• 대한생식의학회:학술대회논문집
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• 2001.06a
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• pp.52.1-52.1
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• 2001

• Biomedical Science Letters
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• v.28 no.2
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• pp.109-119
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• 2022

Histone proteins can be modified by the addition of acetyl group or methyl group to specific amino acids. The modifications have different distribution patterns in chromatin. Recently, histone modifications are studied based on ChIP-seq data, which requires reasonable analysis of sequencing data depending on their distribution patterns. Here we have analyzed histone H3K27ac and H3K27me3 ChIP-seq data and it showed that the H3K27ac is enriched at narrow regions while H3K27me3 distributes broadly. To properly analyze the ChIP-seq data, we called peaks for H3K27ac and H3K27me3 using MACS2 (narrow option and broad option) and SICER methods, and compared propriety of the peaks using signal-to-background ratio. As results, H3K27ac-enriched regions were well identified by both methods while H3K27me3 peaks were properly identified by SICER, which indicates that peak calling method is more critical for histone modifications distributed broadly. When ChIP-seq data were compared in different sequencing depth (15, 30, 60, 120 M), high sequencing depth caused high false-positive rate in H3K27ac peak calling, but it reflected more properly the broad distribution pattern of H3K27me3. These results suggest that sequencing depth affects peak calling from ChIP-seq data and high sequencing depth is required for H3K27me3. Taken together, peak calling tool and sequencing depth should be chosen depending on the distribution pattern of histone modification in ChIP-seq analysis.

• Bulletin of the Korean Space Science Society
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• 2005.04a
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• pp.27-27
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• 2005

• Korean Journal of Microbiology
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• v.38 no.3
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• pp.168-172
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• 2002

Budding yeasts maintain an effective system to regulate intracellular pH in response to environmental pH fluctuation. In a previous study we reported that SHC1 plays a role in cell growth at alkaline condition, not at acid pH. We constructed a null mutant deleted an entire open reading frame for SHC1. To test whether the retardation in cell growth was caused by the absence of intracellular pH buffering capacity, we measured intracellular pH with a pH-sensitive fluorescent dye, C.SNARE. The intracellular pH of the mutant cell was much higher than that of wild-type cells, indicating that the mutant cells lack some types of buffering capacity. We also investigated the level of $Na^＋ and K^＋$ content with atomic mass spectroscopy after alkali shock. Wild-type cell showed a higher level of intracellular K^＋$ content, whereas there was no difference in $Na^＋$ level. The result suggested that K^＋$ is more important in the regulation of intracellular pH in yeasts.

• Korean Journal of Environmental Agriculture
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• v.17 no.4
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• pp.362-367
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• 1998

To investigate the effects of simulated acid rain(SAR) on the downward movement of mineral nutrients, SARs of different pH were applied to the soil. SAR of pH 2.0 decreased the soil pH greatly, while SAR of pH 4.0 and 6.0 did not change the soil pH to compare to that of SAR of pH 2.0. Decrease in soil pH was in the order of sandy loam > loam > clay loam. The amoumt of leached exchangeable and soluble bases from the soil due to the penetration of SAR was in the order of Ca >Mg > K. After application of 1200mm SAR of pH 2.0 in to the soil downward mean movements of the exchangeable and soluble bases was in the order of Mg > Ca > K in sandy loam and loam soil and Ca > Mg > K in clay loam soil. Downward movements of the those bases under pH 4.0 into the soil was in the order of Mg > K > Ca in sandy loam and clay loam, and K > Mg > Ca in loam soil. Available phosphorus moved slightly downward with increasing acidity of the SAR.

• Honam Mathematical Journal
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• v.32 no.2
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• pp.333-362
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• 2010

We define H*H-fuzzy set and form a new category Set(H*H) consisting of H*H-fuzzy sets and morphisms between them. First, we study it in the sense of topological universe and obtain an exponential objects of Set(H*H). Second, we investigate some relationships among the categories Set(H*H), Set(H) and ISet(H).

• Proceedings of the KIPE Conference
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• 2016.07a
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• pp.103-104
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• 2016

기존 Cascade H-bridge 인버터 토폴로지는 커패시터나 다이오드가 없이 스위치로 구성되어 있으며, 필터 없이 정현파와 유사하게 구현할 수 있다. 또한 출력전압 레벨이 높을수록 정현파와 유사하게 되어 고주파가 줄어들며, 각 셀을 직렬로 연결하면 입력전압보다 높은 출력전압 갖는다. 본 논문에서는 기존 Cascade H-bridge 인버터와 NPC(Neutral Point Clamped)가 결합한 Cascade H-bridge NPC 인버터를 제안하였다. Cascade H-bridge NPC 인버터는 기존 Cascade H-bridge 인버터 특성과 유사하며, Cascade H-bridge 인버터와 NPC 인버터의 장점을 가지고 있다. Cascade H-bridge 인버터와 Cascade H-bridge NPC 인버터를 시뮬레이션 통해 THD(Total Harmonic Distortion) 비교분석하였고 시뮬레이션은 PSIM 9.1.4을 가지고 검증하였다.

• Journal of the Korean Mathematical Society
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• v.42 no.1
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• pp.129-134
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• 2005

Lpt X be a reduced Stein space and L a holomorphic line bundle on X. L is spanned by its global sections and the associated holomorphic map $h_L\;:\;X{\to}P(H^0(X, L)^{\ast})$ is an embedding. Choose any locally convex vector topology ${\tau}\;on\;H^0(X, L)^{\ast}$ stronger than the weak-topology. Here we prove that $h_L(X)$ is sequentially closed in $P(H^0(X, L)^{\ast})$ and arithmetically Cohen -Macaulay. i.e. for all integers $k{\ge}1$ the restriction map ${\rho}_k\;:\;H^0(P(H^0(X, L)^{\ast}),\;O_{P(H^0(X, L)^{\ast})}(k)){\to}H^0(h_L(X),O_{hL_(X)}(k)){\cong}H^0(X, L^{\otimes{k}})$ is surjective.

• Proceedings of the Korean Magnetic Resonance Society Conference
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• 2000.01a
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• pp.31-31
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• 2000

• Kyungpook Mathematical Journal
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• v.56 no.3
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• pp.647-655
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• 2016

Let H be a graph, and $k{\geq}{\chi}(H)$ an integer. We say that H has a cyclic Gray code of k-colourings if and only if it is possible to list all its k-colourings in such a way that consecutive colourings, including the last and the first, agree on all vertices of H except one. The Gray code number of H is the least integer $k_0(H)$ such that H has a cyclic Gray code of its k-colourings for all $k{\geq}k_0(H)$. For complete bipartite graphs, we prove that $k_0(K_{\ell},r)=3$ when both ${\ell}$ and r are odd, and $k_0(K_{\ell},r)=4$ otherwise.