• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.205-205
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• 2002

Two formulations of tiropramide {(${\pm}$)${\alpha}$-(benzoylamino)-4-[2-(diethylamino)-ethoxy]-N,N-dipropyl-benzenepropanamide hydrochloride}, an antispasmodic agent, were orally administered to 16 healthy Korean male volunteers by Latin crossover design with the purpose of evaluating bioeqivalence and phamacokinetics of tiropramide. Tiropramide in human plasma was determined by a gas chromatography/nitrogen phosphorus detector. Detection limit of tiropramide was 5 ng/ml. C$\_$max/ values in test and reference formulations were 93.9 ${\pm}$ 54.3 and 96.4 ${\pm}$ 51.6 ng/ml, respectively. AUC$\_$0\longrightarrowlast/ and AUC$\_$0\longrightarrowinf/ were, respectively, 330.7 ${\pm}$ 193.9 and 349.5 ${\pm}$ 205.3 ng.hr/ml for test formulation, 348.9 ${\pm}$ 207.7 and 380.8 ${\pm}$ 239.0 ng.hr/ml for reference formulation. Terminal half-life was 2.3-2.6 hr. Bioavailability differences for C/aub max/ and AUC$\_$0\longrightarrowlast/ were 2.48% and 5.22%, respectively. Minimum detection differences were less than 20% in both C$\_$max/ AUC. Based on this results, two formulations of tiropramide were considered to be bioequivalent

• Journal of Korean Society for Atmospheric Environment
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• v.16 no.4
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• pp.309-316
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• 2000

Chemical compositions of air pollutants with fine particles (<2.5 ${\mu}{\textrm}{m}$, PB2.5) were evaluated at background site. Kangwha. in Korea during the winter season. The data set was obtained for seventeed days with 24-hour sampling from December 11 to 16, 1996 and from January 9 to 1997. The chemical species have been measured {{{{ {SO }`_{4 } ^{2- } }}}}, {{{{ { NO}`_{3 } ^{- } }}}}, {{{{ { NH}`_{4 } ^{+ } }}}}. OC and EC in the particulate phase, NH3 HNO3, HCl and SO2 in the gas phase using the three stage filter pack method. Mean concentration ($\mu\textrm{g}$/m3) of this study were : 35.42 for PM2.5 8.78 for organic carbon (OC) 7.25 for nss {{{{ {SO }`_{4 } ^{2- } }}}}, 4.94 for {{{{ { NO}`_{3 } ^{- } }}}}, 3.58 for {{{{ { NH}`_{4 } ^{+ } }}}} and 1.48 for elemental carbon (EC) respectively. Contributive rates of major particulate components in PM2.5 were OC (25%) nss- {{{{ {SO }`_{4 } ^{2- } }}}}(20%) ,{{{{ { NO}`_{3 } ^{- } }}}}(14%) {{{{ { NH}`_{4 } ^{+ } }}}}(10%) and EC (4%) respectively and these components could be accounted for 73% of PM2.5 mass. Reactive forms of {{{{ { NH}`_{4 } ^{+ } }}}} were considered as NH4HO3 and NH4{{{{ {SO }`_{4 } ^{2- } }}}} during the sampling periods. {{{{ { NO}`_{3 } ^{- } }}}}/({{{{ { NO}`_{3 } ^{- } }}}} + HNO3) and {{{{ {SO }`_{4 } ^{2- } }}}}/({{{{ {SO }`_{4 } ^{2- } }}}} + SO2) were calculated 0.8 and 0.9 respectively. Most of these compounds might be formed in partiiculate phase in the air. Correlation coefficient between OC and EC was 0.866 which might have the same sources during the sampling periods,.

• Journal of Astronomy and Space Sciences
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• v.26 no.4
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• pp.417-420
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• 2009

We have used the near-infrared $JHK_S$ photometric data of resolved stars in a nearby dwarf elliptical galaxy NGC 205 to determine the magnitudes of the red giant branch tip (TRGB). By applying Savitzky-Golay filter to the observed luminosity functions (LFs) in each band, we derived the second derivatives of the LFs so as to determine the magnitudes of the TRGB. Absolute magnitudes of the TRGB in $JHK_S$ bands were measured from the Yonsei-Yale isochrones. By comparing the determined apparent magnitudes and the theoretical absolute magnitudes of the TRGB, we estimated the distance moduli of NGC 205 to be (m - M) = $24.10{\pm}0.08$, $24.08{\pm}0.12$ and $24.14{\pm}0.14$ in J, H, and $K_S$ bands, respectively.

• Asian Journal of Atmospheric Environment
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• v.9 no.3
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• pp.205-213
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• 2015

The objective of the current study was to assess the comparative risk associated with exposure to particulate matter (PM) while commuting via different public transport modes in Fukuoka, Japan. For the given routes and measuring days, a trip-maker carried a lightweight portable bag loaded the real-time measurement devices which take simultaneous measurement for size-fractioned particle number concentration, $PM_{2.5}$ mass concentration, and total suspended particle (TSP) collection. The results of the present study have shown significant differences between public transports as commuting modes in Fukuoka. The PM exposure levels on subway platform and inside subway train were overwhelmingly higher than those of other points on commuting route. The relative ratio between modes (i.e., the ratio of $PM_{2.5}$ inside subway to that inside bus) provides an idea for choosing a right commuting mode for our health. This study clearly provided evidence of the extremely high levels of iron exposure by subway uses compared to bus uses. The result of theoretically reconstructed mass concentration of $PM_{2.0-0.3}$ collected on subway platform suggests that the PM of underground subway will be associated with PM both generated in subway system and inleakaged from outdoor environment.

• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.35.3-36
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• 2009

To investigate properties of the stellar contents of the resolved asymptotic giant branch stars in the nearby dwarf galaxies, we obtained wide-field JHKs images of the dwarf irregular galaxies NGC 6822, IC 1613 and the dwarf elliptical galaxy NGC 205, using the WIRCam near-infrared imager of the CFHT. The obtained (J-Ks, Ks) and (H-Ks, Ks) color-magnitude diagrams for the resolved stars in the galaxies contain populations of foreground stars, super giant stars, red giant stars and the asymptotic giant branch (AGB) stars. Using corollary photometric data in the visible bands, AGB stars were selected in the color-magnitude diagrams with a wide wavelength baseline in color indices. In color-color diagrams of the resolved AGB stars, we identified C stars from M giant stars for each galaxies, i.e., 726 C stars in NGC 6822, 126 C stars in IC 1613 and 593 C stars in NGC 205. The number ratios of C stars to M-giants were estimated to be $0.59\pm0.03$ in NGC 6822, $0.30\pm0.03$ in IC 1613 and $0.14\pm0.01$ in NGC 205. From analyses of the correlations of the spatial distribution of the C/M ratios with the HI properties and dynamical structures of the target galaxies, we discuss environmental effects of the star formation in the galaxies. We also discuss the epochs of the AGB star formation in the galaxies by comparing theoretical isochrones with the color distributions and luminosity functions of the AGB stars.

• Journal of Korean Neurosurgical Society
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• v.49 no.4
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• pp.205-211
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• 2011

Objective : We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats. Methods : The animals were divided into two groups : the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-${\beta}$-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups. Results : At 14 days after SCI, the AT group showed significant improvement of the BBB score by $16.7{\pm}3.4%$, platform hang by $40.0{\pm}9.1%$ and hind foot bar grab by $30.8{\pm}8.4%$ (p<0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group ($0.98{\pm}0.38$) than the control group ($1.34{\pm}0.24$) (p<0.05). The lesion volume in lesion periphery was $32.1{\pm}2.4\;{\mu}L$ in the control and $24.5{\pm}2.3\;{\mu}L$ in the AT group, respectively (p<0.05), and the motor neuron cell number of the anterior horn in lesion periphery was $8.3{\pm}5.1$ cells/HPF in the control and $13.4{\pm}6.3$ cells/HPF in the AT group, respectively (p<0.05). Conclusion : Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery.

• Korean Journal of Applied Biomechanics
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• v.18 no.1
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• pp.53-62
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• 2008

The purpose of this research was to analyze the kinematics of the 205B movement in platform diving. For the experiment, 2 athlete from the national diving team were chosen as the subject and two S -VHS video cameras were used. For this diving players preparing for the olympics participated. It was shown that the mean total took $1.112{\pm}0.12s$. In order to perform better, the divers time must be increased, at take off and rotation must be done high up and the horizontal distance must be shorted to main entrance of the water. To enter the water safely, the jump has to be high, the horizontal speed slow and the vertical speed as fast as possible. At E1 the lower limbs change in speed should decrease and after the rotation begins at E2. At take off, the jump is more important than the rotation for the performance of the dive. At take off, the trunk angular velocity was high, and this was needed to jump high for moment of inertia for rotation because for efficient jumping the upper body has to spread out and increase the height of the center of mass.

• Journal of Digital Convergence
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• v.16 no.10
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• pp.531-536
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• 2018

The purpose of this study is to investigate eye fatigue and analyze symptoms of visual discomfort according to near work in young adults. A survey was conducted on 347 young adults aged 25.37 years (142 male and 205 female participants). The eye fatigue using Conlon questionnaire were surveyed and near work was investigated amounts of daily computer and smartphone. The score of eye fatigue was $13.65{\pm}7.11$ in less than 2 h/d, $16.83{\pm}6.77$ in 2~4 h/d, $18.88{\pm}6.60$ in 4~6 h/d, and $18.83{\pm}5.62$ in more than 6 hours(p=0.001). Also, headache(p<0.030), re-reading(p<0.036), and movement and fading(p<0.001) symptoms increased according to amounts of near work.

• Archives of Pharmacal Research
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• v.16 no.3
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• pp.205-208
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• 1993

($\pm$)-Myodesmone was synthesized, starting from 2-cyclopentenone. The key reaction involved $\alpha$-dimethoxymethylation of 2-cyclopentenone and organocopper conjugate addition reaction.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.666-670
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• 1995

The plasmin activity of euglobulin fraction treated with earthworm extract(EWE) increased concentration dependently when EWE(0.5, 1.0 and 2.0 mg each) were added to normal plasma. It was shown that lumbrokinase in EWE may be moved to euglobulin fraction and activated plasminogen. Also anticoagulation and fibbrinolysis were studied when EWE(7.5, 30 and 120 mg/kg) were added to rat model. Prothrombin time (PT) were 19.7${\pm}$ 3.8, 22.5${\pm}$ 2.5 and 24.5${\pm}$ 5.0sec. activated partial thromboplastin time (APTT) were 25.7${\pm}$ 5.9, 28.7${\pm}$ 5.2 and 36.5${\pm}$ 19.1 sec. After 15 days, the production of D-dimer were 242.3${\pm}$ 47.4, 250.0${\pm}$ 11.9 and 205.8${\pm}$ 12.2mg/ml plasma, respectively. These data showed that EWE acted on the coagulation factor of intrinsic and extrinsic system.