Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury
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Kim, Kyoung-Tae
(Department of Neurosurgery, Kyungpook National University Hospital)
Nam, Taek-Kyun (Department of Neurosurgery, College of Medicine, Chung-Ang University) Park, Yong-Sook (Department of Neurosurgery, College of Medicine, Chung-Ang University) Kim, Young-Baeg (Department of Neurosurgery, College of Medicine, Chung-Ang University) Park, Seung-Won (Department of Neurosurgery, College of Medicine, Chung-Ang University) |
1 | Xu B, Chang SK : Total phenolic, phenolic acid, anthocyanin, flavan-3-ol, and flavonol profiles and antioxidant properties of pinto and black beans (phaseolus vulgaris l.) as affected by thermal processing. J Agric Food Chem 57 : 4754-4764, 2009 DOI ScienceOn |
2 | Yeo SJ, Hwang SN, Park SW, Kim YB, Min BK, Kwon JT, et al. : Development of a rat model of graded contusive spinal cord injury using a pneumatic impact device. J Korean Med Sci 19 : 574-580, 2004 DOI ScienceOn |
3 | Youdim KA, Shukitt-Hale B, MacKinnon S, Kalt W, Joseph JA : Polyphenolics enhance red blood cell resistance to oxidative stress : In vitro and in vivo. Biochim Biophys Acta 1523 : 117-122, 2000 DOI ScienceOn |
4 | Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C : Interaction between flavonoids and the blood-brain barrier : In vitro studies. J Neurochem 85 : 180-192, 2003 DOI ScienceOn |
5 | Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D : Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51 : 675-683, 2007 DOI ScienceOn |
6 | Park E, Velumian AA, Fehlings MG : The role of excitotoxicity in secondary mechanisms of spinal cord injury : a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 21 : 754-774, 2004 DOI ScienceOn |
7 | Qin Y, Xia M, Ma J, Hao Y, Liu J, Mou H, et al. : Anthocyanin supplementation improves serum IDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr 90 : 485-492, 2009 DOI ScienceOn |
8 | Romero I, Teresa Sanchez-Ballesta M, Maldonado R, Isabel Escribano M, Merodio C : Anthocyanin, antioxidant activity and stress-induced gene expression in high CO2-treated table grapes stored at low temperature. J Plant Physiol 165 : 522-530, 2008 DOI ScienceOn |
9 | Seki T, Hida K, Tada M, Koyanagi I, Iwasaki Y : Graded contusion model of the mouse spinal cord using a pneumatic impact device. Neurosurgery 50 : 1075-1081; discussion 1081-1082, 2002 |
10 | Shichinohe H, Kuroda S, Yasuda H, Ishikawa T, Iwai M, Horiuchi M, et al. : Neuroprotective effects of the free radical scavenger edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res 1029 : 200-206, 2004 DOI ScienceOn |
11 | Springer JE, Rao RR, Lim HR, Cho SI, Moon GJ, Lee HY, et al. : The functional and neuroprotective actions of Neu2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury. J Neurotrauma 27 : 139-149, 2010 DOI ScienceOn |
12 | Shin WH, Park SJ, Kim EJ : Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats. Life Sci 79 : 130-137, 2006 DOI ScienceOn |
13 | SiesjO BK, Agardh CD, Bengtsson F : Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1 : 165-211, 1989 |
14 | Spormann TM, Albert FW, Rath T, Dietrich H, Will F, Stockis JP, et al. : Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiol Biomarkers Prev 17 : 3372-3380, 2008 DOI ScienceOn |
15 | Steed LE, Truong VD : Anthocyanin content, antioxidant activity, and selected physical properties of flowable purple-fleshed sweetpotato purees. J Food Sci 73 : S215-S221, 2008 DOI |
16 | Tsuda T, Horio F, Kitoh J, Osawa T : Protective effects of dietary cyanidin 3-O-beta-D-glucoside on liver ischemia-reperfusion injury in rats. Arch Biochem Biophys 368 : 361-366, 1999 DOI ScienceOn |
17 | Hausmann ON : Post-traumatic inflammation following spinal cord injury. Spinal Cord 41 : 369-378, 2003 DOI ScienceOn |
18 | Iwai M, Liu HW, Chen R, Ide A, Okamoto S, Hata R, et al. : Possible inhibition of focal cerebral ischemia by angiotensin ii type 2 receptor stimulation. Circulation 110 : 843-848, 2004 DOI ScienceOn |
19 | Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, et al. : Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19 : 8114-8121, 1999 |
20 | Kang TH, Hur JY, Kim HB, Ryu JH, Kim SY : Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia. Neurosci Lett 391 : 122-126, 2006 DOI ScienceOn |
21 | Koide T, Hashimoto Y, Kamei H, Kojima T, Hasegawa M, Terabe K : Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo. Cancer Biother Radiopharm 12 : 277-280, 1997 |
22 | Liu S, Liu M, Peterson S, Miyake M, Vallyathan V, Liu KJ : Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke. J Neurosci Res 71 : 882-888, 2003 DOI ScienceOn |
23 | Kuhn PL, Wrathall JR : A mouse model of graded contusive spinal cord injury. J Neurotrauma 15 : 125-140, 1998 DOI ScienceOn |
24 | Kuroda S, Siesjo BK : Reperfusion damage following focal ischemia : pathophysiology and therapeutic windows. Clin Neurosci 4 : 199-212, 1997 |
25 | Liu D, Liu J, Sun D, Wen J : The time course of hydroxyl radical formation following spinal cord injury : the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma 21 : 805-816, 2004 DOI ScienceOn |
26 | Matsumoto H, Inaba H, Kishi M, Tominaga S, Hirayama M, Tsuda T : Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J Agric Food Chem 49 : 1546-51, 2001 DOI ScienceOn |
27 | Miyazawa T, Nakagawa K, Kudo M, Muraishi K, Someya K : Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. J Agric Food Chem 47 : 1083-1091, 1999 DOI ScienceOn |
28 | Aoyama T, Hida K, Kuroda S, Seki T, Yano S, Shichinohe H, et al. : Edaravone (mci-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model. Neurol Med Chir (Tokyo) 48 : 539-545; discussion 545, 2008 DOI ScienceOn |
29 | Bao F, Liu D : Hydroxyl radicals generated in the rat spinal cord at the level produced by impact injury induce cell death by necrosis and apoptosis : protection by a metalloporphyrin. Neuroscience 126 : 285-295, 2004 DOI ScienceOn |
30 | Basso DM, Beattie MS, Bresnahan JC : A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12 : 1-21, 1995 DOI ScienceOn |
31 | Basso DM, Beattie MS, Bresnahan JC : Graded histological and locomo tor outcomes after spinal cord contusion using the nyu weight-drop device versus transection. Exp Neurol 139 : 244-256, 1996 DOI ScienceOn |
32 | Beekwilder J, Hall RD, de Vos CH : Identification and dietary relevance of antioxidants from raspberry. Biofactors 23 : 197-205, 2005 DOI ScienceOn |
33 | Cohen DM, Patel CB, Ahobila-Vajjula P, Sundberg LM, Chacko T, Liu SJ, et al. : Blood-spinal cord barrier permeability in experimental spinal cord injury : Dynamic contrast-enhanced MRI. NMR Biomed 22 : 332-341, 2009 DOI ScienceOn |
34 | Bellido GG, Beta T : Anthocyanin composition and oxygen radical scavenging capacity (ORAC) of milled and pearled purple, black, and common barley. J Agric Food Chem 57 : 1022-8, 2009 DOI ScienceOn |
35 | Blight AR : Miracles and molecules--progress in spinal cord repair. Nat Neurosci 5 Suppl : 1051-1054, 2002 DOI |
36 | Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, et al. : Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 7 : 309-316, 2004 DOI ScienceOn |
37 | Elisia I, Kitts DD : Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells. Mol Cell Biochem 312 : 139-145, 2008 DOI |
38 | Gabrielska J, Oszmianski J, Komorowska M, Langner M : Anthocyanin extracts with antioxidant and radical scavenging effect. Z Naturforsch C 54 : 319-324, 1999 |
39 | Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA : Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging 27 : 344-350, 2006 DOI ScienceOn |
40 | Amorini AM, Lazzarino G, Galvano F, Fazzina G, Tavazzi B, Galvano G : Cyanidin-3-o-beta-glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free Radic Res 37 : 453-460, 2003 DOI ScienceOn |
41 | Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF : Direct inhibition of the mitochondrial permeability transition pore : a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J 18 : 869-871, 2004 DOI |
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