• Journal of Microbiology and Biotechnology
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• v.3 no.2
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• pp.134-138
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• 1993

Monascus anka 732Y3 was induced from Monascus anka KFCC 11832 (IFO 4478, ATCC 16360) by ultra-violet light irradiation. The growth of this new fungus is frequently more dependent on sexual propagation than asexual propagation, compared with that of its parental strain, M. anka KFCC 11832. Less conidia than those of M. anka KFCC 11832 were observed by a microscope. The optical density of the red pigments ($OD_{500}$) produced by M. anka 732Y3 was 157, which was about 10 times higer than that of M. anka KFCC 11832. Such high production of the red pigments by the mutant could be explained by the following observations.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.618-629
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• 2006

This Paper is about optimizing preventive maintenance period of connected (r,s) out of(m,n) : F lattice system that one of multi-component system, (m,n) matrix failure of whole system is occurrence when parts that belong in (r,s) matrix part procession of parts arranged with procession are breakdown all. The preventive maintenance about system is very important viewing from system reliability and operational expense viewpoint. Preventive maintenance that misses a time calls big loss by system failure and expense of frequent full equipment is paid excessively in preventive maintenance itself but expense is paid much in preventive maintenance itself and whole expense escalation can be achieved preferably. Through this research, reliability model is constructed that do expense by smallest under full equipment policy chosen through comparison of each full equipment policy and preventive maintenance expense full equipment cycle and r ,s value are made using simulated annealing algorithm and simulated annealing algorithm that converge fast in multi-component system certified most suitable to optimization decision

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 1996.11a
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• pp.286-294
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• 1996

In a remarkable paper 〔3〕, Hammons et al. showed that, when properly defined, the binary nonlinear Preparata code can be considered as the Gray map of a linear code eve. Z$_4$, the so-called Preparata code eve. Z$_4$. Recently, Yang and Helleseth 〔12〕 considered the generalized Hamming weights d$\_$r/(m) for Preparata codes of length 2$\^$m/ over Z$_4$ and exactly determined d$\_$r/, for r = 0.5,1.0,1.5,2,2.5 and 3.0. In particular, they completely determined d$\_$r/(m) for any r in the case of m $\leq$ 6. In this paper we show that the Preparata code of length 16 over Z$_4$ does not satisfy the chain condition.

• Journal of applied mathematics & informatics
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• v.27 no.5_6
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• pp.1119-1132
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• 2009

In this paper, we consider the quasilinear elliptic system $\\div(|{\nabla}u|^{p-2}{\nabla}u)=u(a_1u^{m1}+b_1(x)u^m+{\delta}_1v^n),\;\\div(|{\nabla}_v|^{q-2}{\nabla}v)=v(a_2v^{r1}+b_2(x)v^r+{\delta}_2u^s)$, in $\Omega$ where m > $m_1$ > p-2, r > $r_1$ > q-, p, q $\geq$ 2, and ${\Omega}{\subset}R^N$ is a smooth bounded domain. By constructing certain super and subsolutions, we show the existence of positive blow-up solutions and give a global estimate.

• Molecules and Cells
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• v.40 no.5
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• pp.322-330
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• 2017

This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anti-cancer drug-resistant $Malme3M^R$ cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and $Malme3M^R$ cells. Furthermore, the self-renewal activity and the tumorigenic potential of $Malme3M^R$-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.

• Kyungpook Mathematical Journal
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• v.59 no.1
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• pp.149-161
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• 2019

In the present paper, we study curvature properties of ${\eta}$-Ricci solitons on para-Kenmotsu manifolds. We obtain some results of ${\eta}$-Ricci solitons on para-Kenmotsu manifolds satisfying $R({\xi},X).C=0$, $R({\xi},X).{\tilde{M}}=0$, $R({\xi},X).P=0$, $R({\xi},X).{\tilde{C}}=0$ and $R({\xi},X).H=0$, where $C,\;{\tilde{M}},\;P,\;{\tilde{C}}$ and H are a quasi-conformal curvature tensor, a M-projective curvature tensor, a pseudo-projective curvature tensor, and a concircular curvature tensor and conharmonic curvature tensor, respectively.

• Journal of the Korea Society of Computer and Information
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• v.16 no.8
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• pp.103-108
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• 2011

Generally, Miller-Rabin method has been the most popular primality test. This method arbitrary selects m at k-times from m=[2, n-1] range and (m,n)=1. Miller-Rabin method performs $k{\times}r$ times and reports prime as $m^d\;{\equiv}\;1(mod\;n)$ or $m^{2^rd}\;{\equiv}\;-1(mod n)$ such that n-1=$2^sd$, $0\;{\leq}\;r\;{\leq}\;s-1$. This paper suggests more simple primality test than Miller-Rabin method. This test method computes c=$p^{\frac{n-1}{2}}(mod\;n)$ for k times and reports prime as c=-1. The proposed primality test method reduces $k{\times}r$ times of Miller-Rabin method to k times.

• Applied Biological Chemistry
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• v.32 no.3
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• pp.315-320
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• 1989

Bacteria utilizing naphthalene as a sole carbon source for growth were isolated and identified and code named as Acinetobacter calcoaceticus R-88, Pseudomonas testosteroni R-87 and Pseudomonas putida R-89. Among these isolates, A. calcoaceticus R-88 found most effective in utilizing naphthalene. The optimal pH, temperature and concentration of naphthalene was 7.0, $30^{\circ}C$ and 10mM, respectively. The strain degraded naphthalene to salicylic acid as an intermediate. And the strain showed to be resistant to ampicillin, tetracyclin, chloramphenicol and kanamycin. A. calcoaceticus R-88 harbored plasmid DNA which was believed to be involved in naphthalene degradation.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.4
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• pp.337-343
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• 2009

Purpose: ((R)-1-(2-chlorophenyl)-N-1-[$^{11}$C]methyl-N(1-propyl)-3-isoquinoline carboxamide ((R)-PK11195) is a specific ligand for the peripheral type benzodiazepine receptor and a marker of activated microglia, used to measure inflammation in neurologic disorders. We report here that a direct and simple radiosynthesis of [$^{11}$C](R)-PK11195 in mild condition using NaH suspension in DMF and one-step loop method. Materials and Methods: (R)-N-Desmethyl-PK11195 (1 mg) in DMSO (0.1 mL) and NaH suspension in DMF (0.1 mL) were injected into a semi-prep HPLC loop. [$^{11}$C]methyl iodide was passed through HPLC loop at room temperature. Purification was performed using semi-preparative HPLC. Aliquots eluted at 11.3 min were collected and analyzed by analytical HPLC and mass spectrometer. Results: The labeling efficiency of [$^{11}$C](R)-PK11195 was 71.8$\pm$8.5%. The specific activity was 11.8:$\pm$6.4 GBq/$\mu$mol and radiochemical purity was higher than 99.2%. The mass spectrum of the product eluted at 11.3 min showed m/z peaks at 353.1 (M+1), indicating the mass and structure of (R)-PK11195. Conclusion: By the one-step loop method with the [$^{11}$C]CH3l automated synthesis module, [$^{11}C$](R)-PK11195 could be easily prepared in high radiochemical yield using NaH suspension in DMF.

• Journal of Microbiology and Biotechnology
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• v.25 no.5
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• pp.672-680
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• 2015

As a global regulatory gene in Streptomyces, afsR can activate the biosynthesis of many secondary metabolites. The effect of afsR on the biosynthesis of a phenazine metabolite, lomofungin, was studied in Streptomyces lomondensis S015. There was a 2.5-fold increase of lomofungin production in the afsR-overexpressing strain of S. lomondensis S015 N1 compared with the wild-type strain. Meanwhile, the transcription levels of afsR and two important genes involved in the biosynthesis of lomofungin (i.e., phzC and phzE) were significantly upregulated in S. lomondensis S015 N1. The optimization of metal chlorides was investigated to further increase the production of lomofungin in the afsR-overexpressing strain. The addition of different metal chlorides to S. lomondensis S015 N1 cultivations showed that CaCl₂, FeCl₂, and MnCl₂ led to an increase in lomofungin biosynthesis. The optimum concentrations of these metal chlorides were obtained using response surface methodology. CaCl₂ (0.04 mM), FeCl₂ (0.33 mM), and MnCl₂ (0.38 mM) gave a maximum lomofungin production titer of 318.0 ± 10.7 mg/l, which was a 4.1-fold increase compared with that of S. lomondensis S015 N1 without the addition of a metal chloride. This work demonstrates that the biosynthesis of phenazine metabolites can be induced by afsR. The results also indicate that metal chlorides addition might be a simple and useful strategy for improving the production of other phenazine metabolites in Streptomyces.