• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility
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• pp.156.2-156.2
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• 2006

• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.283-286
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• 2006

The present study aimed to investigate the interaction of nucleoside analogs with human organic anion transporter 1 and 3(hOAT1 and hOAT3) that play a primary role in the tubular uptake of endogenous and exogenous organic anions in the kidney. The interactions of ddC, ara-C, ara-A and ara-U with hOAT1 and hOAT3 were examined using MDCK cells stably overexpressing hOAT1 or hOAT3. Among the tested drugs, ddC showed the highest affinity to hOAT1 with $IC_{50}$ values of 5.2 mM, while ara-A, ara-C and ara-U weakly inhibited the cellular uptake of $[^3H]-PAH$ in MDCK-hOAT1 cells at 1 mM. In contrast, all the tested drugs did not have any inhibition effect on the cellular uptake of $[^3H]-estrone$ sulfate in MDCK-hOAT3 cells over the drug concentration of 0.01-2 mM, implying that they might not interact with hOAT3. Taken all together, the present study suggests that hOAT1 could weakly interact with nucleoside analogues such as ddC, ara-C, ara-A and ara-U but the interaction with hOAT3 during the urinary excretion of these nucleoside analogues may be negligible in the kidney.

• Archives of Pharmacal Research
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• 제29권7호
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• pp.535-540
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• 2006

Several novel 1-[2-(1H-tetrazol-5-yl) ethyl]-1H-benzo[d][1,2,3]triazoles (3a-h) have been synthesized by the condensation of 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) and appropriate acid chlorides. 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) was synthesized by reacting 3-(1H-benzo[d][1,2,3]triazol-1-yl)propanenitrile with sodium azide and ammonium chloride in the presence of dimethylformamide. The synthesized compounds were characterized by IR and PMR analysis. The titled compounds were evaluated for their in vitro antibacterial and antifungal activity by the cup plate method and anticonvulsant activity evaluated by the maximal electroshock induced convulsion method in mice. All synthesized compounds exhibited moderate antibacterial activity against Bacillus subtilis and moderate antifungal activity against Candida albicans. Compounds 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol-1-yl)(4-aminophenyl)methanone 3d and 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol-1-yl)(2-aminophenyl)methanone 3e elicited excellent anticonvulsant activity.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.388-394
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• 2020

최근 우리나라는 축산농가의 사육환경 개선을 위해 양돈 농가를 대상으로 새로운 동물복지형 사육기준을 도입하려고 한다. 이에 모돈의 군사사육 도입 규정에 대응할 수 있는 모돈사 바닥에 대한 연구들이 필요한 실정이다. 본 연구의 목적은 모돈의 군사사육 방식이면서 바닥의 형태가 각각 깔짚과 슬랏 바닥의 형태로 되어 있는 농가 2곳을 섭외하여 동물복지 수준과 환경 수준 및 모돈의 행동을 평가 및 비교하였다. 동물복지 수준평가는 실험농가 모돈의 몸상처와 외음부상처 평가, 환경 수준은 돈사 안의 황화수소, 암모니아, 이산화탄소 농도를 한 달에 1번씩, 총 4 개월간 측정하였다. 연구 결과 동물복지 수준은 모돈의 몸과 외음부 상처비율이 깔짚 바닥 농가(K 농가)에 비해 콘크리트 슬랏 바닥 농가(H 농가)에서 높게 관찰 되었다. 모돈의 돈방 내의 환경수준은 각각 황화수소 (H2S; H 농가 1.0 ppm, K 농가 0.0 ppm), 암모니아 (NH3; H 농가 45.4 ppm, K 농가 1.3 ppm), 및 이산화탄소 (CO2; H 농가 1102.3 ppm, K 농가 258.8 ppm) 농도가 H 농가에서 높게 측정 되었다. 모돈의 행동분석 중 투쟁행동은 H 농가에서 주로 발생 하였다. 이와 같은 결과는, 동일한 군사형태의 사육시설이지만 바닥재의 차이로 인해 공격행동과 환경수준의 변화를 나타나는데, 향후 추가적으로 바닥재의 종류 및 바닥의 변화들을 제시하면서 행동변화, 동물복지 및 환경수준을 측정하는 연구가 필요 할 것으로 판단된다.

• 호남수학학술지
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• 제32권3호
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• pp.413-439
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• 2010

W. A. Dudek, M. Shabir and M. Irfan Ali discussed the properties of (${\alpha},{\beta}$)-fuzzy ideals of hemirings in [9]. In this paper, we discuss the generalization of their results on (${\alpha},{\beta}$)-fuzzy ideals of hemirings. As a generalization of the notions of $({\alpha},\;\in{\vee}q)$-fuzzy left (right) ideals, $({\alpha},\;\in{\vee}q)$-fuzzy h-ideals and $({\alpha},\;\in{\vee}q)$-fuzzy k-ideals, the concepts of $({\alpha},\;\in{\vee}q_m)$-fuzzy left (right) ideals, $({\alpha},\;\in{\vee}q_m)$-fuzzy h-ideals and $({\alpha},\;\in{\vee}q_m)$-fuzzy k-ideals are defined, and their characterizations are considered. Using a left (right) ideal (resp. h-ideal, k-ideal), we construct an $({\alpha},\;\in{\vee}q_m)$-fuzzy left (right) ideal (resp. $({\alpha},\;\in{\vee}q_m)$-fuzzy h-ideal, $({\alpha},\;\in{\vee}q_m)$-fuzzy k-ideal). The implication-based fuzzy h-ideals (k-ideals) of a hemiring are considered.

• Asian-Australasian Journal of Animal Sciences
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• 제18권1호
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• pp.102-106
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• 2005

This study was carried out to find the attributes for liquid-type yogurt with Lactobacillus casei 911LC during 72 h fermentation at $37^{\circ}C$. The pH decreased up to 32 h and plauteaued thereafter, and the titratable acidity increased up to 40 h. The growth of lactic acid bacteria sharply increased with $3.5{\times}10^7$ cfu/ml up to 40 h of fermentation and slowly decreased thereafter. The free amino acids produced during fermentation reached the maximum value at 44 h and gradually decreased thereafter. Bitterness sensory scores were the highest at 44 h of fermentation. In the result of electrophoresis, the band mostly disappeared at 72 h fermentation. The present data showed that the range of optimum fermentation time for liquid-type yogurt using Lactobacillus casei 911LC was from 40 to 44 h.

• 한국진공학회지
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• 제6권S1호
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• pp.59-65
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• 1997

Efficient Si(100) etching by thermal H atoms at low substrate temperatures has been achieved. Gas-phase etching product $SiH_4$(g) upon H atom bombardment resulting from direct abstraction of $SiH_3$(a) by impinging H atoms was detected with a quadrupole mass spectrometer over the substrate temperature range of 105-408 K Facile depletion of all surface silyl ($SiH_3$) groups the dissociative adsorption product of disilane ($Si_2H_6$) at 105K from Si(100)2$\times$1 by D atoms and continuous regeneration and removal of $SiD_3$(a) were all consumed. These results provide direct evidence for efficient silicon surface etching by thermal hydrogen bombardment at cryogenic temperatures as low as 105K We attribute the high etching efficiency to the formation and stability of $SiH_3$(a) on Si(100) at lowered surface temperatures allowing the $SiH_3$(a) abstraction reaction by additional H atom to produce $SiH_4$((g).

• 대한전기학회:학술대회논문집
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• 대한전기학회 1995년도 하계학술대회 논문집 C
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• pp.1019-1021
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• 1995

Light induced degradation of hydrogenated amorphous silicon(a-Si:H) are related to the number of weak dangling bonds which are thought to be responsible for the Staebler-Wronski effects, and caused the many photoelectric problems in applications of thin film transistors and solar cell, etc. In this paper, we deposited fluorinated amorphous silicon films(a-Si:H;F) with $SiH_4$ and $SiF_4$ gas mixture and investigated the effects of fluorine atoms on the evoluations of the crystallinity and improvements of light instability. We have found that micro-crystallinity produced in a-SI:H;F films and marked maximum value of 22% at the flow rate of $SiH_4:SiF_4$=2:10 sccm by UV spectrophotometer measurement, while n-Si:H film deposited with only $SiH_4$ gas showed no crystallinity. Light-induced degradation property of a-Si:H;F films is also improved which is mainly due to the etching effects of fluorine atoms on the weak Si-Si bonds and unstable hydrogen bonds. It is considered that involving fluorine atoms in a-Si:H films may contribute to the suppression of light-induced degradation and evolution of micro-crystallinity.

• Asian-Australasian Journal of Animal Sciences
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• 제19권11호
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• pp.1561-1565
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• 2006

The objective of this study was to investigate the anti-oxidative effects of taurine on sperm characteristics for in vitro storage of boar semen. Semen was randomly divided into 10 groups in conical tubes and treated with different concentrations of taurine (25-100 mM) with or without $250{\mu}M$ $H_2O_2$. The percentage of motile spermatozoa in taurine groups after 6 and 9 h were significantly higher at >94% and 87%, respectively, compared to the control group ($85.1{\pm}0.5$ and $72.4{\pm}0.3$, p<0.05). The sperm motility in taurine with $H_2O_2$ after 6 h incubation was slightly decreased compared to the taurine alone treatment, but after 9 and 12 h incubation % sperm motility dropped sharply in taurine with $H_2O_2$ ($75.3{\pm}0.3$ and $69.6{\pm}2.9$, p<0.05). For 3, 9 and 12 h incubation, sperm viability in the control was lower than in taurine groups, irrespective of taurine concentration. In eosin Y and nigrosin staining (ENS), the sperm survival rates (%) for 6 h incubation were significantly higher in 25 mM ($76.0{\pm}0.6$) and 50 mM taurine groups ($78.0{\pm}0.7$), respectively. Sperm survival rates for 9 and 12 h incubation were higher in taurine groups (${\geq}48%$ in 9 h and ${\geq}42%$ in 12 h) compared to controls ($43.0{\pm}2.1$ and $31.0{\pm}0.6$, respectively). In the hyoosmotic swelling test (HOST), sperm membrane integrity was similar to the results of sperm survival. These experiments indicate that supplementation of taurine to the semen extender can increase the sperm characteristics(motility, viability, survival and membrane integrity).

• 대한화학회지
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• 제33권3호
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• pp.273-280
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• 1989

Co(II)-CyDTA 착물의 흡수스펙트럼을 pH = $6.0{\sim}13.2$의 수용액에서 측정하였다. 흡수에너지는 pH가 증가할수록 낮은 에너지로 이동하였고, 이 현상은 $CoCyDTA^{2-}$와 $CoCyDTA(OH)^{3-}$간의 평형상수 $K_{OH} = [CoCyDTA(OH)^{3-}]/[CoCyDTA^{2-}][OH^-]$로 설명할 수 있었고, 그 값은 $40^{\circ}C$에서 $75M^{-1}$이었다. Co(II)-CyDTA와 Fe(III)-CN 착이온간의 전자이동반응은 $K_{OH}$ 측정과 같은 용액조건에서 분광광도법을 이용하여 고찰하였다. 측정한 $k_{obs}$는 pH = 10.8까지는 거의 일정하였으나 pH > 10.8에서는 pH의 증가에 따라 증가하였다. pH = $6.0{\sim}13.0$에서 적용할 수 있는 속도법칙은 $k_{obs} = (k_3[CoCyDTA^{2-}] + k_4[CoCyDTA(OH)^{3-}])/(1+K_1[CoCyDTA^{2-}])$이었다. 반응 (3a)와 (3b)의 속도상수 $k_3$와 $k_4$는 $40^{\circ}C$에서 각각 $0.529M^{-1}sec^{-1}$와 $4.500M^{-1}sec^{-1}$이었다. 활성화엔트로피(147{\pm}1.1JK^{-1} mol^{-1}, pH = 10.8)$와 활성화체적$(6.25cm^3mol^{-1}, pH = 10.8)$은 pH가 증가할수록 증가하였지만, 활성화엔탈피$(12.44{\pm}0.20 kcal mol^{-1})$는 pH의 영향을 받지 않았다. 속도상수, 활성화엔트로피, 활성화체적에 대한 pH의 영향을 각각이용하여 Co(II)-Fe(III)의 전자이동 반응메카니즘을 논의하였다.