• Geomechanics and Engineering
• /
• v.21 no.2
• /
• pp.201-206
• /
• 2020

A stress-induced brittle failure in deep tunneling generates spalling and slabbing, eventually causing a v-shaped notch formation. An empirical relationship for the depth of the notch to the maximum tangential stress assuming an equivalent circular cross-section was proposed (Martin et al. 1999). While this empirical approach has been well recognized in the industry and used as a design guideline in many projects, its applicability to a non-circular opening is worth revisiting due to the use of equivalent circular profile. Moreover, even though the extent of the notch also contributes to notch failure, it has not been estimated to date. When the estimate of both the depth and the extent of notch are combined, a practical and economically justifiable support design can be achieved. In this study, a new methodology to assess the depth as well as the extent of notch failure is developed. Field data and numerical simulations using the Cohesion Weakening Frictional Strengthening (CWFS) model were collected and correlated with the three most commonly accepted failure criteria (σ₁/σ₃, D_is=σ_max/σ_c, σ_dev/σ_cm). For the numerical analyses, the D-shaped tunnel was used since most civil tunnels are built to this profile. Inferential statistical analysis is applied to predict the failure range with a 95% confidence level. Considering its accuracy and simplicity, the new correlation can be used as an enhanced version of failure assessment.

• Bulletin of the Korean Chemical Society
• /
• v.34 no.2
• /
• pp.489-494
• /
• 2013

An improved method for the preparation of monomethine cyanine dyes with quinoline nucleus by one-pot three-component using 1-methyl-2-quinolinethione, quaternized 2- or 4-methylheterocyclic compounds and methyl p-toluenesulfonate as starting materials was described. Compared with the traditional methods, the new synthetic method reduced the reaction steps, shortened the reaction time, avoided the separation and purification of the intermediate and reduced cost. The dyes absorbed in the region 478.0-563.0 nm and had molar extinction coefficients of $1.3{\times}10^4-9.4 {\times}10^4L\;mol^{-1}\;cm^{-1}$. Their fluorescence maxima and Stokes shifts were in the range of 525.2-594.4 nm and 16.2-80.6 nm in different solvents, respectively. From the spectral properties of the dyes in different solvents, it could be found that the ${\lambda}_{max}$ of the dyes were shorter in protonic solvents, and showed hypsochromic shifts with the increase of polarity of the solvents.

• Korean Journal of Crystallography
• /
• v.13 no.1
• /
• pp.21-24
• /
• 2002

The crystal structure of cholesteryl crotonate was investigated by X-ray diffraction. Crystallo-graphic data for the title compound: P2₁, a = 13.446(4) , b = 11.802(3) , c = 18.782(5) , β = 103.99(2)°, Z = 4. Reflections were collected with an Enraf-Nonius CAD-4 diffractometer equipped with a graphite monochromator. The structure was solved by direct methods and refined by least-squares analyses. The final R value was 0.092 for 1604 reflections. The cholesterol fragment of the title compound were in good agreement with those for related cholesterol derivatives. The molecules were stacked in clearly separated layers. At the center of the layers, there were cholesterol-cholesteryl interactions between the symmetry-related A molecules and the cholesteryl-C(17) side chain of B molecules. There were also interactions between the C(17) side chain of A molecules and the crotonate chains off and B molecules in the interface region between layers. The crystal structure of the title compound turned out to be isostructural with those of cholesteryl ethylcarbonate, cholesteryl propylcarbonate, and cholesterol crotylcarbonate. The crystals show the liquid crystalline state having the cholesteric phase.

• Journal of the Korean Vacuum Society
• /
• v.19 no.3
• /
• pp.169-176
• /
• 2010

Cryopumps can provide economical profits with a relatively high pumping speed per size. However, it is somewhat doubtful that pumping performance of cryopums, which is very sensitive to the temperature of the adsorption panel, can be maintained or recovered fast for large continuous or impulsive gas loads. The official evaluation items indicating cryopump performance for gas loads are the maximum throughput and the crossover value. There are two other, unofficial but widely used, items, the Ar recovery time and gulp characteristics. Although these evaluation items look absolutely different with each other, there are close relations and even duplications in their test schemes. Therefore, it is necessary to study how to improve practically each test procedure, and combine or unify some procedures.

• Tuberculosis and Respiratory Diseases
• /
• v.78 no.2
• /
• pp.78-84
• /
• 2015

Background: Reports of therapeutic drug monitoring (TDM) for second-line medications to treat multidrug-resistant tuberculosis (MDR-TB) remain limited. Methods: A retrospective cohort from the Virginia state tuberculosis (TB) registry, 2009-2014, was analyzed for TDM usage in MDR-TB. Drug concentrations, measured at time of estimated peak ($C_{max}$), were compared to expected ranges. Results: Of 10 patients with MDR-TB, 8 (80%) had TDM for at least one drug (maximum 6 drugs). Second-line drugs tested were cycloserine in seven patients (mean $C_{2hr}$, $16.6{\pm}10.2{\mu}g/mL$; 4 [57%] below expected range); moxifloxacin in five (mean $C_{2hr}$, $3.2{\pm}1.5{\mu}g/mL$; 1 [20%] below); capreomycin in five (mean $C_{2hr}$, $21.5{\pm}14.0{\mu}g/mL$; 3 [60%] below); para-aminosalicylic acid in five (mean $C_{6hr}$, $65.0{\pm}29.1{\mu}g/mL$; all within or above); linezolid in three (mean $C_{2hr}$, $11.4{\pm}4.1{\mu}g/mL$, 1 [33%] below); amikacin in two (mean $C_{2hr}$, $35.3{\pm}3.7{\mu}g/mL$; 1 [50%] below); ethionamide in one ($C_{2hr}$, $1.49{\mu}g/mL$, within expected). Two patients died: a 38-year-old woman with human immunodeficiency virus/acquired immune deficiency syndrome and TB meningitis without TDM, and a 76-year-old man with fluoroquinolone-resistant (pre-extensively drug-resistant) pulmonary TB and low linezolid and capreomycin concentrations. Conclusion: Individual pharmacokinetic variability was common. A more standardized approach to TDM for MDR-TB may limit over-testing and maximize therapeutic gain.

• Preventive Nutrition and Food Science
• /
• v.19 no.4
• /
• pp.321-326
• /
• 2014

In this study, we developed a method to quantify esculetin (6,7-dihydroxycoumarin) in plasma and tissues using HPLC coupled with ultraviolet detection and measured the level of esculetin in rat plasma after oral administration. The calibration curve for esculetin was linear in the range of 4.8 ng/mL to 476.2 ng/mL, with a correlation coefficient ($r^2$) of 0.996, a limit of detection value of 33.2 ng/mL, and a limit of quantification value of 100.6 ng/mL. Recovery rates for the 95.2 ng/mL and 190.5 ng/mL samples were 95.2% and 100.3%, within-runs and 104.8% and 101.0% between-runs, respectively. The relative standard deviation was less than 7% for both runs. In the pharmacokinetic analysis, the peak plasma esculetin level was reached 5 min after administration ($C_{max}=173.3ng/mL$; $T_{1/2}=45min$; $AUC_{0{\sim}180min}=5,167.5ng{\cdot}min/mL$). At 180 min post-administration (i.e., after euthanasia), esculetin was only detectable in the liver ($30.87{\pm}11.33ng/g$) and the kidney ($20.29{\pm}7.02ng/g$).

• Journal of KIISE:Software and Applications
• /
• v.32 no.1
• /
• pp.1-9
• /
• 2005

In this paper we propose a modified fuzzy min-max neural network model for pattern classification and discuss the usefulness of the model. We define a new hypercube membership function which has a weight factor to each of the feature within a hyperbox. The weight factor makes it possible to consider the degree of relevance of each feature to a class during the classification process. Based on the proposed model, a knowledge extraction method is presented. In this method, a list of relevant features for a given class is extracted from the trained network using the hyperbox membership functions and connection weights. Ft)r this purpose we define a Relevance Factor that represents a degree of relevance of a feature to the given class and a similarity measure between fuzzy membership functions of the hyperboxes. Experimental results for the proposed methods and discussions are presented for the evaluation of the effectiveness and feasibility of the proposed methods.

• Journal of Communications and Networks
• /
• v.10 no.4
• /
• pp.412-421
• /
• 2008

We observe simultaneous transmission of relay stations (RSs) allowed in current IEEE 802.16j draft standard for multi-hop relay networks may involve severe interference among the RSs, hence leading to throughput degradation. Allowing only 1/3 of the RSs to simultaneously transmit instead of 1/2 RSs as in the current draft standard reduces the interference but results in reduced throughput. To remedy this problem, we devise schemes to incorporate network coding at link-layer level (decode-and-forward) into the simultaneous transmission of RSs. Data movement is rearranged to maximize coding gain. Formula is derived to dictate exact movement of packets traveling between base station (BS) and mobile stations (MSs) via intermediate RSs. The frame structure in the current IEEE 802.16j draft standard does not allow broadcast needed for network coding. We devise a new frame structure which supports the broadcast. A new R-MAP (pointers to the burst data) is introduced to implement the broadcast. Since our new frame structure is used only for BS to RS or RS to RS communication, our schemes retain backward compatibility with legacy MSs based on IEEE 802.16e standard. Simulation based on simple configuration of RSs shows considerable improvement in terms of system throughput and round trip delay. For a 4-hop relay network with 1 BS and 4 RSs with symmetric traffic in uplink (UL) and downlink (DL), throughput is improved by 49% in DL and by 84% in UL traffic compared with IEEE 802.16j draft standard under the assumption that omni-directional antennae are used in BS and RSs.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.48 no.5
• /
• pp.413-418
• /
• 2003

Genetic diversity and soybean sprout-related traits were evaluated in a total of 72 soybean accessions (60 Glycine max, 7 Glycine soja, and 5 Glycine gracilis). 100-seed weight (SW) was greatly varied and ranged from 3.2g to 32.3g in 72 soybean accessions. Positive correlation was observed between GR and hypocotyl length (HL), whereas negative correlation was observed between SW and hypocotyl diameter (HD). Re-evaluation by discarding two soybean genotypes characterized with low GR indicated that much higher correlation of sprout yield (SY) with HD and SW. Based on the principal component analysis (PCA) for sprout-related traits, 57 accessions were classified. Soybean genotypes with better traits for sprout, such as small size of seeds and high SY, were characterized with high PCA 1 and PCA 2 values. The seed size in second is small but showed low GR and SY, whereas the third has large seed, high GR and more than 400% SY. In genetic similarity analysis using 60 SSR marker genotyping, 72 accessions were classified into three major and several minor groups. Nine of twelve accessions that were identified as the representatives of soybean for sprout based on PCA were in a group by the SSR marker analysis, indicating the SSR marker selection of parental genotypes for soybean sprout improvement program.

• Journal of the Korean Magnetic Resonance Society
• /
• v.23 no.4
• /
• pp.87-92
• /
• 2019

Allium hookeri (Liliaceae) has been received the increasing attention as a bioactive resource due to its potent biological activities including anti-oxidant, anti-obesity, anti-microbial and lipid-regulating activities. The beneficial effects of A. hookeri are known contributed from the high content of organosulfur compounds in A. hookeri. Though a variety of articles demonstrated that A. hookeri contains 'saponin' as a bioactive constituent, the scientific evidence to prove it was limited. In the present study, we have attempted to identify saponin contained in A. hookeri through chromatographic isolation and NMR spectroscopic methods. As a result, a spirostane-type steroidal saponin (1) has been successfully isolated from the methanolic extract of A. hookeri roots. The structure of 1 was elucidated by extensive 1D and 2D spectroscopic methods including ¹H-NMR, ¹³C-NMR, ¹H-¹H COSY, HSQC, HMBC and NOESY; identified as (3β, 22R, 25S)-spirost-5-en-3yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[6-deoxy-α-L-mannopyranosyl-(1→2)]-β-D-gluco pyranoside. 1 showed the significant inhibitory activity on mushroom tyrosinase with IC₅₀ values of 248.7 μM while the inhibition on alpha-glucosidase was not significant.