• 디지털융복합연구
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• 제11권4호
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• pp.303-309
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• 2013

TRAINER for Kids ($T4K^{TM}$, Myofunctional. Research Co, Australia)는 주로 구강악습관으로 혀내밀기, 구호흡, 혀의 하방위치, 혀, 손가락 빨기에 의한 변형 등에 의한 부정교합이 야기되었거나 발생하고 있는 어린이들에게 쓰이고 있는 기성 근기능 교정장치이다. Trainer 장치는 기성품으로서 작은 부피와 부드러운 질감으로 어린 환자들의 장착 동의율을 높이는 데 장점을 가진다. 장치에 포함된 lip bumper는 과도한 하순의 힘을 차단하여 주고, 하순 내측 전정을 자극하는 요소가 포함되어 있다. 부적절한 혀의 위치를 교정할 수 있는 요소는 환자들이 장치를 장착하는 동안 부가적인 혀 운동을 할 필요성을 감소시킨다. 본 연구의 목적은 원광대학교 치과대학 산본치과병원에 2010년 1월과 6월에 내원한 혼합치열기의 II급 부정교합 환자에게 약 6~10개월간 Trainer를 착용한 후 동일한 환자를 3년간 정기적으로 예후관찰(follow up)한 결과 값을 가지고 이 장치의 임상적 효용 가치에 대해 분석하기 위해 진행되었다. 연구 결과, 첫째, 구강 내 장치의 일종인 Trainer를 혼합치열기 2급 부정교합 환자에게 사용한 결과 치료 전 존재하였던 상악 전치부 전돌 증상이 개선되어 안모의 심미적인 개선효과가 있었다. 둘째, 정상 교합에 비교하여 과도한 수직, 수평 피개 교합이 개선되었다. 셋째, 치료기간 및 예후 관찰기간동안 SNB 값은 증가하고, ANB 값은 감소하여 하악이 전방으로 성장한 것을 알 수 있었다. 그러므로, Trainer system은 혼합치열기 2급 부정교합 어린이에서 조기 교정 전치료로 임상에 활용 가능한 방법이다.

• Journal of Korean Neurosurgical Society
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• 제46권4호
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• pp.305-311
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• 2009

Objective : The purpose of this study was to determine the efficacy, radiological findings, clinical outcomes and complications in patients with lumbar stenosis and osteoporosis after the use of polymethylmethacrylate (PMMA) augmentation of a cannulated pedicle screw. Methods : Thirty-seven patients with degenerative spinal stenosis and osteoporosis (T-score < -2.5) underwent lumbar fusion using the Dream Technology Pedicle Screw ($DTPS^{TM}$, Dream Spine Total Solutions, Dream STS, Seoul. Korea) between 2005 and 2007. The clinical outcomes were evaluated by using the visual analog scale (VAS) and the Prolo scale. Radiologic findings were documented through computed tomography (CT) and plain films. Results : Thirty-seven patients were evaluated and included, 2 males and 35 females with an average bone mineral density (BMD) of $0.47g/cm^2$. The average age of the patients was 68.7 (range, 57-88). The preoperative VAS for low back and leg pain ($7.87{\pm}0.95$ and $8.82{\pm}0.83$) were higher as compared with postoperative VAS ($2.30{\pm}1.61$ and $1.42{\pm}0.73$) with statistical significance (p = 0.006, p = 0.003). According to the Prolo scale, 11, 22, one and three patients were in excellent, good, fair and poor conditions, respectively. The average amount of the injected cement per one cannulated screw was $1.83{\pm}0.11\;mL$. Conclusion : The results show favorable outcome both clinically and radiographically for 37 patients who underwent lumbar fusion using $DTPS^{TM}$ and PMMA. Based on the results, the use of this surgical method can be a safe and effective option for the operation on the osteoporotic spine.

• Molecular & Cellular Toxicology
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• 제1권4호
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• pp.230-236
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• 2005

Formaldehyde is a common environmental contaminant found in tobacco smoke, paint, garments, diesel and exhaust, and medical and industrial products. Formaldehyde has been considered to be potentially carcinogenic, making it a subject of major environmental concern. However, only a little information on the mechanism of immunological sensitization and asthma by this compound has been known. So, we performed with Jurkat cell line, a human T lymphocyte, to assess the induction of DNA damage and to identify the DEGs related to immune response or toxicity by formaldehyde. In this study, we investigated the induction of DNA single strand breaks by formaldehyde using single cell gel electrophoresis assay (comet assay). And we compared gene expression between control and formaldehyde treatment to identify genes that are specifically or predominantly expressed by employing annealing control primer (ACP)-based $GeneFishing^{TM}$ method. The cytotoxicity ($IC_{30}$) of formaldehyde was determined above the 0.65 mM in Jurkat cell in 48 h treatment. Based on the $IC_{30}$ value from cytotoxicity test, we performed the comet assay in this concentration. From these results, 0.65 mM of formaldehyde was not revealed significant DNA damages in the absence of S-9 metabolic activation system. And the one differentially expressed gene (DEG) of formaldehyde was identified to zinc finger protein 292 using $GeneFishing^{TM}$ method. Through further investigation, we will identify more meaningful and useful DEGs on formaldehyde, and then can get the information on the associated mechanism and pathway with immune response or other toxicity by formaldehyde exposure.

• 동의생리병리학회지
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• 제21권5호
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• pp.1135-1141
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• 2007

In recent year, We are concerned in anti-aging, disease-protection, long-life, many method are used in solving this problem. Recently, We heard that Luffae Fructus Retinervus(LFR) has effect of anti-aging, disease-protection, long-life. So I let made a experiment for this result. The purpose of this study is to; 1) the anti-oxidant effect of Luffae Fructus Retinervus(LFR) used for 3 methods, those are DPPH radical scavenging activity, Nitric oxide(NO) radical scavenging activity, Superoxide anion radical scavenging activity, 2) cultivation 3T3-L 1 Preadipocytes and Protein chip used for ProteoPlexTM 16-Well Murine Cytokine Array Kit. We measured level of DPPH radical scavenging activity. And we experienced that the ability of DPPH radical's elimination was increased by rising concentration of LFR. When the concentration of LFR was 5 mg/ml, the ability of DPPH radical's elimination was Maximum. We measured level of Nitric oxide(NO) radical scavenging activity. And we founded that the ability of NO radical's elimination was significant when concentration of LFR was from 1.25 mg/ml to 2.5 mg/ml. We measured level of Superoxide anion radical scavenging activity. And we founded that the ability of Superoxide anion radical's elimination was maximum when concentration of LFR was 0.3125 mg. When we inspected Antioxidative Effects with BSA, we experienced that ability of defense was increased by rising concentration of LFR. We known the immunity of LFR about 3T3-L1 Preadipocytes and gained the increase of Cytokines(IL-2, IL-4, GM-CSF) without IL-12p70, $INF-{\gamma}$, $TNF-{\alpha}$ So I guess that Luffae Fructus Retinervus(LFR) has effects of anti-aging, disease-protection, long-life, etc.

• 한국균학회지
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• 제26권2호통권85호
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• pp.256-264
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• 1998

한국에서 자생하고 소나무와 외생균근을 갖는 송이에 대한 18S ribosmal DNA의 DNA 서열을 조사하였다. 4개의 지역에서 채집된 송이의 514 bp 분석결과 18S rDNA의 서열는 모두 동일하였고, 경북대학교 미생물연구실의 연구 결과와는 4 bp가 차이가 나타났다. NCBI의 BLAST search결과, T. matstake와 제일 유사한 것으로 나타났다. 분석된 514 bp의 서열비교에서는 다른 버섯균과 차이가 있는 서얼 부분을 파악하였다. 또한, 이러한 자료를 이용하여 유사도 분석에서 각각의 속에 속하는 균들은 같은 묶음을 나타내고 있으나, 과 혹은 그 이상의 단위에서의 비교는 좋은 결과가 나오지 않았다. 본 연구를 통해 외생균근의 확인 작업에 필요한 primer 제작을 위한 사전 자료를 얻었으며, 또한 조사된 염기서열도 분석할 수 있었다.

• 한국식품과학회지
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• 제27권6호
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• pp.958-963
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• 1995

키조개의 부산물을 향미제로 개발하기 위하여 반응표면분석법으로 가수분해조건을 디자인하여 키조개 부산물의 가수분해물 제조를 시도한 결과, 상업용 단백질 분해효소 11종 가운데 효소활성을 판매가격에 대한 비율로 환산했을 때 APL 440이 가장 경제성이 있었다. 그리고 키조개 부산물 가수분해과정 중 자가소화 효소에 의한 영향은 무시할 정도로 적었다. 반응표면분석결과 얻어진 가수분해율(%DH)은 $%DH=51.126+2.419pH+2.415T-2.426S-2.846pH^2-4.211T^2-3.014t^2+2.419S2$였다. 그러나 정상점이 안장점을 나타내am로 능선분석(반경 0.5) 결과 최대점은 pH 10.2, 온도 $61.4^{\circ}C$, 기질농도 30.9%, 기질에 대한 효소농도 0.32%에서 2.58시간 가수분해할 때이며, 실제 이 조건에서 61.80%의 가수분해율을 보였다. 분말화한 가수분해물은 아미노질소 및 염도가생시료에 비하여 각각 3.5배 및 7.7배 증가하였다.

• 한국패류학회지
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• 제27권4호
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• pp.387-393
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• 2011

The objective of this study was to develop a real-time PCR method for the rapid detection and quantification of the protozoan pathogen Perkinsus olseni using a TaqMan probe. For the standard, genomic DNA was extracted from $10^5$ in vitro-cultured P. olseni trophozoites, and then 10-fold serial dilutions to the level of a single cell were prepared. To test the reliability of the technique, triplicates of genomic DNA were extracted from $5{\times}10^4$ cells and 10-fold serial dilutions to the level of 5 cells were prepared. The standards and samples were analyzed in duplicate using an $Exicycler^{TM}$ 96 real-time quantitative thermal block. For quantification, the threshold cycle ($C_T$) values of samples were compared with those obtained from standard dilutions. There was a strong linear relationship between the $C_T$ value and the log concentration of cells in the standard ($r^2$ = 0.996). Detection of DNA at a concentration as low as the equivalent of a single cell showed that the assay was sensitive enough to detect a single cell of P. olseni. The estimated number of P. olseni cells was similar to the original cell concentrations, indicating the reliability of P. olseni quantification by real-time PCR. Accordingly, the designed primers and probe may be used for the rapid detection and quantification of P. olseni from clam tissue, environmental water, and sediment samples.

• Journal of information and communication convergence engineering
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• 제14권4호
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• pp.252-257
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• 2016

An edge-located electromagnetic bandgap (EL-EBG) structure using a defected ground structure (DGS) is proposed to suppress resonant modes induced by edge excitation in a two-dimensional planar parallel plate waveguide (PPW). The proposed EL-DGS-EBG PPW significantly mitigates multiple transverse-magnetic (TM) modes in a wideband frequency range corresponding to an EBG stopband. To verify the wideband suppression, test vehicles of a conventional PPW, a PPW with a mushroom-type EBG structure, and an EL-DGS-EBG PPW are fabricated using a commercial process involving printed circuit boards (PCBs). Measurements of the input impedances show that multiple resonant modes of the previous PPWs are significantly excited through an input port located at a PPW edge. In contrast, resonant modes in the EL-DGS-EBG PPW are substantially suppressed over the frequency range of 0.5 GHz to 2 GHz. In addition, we have experimentally demonstrated that the EL-DGS-EBG PPW reduces the radiated emission from -24 dB to -44 dB as compared to the conventional PPW.

• 대한치과보철학회지
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• 제51권4호
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• pp.269-275
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• 2013

연구 목적: 이 연구는 임플란트 직경, 길이 및 식립 부위가 임플란트의 안정성에 미치는 영향을 후향적 평가를 통해 비교, 분석하고자 하였다. 연구 대상 및 방법: 72명의 환자에게 식립된 총 90개의 임플란트(US II plus$^{TM}$, Osstem co, Busan, Korea)를 대상으로 임플란트 식립 직후와 인상 채득 당시에 공진주파수분석법(RFA)으로 임플란트 안정성 지수(ISQ)가 측정되었다. 상 하악에 식립된 직경은 4 mm와 5 mm이고 길이는 10 mm, 11.5 mm, 13 mm인 임플란트가 실험대상으로 선택되었다. 측정된 ISQ 값의 평균과 표준편차를 구하고 우선적으로 성별에 따른 차이를 확인하기 위하여 Independent t-test를 시행하였다. 임플란트 직경, 길이, 식립부위에 따른 ISQ 값의 실험군간 차이는 One-way ANOVA를 이용해 분석하였고, 사후검정을 위해 Tukey HSD test가 사용되었다. 임플란트 식립시와 인상채득시의 차이는 paired t-test로 분석하였다. 결과:인상채득시가 임플란트 식립 직후보다 임플란트 안정성의 증가가 관찰되었다. 임플란트 길이가 증가할수록 ISQ 값은 증가하였으나 통계적으로 유의적인 차이를 보이지 않았다. 직경 5 mm 임플란트는 4 mm 임플란트 보다 유의성 있게 높은 ISQ 값을 보였다(P<.05). 하악에 식립된 임플란트가 상악보다 더 높은 ISQ값을 보였다(P<.05). 결론:본연구결과, 임플란트 안정성을 높이기 위해서는 직경이 큰 임플란트를 사용하는 것이 효과적임을 알 수 있었다. 또한, 상악보다는 하악에서 더 높은 임플란트 안정성이 확인되었다. 임플란트 식립 직후의 일차 안정성보다 골유착 후 이차 안정성이 더 높게 나타남으로서 RFA를 이용한 방법이 골유착을 통한 임플란트 안정성의 변화를 평가함에 있어 임상적으로 유용한 것으로 판단된다. 임플란트 안정성 평가와 이에 영향을 주는 요소들에 대한 고려는 임플란트 하중 시기를 결정하고 임플란트 성공률을 증가시키는데 도움이 될 것이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제14권4호
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• pp.305-313
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• 1992

Facial asymmetry can be most distressing for the young child and parents. It can cause functional problems as a result of malocclusion. Classification of facial asymmetry has not been yet well-organized because of its varieties on etiologic factors, involved sites and clinical expressions. Even though, we don't know its causes definitely. It is generally believed that problems with aberrant pattern of condylar growth are related to facial asymmetry. This is a case report on surgical correction of the patients who had severe facial asymmetry. One patient was diagnosed as condylar hyperplasia and the other was diagnosed as a condylar hypoplasia related to trauma. We performed a simultaneous two-jaw surgery, condylar shaving, inferior border ostectomy of affected mandible in the former case, and a simultaneous two-jaw surgery, reverse-L osteotomy and alloplastic implantation with $Biocoral^{TM}$ in the latter case. The postoperative results of the two cases were excellent functionally and esthetically.