speed 6.1m/min.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.1 s.104
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• pp.8-16
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• 2006

In this paper, updating schemes for the alternating-direction implicit finite-difference time-domain method(ADI-FDTD) are studied, which method has the potential to considerably reduce the number of time iterations especially in case where the fine spatial lattice relative to the wavelength is used to resolve fine geometrical features. In numerical simulations for microwave structure using ADI-FDTD, time marching scheme comprises of two sub-iterations. Two different updating equation sets for ADI-FDTD simulations are presented. In order to discuss the characteristics of those schemes especially in view of applying boundary conditions, we solved two complementary 2-D problems.

• Physical Therapy Korea
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• v.13 no.4
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• pp.56-63
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• 2006

This study examined the effects of the abdominal drawing-in (ADI) maneuver using a pressure biofeedback on muscle recruitment pattern of erector spinae and hip extensors and anterior pelvic tilt during hip extension in the prone position. Fourteen able-bodied volunteers, who had no medical history of lower extremity or lumbar spine disease, were recruited for this study. The muscle onset time of erector spinae, gluteus maximus, and medial hamstring and angle of anterior pelvic tilt during hip extension in prone position were measured in two conditions: ADI maneuver condition and non-ADI maneuver condition. Muscle onset time was measured using a surface electromyography (EMG). Kinematic data for angle of anterior pelvic tilt were measured using a motion analysis system. The muscle onset time and angle of anterior pelvic tilt were compared using a paired t-test. The study showed that in ADI maneuver during hip extension in prone position, the muscle onset time for the erector spinae was delayed significantly by a mean of 43.20 ms (SD 43.12), and the onset time for the gluteus maximus preceded significantly by a mean of -4.83 ms (SD 14.10) compared to non-ADI maneuver condition (p<.05). The angle of anterior pelvic tilt was significantly lower in the ADI maneuver condition by a mean of 7.03 degrees (SD 2.59) compared to non-ADI maneuver condition (15.01 degrees) (p<.05). The findings of this study indicated that prone hip extension with the ADI maneuver was an effective method to recruit the gluteus maximus earlier than erector spinae and to decrease anterior pelvic tilting.